KEGG   PATHWAY: lbb03013
Entry
lbb03013                    Pathway                                
Name
Nucleocytoplasmic transport - Lycium barbarum (goji berry)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
lbb03013  Nucleocytoplasmic transport
lbb03013

Other DBs
GO: 0050658
Organism
Lycium barbarum (goji berry) [GN:lbb]
Gene
132609166  aladin [KO:K14320]
132636949  zinc finger CCCH domain-containing protein 16 isoform X1 [KO:K14321]
132641178  mRNA export factor GLE1 isoform X1 [KO:K18723]
132606928  DEAD-box ATP-dependent RNA helicase 38 [KO:K18655] [EC:5.6.2.7]
132619678  protein RAE1-like [KO:K14298]
132606407  protein RAE1-like [KO:K14298]
132633042  nuclear pore complex protein NUP96 [KO:K14297]
132621531  nuclear pore complex protein NUP98A-like [KO:K14297]
132622268  nuclear pore complex protein NUP98A isoform X1 [KO:K14297]
132626500  nuclear pore complex protein NUP214 isoform X1 [KO:K14317]
132598760  nuclear pore complex protein NUP88 [KO:K14318]
132610967  RAN GTPase-activating protein 1-like [KO:K14319]
132644963  RAN GTPase-activating protein 2 [KO:K14319]
132632019  SUMO-conjugating enzyme UBC9 [KO:K10577]
132632634  SUMO-conjugating enzyme SCE1-like [KO:K10577]
132617189  SUMO-conjugating enzyme SCE1-like [KO:K10577]
132604084  SUMO-conjugating enzyme SCE1-like [KO:K10577]
132604085  SUMO-conjugating enzyme SCE1-like [KO:K10577]
132621726  SUMO-conjugating enzyme SCE1-like [KO:K10577]
132627834  SUMO-conjugating enzyme SCE1 [KO:K10577]
132609922  ubiquitin-conjugating enzyme E2 10 [KO:K10577]
132598547  nuclear pore complex protein NUP160 isoform X1 [KO:K14303]
132635818  nuclear pore complex protein NUP85 [KO:K14304]
132633408  protein transport protein SEC13 homolog B-like [KO:K14004]
132616801  protein transport protein SEC13 homolog B-like [KO:K14004]
132621217  protein transport protein SEC13 homolog B [KO:K14004]
132603757  nuclear pore complex protein NUP107 isoform X1 [KO:K14301]
132616955  nuclear pore complex protein NUP133 [KO:K14300]
132634808  protein SEH1 [KO:K14299]
132602908  nuclear pore complex protein NUP43 [KO:K14305]
132645764  nuclear pore complex protein NUP62 [KO:K14306]
132621504  nuclear pore complex protein NUP58 [KO:K14307]
132617184  nuclear pore complex protein NUP54 [KO:K14308]
132636722  nuclear pore complex protein NUP205 [KO:K14310]
132606141  uncharacterized protein LOC132606141 isoform X1 [KO:K14311]
132641639  nuclear pore complex protein NUP155 isoform X1 [KO:K14312]
132613511  nuclear pore complex protein NUP93A-like [KO:K14309]
132633406  nuclear pore complex protein NUP35 [KO:K14313]
132632386  uncharacterized protein LOC132632386 [KO:K14315]
132623441  nuclear pore complex protein GP210 [KO:K14314]
132616903  uncharacterized protein LOC132616903 [KO:K20724]
132643105  nuclear-pore anchor [KO:K09291]
132634976  uncharacterized protein LOC132634976 isoform X1 [KO:K14295]
132612728  importin subunit alpha-2-like [KO:K15042]
132598462  importin subunit alpha-4 [KO:K15042]
132605568  importin subunit alpha isoform X1 [KO:K15042]
132624019  importin subunit alpha-1a-like [KO:K15042]
132607097  importin subunit alpha-9 [KO:K15042]
132626651  importin subunit alpha-2-like [KO:K15042]
132609079  importin subunit alpha-2-like isoform X1 [KO:K15042]
132630906  importin subunit beta-1-like [KO:K14293]
132632107  importin subunit beta-1 [KO:K14293]
132639698  importin subunit beta-1-like [KO:K14293]
132599352  transportin-1 [KO:K18752]
132601121  transportin MOS14 [KO:K15436]
132623038  transportin MOS14 isoform X1 [KO:K15436]
132598694  uncharacterized protein LOC132598694 [KO:K20221]
132616053  uncharacterized protein LOC132616053 [KO:K20222]
132636808  uncharacterized protein LOC132636808 isoform X1 [KO:K20222]
