KEGG   PATHWAY: lcat03040
Entry
lcat03040                   Pathway                                
Name
Spliceosome - Lemur catta (Ring-tailed lemur)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
lcat03040  Spliceosome
lcat03040

Other DBs
GO: 0005681
Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123621436  U1 spliceosomal RNA [KO:K14276]
123636051  U1 spliceosomal RNA [KO:K14276]
123640960  U1 spliceosomal RNA [KO:K14276]
123621275  U1 spliceosomal RNA [KO:K14276]
123649590  U1 spliceosomal RNA [KO:K14276]
123621274  U1 spliceosomal RNA [KO:K14276]
123621435  U1 spliceosomal RNA [KO:K14276]
123630986  U1 spliceosomal RNA [KO:K14276]
123636061  U1 spliceosomal RNA [KO:K14276]
123636052  U1 spliceosomal RNA [KO:K14276]
123636066  U1 spliceosomal RNA [KO:K14276]
123647916  U1 spliceosomal RNA [KO:K14276]
123647913  U1 spliceosomal RNA [KO:K14276]
123630988  U1 spliceosomal RNA [KO:K14276]
123636057  U1 spliceosomal RNA [KO:K14276]
123637503  U2 spliceosomal RNA [KO:K14277]
123643174  U2 spliceosomal RNA [KO:K14277]
123621279  U2 spliceosomal RNA [KO:K14277]
123630999  U2 spliceosomal RNA [KO:K14277]
123631015  U2 spliceosomal RNA [KO:K14277]
123637504  U2 spliceosomal RNA [KO:K14277]
123621282  U2 spliceosomal RNA [KO:K14277]
123621284  U2 spliceosomal RNA [KO:K14277]
123624924  U2 spliceosomal RNA [KO:K14277]
123631040  U4 spliceosomal RNA [KO:K14278]
123626299  U4 spliceosomal RNA [KO:K14278]
123627153  U4 spliceosomal RNA [KO:K14278]
123633601  U4 spliceosomal RNA [KO:K14278]
123628921  U4 spliceosomal RNA [KO:K14278]
123626301  U4 spliceosomal RNA [KO:K14278]
123631036  U4 spliceosomal RNA [KO:K14278]
123622011  U4 spliceosomal RNA [KO:K14278]
123636111  U4 spliceosomal RNA [KO:K14278]
123643014  U4 spliceosomal RNA [KO:K14278]
123638960  U4 spliceosomal RNA [KO:K14278]
123625560  U4 spliceosomal RNA [KO:K14278]
123621305  U4 spliceosomal RNA [KO:K14278]
123640800  U4 spliceosomal RNA [KO:K14278]
123631035  U4 spliceosomal RNA [KO:K14278]
123643015  U4 spliceosomal RNA [KO:K14278]
123631041  U4 spliceosomal RNA [KO:K14278]
123644293  U4 spliceosomal RNA [KO:K14278]
123623724  U4 spliceosomal RNA [KO:K14278]
123637526  U4 spliceosomal RNA [KO:K14278]
123628927  U5 spliceosomal RNA [KO:K14279]
123636118  U5 spliceosomal RNA [KO:K14279]
123631052  U5 spliceosomal RNA [KO:K14279]
123627155  U5 spliceosomal RNA [KO:K14279]
123631053  U5 spliceosomal RNA [KO:K14279]
123636115  U5 spliceosomal RNA [KO:K14279]
123640814  U5 spliceosomal RNA [KO:K14279]
123644176  U5 spliceosomal RNA [KO:K14279]
123633632  U6 spliceosomal RNA [KO:K14280]
123625566  U6 spliceosomal RNA [KO:K14280]
123633644  U6 spliceosomal RNA [KO:K14280]
123636133  U6 spliceosomal RNA [KO:K14280]
123646841  U6 spliceosomal RNA [KO:K14280]
123638966  U6 spliceosomal RNA [KO:K14280]
123650539  U6 spliceosomal RNA [KO:K14280]
123631067  U6 spliceosomal RNA [KO:K14280]
123647808  U6 spliceosomal RNA [KO:K14280]
123645303  U6 spliceosomal RNA [KO:K14280]
123621961  U6 spliceosomal RNA [KO:K14280]
123636121  U6 spliceosomal RNA [KO:K14280]
123644182  U6 spliceosomal RNA [KO:K14280]
123645313  U6 spliceosomal RNA [KO:K14280]
123636153  U6 spliceosomal RNA [KO:K14280]
123644195  U6 spliceosomal RNA [KO:K14280]
123636122  U6 spliceosomal RNA [KO:K14280]
123631087  U6 spliceosomal RNA [KO:K14280]
123631198  U6 spliceosomal RNA [KO:K14280]
123649532  U6 spliceosomal RNA [KO:K14280]
123631104  U6 spliceosomal RNA [KO:K14280]
123640855  U6 spliceosomal RNA [KO:K14280]
123631080  U6 spliceosomal RNA [KO:K14280]
123622019  U6 spliceosomal RNA [KO:K14280]
123643048  U6 spliceosomal RNA [KO:K14280]
123646724  U6 spliceosomal RNA [KO:K14280]
123626739  U6 spliceosomal RNA [KO:K14280]
123638968  U6 spliceosomal RNA [KO:K14280]
123645305  U6 spliceosomal RNA [KO:K14280]
123631090  U6 spliceosomal RNA [KO:K14280]
123648677  U6 spliceosomal RNA [KO:K14280]
123638965  U6 spliceosomal RNA [KO:K14280]
