KEGG   PATHWAY: nni04060
Entry
nni04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Nipponia nippon (crested ibis)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
nni04060  Cytokine-cytokine receptor interaction
nni04060

Organism
Nipponia nippon (crested ibis) [GN:nni]
Gene
104012657  C-C motif chemokine 19-like [KO:K05512]
104017603  uncharacterized protein LOC104017603 [KO:K05512]
104012556  LOW QUALITY PROTEIN: C-C motif chemokine 26-like [KO:K16062]
104017597  CCL21; C-C motif chemokine 21 [KO:K16062]
104018085  C-C motif chemokine 3-like 1 [KO:K05408]
104012433  C-C motif chemokine 4-like [KO:K12964]
104012434  C-C motif chemokine 4 homolog isoform X1 [KO:K12964]
104017425  CCL17; C-C motif chemokine 17 [KO:K21083]
104012432  C-C motif chemokine 5-like [KO:K12499]
104019156  LOW QUALITY PROTEIN: C-C motif chemokine 28-like [KO:K05513]
104016397  CCL20; C-C motif chemokine 20 [KO:K14625]
104015862  interleukin-8-like [KO:K10030]
104015863  interleukin-8 [KO:K10030]
104015873  interleukin-8-like [KO:K10030]
104015874  uncharacterized protein LOC104015874 [KO:K10029]
104023389  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
104023390  alveolar macrophage chemotactic factor-like [KO:K10032]
104013182  CXCL12; stromal cell-derived factor 1 [KO:K10031]
104011994  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
104014151  lymphotactin-like [KO:K05507]
104017470  CX3CL1; fractalkine [KO:K05508]
104012053  interleukin-4-like [KO:K05430]
104015953  IL15; interleukin-15 [KO:K05433]
104019142  IL21; interleukin-21 [KO:K05434]
104012051  interleukin-5-like [KO:K05428]
104012273  somatotropin [KO:K05438]
104021796  PRL; prolactin [KO:K05439]
104015698  THPO; thrombopoietin [KO:K06854]
104012528  CSF3; granulocyte colony-stimulating factor [KO:K05423]
104013985  IL6; interleukin-6 [KO:K05405]
104011599  IL12A; interleukin-12 subunit alpha [KO:K05406]
104019032  IL12B; interleukin-12 subunit beta [KO:K05425]
104013742  IL23A; interleukin-23 subunit alpha [KO:K05426]
104018806  EBI3; interleukin-27 subunit beta [KO:K24476]
104018842  CLCF1; cardiotrophin-like cytokine factor 1 [KO:K05421]
104010534  CNTF; ciliary neurotrophic factor [KO:K05420]
104010590  LIF; leukemia inhibitory factor [KO:K05419]
104013114  IL10; interleukin-10 [KO:K05443]
104013193  interleukin-20-like [KO:K22667]
104011008  IL22; interleukin-22 [KO:K05445]
104010164  interferon lambda-3-like [KO:K22669]
104017291  interferon-like [KO:K05414]
104017293  interferon-like [KO:K05414]
104013672  IFNE; interferon epsilon [KO:K05414]
104017929  interferon kappa-like [KO:K05414]
104017595  LOW QUALITY PROTEIN: interferon-like [KO:K05415]
104011009  IFNG; interferon gamma [KO:K04687]
104022599  interleukin-1 receptor antagonist protein-like [KO:K04519]
104019045  IL18; interleukin-18 [KO:K05482]
104014678  IL17A; interleukin-17A [KO:K05489]
104014679  interleukin-17F-like [KO:K05494]
104018971  IL17B; interleukin-17B [KO:K05490]
104023646  IL17C; interleukin-17C [KO:K05491]
104017103  IL16; pro-interleukin-16 [KO:K22628]
104017448  IL34; interleukin-34 [KO:K22633]
104018429  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
104014967  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
104010400  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
104022171  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
104022070  TNFSF10; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 10 [KO:K04721]
104012922  EDA; ectodysplasin-A [KO:K05480]
104010337  NGF; beta-nerve growth factor [KO:K02582]
