KEGG   PATHWAY: ncar04914
Entry
ncar04914                   Pathway                                
Name
Progesterone-mediated oocyte maturation - Sciurus carolinensis (gray squirrel)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
ncar04914  Progesterone-mediated oocyte maturation
ncar04914

Other DBs
GO: 0001556
Organism
Sciurus carolinensis (gray squirrel) [GN:ncar]
Gene
124958802  progesterone receptor isoform X1 [KO:K08556]
124986648  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
124968815  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
124993166  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
124993330  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
124963509  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
124986765  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
124994121  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
124984745  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
124988515  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
124989076  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
124978202  mitogen-activated protein kinase 14-like isoform X1 [KO:K04441] [EC:2.7.11.24]
124982485  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
124982486  LOW QUALITY PROTEIN: mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
124992673  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
124988012  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
124991078  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
124990345  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
124987010  adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
124962927  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
124978229  LOW QUALITY PROTEIN: adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
124992559  adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
124983776  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
124966834  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
124965096  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
124970113  LOW QUALITY PROTEIN: adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
124985819  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
124969119  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
124976004  aurora kinase A [KO:K11481] [EC:2.7.11.1]
124986623  cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
124994949  cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602]
124984539  LOW QUALITY PROTEIN: cytoplasmic polyadenylation element-binding protein 3-like [KO:K02602]
124977510  cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602]
124963110  speedy protein A isoform X1 [KO:K08694]
124970661  speedy protein E4-like [KO:K08694]
124970662  speedy protein E4-like [KO:K08694]
124970664  speedy protein E4-like [KO:K08694]
124970666  speedy protein E4-like [KO:K08694]
124970667  speedy protein E4A-like [KO:K08694]
124970668  speedy protein E4-like [KO:K08694]
124970669  speedy protein E4-like [KO:K08694]
124970670  speedy protein E4A-like [KO:K08694]
124963520  putative speedy protein E7 [KO:K08694]
124982038  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
124984914  LOW QUALITY PROTEIN: cyclin-dependent kinase 1-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
124994687  LOW QUALITY PROTEIN: cyclin-A2-like [KO:K06627]
124985165  cyclin-A1 [KO:K06627]
124963701  proto-oncogene serine/threonine-protein kinase mos-like [KO:K04367] [EC:2.7.11.1]
124988389  heat shock protein HSP 90-beta [KO:K04079]
124977378  heat shock protein HSP 90-alpha [KO:K04079]
124983444  heat shock protein HSP 90-beta-like [KO:K04079]
124977990  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124990635  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124970294  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
124988357  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
124985017  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
124971903  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
124972555  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
124970177  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
124987022  G2/mitotic-specific cyclin-B1 [KO:K05868]
124970575  G2/mitotic-specific cyclin-B2 [KO:K21770]
124972154  G2/mitotic-specific cyclin-B3-like [KO:K21771]
124987675  serine/threonine-protein kinase 10 isoform X1 [KO:K08837] [EC:2.7.11.1]
124970412  serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
124969415  M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
124975972  M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
124987233  M-phase inducer phosphatase 3-like isoform X1 [KO:K05867] [EC:3.1.3.48]
124960685  insulin [KO:K04526]
124983128  insulin-like growth factor I isoform X1 [KO:K05459]
124978062  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
124962260  LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
124976076  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124966582  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124958301  cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
124961340  LOW QUALITY PROTEIN: uncharacterized protein LOC124961340 [KO:K13296] [EC:3.1.4.17]
124991017  GTPase KRas-like [KO:K07827]
124982118  GTPase KRas isoform X1 [KO:K07827]
124971762  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
124990234  LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
124971006  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
124963154  mitotic checkpoint serine/threonine-protein kinase BUB1-like [KO:K02178] [EC:2.7.11.1]
124970253  mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
124994765  LOW QUALITY PROTEIN: mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
124994892  mitotic spindle assembly checkpoint protein MAD2A-like isoform X1 [KO:K02537]
124982415  mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
124968461  fizzy-related protein homolog isoform X1 [KO:K03364]
124963058  anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
124964771  anaphase-promoting complex subunit 2 [KO:K03349]
124979876  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
124994098  anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
124990690  anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
124984879  cell division cycle protein 16 homolog [KO:K03353]
124991612  anaphase-promoting complex subunit 7 [KO:K03354]
124994459  anaphase-promoting complex subunit 10 [KO:K03357]
124979693  anaphase-promoting complex subunit 11 [KO:K03358]
124964718  anaphase-promoting complex subunit CDC26 [KO:K03359]
124990583  anaphase-promoting complex subunit 13-like [KO:K12456]
124992568  anaphase-promoting complex subunit 13 [KO:K12456]
124958183  anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
124984352  anaphase-promoting complex subunit 16 [KO:K25229]
124969787  kinesin-like protein KIF22 isoform X1 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
ncar04010  MAPK signaling pathway
ncar04110  Cell cycle
KO pathway
ko04914   
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