KEGG   PATHWAY: mrv04144
Entry
mrv04144                    Pathway                                
Name
Endocytosis - Mauremys reevesii (Reeves's turtle)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
mrv04144  Endocytosis
mrv04144

Other DBs
GO: 0006897
Organism
Mauremys reevesii (Reeves's turtle) [GN:mrv]
Gene
120404818  ARF6; ADP-ribosylation factor 6 [KO:K07941]
120388712  ADP-ribosylation factor 6-like [KO:K07941]
120391645  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
120390344  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
120408413  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
120386958  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
120372696  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
120381526  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
120386721  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
120369837  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
120391310  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
120408153  CLTA; clathrin light chain A [KO:K04644]
120371129  CLTB; clathrin light chain B isoform X1 [KO:K04645]
120386403  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
120387141  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
120403786  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
120388248  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
120387139  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
120371628  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
120388830  AP2S1; AP-2 complex subunit sigma [KO:K11827]
120388746  EHD2; EH domain-containing protein 2 [KO:K12469]
120396661  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
120375044  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
120398476  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
120408323  ZFYVE16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
120369880  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
120373120  protein PML-like isoform X1 [KO:K10054] [EC:2.3.2.-]
120373385  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
120408025  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
120373294  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
120371731  TFRC; transferrin receptor protein 1 [KO:K06503]
120397061  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
120407146  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
120368575  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
120406018  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
120375536  fibroblast growth factor receptor 3-like isoform X1 [KO:K05094] [EC:2.7.10.1]
120375538  fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
120375622  fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
120370519  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
120372851  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
120375674  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
120390287  CBLC; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K04707] [EC:2.3.2.27]
120371363  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
120394495  LOW QUALITY PROTEIN: SH3 domain-containing kinase-binding protein 1-like [KO:K12470]
120400488  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
120391715  SH3GL1; endophilin-A2 isoform X1 [KO:K11247]
120373862  SH3GL3; endophilin-A3 isoform X1 [KO:K11247]
120408537  SH3GL2; endophilin-A1 isoform X1 [KO:K11247]
120370335  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
120386869  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
120375215  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
120397923  AMPH; amphiphysin isoform X1 [KO:K12562]
120384072  EPN3; epsin-3 isoform X1 [KO:K12471]
120373645  EPN2; epsin-2 isoform X1 [KO:K12471]
120388757  EPN1; epsin-1 isoform X1 [KO:K12471]
120370325  EPS15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
120391600  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
120404629  SPART; spartin isoform X1 [KO:K19366]
120372777  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
120408172  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
120383248  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
120404545  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
120391023  RNF41; E3 ubiquitin-protein ligase NRDP1 isoform X1 [KO:K11981] [EC:2.3.2.27]
120380596  ITCH; E3 ubiquitin-protein ligase Itchy homolog [KO:K05632] [EC:2.3.2.26]
120382836  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
120373564  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
120396623  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
120391077  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
120389224  LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
120400768  low density lipoprotein receptor adapter protein 1-like isoform X1 [KO:K12474]
120408366  DAB2; disabled homolog 2 [KO:K12475]
120398704  C-C chemokine receptor type 5-like [KO:K04180]
120399473  C-C chemokine receptor type 5-like [KO:K04180]
120399474  C-C chemokine receptor type 5-like [KO:K04180]
120374289  C-X-C chemokine receptor type 2-like [KO:K05050]
120374244  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
120372669  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
120381865  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
120393445  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
120386194  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
120370306  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
120405942  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
120399467  G protein-coupled receptor kinase 5-like [KO:K08291] [EC:2.7.11.16]
120409578  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
120381927  ARRB2; LOW QUALITY PROTEIN: beta-arrestin-2 [KO:K04439]
120398292  beta-arrestin-1 isoform X1 [KO:K04439]
120388775  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
120369118  actin-related protein 2-B-like [KO:K17260]
120400672  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
120374798  ACTR3; actin-related protein 3 [KO:K18584]
120398033  ACTR3B; LOW QUALITY PROTEIN: actin-related protein 3B [KO:K18584]
