KEGG   PATHWAY: mmyo04120
Entry
mmyo04120                   Pathway                                
Name
Ubiquitin mediated proteolysis - Myotis myotis (greater mouse-eared bat)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
mmyo04120  Ubiquitin mediated proteolysis
mmyo04120

Other DBs
GO: 0016567
Organism
Myotis myotis (greater mouse-eared bat) [GN:mmyo]
Gene
118666406  polyubiquitin [KO:K04551]
118677213  polyubiquitin-like [KO:K04551]
118655509  UBC; polyubiquitin-C isoform X1 [KO:K08770]
118665501  ubiquitin-like [KO:K02927]
118651897  ubiquitin-60S ribosomal protein L40-like isoform X1 [KO:K02927]
118667612  ubiquitin [KO:K02927]
118664569  ubiquitin-like [KO:K02927]
118657591  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
118668681  ubiquitin-like [KO:K02977]
118668994  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
118654665  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
118656810  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
118653252  UBA1; ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
118652771  SAE1; SUMO-activating enzyme subunit 1 isoform X1 [KO:K10684] [EC:6.2.1.45]
118674123  UBA2; SUMO-activating enzyme subunit 2 isoform X1 [KO:K10685] [EC:6.2.1.45]
118667899  UBA3; NEDD8-activating enzyme E1 catalytic subunit isoform X1 [KO:K10686] [EC:6.2.1.64]
118668468  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
118669309  UBA6; ubiquitin-like modifier-activating enzyme 6 isoform X1 [KO:K10699] [EC:6.2.1.45]
118654541  UBE2A; ubiquitin-conjugating enzyme E2 A isoform X1 [KO:K10573] [EC:2.3.2.23]
118658981  UBE2B; ubiquitin-conjugating enzyme E2 B isoform X1 [KO:K10574] [EC:2.3.2.23]
118663107  UBE2C; ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
118665856  UBE2D4; ubiquitin-conjugating enzyme E2 D4 isoform X1 [KO:K06689] [EC:2.3.2.23]
118653470  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
118654686  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
118670020  UBE2D1; ubiquitin-conjugating enzyme E2 D1 isoform X1 [KO:K06689] [EC:2.3.2.23]
118671942  UBE2D3; ubiquitin-conjugating enzyme E2 D3 isoform X1 [KO:K06689] [EC:2.3.2.23]
118657736  UBE2D2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
118668232  ubiquitin-conjugating enzyme E2 E2 [KO:K20217] [EC:2.3.2.23]
118668235  UBE2E1; ubiquitin-conjugating enzyme E2 E1 isoform X1 [KO:K20217] [EC:2.3.2.23]
118661295  UBE2E3; ubiquitin-conjugating enzyme E2 E3 [KO:K20217] [EC:2.3.2.23]
118649860  NEDD8-conjugating enzyme UBE2F-like [KO:K10687] [EC:2.3.2.34]
118661146  UBE2F; NEDD8-conjugating enzyme UBE2F isoform X1 [KO:K10687] [EC:2.3.2.34]
118660677  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
118671998  UBE2G1; ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
118676380  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
118666413  UBE2H; ubiquitin-conjugating enzyme E2 H isoform X1 [KO:K10576] [EC:2.3.2.23]
118656067  UBE2I; SUMO-conjugating enzyme UBC9 isoform X1 [KO:K10577]
118676586  SUMO-conjugating enzyme UBC9-like [KO:K10577]
118659985  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
118655572  UBE2J2; ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
118667882  UBE2K; ubiquitin-conjugating enzyme E2 K isoform X1 [KO:K04649] [EC:2.3.2.23]
118678206  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
118655696  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
118665012  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
118657433  UBE2M; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
118649957  UBE2N; ubiquitin-conjugating enzyme E2 N isoform X1 [KO:K10580] [EC:2.3.2.23]
118652103  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
118654375  LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
118654555  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
118671136  UBE2O; (E3-independent) E2 ubiquitin-conjugating enzyme isoform X1 [KO:K10581] [EC:2.3.2.24]
118673075  UBE2Q1; LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 Q1 [KO:K10582] [EC:2.3.2.23]
118679121  UBE2Q2; ubiquitin-conjugating enzyme E2 Q2 isoform X1 [KO:K10582] [EC:2.3.2.23]
118656712  UBE2QL1; ubiquitin-conjugating enzyme E2Q-like protein 1 isoform X1 [KO:K10582] [EC:2.3.2.23]
118651212  ubiquitin-conjugating enzyme E2 R2-like [KO:K02207] [EC:2.3.2.23]
118657750  CDC34; ubiquitin-conjugating enzyme E2 R1 isoform X1 [KO:K02207] [EC:2.3.2.23]
