KEGG   PATHWAY: ncar05213
Entry
ncar05213                   Pathway                                
Name
Endometrial cancer - Sciurus carolinensis (gray squirrel)
Description
Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification.
Class
Human Diseases; Cancer: specific types
Pathway map
ncar05213  Endometrial cancer
ncar05213

Organism
Sciurus carolinensis (gray squirrel) [GN:ncar]
Gene
124994951  pro-epidermal growth factor-like isoform X1 [KO:K04357]
124990601  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
124993166  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
124993330  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
124963509  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
124986648  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
124968815  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
124984679  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
124970168  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
124958328  LOW QUALITY PROTEIN: integrin-linked protein kinase-like [KO:K06272] [EC:2.7.11.1]
124962260  LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
124976076  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124966582  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124966493  caspase-9-like [KO:K04399] [EC:3.4.22.62]
124958534  bcl2-associated agonist of cell death-like [KO:K02158]
124989730  forkhead box protein O3 [KO:K09408]
124980188  growth factor receptor-bound protein 2 [KO:K04364]
124977045  son of sevenless homolog 2 [KO:K03099]
124963384  son of sevenless homolog 1 isoform X1 [KO:K03099]
124974041  LOW QUALITY PROTEIN: son of sevenless homolog 2-like [KO:K03099]
124958599  GTPase HRas isoform X1 [KO:K02833]
124991017  GTPase KRas-like [KO:K07827]
124982118  GTPase KRas isoform X1 [KO:K07827]
124962389  GTPase NRas [KO:K07828]
124971762  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
124990234  LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
124971006  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
124977990  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124969568  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
124990635  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124970294  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
124971802  ETS domain-containing protein Elk-1 [KO:K04375]
124968330  DNA mismatch repair protein Mlh1 [KO:K08734]
124966611  cadherin-1 [KO:K05689]
124969493  catenin beta-1 [KO:K02105]
124987558  catenin alpha-1 [KO:K05691]
124984438  LOW QUALITY PROTEIN: catenin alpha-1-like [KO:K05691]
124985318  catenin alpha-3 isoform X1 [KO:K05691]
124963367  catenin alpha-2 isoform X1 [KO:K05691]
124970513  axin-1 isoform X1 [KO:K02157]
124980732  axin-2 isoform X1 [KO:K04385]
124986583  adenomatous polyposis coli protein isoform X1 [KO:K02085]
124967865  adenomatous polyposis coli protein 2-like isoform X1 [KO:K02085]
124992642  LOW QUALITY PROTEIN: glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
124986637  transcription factor 7 isoform X1 [KO:K02620]
124963199  transcription factor 7-like 1 isoform X1 [KO:K04490]
124984748  transcription factor 7-like 2 isoform X1 [KO:K04491]
124994528  lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
124965808  myc proto-oncogene protein [KO:K04377]
124958520  G1/S-specific cyclin-D1 [KO:K04503]
124980281  cellular tumor antigen p53 [KO:K04451]
124989493  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
124987492  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
124968653  growth arrest and DNA damage-inducible protein GADD45 beta isoform X1 [KO:K04402]
124965544  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
124966672  apoptosis regulator BAX isoform X1 [KO:K02159]
124988289  bcl-2 homologous antagonist/killer-like [KO:K14021]
124988679  bcl-2 homologous antagonist/killer [KO:K14021]
124974602  bcl-2 homologous antagonist/killer-like [KO:K14021]
124960240  DNA damage-binding protein 2 [KO:K10140]
124986876  DNA polymerase kappa-like isoform X1 [KO:K03511] [EC:2.7.7.7]
124979806  receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Related
pathway
ncar04010  MAPK signaling pathway
ncar04012  ErbB signaling pathway
ncar04060  Cytokine-cytokine receptor interaction
ncar04110  Cell cycle
ncar04115  p53 signaling pathway
ncar04151  PI3K-Akt signaling pathway
ncar04310  Wnt signaling pathway
ncar04520  Adherens junction
KO pathway
ko05213   
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