KEGG   PATHWAY: malb04371
Entry
malb04371                   Pathway                                
Name
Apelin signaling pathway - Monopterus albus (swamp eel)
Description
Apelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various tissues and organ systems. They are implicated in different key physiological processes such as angiogenesis, cardiovascular functions, cell proliferation and energy metabolism regulation. On the other hand, this ligand receptor couple is also involved in several pathologies including diabetes, obesity, cardiovascular disease and cancer.
Class
Environmental Information Processing; Signal transduction
Pathway map
malb04371  Apelin signaling pathway
malb04371

Other DBs
GO: 0060183
Organism
Monopterus albus (swamp eel) [GN:malb]
Gene
109961254  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
109957656  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
109958353  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
109971723  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
109952263  LOW QUALITY PROTEIN: adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
109974016  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
109966043  adcy6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
109968886  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
109955816  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
109971087  LOW QUALITY PROTEIN: adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
109970259  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
109972278  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
109972902  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
109952408  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
109957708  cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
109958253  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
109965931  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
109954692  lipe; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
109958776  LOW QUALITY PROTEIN: hormone-sensitive lipase-like [KO:K07188] [EC:3.1.1.79]
109956057  apln; apelin [KO:K05225]
109954876  apelin receptor A [KO:K04174]
109963468  apelin receptor B-like [KO:K04174]
109973078  apelin receptor B-like [KO:K04174]
109958995  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
109964464  guanine nucleotide-binding protein G(i) subunit alpha-2-like isoform X1 [KO:K04630]
109967176  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
109969698  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
109971728  guanine nucleotide-binding protein G(k) subunit alpha-like [KO:K04630]
109959036  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like [KO:K04536]
109967164  gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
109959438  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
109968899  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3-like isoform X1 [KO:K07825]
109966206  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3-like [KO:K07825]
109958248  gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
109955809  guanine nucleotide-binding protein subunit beta-5-like [KO:K04539]
109972228  gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
109973363  gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
109960430  gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1 [KO:K04540]
109962013  gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
109955359  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
109958219  gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
109952051  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
109959564  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
109957807  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
109954287  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
109972360  gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
109969391  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
109969468  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
109965721  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like isoform X1 [KO:K04347]
109968244  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13-like [KO:K04547]
109968165  guanine nucleotide-binding protein G(T) subunit gamma-T1-like [KO:K04548]
109974891  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2-like [KO:K04549]
109961546  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
109972348  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
109961174  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
109962200  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
109962203  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
109965817  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
109968365  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
109956043  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
109956224  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
109970756  itpr2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
109970976  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
109963283  ryanodine receptor 1-like isoform X1 [KO:K04961]
109959404  LOW QUALITY PROTEIN: ryanodine receptor 1-like [KO:K04961]
109960630  LOW QUALITY PROTEIN: ryanodine receptor 2-like [KO:K04962]
109966672  ryr2; ryanodine receptor 2 isoform X1 [KO:K04962]
109962306  LOW QUALITY PROTEIN: ryanodine receptor 3-like [KO:K04963]
109951636  ryanodine receptor 3-like [KO:K04963]
109963360  calml4; calmodulin-like protein 4 [KO:K02183]
109959045  calml6; calmodulin-like protein 6 isoform X1 [KO:K02183]
109974113  calm2; calmodulin [KO:K02183]
109973529  calm3; calmodulin [KO:K02183]
109972810  calmodulin [KO:K02183]
109969805  calmodulin-alpha-like [KO:K02183]
109959109  nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
109963057  prkce; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
109963810  protein kinase C epsilon type-like [KO:K18050] [EC:2.7.11.13]
109954622  Na(+)/H(+) exchanger beta-like isoform X1 [KO:K05742]
109958593  Na(+)/H(+) exchanger beta-like [KO:K05742]
109961073  slc8a1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
109960408  sodium/calcium exchanger 1-like [KO:K05849]
109952170  sodium/calcium exchanger 2-like isoform X1 [KO:K05849]
109973382  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
109973759  sodium/calcium exchanger 2-like [KO:K05849]
109971832  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
109965816  sodium/calcium exchanger 1-like [KO:K05849]
109970425  mylk; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
109963086  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
