KEGG   PATHWAY: llv04145
Entry
llv04145                    Pathway                                
Name
Phagosome - Lutra lutra (Eurasian river otter)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
llv04145  Phagosome
llv04145

Other DBs
GO: 0045335
Organism
Lutra lutra (Eurasian river otter) [GN:llv]
Gene
125097184  vesicle-associated membrane protein 3 [KO:K13505]
125098279  syntaxin-12 [KO:K13813]
125102294  syntaxin-7 [KO:K08488]
125083044  LOW QUALITY PROTEIN: syntaxin-7-like [KO:K08488]
125092924  actin, cytoplasmic 2-like [KO:K05692]
125093566  actin, cytoplasmic 2-like [KO:K05692]
125102727  actin, cytoplasmic 2-like [KO:K05692]
125087003  actin, cytoplasmic 2 [KO:K05692]
125090635  actin, cytoplasmic 1 [KO:K05692]
125090202  coronin-1A [KO:K13882]
125093536  syntaxin-18 [KO:K08492]
125098317  vesicle-trafficking protein SEC22b [KO:K08517]
125099812  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
125101548  uncharacterized protein LOC125101548 [KO:K06751]
125101549  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
125101800  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
125101803  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
125101804  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
125101807  LOW QUALITY PROTEIN: DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
125101827  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
125102525  LOW QUALITY PROTEIN: DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
125101704  HLA class II histocompatibility antigen, DQ alpha 2 chain-like isoform X1 [KO:K06752]
125101705  HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X1 [KO:K06752]
125101706  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like isoform X1 [KO:K06752]
125102650  HLA class II histocompatibility antigen, DM beta chain-like isoform X1 [KO:K06752]
125102651  HLA class II histocompatibility antigen, DM alpha chain-like [KO:K06752]
125103079  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
125103096  HLA class II histocompatibility antigen, DO alpha chain-like [KO:K06752]
125103134  RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
125103156  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
125103158  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
125103275  HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
125104900  ras-related protein Rab-5A [KO:K07887]
125106523  LOW QUALITY PROTEIN: ras-related protein Rab-5B-like [KO:K07888]
125098886  LOW QUALITY PROTEIN: ras-related protein Rab-5B-like [KO:K07888]
125087087  ras-related protein Rab-5C [KO:K07889]
125106542  early endosome antigen 1 isoform X1 [KO:K12478]
125082224  phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
125102774  transferrin receptor protein 1 isoform X1 [KO:K06503]
125087905  hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
125097455  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
125108782  V-type proton ATPase subunit B, kidney isoform [KO:K02147]
125092834  V-type proton ATPase subunit B, brain isoform [KO:K02147]
125081403  LOW QUALITY PROTEIN: V-type proton ATPase subunit B, brain isoform-like [KO:K02147]
125108633  V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
125098060  V-type proton ATPase subunit C 1 [KO:K02148]
125105210  V-type proton ATPase subunit D [KO:K02149]
125109441  V-type proton ATPase subunit E 2 [KO:K02150]
125109920  LOW QUALITY PROTEIN: V-type proton ATPase subunit E 1-like [KO:K02150]
125106757  V-type proton ATPase subunit E 1 [KO:K02150]
125080880  V-type proton ATPase subunit F [KO:K02151]
125083675  V-type proton ATPase subunit G 1 [KO:K02152]
125102163  V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
125086402  V-type proton ATPase subunit G 3 isoform X1 [KO:K02152]
125082392  V-type proton ATPase subunit G 1-like [KO:K02152]
125099965  V-type proton ATPase subunit e 1 [KO:K02153]
125081016  V-type proton ATPase subunit e 2 [KO:K02153]
125078798  V-type proton ATPase 116 kDa subunit a 3 [KO:K02154]
125087008  V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
125081108  V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
125081901  V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154]
125089625  V-type proton ATPase subunit d 1 [KO:K02146]
125098826  V-type proton ATPase subunit d 2 [KO:K02146]
125098363  V-type proton ATPase subunit H isoform X1 [KO:K02144]
125090416  V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
125098461  V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
125091308  V-type proton ATPase subunit S1 [KO:K03662]
125107830  ras-related protein Rab-7a [KO:K07897]
125086292  ras-related protein Rab-7b [KO:K07898]
125086816  rab-interacting lysosomal protein-like isoform X1 [KO:K13883]
125103645  cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
125079348  cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
125095719  cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
125081214  cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
125105539  cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
125089302  cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
125085593  LOW QUALITY PROTEIN: tubulin alpha chain-like [KO:K07374]
125086043  tubulin alpha-8 chain-like [KO:K07374]
125094690  tubulin alpha-1C chain-like [KO:K07374]
125095116  tubulin alpha-4A chain-like [KO:K07374]
125095140  tubulin alpha-4A chain [KO:K07374]