123631059  U6 spliceosomal RNA [KO:K14280]
123644180  U6 spliceosomal RNA [KO:K14280]
123631134  U6 spliceosomal RNA [KO:K14280]
123624943  U6 spliceosomal RNA [KO:K14280]
123648696  U6 spliceosomal RNA [KO:K14280]
123626740  U6 spliceosomal RNA [KO:K14280]
123631078  U6 spliceosomal RNA [KO:K14280]
123643033  U6 spliceosomal RNA [KO:K14280]
123636196  U6 spliceosomal RNA [KO:K14280]
123636128  U6 spliceosomal RNA [KO:K14280]
123633653  U6 spliceosomal RNA [KO:K14280]
123650470  U6 spliceosomal RNA [KO:K14280]
123621313  U6 spliceosomal RNA [KO:K14280]
123628937  U6 spliceosomal RNA [KO:K14280]
123638967  U6 spliceosomal RNA [KO:K14280]
123643037  U6 spliceosomal RNA [KO:K14280]
123640823  U6 spliceosomal RNA [KO:K14280]
123631092  U6 spliceosomal RNA [KO:K14280]
123638972  U6 spliceosomal RNA [KO:K14280]
123624937  U6 spliceosomal RNA [KO:K14280]
123640842  U6 spliceosomal RNA [KO:K14280]
123631085  U6 spliceosomal RNA [KO:K14280]
123622994  U6 spliceosomal RNA [KO:K14280]
123645321  U6 spliceosomal RNA [KO:K14280]
123631083  U6 spliceosomal RNA [KO:K14280]
123650542  U6 spliceosomal RNA [KO:K14280]
123638969  U6 spliceosomal RNA [KO:K14280]
123637787  DDX46; probable ATP-dependent RNA helicase DDX46 isoform X1 [KO:K12811] [EC:5.6.2.7]
123631718  DDX39B; spliceosome RNA helicase DDX39B isoform X1 [KO:K12812] [EC:5.6.2.7]
123631690  DHX16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
123625000  DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1 [KO:K12815] [EC:5.6.2.6]
123633158  CDC40; pre-mRNA-processing factor 17 [KO:K12816]
123625324  PRPF18; pre-mRNA-splicing factor 18 isoform X1 [KO:K12817]
123621002  DHX8; ATP-dependent RNA helicase DHX8 isoform X1 [KO:K12818] [EC:5.6.2.6]
123638001  SLU7; pre-mRNA-splicing factor SLU7 isoform X1 [KO:K12819]
123637337  DHX15; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
123622519  SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 [KO:K11086]
123621911  SNRPD1; small nuclear ribonucleoprotein Sm D1 isoform X1 [KO:K11087]
123638297  small nuclear ribonucleoprotein Sm D2-like [KO:K11096]
123623945  SNRPD2; small nuclear ribonucleoprotein Sm D2 [KO:K11096]
123625708  SNRPD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
123629625  small nuclear ribonucleoprotein E-like [KO:K11097]
123637467  small nuclear ribonucleoprotein E-like [KO:K11097]
123626852  SNRPE; small nuclear ribonucleoprotein E [KO:K11097]
123639426  SNRPF; small nuclear ribonucleoprotein F isoform X1 [KO:K11098]
123637023  SNRPG; small nuclear ribonucleoprotein G [KO:K11099]
123630167  small nuclear ribonucleoprotein G-like [KO:K11099]
123622386  small nuclear ribonucleoprotein G-like [KO:K11099]
123636451  small nuclear ribonucleoprotein G-like [KO:K11099]
123622161  small nuclear ribonucleoprotein G-like [KO:K11099]
123648276  small nuclear ribonucleoprotein G-like [KO:K11099]
123623838  SNRNP70; U1 small nuclear ribonucleoprotein 70 kDa isoform X1 [KO:K11093]
123624302  SNRPA; U1 small nuclear ribonucleoprotein A [KO:K11091]
123646014  U1 small nuclear ribonucleoprotein C-like [KO:K11095]
123632836  SNRPC; U1 small nuclear ribonucleoprotein C [KO:K11095]
123650122  U1 small nuclear ribonucleoprotein C-like [KO:K11095]
123640407  PRPF40B; pre-mRNA-processing factor 40 homolog B isoform X1 [KO:K12821]
123643655  PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
123647161  RBM25; RNA-binding protein 25 isoform X1 [KO:K12822]
123620535  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
123637930  TCERG1; transcription elongation regulator 1 isoform X1 [KO:K12824]
123632692  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
123644362  SNRPA1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
123622125  SNRPB2; U2 small nuclear ribonucleoprotein B'' [KO:K11094]
123642425  U2 small nuclear ribonucleoprotein B'' [KO:K11094]
123625832  SF3A1; splicing factor 3A subunit 1 isoform X1 [KO:K12825]