109961257  mylk4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
109964253  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
109957741  myosin light chain kinase 2, skeletal/cardiac muscle-like [KO:K00907] [EC:2.7.11.18]
109955954  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
109959694  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
109955390  myosin light chain 4-like [KO:K12749]
109960656  myosin light chain 4-like [KO:K12750]
109972666  myosin light chain 4-like [KO:K12750]
109970774  hras; GTPase HRas [KO:K02833]
109958833  GTPase HRas-like [KO:K07827]
109970760  kras; GTPase KRas isoform X1 [KO:K07827]
109965701  rras2; ras-related protein R-Ras2 [KO:K07830]
109964791  rras; ras-related protein R-Ras [KO:K07830]
109968557  mras; ras-related protein M-Ras [KO:K07831]
109966113  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109971216  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
109974179  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
109967020  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
109958888  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
109951143  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109956821  ribosomal protein S6 kinase beta-2-like isoform X1 [KO:K04688] [EC:2.7.11.1]
109960282  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
109967059  ribosomal protein S6 kinase beta-1-like isoform X1 [KO:K04688] [EC:2.7.11.1]
109961406  rps6; 40S ribosomal protein S6 [KO:K02991]
109961003  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
109970413  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform-like [KO:K21289] [EC:2.7.1.153]
109966248  pik3r5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
109966267  phosphoinositide 3-kinase regulatory subunit 6-like isoform X1 [KO:K21290]
109973467  phosphoinositide 3-kinase regulatory subunit 6-like [KO:K21290]
109973481  phosphoinositide 3-kinase regulatory subunit 5-like isoform X1 [KO:K21290]
109962723  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109960381  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109974815  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
109968350  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109972703  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
109967123  mtor; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
109971184  egr1; early growth response protein 1 [KO:K09203]
109974215  early growth response protein 1-like [KO:K09203]
109961166  jag1; protein jagged-1 [KO:K06052]
109965910  neurogenic locus notch homolog protein 2-like [KO:K20995]
109967859  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
109963611  pde3b; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
109971461  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
109970105  pik3r4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
109963002  becn1; beclin-1 [KO:K08334]
109962563  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
109956995  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
109966899  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
109971783  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
109971334  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
109962062  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
109960834  prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
109954814  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
109969252  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
109952774  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
109955726  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
109964519  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
109957758  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
109974987  prkag2; 5'-AMP-activated protein kinase subunit gamma-2 [KO:K07200]
109966545  ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
109959911  nrf1; nuclear respiratory factor 1 isoform X1 [KO:K11831]
109952461  tfam; transcription factor A, mitochondrial [KO:K11830]
109955375  Krueppel-like factor 2 [KO:K17845]
109972180  Krueppel-like factor 2 [KO:K17845]
109958866  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
109970180  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
109966257  sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
109964702  guanine nucleotide-binding protein subunit alpha-13-like [KO:K04639]
109967924  guanine nucleotide-binding protein subunit alpha-13-like [KO:K04639]
109965258  camk4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
109960503  histone deacetylase 4-like isoform X1 [KO:K11406] [EC:3.5.1.98]
109951094  hdac5; histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
109966311  histone deacetylase 4-like [KO:K11406] [EC:3.5.1.98]
109966546  mef2a; myocyte-specific enhancer factor 2A isoform X1 [KO:K09260]
109966958  mef2b; myocyte-specific enhancer factor 2B isoform X1 [KO:K09261]
109953179  myocyte-specific enhancer factor 2C-like [KO:K04454]
109956951  mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
109958584  myocyte-specific enhancer factor 2D homolog isoform X1 [KO:K09262]
109970062  myocyte-specific enhancer factor 2D homolog isoform X1 [KO:K09262]
109965533  TGF-beta receptor type-1-like isoform X1 [KO:K04674] [EC:2.7.11.30]
109959661  LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 2-like [KO:K04500]
109971207  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
109963341  mothers against decapentaplegic homolog 3 [KO:K23605]
109961575  mothers against decapentaplegic homolog 4 [KO:K04501]
109974571  LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 4-like [KO:K04501]
109970820  mothers against decapentaplegic homolog 4-like [KO:K04501]
109970860  mothers against decapentaplegic homolog 4-like [KO:K04501]
109969639  actin, alpha skeletal muscle B-like [KO:K12313]
109960058  cdh1; cadherin-1 [KO:K05689]
109962147  ctgf; connective tissue growth factor [KO:K06827]
109961497  agtr1; type-1 angiotensin II receptor [KO:K04166]
109956492  plat; LOW QUALITY PROTEIN: tissue-type plasminogen activator [KO:K01343] [EC:3.4.21.68]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00290  Fibrin
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
Reference
PMID:26143239
  Authors
Yang P, Maguire JJ, Davenport AP
  Title
Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system.
  Journal
Trends Pharmacol Sci 36:560-7 (2015)
DOI:10.1016/j.tips.2015.06.002
Reference
PMID:22140623
  Authors
Andersen CU, Hilberg O, Mellemkjaer S, Nielsen-Kudsk JE, Simonsen U
  Title
Apelin and pulmonary hypertension.