132604637  uncharacterized protein LOC132604637 [KO:K20222]
132624909  uncharacterized protein LOC132624909 isoform X1 [KO:K20222]
132624936  uncharacterized protein LOC132624936 isoform X1 [KO:K20222]
132624961  uncharacterized protein LOC132624961 [KO:K20222]
132626479  uncharacterized protein LOC132626479 [KO:K20222]
132611138  importin beta-like SAD2 [KO:K20223]
132641869  uncharacterized protein LOC132641869 [KO:K20224]
132630871  uncharacterized protein LOC132630871 isoform X1 [KO:K25201]
132634702  uncharacterized protein LOC132634702 isoform X1 [KO:K13151]
132632233  protein EXPORTIN 1A isoform X1 [KO:K14290]
132633319  exportin-2-like [KO:K18423]
132633532  exportin-T [KO:K14288]
132618594  uncharacterized protein LOC132618594 isoform X1 [KO:K25203]
132645217  protein HASTY 1 isoform X1 [KO:K14289]
132626568  uncharacterized protein LOC132626568 isoform X1 [KO:K18460]
132635774  GTP-binding nuclear protein Ran-3 [KO:K07936]
132636744  GTP-binding nuclear protein Ran2-like [KO:K07936]
132636761  GTP-binding nuclear protein Ran-3-like [KO:K07936]
132637953  GTP-binding nuclear protein Ran-3-like [KO:K07936]
132626570  GTP-binding nuclear protein Ran-B1-like [KO:K07936]
132609784  GTP-binding nuclear protein Ran-3-like [KO:K07936]
132600368  elongation factor 1-alpha-like [KO:K03231]
132600444  elongation factor 1-alpha [KO:K03231]
132605115  elongation factor 1-alpha-like [KO:K03231]
132605945  elongation factor 1-alpha-like [KO:K03231]
132605946  elongation factor 1-alpha-like [KO:K03231]
132605948  elongation factor 1-alpha-like [KO:K03231]
132605949  elongation factor 1-alpha-like [KO:K03231]
132628019  uncharacterized protein LOC132628019 [KO:K14291]
132627445  nuclear cap-binding protein subunit 1 [KO:K12882]
132621624  nuclear cap-binding protein subunit 2-like isoform X1 [KO:K12883]
132626892  nuclear cap-binding protein subunit 2-like [KO:K12883]
132614403  uncharacterized protein LOC132614403 [KO:K07562]
132642668  uncharacterized protein LOC132642668 [KO:K07562]
132627105  RNA-binding protein Y14A-like [KO:K12876]
132644031  RNA-binding protein Y14A-like [KO:K12876]
132611087  protein mago nashi homolog [KO:K12877]
132638562  protein mago nashi homolog isoform X1 [KO:K12877]
132613923  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:5.6.2.7]
132627470  uncharacterized protein LOC132627470 isoform X1 [KO:K12875]
132627471  uncharacterized protein LOC132627471 [KO:K12875]
132640622  histone deacetylase complex subunit SAP18 [KO:K14324]
132627484  serine/arginine-rich splicing factor SR45 isoform X1 [KO:K14325]
132598736  uncharacterized protein LOC132598736 [KO:K13114]
132613677  THO complex subunit 4D-like isoform X1 [KO:K12881]
132616185  THO complex subunit 4D-like [KO:K12881]
132606119  THO complex subunit 4A-like [KO:K12881]
132606865  THO complex subunit 4A-like [KO:K12881]
132643535  THO complex subunit 4B [KO:K12881]
132615373  regulator of nonsense transcripts UPF2 [KO:K14327]
132598631  regulator of nonsense transcripts UPF3 [KO:K14328]
132636226  DEAD-box ATP-dependent RNA helicase 15 [KO:K12812] [EC:5.6.2.7]
132639934  DEAD-box ATP-dependent RNA helicase 15-like [KO:K12812] [EC:5.6.2.7]
132631567  uncharacterized protein LOC132631567 isoform X1 [KO:K13171]
132598725  partner of Y14 and mago isoform X1 [KO:K14294]
132645360  THO complex subunit 1 isoform X1 [KO:K12878]
132640974  THO complex subunit 2 isoform X1 [KO:K12879]
132627851  THO complex subunit 5B-like [KO:K13174]
132600765  THO complex subunit 7A-like [KO:K13176]
132626277  THO complex subunit 7A-like [KO:K13176]
132618560  THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
lbb03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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