KEGG   PATHWAY: llv04152
Entry
llv04152                    Pathway                                
Name
AMPK signaling pathway - Lutra lutra (Eurasian river otter)
Description
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class
Environmental Information Processing; Signal transduction
Pathway map
llv04152  AMPK signaling pathway
llv04152

Other DBs
GO: 2000479
Organism
Lutra lutra (Eurasian river otter) [GN:llv]
Gene
125102400  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
125088813  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
125095179  calcium-binding protein 39 [KO:K08272]
125096412  LOW QUALITY PROTEIN: calcium-binding protein 39-like [KO:K08272]
125087834  STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
125095004  STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
125081429  leptin [KO:K05424]
125097207  leptin receptor isoform X1 [KO:K05062]
125081965  calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
125092982  alpha-1A adrenergic receptor isoform X1 [KO:K04135]
125101922  adiponectin [KO:K07296]
125085711  adiponectin receptor protein 1 [KO:K07297]
125106411  adiponectin receptor protein 2 isoform X1 [KO:K07297]
125100268  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
125096749  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
125097369  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
125081898  5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
125096032  5'-AMP-activated protein kinase subunit gamma-3-like isoform X1 [KO:K07200]
125080474  5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
125107078  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
125082434  6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1 [KO:K19028] [EC:2.7.1.105 3.1.3.46]
125085420  6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2-like isoform X1 [KO:K19029] [EC:2.7.1.105 3.1.3.46]
125106204  6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X1 [KO:K01103] [EC:2.7.1.105 3.1.3.46]
125080722  6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform X1 [KO:K19030] [EC:2.7.1.105 3.1.3.46]
125083640  fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
125083850  fructose-1,6-bisphosphatase isozyme 2 isoform X1 [KO:K03841] [EC:3.1.3.11]
125107773  ATP-dependent 6-phosphofructokinase, muscle type isoform X1 [KO:K00850] [EC:2.7.1.11]
125107931  ATP-dependent 6-phosphofructokinase, platelet type isoform X1 [KO:K00850] [EC:2.7.1.11]
125093473  ATP-dependent 6-phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
125108964  hepatocyte nuclear factor 4-alpha isoform X1 [KO:K07292]
125108890  LOW QUALITY PROTEIN: glucose-6-phosphatase 3-like [KO:K01084] [EC:3.1.3.9]
125086776  glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
125087871  glucose-6-phosphatase catalytic subunit 1 isoform X1 [KO:K01084] [EC:3.1.3.9]
125096440  glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
125109569  phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
125104311  phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
125085649  CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
125095039  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
125083953  cyclic AMP-responsive element-binding protein 3-like [KO:K09048]
125085653  cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
125086626  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
125079521  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
125080714  cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
125080867  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
125093590  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
125085866  ELAV-like protein 1 [KO:K13088]
125078419  G1/S-specific cyclin-D1 [KO:K04503]
125084483  LOW QUALITY PROTEIN: cyclin-A1-like [KO:K06627]
125093344  cyclin-A2 isoform X1 [KO:K06627]
125095240  cyclin-A1 [KO:K06627]
125090279  eukaryotic elongation factor 2 kinase [KO:K08292] [EC:2.7.11.20]
125086738  elongation factor 2 [KO:K03234]
125096352  forkhead box protein O1 isoform X1 [KO:K07201]
125101725  LOW QUALITY PROTEIN: forkhead box protein O3-like [KO:K09408]
125084753  NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
125086801  solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
125107979  glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
125089398  glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
125088629  hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
125100135  3-hydroxy-3-methylglutaryl-coenzyme A reductase [KO:K00021] [EC:1.1.1.34]
125087485  sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
125087726  fatty acid synthase-like isoform X1 [KO:K00665] [EC:2.3.1.85]
125087711  acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
125085172  stearoyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
125094210  stearoyl-CoA desaturase 5-like [KO:K00507] [EC:1.14.19.1]
125081691  acetyl-CoA carboxylase 2 isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
125088712  malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
125078256  carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