  Journal
Pulm Circ 1:334-46 (2011)
DOI:10.4103/2045-8932.87299
Reference
PMID:25275559
  Authors
Chapman NA, Dupre DJ, Rainey JK
  Title
The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR.
  Journal
Biochem Cell Biol 92:431-40 (2014)
DOI:10.1139/bcb-2014-0072
Reference
PMID:18272138
  Authors
Japp AG, Newby DE
  Title
The apelin-APJ system in heart failure: pathophysiologic relevance and therapeutic potential.
  Journal
Biochem Pharmacol 75:1882-92 (2008)
DOI:10.1016/j.bcp.2007.12.015
Reference
PMID:25652330
  Authors
Folino A, Montarolo PG, Samaja M, Rastaldo R
  Title
Effects of apelin on the cardiovascular system.
  Journal
Heart Fail Rev 20:505-18 (2015)
DOI:10.1007/s10741-015-9475-x
Reference
PMID:23943882
  Authors
O'Carroll AM, Lolait SJ, Harris LE, Pope GR
  Title
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis.
  Journal
J Endocrinol 219:R13-35 (2013)
DOI:10.1530/JOE-13-0227
Reference
PMID:23973488
  Authors
Liu QF, Yu HW, You L, Liu MX, Li KY, Tao GZ
  Title
Apelin-13-induced proliferation and migration induced of rat vascular smooth muscle cells is mediated by the upregulation of Egr-1.
  Journal
Biochem Biophys Res Commun 439:235-40 (2013)
DOI:10.1016/j.bbrc.2013.08.051
Reference
PMID:26254105
  Authors
Novakova V, Sandhu GS, Dragomir-Daescu D, Klabusay M
  Title
Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia.
  Journal
Vascul Pharmacol 76:1-10 (2016)
DOI:10.1016/j.vph.2015.08.005
Reference
PMID:21725702
  Authors
Castan-Laurell I, Dray C, Attane C, Duparc T, Knauf C, Valet P
  Title
Apelin, diabetes, and obesity.
  Journal
Endocrine 40:1-9 (2011)
DOI:10.1007/s12020-011-9507-9
Reference
PMID:23924696
  Authors
Li L, Li L, Xie F, Zhang Z, Guo Y, Tang G, Lv D, Lu Q, Chen L, Li J
  Title
Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation.
  Journal
Acta Biochim Biophys Sin (Shanghai) 45:875-81 (2013)
DOI:10.1093/abbs/gmt085
Reference
PMID:24990699
  Authors
Wu D, He L, Chen L
  Title
Apelin/APJ system: a promising therapy target for hypertension.
  Journal
Mol Biol Rep 41:6691-703 (2014)
DOI:10.1007/s11033-014-3552-4
Reference
PMID:20539939
  Authors
Liu C, Su T, Li F, Li L, Qin X, Pan W, Feng F, Chen F, Liao D, Chen L
  Title
PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13.
  Journal
Acta Biochim Biophys Sin (Shanghai) 42:396-402 (2010)
DOI:10.1093/abbs/gmq035
Reference
PMID:26607438
  Authors
Xie F, Liu W, Feng F, Li X, He L, Lv D, Qin X, Li L, Li L, Chen L
  Title
Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy.
  Journal
Acta Biochim Biophys Sin (Shanghai) 47:969-80 (2015)
DOI:10.1093/abbs/gmv111
Reference
PMID:27979574
  Authors
Lu L, Wu D, Li L, Chen L
  Title
Apelin/APJ system: A bifunctional target for cardiac hypertrophy.
  Journal
Int J Cardiol 230:164-170 (2017)
DOI:10.1016/j.ijcard.2016.11.215
Reference
PMID:16182514
  Authors
Carmen GY, Victor SM
  Title
Signalling mechanisms regulating lipolysis.
  Journal
Cell Signal 18:401-8 (2006)
DOI:10.1016/j.cellsig.2005.08.009
Reference
PMID:27650065
  Authors
Hu H, He L, Li L, Chen L
  Title
Apelin/APJ system as a therapeutic target in diabetes and its complications.
  Journal
Mol Genet Metab 119:20-7 (2016)
DOI:10.1016/j.ymgme.2016.07.012
Reference
PMID:25914650
  Authors
Bertrand C, Valet P, Castan-Laurell I
  Title
Apelin and energy metabolism.
