KEGG   PATHWAY: lruf04141
Entry
lruf04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Lynx rufus (bobcat)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
lruf04141  Protein processing in endoplasmic reticulum
lruf04141

Other DBs
GO: 0030433 0034976
Organism
Lynx rufus (bobcat) [GN:lruf]
Gene
124502268  protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
124523778  protein transport protein Sec61 subunit alpha [KO:K10956]
124502337  protein transport protein Sec61 subunit beta [KO:K09481]
124524766  protein transport protein Sec61 subunit gamma [KO:K07342]
124526279  translocation protein SEC62 [KO:K12275]
124528181  translocation protein SEC63 homolog isoform X1 [KO:K09540]
124524050  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
124503548  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
124508801  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
124514765  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
124526017  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
124505043  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
124509546  magnesium transporter protein 1 [KO:K19478]
124521024  tumor suppressor candidate 3 [KO:K19478]
124520821  oligosaccharyltransferase complex subunit OSTC [KO:K26501]
124505090  transmembrane protein 258 [KO:K26502]
124503494  mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
124502096  cytoskeleton-associated protein 4-like [KO:K13999]
124503346  ribosome-binding protein 1 isoform X1 [KO:K14000]
124516206  nucleotide exchange factor SIL1 isoform X1 [KO:K14001]
124505397  hypoxia up-regulated protein 1 isoform X1 [KO:K09486]
124504115  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
124526817  dnaJ homolog subfamily B member 11 [KO:K09517]
124501291  dnaJ homolog subfamily C member 1 isoform X1 [KO:K09521]
124513269  dnaJ homolog subfamily C member 3 isoform X1 [KO:K09523]
124515315  dnaJ homolog subfamily C member 10 isoform X1 [KO:K09530] [EC:1.8.4.-]
124501451  endoplasmin [KO:K09487]
124504941  neutral alpha-glucosidase AB isoform X1 [KO:K05546] [EC:3.2.1.207]
124524109  glucosidase 2 subunit beta isoform X1 [KO:K08288]
124514713  calnexin isoform X1 [KO:K08054]
124508646  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
124523757  calreticulin [KO:K08057]
124528670  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [KO:K01230] [EC:3.2.1.113]
124515010  mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform X1 [KO:K01230] [EC:3.2.1.113]
124515057  mannosyl-oligosaccharide 1,2-alpha-mannosidase IB isoform X1 [KO:K01230] [EC:3.2.1.113]
124522323  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like isoform X1 [KO:K23741] [EC:3.2.1.209]
124522354  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like isoform X1 [KO:K23741] [EC:3.2.1.209]
124520026  vesicular integral-membrane protein VIP36 isoform X1 [KO:K10082]
124517065  protein ERGIC-53 isoform X1 [KO:K10080]
124508408  uncharacterized protein LOC124508408 isoform X1 [KO:K10081]
124503305  prolactin regulatory element-binding protein isoform X1 [KO:K14003]
124506868  GTP-binding protein SAR1a [KO:K07953] [EC:3.6.5.-]
124515769  GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
124523767  protein SEC13 homolog [KO:K14004]
124520123  protein transport protein Sec31A isoform X1 [KO:K14005]
124507063  protein transport protein Sec31B-like [KO:K14005]
124503488  protein transport protein Sec23B [KO:K14006]
124508920  protein transport protein Sec23A [KO:K14006]
124520047  protein transport protein Sec24B isoform X1 [KO:K14007]
124520199  protein transport protein Sec24D isoform X1 [KO:K14007]
124506911  protein transport protein Sec24C isoform X1 [KO:K14007]
124515780  protein transport protein Sec24A [KO:K14007]
124513281  UDP-glucose:glycoprotein glucosyltransferase 2 [KO:K11718] [EC:2.4.1.-]
124514701  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1 [KO:K11718] [EC:2.4.1.-]
124523085  ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
124503048  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
124510157  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
124522502  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
124524096  protein disulfide-isomerase A4 [KO:K09582] [EC:5.3.4.1]
124503422  protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
124518332  endoplasmic reticulum resident protein 29 [KO:K09586]
124528695  thioredoxin domain-containing protein 5 [KO:K13984] [EC:5.3.4.1]
124512189  ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
124518596  ERO1-like protein beta isoform X1 [KO:K10976] [EC:1.8.4.-]
124501161  protein OS-9 isoform X1 [KO:K10088]
124504309  endoplasmic reticulum lectin 1 isoform X1 [KO:K14008]
124527952  translocon-associated protein subunit alpha [KO:K13249]
124521742  translocon-associated protein subunit beta [KO:K13250]
124526324  translocon-associated protein subunit gamma [KO:K13251]
124525856  translocon-associated protein subunit delta isoform X1 [KO:K04571]
124525818  B-cell receptor-associated protein 31 [KO:K14009]
124520546  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
124507705  translocating chain-associated membrane protein 1 [KO:K14010]
124507777  derlin-1 isoform X1 [KO:K11519]
124519471  derlin-2 isoform X1 [KO:K13989]
124519849  derlin-3 isoform X1 [KO:K13989]
124504947  UBX domain-containing protein 1 [KO:K24348]
124514937  UBX domain-containing protein 4 [KO:K24348]
124504301  UBX domain-containing protein 2A isoform X1 [KO:K24349]
124523746  UBX domain-containing protein 6 isoform X1 [KO:K14011]
124520224  UBX domain-containing protein 8 isoform X1 [KO:K24351]
124503508  NSFL1 cofactor p47 [KO:K14012]
124505166  small VCP/p97-interacting protein [KO:K14014]
124501566  transitional endoplasmic reticulum ATPase isoform X1 [KO:K13525]