118665990  ubiquitin-conjugating enzyme E2 R2-like [KO:K02207] [EC:2.3.2.23]
118665992  ubiquitin-conjugating enzyme E2 R2-like [KO:K02207] [EC:2.3.2.23]
118667387  UBE2R2; ubiquitin-conjugating enzyme E2 R2 isoform X1 [KO:K02207] [EC:2.3.2.23]
118660284  ubiquitin-conjugating enzyme E2 R2-like [KO:K02207] [EC:2.3.2.23]
118677128  ubiquitin-conjugating enzyme E2 R2-like [KO:K02207] [EC:2.3.2.23]
118655184  UBE2S; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
118675123  UBE2U; ubiquitin-conjugating enzyme E2 U isoform X1 [KO:K10584] [EC:2.3.2.23]
118670945  UBE2W; ubiquitin-conjugating enzyme E2 W isoform X1 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
118671266  UBE2Z; ubiquitin-conjugating enzyme E2 Z isoform X1 [KO:K10585] [EC:2.3.2.23]
118669118  BIRC6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
118653049  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
118678444  UBE3B; ubiquitin-protein ligase E3B isoform X1 [KO:K10588] [EC:2.3.2.26]
118679469  UBE3C; ubiquitin-protein ligase E3C isoform X1 [KO:K10589] [EC:2.3.2.26]
118659357  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
118671580  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
118663358  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
118670456  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
118674373  WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1 [KO:K05630] [EC:2.3.2.26]
118661154  TRIP12; E3 ubiquitin-protein ligase TRIP12 isoform X1 [KO:K10590] [EC:2.3.2.26]
118652463  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
118662933  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
118653923  HUWE1; E3 ubiquitin-protein ligase HUWE1 isoform X1 [KO:K10592] [EC:2.3.2.26]
118670684  UBR5; E3 ubiquitin-protein ligase UBR5 isoform X1 [KO:K10593] [EC:2.3.2.26]
118653349  HERC1; probable E3 ubiquitin-protein ligase HERC1 isoform X1 [KO:K10594] [EC:2.3.2.26]
118653074  HERC2; E3 ubiquitin-protein ligase HERC2 isoform X1 [KO:K10595] [EC:2.3.2.26]
118671375  HERC3; probable E3 ubiquitin-protein ligase HERC3 isoform X1 [KO:K10614] [EC:2.3.2.26]
118670065  HERC4; probable E3 ubiquitin-protein ligase HERC4 isoform X1 [KO:K10615] [EC:2.3.2.26]
118664235  UBE4A; ubiquitin conjugation factor E4 A [KO:K10596] [EC:2.3.2.27]
118675271  UBE4B; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
118652929  STUB1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
118678234  PPIL2; RING-type E3 ubiquitin-protein ligase PPIL2 isoform X1 [KO:K10598] [EC:5.2.1.8]
118677172  LOW QUALITY PROTEIN: RING-type E3 ubiquitin-protein ligase PPIL2-like [KO:K10598] [EC:5.2.1.8]
118649037  PRPF19; pre-mRNA-processing factor 19 isoform X1 [KO:K10599] [EC:2.3.2.27]
118662616  UBOX5; RING finger protein 37 isoform X1 [KO:K10600]
118650326  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
118664184  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
118676386  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
118674590  CBLC; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
118660195  PRKN; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
118674530  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
118661359  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
118654250  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
118675706  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
118665127  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
118656004  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
118673610  COP1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
118669918  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
118677457  LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 2-like [KO:K16060]
118664470  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
118664472  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
118653756  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
118654449  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
118662831  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
118664152  LOW QUALITY PROTEIN: E3 SUMO-protein ligase PIAS2-like [KO:K16063] [EC:2.3.2.-]
118673135  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
118658170  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X1 [KO:K16065] [EC:2.3.2.27]
118665324  SYVN1; E3 ubiquitin-protein ligase synoviolin isoform X1 [KO:K10601] [EC:2.3.2.27]
118677260  NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [KO:K10602] [EC:2.3.2.27]
