Entry
Name
VEGF signaling pathway - Microcebus murinus (gray mouse lemur)
Description
There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic angiogenesis. The binding of VEGF to VEGFR-2 leads to a cascade of different signaling pathways, resulting in the up-regulation of genes involved in mediating the proliferation and migration of endothelial cells and promoting their survival and vascular permeability. For example, the binding of VEGF to VEGFR-2 leads to dimerization of the receptor, followed by intracellular activation of the PLCgamma;PKC-Raf kinase-MEK-mitogen-activated protein kinase (MAPK) pathway and subsequent initiation of DNA synthesis and cell growth, whereas activation of the phosphatidylinositol 3' -kinase (PI3K)-Akt pathway leads to increased endothelial-cell survival. Activation of PI3K, FAK, and p38 MAPK is implicated in cell migration signaling.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Microcebus murinus (gray mouse lemur) [GN:
mmur ]
Gene
105865830 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
105868798 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105863295 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105857150 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105872262 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
105873610 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
105862660 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
105855821 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
105886063 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
105881219 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
105855026 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
105877483 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
105868254 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
105883746 RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
105878067 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Cross MJ, Dixelius J, Matsumoto T, Claesson-Welsh L.
Title
VEGF-receptor signal transduction.
Journal
Reference
Authors
Matsumoto T, Claesson-Welsh L.
Title
VEGF receptor signal transduction.
Journal
Reference
Authors
Hoeben A, Landuyt B, Highley MS, Wildiers H, Van Oosterom AT, De Bruijn EA.
Title
Vascular endothelial growth factor and angiogenesis.
Journal
Reference
Authors
Takahashi H, Shibuya M.
Title
The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions.
Journal
Reference
Authors
Zachary I.
Title
VEGF signalling: integration and multi-tasking in endothelial cell biology.
Journal
Reference
Authors
Munoz-Chapuli R, Quesada AR, Angel Medina M.
Title
Angiogenesis and signal transduction in endothelial cells.
Journal
Reference
Authors
Lamalice L, Houle F, Jourdan G, Huot J.
Title
Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38.
Journal
Reference
Authors
Shu X, Wu W, Mosteller RD, Broek D.
Title
Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases.
Journal
Related pathway
KO pathway
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