125106776  carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
125089298  LOW QUALITY PROTEIN: carnitine O-palmitoyltransferase 1, brain isoform-like [KO:K19524] [EC:2.3.1.21]
125082340  cell death activator CIDE-A-like [KO:K25893]
125100552  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
125092347  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
125080841  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
125078654  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like [KO:K03456]
125088881  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
125084629  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
125100707  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
125092893  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
125093522  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform X1 [KO:K04354]
125092240  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like isoform X1 [KO:K11583]
125104060  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
125104143  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
125102373  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
125078767  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
125086066  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
125104126  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
125104827  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
125093627  TBC1 domain family member 1 isoform X1 [KO:K18341]
125097538  ras-related protein Rab-2A [KO:K07877]
125095697  ras-related protein Rab-8A-like [KO:K07901]
125083046  ras-related protein Rab-8A [KO:K07901]
125108699  ras-related protein Rab-10 [KO:K07903]
125085942  ras-related protein Rab-11B [KO:K07905]
125083240  ras-related protein Rab-14 [KO:K07881]
125081083  cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
125081462  platelet glycoprotein 4 [KO:K06259]
125106739  insulin-like growth factor I isoform X1 [KO:K05459]
125105350  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
125079072  insulin [KO:K04526]
125085453  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
125095145  insulin receptor substrate 1 [KO:K16172]
125094825  LOW QUALITY PROTEIN: insulin receptor substrate 2-like [KO:K07187]
125090697  insulin receptor substrate 1-like [KO:K17445]
125092461  insulin receptor substrate 4-like [KO:K17446]
125100627  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125103868  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
125096824  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125099801  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125082268  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
125097558  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
125090410  3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
125086439  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125104283  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125089561  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125090843  tuberin isoform X1 [KO:K07207]
125083259  hamartin isoform X1 [KO:K07206]
125080476  GTP-binding protein Rheb [KO:K07208]
125097001  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
125087610  LOW QUALITY PROTEIN: regulatory-associated protein of mTOR-like [KO:K07204]
125089749  proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
125079637  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
125088191  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
125092750  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
125108518  peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
125081694  serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
Compound
C00003  NAD+
C00008  ADP
C00020  AMP
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00085  D-Fructose 6-phosphate
C00162  Fatty acid
C00354  D-Fructose 1,6-bisphosphate
C00389  Quercetin
C00665  beta-D-Fructose 2,6-bisphosphate
C00668  alpha-D-Glucose 6-phosphate
C00698  Cl-
C00757  Berberine
C01172  beta-D-Glucose 6-phosphate
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07151  Metformin
C09731  Epigallocatechin gallate
D08351  Phenformin (BAN)
Reference
PMID:19584320
  Authors
Steinberg GR, Kemp BE
  Title
AMPK in Health and Disease.
  Journal
Physiol Rev 89:1025-78 (2009)
DOI:10.1152/physrev.00011.2008
Reference
PMID:15509864
  Authors
Hardie DG.
  Title
The AMP-activated protein kinase pathway--new players upstream and downstream.
  Journal
J Cell Sci 117:5479-87 (2004)
DOI:10.1242/jcs.01540
Reference
PMID:23747347
  Authors
Russo GL, Russo M, Ungaro P
  Title
AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
  Journal
Biochem Pharmacol 86:339-50 (2013)
DOI:10.1016/j.bcp.2013.05.023
Reference
PMID:19393004
  Authors
Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
  Title
AMPK in the brain: its roles in energy balance and neuroprotection.
  Journal
J Neurochem 109 Suppl 1:17-23 (2009)
DOI:10.1111/j.1471-4159.2009.05916.x
Reference
PMID:20010958
  Authors
Li J, McCullough LD
  Title
Effects of AMP-activated protein kinase in cerebral ischemia.