120373312  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
120373313  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
120374686  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
120385999  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
120409415  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
120386825  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
120369937  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
120392087  WIPF2; WAS/WASL-interacting protein family member 2 isoform X1 [KO:K19475]
120374969  WIPF1; WAS/WASL-interacting protein family member 1 [KO:K19475]
120399075  WIPF3; WAS/WASL-interacting protein family member 3 [KO:K19475]
120385035  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
120385043  heat shock cognate 71 kDa protein-like [KO:K03283]
120393855  heat shock cognate 71 kDa protein-like [KO:K03283]
120375455  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
120390270  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
120390410  heat shock 70 kDa protein 1A-like [KO:K03283]
120370922  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
120370377  WASHC4; WASH complex subunit 4 isoform X1 [KO:K18465]
120397544  WASHC5; WASH complex subunit 5 isoform X1 [KO:K18464]
120368846  WASH complex subunit 2A-like isoform X1 [KO:K18462]
120409419  WASHC1; WASH complex subunit 1 isoform X1 [KO:K18461]
120395853  WASHC3; WASH complex subunit 3 isoform X1 [KO:K18463]
120404497  CAPZA1; F-actin-capping protein subunit alpha-1 isoform X1 [KO:K10364]
120373738  F-actin-capping protein subunit alpha-2-like [KO:K10364]
120387676  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
120408105  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
120387699  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
120386176  VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
120386425  vacuolar protein sorting-associated protein 29-like isoform X1 [KO:K18467]
120375630  VPS26B; vacuolar protein sorting-associated protein 26B isoform X1 [KO:K18466]
120369201  VPS26A; vacuolar protein sorting-associated protein 26A [KO:K18466]
120384599  VPS35; vacuolar protein sorting-associated protein 35 [KO:K18468]
120402360  SNX3; sorting nexin-3 [KO:K17918]
120372551  SNX12; sorting nexin-12 isoform X1 [KO:K17918]
120373812  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
120397761  STAM-binding protein [KO:K11866] [EC:3.4.19.12]
120409085  RAB7A; ras-related protein Rab-7a [KO:K07897]
120384077  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
120374818  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
120397932  STAM; signal transducing adapter molecule 1 [KO:K04705]
120403821  TSG101; tumor susceptibility gene 101 protein isoform X1 [KO:K12183]
120391354  MVB12A; multivesicular body subunit 12A [KO:K12186]
120386673  MVB12B; multivesicular body subunit 12B isoform X1 [KO:K12186]
120397092  VPS28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
120403766  VPS37C; vacuolar protein sorting-associated protein 37C isoform X1 [KO:K12185]
120386227  VPS37B; vacuolar protein sorting-associated protein 37B [KO:K12185]
120387601  VPS37D; vacuolar protein sorting-associated protein 37D isoform X1 [KO:K12185]
120406013  VPS37A; vacuolar protein sorting-associated protein 37A [KO:K12185]
120392209  SNF8; vacuolar-sorting protein SNF8 [KO:K12188]
120373482  VPS36; vacuolar protein-sorting-associated protein 36 isoform X1 [KO:K12190]
120392009  VPS25; vacuolar protein-sorting-associated protein 25 isoform X1 [KO:K12189]
120383791  CHMP6; charged multivesicular body protein 6 [KO:K12195]
120380651  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
120396408  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
120393189  charged multivesicular body protein 2a [KO:K12191]
120394314  charged multivesicular body protein 2a [KO:K12191]
120395572  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
120399336  CHMP7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
120384841  VPS4A; vacuolar protein sorting-associated protein 4A [KO:K12196]
120399026  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
120400724  VTA1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
120372411  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
120384554  CHMP1A; charged multivesicular body protein 1a isoform X1 [KO:K12197]
120398762  CHMP5; charged multivesicular body protein 5 isoform X1 [KO:K12198]
120384463  IST1; IST1 homolog isoform X1 [KO:K19476]
120397610  programmed cell death 6-interacting protein isoform X1 [KO:K12200]
120373016  SPG21; maspardin [KO:K19367]
120400859  IGF2R; cation-independent mannose-6-phosphate receptor isoform X1 [KO:K06564]
120373233  SNX1; sorting nexin-1 [KO:K17917]
120407896  SNX2; sorting nexin-2 isoform X1 [KO:K17917]
120401229  SNX5; sorting nexin-5 isoform X1 [KO:K17920]
120403288  SNX6; sorting nexin-6 [KO:K17920]
120368882  SNX32; sorting nexin-32 [KO:K17920]
120380485  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
120405072  HRAS; GTPase HRas [KO:K02833]
120396028  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
120372096  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
120388814  transforming protein RhoA-like [KO:K04513]
120409295  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
120393307  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
120394812  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
120383803  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
120393297  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
120393790  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
120393792  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
120406095  major histocompatibility complex class I-related gene protein-like [KO:K06751]
120408015  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
120393300  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
120393298  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
120393308  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
120394814  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
120394831  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
120395132  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
