KEGG   PATHWAY: nni04620
Entry
nni04620                    Pathway                                
Name
Toll-like receptor signaling pathway - Nipponia nippon (crested ibis)
Description
Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK.
Class
Organismal Systems; Immune system
Pathway map
nni04620  Toll-like receptor signaling pathway
nni04620

Organism
Nipponia nippon (crested ibis) [GN:nni]
Gene
104021229  TLR2; toll-like receptor 2 [KO:K10159]
104021230  toll-like receptor 2 type-2 [KO:K10159]
104008501  toll-like receptor 2 type-2 [KO:K10159]
104009810  toll-like receptor 1 [KO:K10169]
104022144  CD14; monocyte differentiation antigen CD14 [KO:K04391]
104016168  LY96; lymphocyte antigen 96 [KO:K05400]
104021297  TLR3; toll-like receptor 3 [KO:K05401]
104022122  TLR4; toll-like receptor 4 [KO:K10160]
104019645  TLR5; toll-like receptor 5 [KO:K10168]
104022546  TLR7; toll-like receptor 7 [KO:K05404]
104014432  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
104015059  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104008980  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104023668  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104019595  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104015409  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104018715  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
104020263  AKT2; LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104014534  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104011272  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104010300  TOLLIP; toll-interacting protein isoform X1 [KO:K05402]
104021773  MYD88; LOW QUALITY PROTEIN: myeloid differentiation primary response protein MyD88 [KO:K04729]
104016675  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
104009489  FADD; FAS-associated death domain protein [KO:K02373]
104010196  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
104013612  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
104019573  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
104021621  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
104013777  TAB2; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
104021941  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
104016028  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104011799  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
104021184  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
104022250  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
104017047  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104018809  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104020099  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104015109  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
104014353  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
104014564  MAP2K4; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
104010702  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104010773  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104010338  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
104013235  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
104018444  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104013238  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104019815  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104009262  JUN; transcription factor AP-1 isoform X1 [KO:K04448]
104022599  interleukin-1 receptor antagonist protein-like [KO:K04519]
104013985  IL6; interleukin-6 [KO:K05405]
104011599  IL12A; interleukin-12 subunit alpha [KO:K05406]
104019032  IL12B; interleukin-12 subunit beta [KO:K05425]
104015862  interleukin-8-like [KO:K10030]
104015863  interleukin-8 [KO:K10030]
104015873  interleukin-8-like [KO:K10030]
104012432  C-C motif chemokine 5-like [KO:K12499]
104018085  C-C motif chemokine 3-like 1 [KO:K05408]
104012433  C-C motif chemokine 4-like [KO:K12964]
104012434  C-C motif chemokine 4 homolog isoform X1 [KO:K12964]
104016338  TICAM2; LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 2 [KO:K05409]
104018738  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
104021840  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
104010502  IRF5; interferon regulatory factor 5 [KO:K09446]
104017322  IRF7; interferon regulatory factor 7 [KO:K09447]
104014966  SPP1; osteopontin [KO:K06250]
104013118  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
104011019  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
104014514  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
104018331  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
104015007  T-lymphocyte activation antigen CD80-like [KO:K05412]
104008646  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
104017291  interferon-like [KO:K05414]
104017293  interferon-like [KO:K05414]
104013672  IFNE; interferon epsilon [KO:K05414]
104017929  interferon kappa-like [KO:K05414]
104017595  LOW QUALITY PROTEIN: interferon-like [KO:K05415]
104020173  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
104020172  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
104009246  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
104011367  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
104014274  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
Reference
PMID:17275323
  Authors
Kawai T, Akira S.
  Title
TLR signaling.
  Journal
Semin Immunol 19:24-32 (2007)
DOI:10.1016/j.smim.2006.12.004
Reference
PMID:17457343
  Authors
O'Neill LA, Bowie AG.
  Title
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
  Journal
Nat Rev Immunol 7:353-64 (2007)
DOI:10.1038/nri2079
Reference
PMID:16932750
  Authors
Honda K, Taniguchi T.
  Title
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.
  Journal
Nat Rev Immunol 6:644-58 (2006)
DOI:10.1038/nri1900
Reference
PMID:17395581
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and Type I interferons.
  Journal
J Biol Chem 282:15319-23 (2007)
DOI:10.1074/jbc.R700009200
Reference
PMID:16497588
  Authors
Akira S, Uematsu S, Takeuchi O.
  Title
Pathogen recognition and innate immunity.
  Journal
Cell 124:783-801 (2006)
DOI:10.1016/j.cell.2006.02.015
Reference
PMID:14698224
  Authors
Yamamoto M, Takeda K, Akira S.
  Title
TIR domain-containing adaptors define the specificity of TLR signaling.
  Journal
Mol Immunol 40:861-8 (2004)
DOI:10.1016/j.molimm.2003.10.006
Reference
PMID:12734364
  Authors
Means TK, Hayashi F, Smith KD, Aderem A, Luster AD.
  Title
The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells.
  Journal
J Immunol 170:5165-75 (2003)
DOI:10.4049/jimmunol.170.10.5165
Reference
PMID:14751764
  Authors
Aderem A, Smith KD.
  Title
A systems approach to dissecting immunity and inflammation.
  Journal
Semin Immunol 16:55-67 (2004)
DOI:10.1016/j.smim.2003.10.002
Reference
PMID:17637696
  Authors
Banerjee A, Gerondakis S.
  Title
Coordinating TLR-activated signaling pathways in cells of the immune system.
  Journal
Immunol Cell Biol 85:420-4 (2007)
DOI:10.1038/sj.icb.7100098
Reference
PMID:17507094
  Authors
Loniewski KJ, Patial S, Parameswaran N.
  Title
Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.
  Journal
Mol Immunol 44:3715-23 (2007)
DOI:10.1016/j.molimm.2007.04.002
Reference
PMID:11101877
  Authors
Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG.
  Title
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.
  Journal
Nat Immunol 1:533-40 (2000)
DOI:10.1038/82797
Reference
PMID:16924467
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and innate immunity.
  Journal
J Mol Med 84:712-25 (2006)
DOI:10.1007/s00109-006-0084-y
Related
pathway
nni04010  MAPK signaling pathway
nni04060  Cytokine-cytokine receptor interaction
nni04120  Ubiquitin mediated proteolysis
nni04210  Apoptosis
KO pathway
ko04620   
LinkDB

DBGET integrated database retrieval system