  Journal
J Cereb Blood Flow Metab 30:480-92 (2010)
DOI:10.1038/jcbfm.2009.255
Reference
PMID:22700795
  Authors
Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
  Title
The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
  Journal
Am J Physiol Cell Physiol 303:C475-85 (2012)
DOI:10.1152/ajpcell.00125.2012
Reference
PMID:16644802
  Authors
Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
  Title
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
  Journal
J Physiol 574:41-53 (2006)
DOI:10.1113/jphysiol.2006.108506
Reference
PMID:19629071
  Authors
Shackelford DB, Shaw RJ
  Title
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
  Journal
Nat Rev Cancer 9:563-75 (2009)
DOI:10.1038/nrc2676
Reference
PMID:22885100
  Authors
Chung JH, Manganiello V, Dyck JR
  Title
Resveratrol as a calorie restriction mimetic: therapeutic implications.
  Journal
Trends Cell Biol 22:546-54 (2012)
DOI:10.1016/j.tcb.2012.07.004
Reference
PMID:20357764
  Authors
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
  Title
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
  Journal
Nature 464:1313-9 (2010)
DOI:10.1038/nature08991
Reference
PMID:17307971
  Authors
Towler MC, Hardie DG
  Title
AMP-activated protein kinase in metabolic control and insulin signaling.
  Journal
Circ Res 100:328-41 (2007)
DOI:10.1161/01.RES.0000256090.42690.05
Reference
PMID:23899560
  Authors
Richter EA, Hargreaves M
  Title
Exercise, GLUT4, and skeletal muscle glucose uptake.
  Journal
Physiol Rev 93:993-1017 (2013)
DOI:10.1152/physrev.00038.2012
Reference
PMID:16054041
  Authors
Kahn BB, Alquier T, Carling D, Hardie DG
  Title
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
  Journal
Cell Metab 1:15-25 (2005)
DOI:10.1016/j.cmet.2004.12.003
Reference
PMID:23565491
  Authors
Minokoshi Y, Toda C, Okamoto S
  Title
Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
  Journal
Indian J Endocrinol Metab 16:S562-8 (2012)
DOI:10.4103/2230-8210.105573
Reference
PMID:16723978
  Authors
Guggino WB, Stanton BA
  Title
New insights into cystic fibrosis: molecular switches that regulate CFTR.
  Journal
Nat Rev Mol Cell Biol 7:426-36 (2006)
DOI:10.1038/nrm1949
Reference
PMID:16479585
  Authors
Cheng A, Saltiel AR
  Title
More TORC for the gluconeogenic engine.
  Journal
Bioessays 28:231-4 (2006)
DOI:10.1002/bies.20375
Reference
PMID:19197243
  Authors
Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
  Title
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
  Journal
EMBO J 28:677-85 (2009)
DOI:10.1038/emboj.2009.8
Reference
PMID:19724019
  Authors
Morris DL, Rui L
  Title
Recent advances in understanding leptin signaling and leptin resistance.
  Journal
Am J Physiol Endocrinol Metab 297:E1247-59 (2009)
DOI:10.1152/ajpendo.00274.2009
Reference
PMID:18725075
  Authors
Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
  Title
Role of hypothalamic AMP-kinase in food intake regulation.
  Journal
Nutrition 24:786-90 (2008)
DOI:10.1016/j.nut.2008.06.002
Reference
PMID:23024365
  Authors
Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
  Title
Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
  Journal
J Biol Chem 287:40441-7 (2012)
DOI:10.1074/jbc.M112.384545
Related
pathway
llv00010  Glycolysis / Gluconeogenesis
llv00061  Fatty acid biosynthesis
llv00500  Starch and sucrose metabolism
llv01040  Biosynthesis of unsaturated fatty acids
llv04110  Cell cycle
llv04140  Autophagy - animal
llv04150  mTOR signaling pathway
llv04151  PI3K-Akt signaling pathway
llv04910  Insulin signaling pathway
llv04920  Adipocytokine signaling pathway
KO pathway
ko04152   
LinkDB

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