120406094  major histocompatibility complex class I-related gene protein-like [KO:K06751]
120408016  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
120393804  major histocompatibility complex class I-related gene protein-like [KO:K06751]
120394819  major histocompatibility complex class I-related gene protein-like [KO:K06751]
120371691  FOLR3; folate receptor gamma [KO:K13649]
120372186  folate receptor alpha-like [KO:K13649]
120395997  folate receptor gamma-like isoform X1 [KO:K13649]
120369667  riboflavin-binding protein-like [KO:K13649]
120391236  RTBDN; retbindin [KO:K13649]
120395505  CAV1; caveolin-1 [KO:K06278]
120395509  CAV2; caveolin-2 [KO:K12958]
120409001  CAV3; caveolin-3 [KO:K12959]
120401642  EHD3; EH domain-containing protein 3 [KO:K12476]
120404632  EHD4; EH domain-containing protein 4 [KO:K12477]
120375837  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
120398106  RAB5A; ras-related protein Rab-5A [KO:K07887]
120391170  RAB5B; ras-related protein Rab-5B [KO:K07888]
120392201  RAB5C; ras-related protein Rab-5C [KO:K07889]
120387166  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
120409575  RBSN; rabenosyn-5 isoform X1 [KO:K12481]
120401441  RAB4A; ras-related protein Rab-4A [KO:K07879]
120370965  RUFY1; RUN and FYVE domain-containing protein 1 isoform X1 [KO:K12482]
120368716  RUFY2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
120368735  EHD1; EH domain-containing protein 1 isoform X1 [KO:K12483]
120390220  VPS45; vacuolar protein sorting-associated protein 45 [KO:K12479]
120374976  SNX4; sorting nexin-4 isoform X1 [KO:K17919]
120398878  RAB31; ras-related protein Rab-31 isoform X1 [KO:K07891]
120380317  RAB22A; ras-related protein Rab-22A [KO:K07891]
120399230  ras-related protein Rab-10-like isoform X1 [KO:K07903]
120400539  RAB10; ras-related protein Rab-10 [KO:K07903]
120391614  RAB8A; ras-related protein Rab-8A [KO:K07901]
120403344  ras-related protein Rab-35-like [KO:K07876]
120386456  RAB35; ras-related protein Rab-35 [KO:K07876]
120372988  RAB11A; ras-related protein Rab-11A isoform X1 [KO:K07904]
120390705  ras-related protein Rab-11A-like [KO:K07904]
120391660  RAB11B; ras-related protein Rab-11B isoform X1 [KO:K07905]
120406050  RAB11FIP5; rab11 family-interacting protein 5 isoform X1 [KO:K12484]
120398362  RAB11FIP1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
120369234  RAB11FIP2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
120370134  rab11 family-interacting protein 2-like isoform X1 [KO:K12484]
120369398  ZFYVE27; protrudin isoform X1 [KO:K19368]
120374806  KIF5C; kinesin heavy chain isoform X1 [KO:K10396]
120397652  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
120391318  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
120383405  RAB11FIP4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
120373275  RAB11FIP3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
120397806  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
120384224  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
120396439  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
120380231  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
120387858  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
120371530  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
120387901  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
120389118  SMAP2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
120400916  SMAP1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
120387241  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
120386228  GIT2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
120401772  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
120397585  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
120389160  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
120380840  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like isoform X1 [KO:K12488]
120371305  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
120387881  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
120381511  ACAP1; LOW QUALITY PROTEIN: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
120391553  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
120406772  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
120369968  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
120374425  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
120397573  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
120391298  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
120380966  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
120403275  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 [KO:K12493]
120406941  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
120370456  PSD2; PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
120407670  PSD3; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494]
120399311  PH and SEC7 domain-containing protein 1-like isoform X1 [KO:K12494]
120409110  PSD; PH and SEC7 domain-containing protein 1 [KO:K12494]
120388495  IQSEC2; LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 2 [KO:K12495]
120409485  IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
120409531  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
120383210  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
120395908  CYTH4; cytohesin-4 isoform X1 [KO:K18441]
120374156  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
120388293  cytohesin-2 [KO:K18441]
120397845  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
120380659  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
120409326  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
120385071  ADP-ribosylation factor 2 [KO:K07937]
120397977  ARF1; ADP-ribosylation factor 1 isoform X1 [KO:K07937]
120391309  ARF3; ADP-ribosylation factor 3 [KO:K07938]
120409133  ARF4; ADP-ribosylation factor 4 [KO:K07939]
120395633  ARF5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
mrv04060  Cytokine-cytokine receptor interaction
mrv04070  Phosphatidylinositol signaling system
mrv04130  SNARE interactions in vesicular transport
mrv04142  Lysosome
mrv04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

DBGET integrated database retrieval system