123633063  SF3A2; splicing factor 3A subunit 2 [KO:K12826]
123635734  SF3A3; splicing factor 3A subunit 3 [KO:K12827]
123643340  SF3B1; splicing factor 3B subunit 1 isoform X1 [KO:K12828]
123642901  SF3B2; splicing factor 3B subunit 2 isoform X1 [KO:K12829]
123625452  SF3B3; splicing factor 3B subunit 3 [KO:K12830]
123628675  splicing factor 3B subunit 4-like [KO:K12831]
123633908  SF3B4; splicing factor 3B subunit 4 isoform X1 [KO:K12831]
123633339  SF3B5; splicing factor 3B subunit 5 [KO:K12832]
123636665  SF3B6; splicing factor 3B subunit 6 [KO:K12833]
123640306  PHF5A; PHD finger-like domain-containing protein 5A [KO:K12834]
123620594  DDX42; ATP-dependent RNA helicase DDX42 isoform X1 [KO:K12835] [EC:5.6.2.7]
123630780  U2AF1; splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836]
123624461  U2AF1L4; splicing factor U2AF 26 kDa subunit [KO:K12836]
123641490  splicing factor U2AF 35 kDa subunit-like [KO:K12836]
123624793  U2AF2; splicing factor U2AF 65 kDa subunit isoform X1 [KO:K12837]
123644889  PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838]
123650329  SMNDC1; survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839]
123623573  RBM17; splicing factor 45 isoform X1 [KO:K12840]
123638070  calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
123630136  U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
123647263  retinitis pigmentosa 9 protein [KO:K19604]
123647265  retinitis pigmentosa 9 protein-like isoform X1 [KO:K19604]
123631750  LSM2; U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
123625626  LSM3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
123638822  LSM4; U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
123647237  LSM5; U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
123638466  LSM6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
123633142  LSM7; U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
123647053  LSM8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
123633917  PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
123646511  PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 isoform X1 [KO:K12662]
123634278  PPIH; peptidyl-prolyl cis-trans isomerase H isoform X1 [KO:K09567] [EC:5.2.1.8]
123624665  PRPF31; U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
123640296  SNU13; NHP2-like protein 1 [KO:K12845]
123637010  SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
123637127  USP39; U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
123641282  SART1; U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
123637871  ZMAT2; zinc finger matrin-type protein 2 [KO:K12848]
123635646  PRPF38A; pre-mRNA-splicing factor 38A isoform X1 [KO:K12849]
123634972  PRPF38B; pre-mRNA-splicing factor 38B [KO:K12850]
123621055  EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
123637204  SNRNP200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
123622799  PRPF6; pre-mRNA-processing factor 6 [KO:K12855]
123620687  PRPF8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
123635860  SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
123640440  DDX23; probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
123621574  TXNL4A; thioredoxin-like protein 4A isoform X1 [KO:K12859]
123641117  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
123642770  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
123631943  CDC5L; cell division cycle 5-like protein [KO:K12860]
123635076  BCAS2; pre-mRNA-splicing factor SPF27 [KO:K12861]
123638504  PLRG1; pleiotropic regulator 1 isoform X1 [KO:K12862]
123642198  CWC15; spliceosome-associated protein CWC15 homolog [KO:K12863]
123622355  CTNNBL1; beta-catenin-like protein 1 [KO:K12864]
123631751  heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
123631752  heat shock 70 kDa protein 1-like [KO:K03283]
123631753  heat shock 70 kDa protein 1 [KO:K03283]