118675806  AIRE; autoimmune regulator [KO:K10603]
118657076  MGRN1; E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
118671456  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
118668979  FANCL; E3 ubiquitin-protein ligase FANCL isoform X1 [KO:K10606] [EC:2.3.2.27]
118653973  MID1; E3 ubiquitin-protein ligase Midline-1 [KO:K08285] [EC:2.3.2.27]
118667104  TRIM32; E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
118671710  TRIM37; E3 ubiquitin-protein ligase TRIM37 isoform X1 [KO:K10608] [EC:2.3.2.27]
118650853  RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 [KO:K03868] [EC:2.3.2.32]
118659026  E3 ubiquitin-protein ligase RBX1-like [KO:K03868] [EC:2.3.2.32]
118663966  E3 ubiquitin-protein ligase RBX1-like [KO:K03868] [EC:2.3.2.32]
118663967  E3 ubiquitin-protein ligase RBX1-like [KO:K03868] [EC:2.3.2.32]
118666292  CUL1; cullin-1 isoform X1 [KO:K03347]
118677220  cullin-1-like [KO:K03347]
118659056  S-phase kinase-associated protein 1-like [KO:K03094]
118667519  S-phase kinase-associated protein 1-like [KO:K03094]
118669808  S-phase kinase-associated protein 1-like isoform X1 [KO:K03094]
118657630  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
118672352  S-phase kinase-associated protein 1-like [KO:K03094]
118658168  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
118669829  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
118655860  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
118658074  FBXW7; F-box/WD repeat-containing protein 7 isoform X1 [KO:K10260]
118677580  FBXO2; F-box only protein 2 [KO:K10099]
118656049  FBXO4; F-box only protein 4 isoform X1 [KO:K10291]
118656714  cullin-2-like isoform X1 [KO:K03870]
118664716  LOW QUALITY PROTEIN: cullin-2-like [KO:K03870]
118676439  CUL2; cullin-2 isoform X1 [KO:K03870]
118661708  elongin-C-like [KO:K03872]
118670947  ELOC; elongin-C [KO:K03872]
118656866  ELOB; elongin-B [KO:K03873]
118661781  CUL3; cullin-3 isoform X1 [KO:K03869]
118658140  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
118663270  LOW QUALITY PROTEIN: kelch-like ECH-associated protein 1 [KO:K10456]
118667584  KLHL9; kelch-like protein 9 [KO:K10447]
118654439  KLHL13; kelch-like protein 13 isoform X1 [KO:K10447]
118658899  RHOBTB2; rho-related BTB domain-containing protein 2 [KO:K07868]
118670039  RHOBTB1; rho-related BTB domain-containing protein 1 isoform X1 [KO:K07868]
118650939  CUL4A; cullin-4A isoform X1 [KO:K10609]
118653355  CUL4B; cullin-4B isoform X1 [KO:K10609]
118649040  DDB1; DNA damage-binding protein 1 isoform X1 [KO:K10610]
118665064  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
118656463  ERCC8; DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]
118679208  DET1; DET1 homolog isoform X1 [KO:K10571]
118668109  RNF7; RING-box protein 2 isoform X1 [KO:K10611]
118676345  RING-box protein 2-like [KO:K10611]
118664410  CUL5; cullin-5 [KO:K10612]
118656719  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
118671119  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
118660064  CUL7; cullin-7 isoform X1 [KO:K10613]
118678135  FBXW8; F-box/WD repeat-containing protein 8 isoform X1 [KO:K10264]
118671811  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
118655336  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
118676449  CDC20; cell division cycle protein 20 homolog isoform X1 [KO:K03363]
118658236  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
118655220  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
118671623  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
118667352  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
118678404  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
118659635  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
118678180  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
118658430  CDC23; cell division cycle protein 23 homolog isoform X1 [KO:K03355]
118657968  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
118667166  CDC26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
118667709  anaphase-promoting complex subunit 13-like [KO:K12456]
118668155  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
118664707  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
118670124  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
mmyo03050  Proteasome
KO pathway
ko04120   
LinkDB

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