125096476  tubulin alpha-1C chain-like [KO:K07374]
125088530  tubulin alpha chain-like [KO:K07374]
125097294  tubulin alpha-8 chain-like [KO:K07374]
125106192  tubulin alpha-1A chain [KO:K07374]
125106193  tubulin alpha-1C chain [KO:K07374]
125081884  tubulin alpha-3 chain [KO:K07374]
125081976  tubulin alpha-3 chain-like isoform X1 [KO:K07374]
125106546  LOW QUALITY PROTEIN: tubulin alpha chain-like 3 [KO:K07374]
125106792  tubulin alpha-8 chain isoform X1 [KO:K07374]
125107228  tubulin alpha-1B chain [KO:K07374]
125108883  tubulin beta-1 chain-like isoform X1 [KO:K07375]
125101802  tubulin beta chain [KO:K07375]
125101908  tubulin beta-2A chain [KO:K07375]
125102491  tubulin beta-2B chain [KO:K07375]
125086294  tubulin beta-4A chain [KO:K07375]
125094678  tubulin beta chain-like [KO:K07375]
125082337  tubulin beta-5 chain isoform X1 [KO:K07375]
125082867  tubulin beta-4B chain [KO:K07375]
125089483  uncharacterized protein LOC125089483 [KO:K07375]
125091639  lysosome-associated membrane glycoprotein 2-like isoform X1 [KO:K06528]
125094863  lysosome-associated membrane glycoprotein 1-like isoform X1 [KO:K06528]
125095043  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
125107701  cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
125082424  LOW QUALITY PROTEIN: nitric oxide synthase, brain-like [KO:K13240] [EC:1.14.13.39]
125088054  myeloperoxidase [KO:K10789] [EC:1.11.2.2]
125083577  LOW QUALITY PROTEIN: procathepsin L-like [KO:K01365] [EC:3.4.22.15]
125083642  procathepsin L-like isoform X1 [KO:K01365] [EC:3.4.22.15]
125083644  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
125083645  procathepsin L-like isoform X1 [KO:K01365] [EC:3.4.22.15]
125083647  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
125096876  cathepsin S [KO:K01368] [EC:3.4.22.27]
125107785  protein transport protein Sec61 subunit alpha [KO:K10956]
125107174  protein transport protein Sec61 subunit alpha [KO:K10956]
125083604  protein transport protein Sec61 subunit beta [KO:K09481]
125081039  protein transport protein Sec61 subunit gamma [KO:K07342]
125103272  antigen peptide transporter 1-like [KO:K05653] [EC:7.4.2.14]
125103273  antigen peptide transporter 2-like isoform X1 [KO:K05654] [EC:7.4.2.14]
125083988  calreticulin [KO:K08057]
125099845  calnexin [KO:K08054]
125088835  immunoglobulin alpha Fc receptor-like isoform X1 [KO:K06513]
125099196  high affinity immunoglobulin gamma Fc receptor I-like isoform X1 [KO:K06498]
125086328  low affinity immunoglobulin gamma Fc region receptor III-A [KO:K06463]
125106219  complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
125091026  integrin alpha-M-like isoform X1 [KO:K06461]
125093301  integrin beta-2-like isoform X1 [KO:K06464]
125086252  complement C3-like isoform X1 [KO:K03990]
125109543  collectin-11 isoform X1 [KO:K10066]
125082704  collectin-12 [KO:K10062]
125085160  LOW QUALITY PROTEIN: mannose-binding protein A-like [KO:K03991]
125085159  pulmonary surfactant-associated protein A [KO:K10067]
125085122  pulmonary surfactant-associated protein D-like isoform X1 [KO:K10068]
125094948  LOW QUALITY PROTEIN: integrin alpha-V-like [KO:K06487]
125095857  integrin alpha-V [KO:K06487]
125100104  integrin alpha-2 [KO:K06481]
125106595  integrin alpha-5 [KO:K06484]
125106516  integrin beta-1 isoform X1 [KO:K05719]
125087241  integrin beta-3 [KO:K06493]
125103094  integrin beta-5 isoform X1 [KO:K06588]
125104839  thrombospondin-1 [KO:K16857]
125099919  thrombospondin-4 isoform X1 [KO:K04659]
125085843  thrombospondin-3 isoform X1 [KO:K04659]
125102904  thrombospondin-2 [KO:K04659]
125081937  cartilage oligomeric matrix protein [KO:K04659]
125093126  toll-like receptor 2 [KO:K10159]
125093635  toll-like receptor 6 [KO:K10169]
125083203  toll-like receptor 4 [KO:K10160]
125100878  monocyte differentiation antigen CD14-like [KO:K04391]
125087265  C-type mannose receptor 2 isoform X1 [KO:K06560]
125095449  LOW QUALITY PROTEIN: secretory phospholipase A2 receptor-like [KO:K06560]
125106716  macrophage mannose receptor 1 isoform X1 [KO:K06560]
125085754  CD209 antigen-like protein E isoform X1 [KO:K06563]
125107977  C-type lectin domain family 7 member A-like isoform X1 [KO:K10074]
125107465  natural killer cells antigen CD94-like [KO:K10074]
125091898  macrophage scavenger receptor types I and II-like isoform X1 [KO:K06558]
125096319  macrophage receptor MARCO-like [KO:K13884]
125108000  LOW QUALITY PROTEIN: oxidized low-density lipoprotein receptor 1-like [KO:K08763]
125081851  scavenger receptor class B member 1 isoform X1 [KO:K13885]
125081462  platelet glycoprotein 4 [KO:K06259]
125088746  cytochrome b-245 light chain [KO:K08009]
125091990  LOW QUALITY PROTEIN: cytochrome b-245 heavy chain-like [KO:K21421] [EC:1.-.-.-]
125090900  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
125101158  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
125090471  neutrophil cytosol factor 1 [KO:K08011]
125086177  neutrophil cytosol factor 2 isoform X1 [KO:K08010]
125107787  neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
llv04142  Lysosome
llv04144  Endocytosis
llv04610  Complement and coagulation cascades
llv04612  Antigen processing and presentation
llv04620  Toll-like receptor signaling pathway
llv04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   
LinkDB

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