123647169  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
123641226  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
123648561  heat shock cognate 71 kDa protein [KO:K03283]
123628377  PQBP1; polyglutamine-binding protein 1 isoform X1 [KO:K12865]
123632790  LOW QUALITY PROTEIN: WW domain-binding protein 11-like [KO:K12866]
123639969  WBP11; WW domain-binding protein 11 [KO:K12866]
123646032  SNW1; SNW domain-containing protein 1 isoform X1 [KO:K06063]
123635319  XAB2; pre-mRNA-splicing factor SYF1 [KO:K12867]
123634396  SYF2; pre-mRNA-splicing factor SYF2 [KO:K12868]
123622495  CRNKL1; crooked neck-like protein 1 [KO:K12869]
123625646  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
123631834  PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
123635711  PPIE; peptidyl-prolyl cis-trans isomerase E isoform X1 [KO:K09564] [EC:5.2.1.8]
123623603  CCDC12; coiled-coil domain-containing protein 12 isoform X1 [KO:K12871]
123638064  RBM22; pre-mRNA-splicing factor RBM22 [KO:K12872]
123631575  BUD31; protein BUD31 homolog [KO:K12873]
123621836  AQR; RNA helicase aquarius isoform X1 [KO:K12874]
123620402  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
123620501  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
123633882  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
123640006  MAGOHB; protein mago nashi homolog 2 [KO:K12877]
123635633  MAGOH; protein mago nashi homolog [KO:K12877]
123621901  THOC1; THO complex subunit 1 isoform X1 [KO:K12878]
123628852  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
123623495  THOC3; THO complex subunit 3 [KO:K12880]
123650706  ALYREF; THO complex subunit 4 [KO:K12881]
123645948  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
123630423  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
123636788  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A3-like [KO:K12741]
123644320  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
123638010  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
123646050  heterogeneous nuclear ribonucleoprotein A3-like [KO:K12741]
123639738  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
123647363  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
123626594  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
123650245  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
123620418  heterogeneous nuclear ribonucleoprotein A3-like [KO:K12741]
123643746  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
123621009  HNRNPC; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [KO:K12884]
123628865  RBMX; RNA-binding motif protein, X chromosome isoform X1 [KO:K12885]
123623275  RNA-binding motif protein, X chromosome-like [KO:K12885]
123645771  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
123649622  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein M-like [KO:K12887]
123635650  HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887]
123627553  HNRNPU; heterogeneous nuclear ribonucleoprotein U isoform X1 [KO:K12888]
123637013  PCBP1; poly(rC)-binding protein 1 [KO:K12889]
123620441  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
123620498  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
123632881  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
123622505  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
123647392  SRSF5; serine/arginine-rich splicing factor 5 [KO:K12893]
123634289  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
123636819  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
123625928  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
123630354  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
123647110  TRA2A; transformer-2 protein homolog alpha [KO:K12897]
123633325  LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 10-like [KO:K12900]
123634413  SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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