124522497  nuclear protein localization protein 4 homolog [KO:K14015]
124525663  ubiquitin recognition factor in ER-associated degradation protein 1 isoform X1 [KO:K14016]
124505172  heat shock cognate 71 kDa protein [KO:K03283]
124526648  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
124520272  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
124527622  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
124528066  heat shock 70 kDa protein 1 [KO:K03283]
124528067  heat shock 70 kDa protein 1 [KO:K03283]
124528068  heat shock 70 kDa protein 1-like [KO:K03283]
124511892  dnaJ homolog subfamily A member 1-like [KO:K09502]
124512873  dnaJ homolog subfamily A member 1 [KO:K09502]
124501264  dnaJ homolog subfamily A member 1 isoform X1 [KO:K09502]
124515404  dnaJ homolog subfamily A member 1-like isoform X1 [KO:K09502]
124511288  dnaJ homolog subfamily A member 2 [KO:K09503]
124523242  dnaJ homolog subfamily B member 1 [KO:K09507]
124514776  dnaJ homolog subfamily B member 2 isoform X1 [KO:K09508]
124506892  dnaJ homolog subfamily B member 12 isoform X1 [KO:K09518]
124503224  LOW QUALITY PROTEIN: dnaJ homolog subfamily C member 5G-like [KO:K09525]
124507407  dnaJ homolog subfamily C member 5B [KO:K09525]
124502920  dnaJ homolog subfamily C member 5 [KO:K09525]
124512510  heat shock protein HSP 90-alpha [KO:K04079]
124528527  heat shock protein HSP 90-beta [KO:K04079]
124511361  heat shock protein 105 kDa isoform X1 [KO:K09485]
124520397  heat shock 70 kDa protein 4L [KO:K09485]
124501328  BAG family molecular chaperone regulator 1 [KO:K09555]
124528788  BAG family molecular chaperone regulator 2 [KO:K09556]
124527794  hsp70-binding protein 1 isoform X1 [KO:K09562]
124526903  alpha-crystallin A chain [KO:K09541]
124505814  alpha-crystallin B chain [KO:K09542]
124501115  phospholipase A-2-activating protein isoform X1 [KO:K14018]
124502699  UV excision repair protein RAD23 homolog B [KO:K10839]
124524077  UV excision repair protein RAD23 homolog A isoform X1 [KO:K10839]
124504582  ubiquilin-3-like [KO:K04523]
124521763  ubiquilin-4 isoform X1 [KO:K04523]
124528825  ubiquilin-1 isoform X1 [KO:K04523]
124522300  ubiquilin-2 [KO:K04523]
124526201  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X1 [KO:K01456] [EC:3.5.1.52]
124512567  ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
124514815  ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
124503015  eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
124512103  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
124514555  nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
124502100  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
124510933  protein phosphatase 1 regulatory subunit 15A-like [KO:K14019]
124501398  DNA damage-inducible transcript 3 protein [KO:K04452]
124517105  apoptosis regulator Bcl-2 [KO:K02161]
124509907  cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
124528650  cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
124520606  wolframin [KO:K14020]
124511532  membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
124509407  membrane-bound transcription factor site-2 protease isoform X1 [KO:K07765] [EC:3.4.24.85]
124509409  transcription factor YY2-like [KO:K07765] [EC:3.4.24.85]
124518371  LOW QUALITY PROTEIN: uncharacterized protein LOC124518371 [KO:K09027]
124513530  serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
124522349  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
124528854  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
124523965  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
124520648  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
124506951  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
124514653  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
124510927  apoptosis regulator BAX isoform X1 [KO:K02159]
124528274  bcl-2 homologous antagonist/killer [KO:K14021]
124504804  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
124510321  calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
124504970  caspase-12-like [KO:K04741] [EC:3.4.22.-]
124522575  E3 ubiquitin-protein ligase MARCHF6 isoform X1 [KO:K10661] [EC:2.3.2.27]
124528583  ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
124514978  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
124519706  ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
124526352  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
124505022  E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
124529041  E3 ubiquitin-protein ligase RNF5 [KO:K10666] [EC:2.3.2.27]
124517361  selenoprotein S [KO:K14025]
124504376  protein sel-1 homolog 2 isoform X1 [KO:K14026]
124512593  protein sel-1 homolog 1 [KO:K14026]
124511331  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform X1 [KO:K14027]
124511324  E3 ubiquitin-protein ligase AMFR [KO:K10636] [EC:2.3.2.36]
124525500  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
124520505  ubiquitin-conjugating enzyme E2 D3 isoform X1 [KO:K06689] [EC:2.3.2.23]
124506825  ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
124516310  ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
124528391  E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
124501699  E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
124524656  cullin-1 [KO:K03347]
124515676  S-phase kinase-associated protein 1 [KO:K03094]
124516458  F-box only protein 2 [KO:K10099]
124515094  F-box only protein 6-like isoform X1 [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
lruf00510  N-Glycan biosynthesis
lruf03050  Proteasome
lruf03060  Protein export
lruf04210  Apoptosis
lruf04930  Type II diabetes mellitus
lruf05010  Alzheimer disease
lruf05012  Parkinson disease
lruf05020  Prion disease
KO pathway
ko04141   
LinkDB

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