  Journal
Front Physiol 6:115 (2015)
DOI:10.3389/fphys.2015.00115
Reference
PMID:26385179
  Authors
Yao F, Lv YC, Zhang M, Xie W, Tan YL, Gong D, Cheng HP, Liu D, Li L, Liu XY, Zheng XL, Tang CK
  Title
Apelin-13 impedes foam cell formation by activating Class III PI3K/Beclin-1-mediated autophagic pathway.
  Journal
Biochem Biophys Res Commun 466:637-43 (2015)
DOI:10.1016/j.bbrc.2015.09.045
Reference
PMID:22842084
  Authors
Than A, Cheng Y, Foh LC, Leow MK, Lim SC, Chuah YJ, Kang Y, Chen P
  Title
Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways.
  Journal
Mol Cell Endocrinol 362:227-41 (2012)
DOI:10.1016/j.mce.2012.07.002
Reference
PMID:24055369
  Authors
Yu XH, Tang ZB, Liu LJ, Qian H, Tang SL, Zhang DW, Tian GP, Tang CK
  Title
Apelin and its receptor APJ in cardiovascular diseases.
  Journal
Clin Chim Acta 428:1-8 (2014)
DOI:10.1016/j.cca.2013.09.001
Reference
PMID:25931124
  Authors
Than A, He HL, Chua SH, Xu D, Sun L, Leow MK, Chen P
  Title
Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes.
  Journal
J Biol Chem 290:14679-91 (2015)
DOI:10.1074/jbc.M115.643817
Reference
PMID:25139773
  Authors
Fu J, Li Z, Zhang H, Mao Y, Wang A, Wang X, Zou Z, Zhang X
  Title
Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue.
  Journal
Diabetes Metab Res Rev 31:433-52 (2015)
DOI:10.1002/dmrr.2600
Reference
PMID:21464822
  Authors
Aharoni-Simon M, Hann-Obercyger M, Pen S, Madar Z, Tirosh O
  Title
Fatty liver is associated with impaired activity of PPARgamma-coactivator 1alpha (PGC1alpha) and mitochondrial biogenesis in mice.
  Journal
Lab Invest 91:1018-28 (2011)
DOI:10.1038/labinvest.2011.55
Reference
PMID:22995518
  Authors
McLean DL, Kim J, Kang Y, Shi H, Atkins GB, Jain MK, Chun HJ
  Title
Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report.
  Journal
Arterioscler Thromb Vasc Biol 32:2640-3 (2012)
DOI:10.1161/ATVBAHA.112.300317
Reference
PMID:22028387
  Authors
Pchejetski D, Foussal C, Alfarano C, Lairez O, Calise D, Guilbeau-Frugier C, Schaak S, Seguelas MH, Wanecq E, Valet P, Parini A, Kunduzova O
  Title
Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1.
  Journal
Eur Heart J 33:2360-9 (2012)
DOI:10.1093/eurheartj/ehr389
Reference
PMID:26944568
  Authors
Huang S, Chen L, Lu L, Li L
  Title
The apelin-APJ axis: A novel potential therapeutic target for organ fibrosis.
  Journal
Clin Chim Acta 456:81-8 (2016)
DOI:10.1016/j.cca.2016.02.025
Reference
PMID:19093215
  Authors
Liu G, Han J, Profirovic J, Strekalova E, Voyno-Yasenetskaya TA
  Title
Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis.
  Journal
Angiogenesis 12:1-15 (2009)
DOI:10.1007/s10456-008-9123-3
Reference
PMID:23603510
  Authors
Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ
  Title
Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.
  Journal
Circ Res 113:22-31 (2013)
DOI:10.1161/CIRCRESAHA.113.301324
Reference
PMID:25164121
  Authors
Wang LY, Diao ZL, Zhang DL, Zheng JF, Zhang QD, Ding JX, Liu WH
  Title
The regulatory peptide apelin: a novel inhibitor of renal interstitial fibrosis.
  Journal
Amino Acids 46:2693-704 (2014)
DOI:10.1007/s00726-014-1826-8
Reference
PMID:26756969
  Authors
Zhou Y, Deng L, Zhao D, Chen L, Yao Z, Guo X, Liu X, Lv L, Leng B, Xu W, Qiao G, Shan H
  Title
MicroRNA-503 promotes angiotensin II-induced cardiac fibrosis by targeting Apelin-13.
  Journal
J Cell Mol Med 20:495-505 (2016)
DOI:10.1111/jcmm.12754
Reference
PMID:27825851
  Authors
Zhong JC, Zhang ZZ, Wang W, McKinnie SM, Vederas JC, Oudit GY
  Title
Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases.
  Journal
Biochim Biophys Acta 1863:1942-1950 (2017)
DOI:10.1016/j.bbadis.2016.11.007
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