104010922  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
104022160  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
104012871  CD40LG; CD40 ligand [KO:K03161]
104017361  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
104019653  TGFB2; transforming growth factor beta-2 [KO:K13376]
104020998  TGFB3; transforming growth factor beta-3 [KO:K13377]
104018771  GDF15; growth/differentiation factor 15 [KO:K05504]
104013264  GDF2; growth/differentiation factor 2 [KO:K05503]
104017522  BMP10; bone morphogenetic protein 10 [KO:K22670]
104010047  INHA; inhibin alpha chain [KO:K05500]
104015869  BMP3; bone morphogenetic protein 3 [KO:K05496]
104014047  GDF10; LOW QUALITY PROTEIN: bone morphogenetic protein 3B [KO:K22674]
104017506  GDF11; growth/differentiation factor 11 [KO:K22679]
104014323  MSTN; growth/differentiation factor 8 isoform X1 [KO:K05497]
104012416  INHBA; inhibin beta A chain [KO:K04667]
104020371  INHBB; inhibin beta B chain [KO:K22687]
104013689  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
104016061  NODAL; nodal homolog [KO:K04666]
104012016  GDF9; growth/differentiation factor 9 [KO:K22673]
104015930  inhibin beta C chain-like [KO:K22688]
104009647  AMH; muellerian-inhibiting factor [KO:K04665]
104022480  BMP2; bone morphogenetic protein 2 [KO:K21283]
104019616  bone morphogenetic protein 2-B-like [KO:K21283]
104019440  BMP4; bone morphogenetic protein 4 [KO:K04662]
104019912  GDF5; growth/differentiation factor 5 [KO:K04664]
104014725  GDF7; LOW QUALITY PROTEIN: growth/differentiation factor 7 [KO:K20013]
104012619  BMP15; bone morphogenetic protein 15 [KO:K05498]
104020903  BMP5; bone morphogenetic protein 5 [KO:K04663]
104021901  BMP6; bone morphogenetic protein 6 [KO:K16620]
104013052  BMP7; bone morphogenetic protein 7 [KO:K16621]
104017868  bone morphogenetic protein 8A-like [KO:K16622]
104012169  C-C chemokine receptor type 8-like [KO:K04183]
104012105  C-C chemokine receptor type 8-like [KO:K04183]
104012168  CCR9; C-C chemokine receptor type 9 [KO:K04184]
104012130  ACKR4; atypical chemokine receptor 4 [KO:K04186]
104009851  CCR7; C-C chemokine receptor type 7 [KO:K04182]
104012103  CCR4; C-C chemokine receptor type 4 [KO:K04179]
104012123  C-C chemokine receptor type 2-like [KO:K04180]
104012124  C-C chemokine receptor type 5-like [KO:K04180]
104009935  CCR10; C-C chemokine receptor type 10 [KO:K04185]
104018384  CCR6; C-C chemokine receptor type 6 [KO:K04181]
104010076  C-X-C chemokine receptor type 1-like [KO:K05050]
104016211  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
104009787  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
104010215  ACKR3; atypical chemokine receptor 3 [KO:K04304]
104012119  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
104012121  XCR1; chemokine XC receptor 1 [KO:K04193]
104012104  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
104010490  interleukin-2 receptor subunit alpha-like [KO:K05068]
104021675  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
104012899  IL2RG; LOW QUALITY PROTEIN: cytokine receptor common subunit gamma [KO:K05070]
104015288  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
104018643  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
104010514  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
104015159  IL21R; interleukin-21 receptor [KO:K05075]
104009840  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
104021581  cytokine receptor common subunit beta-like [KO:K04738]
104021674  LOW QUALITY PROTEIN: cytokine receptor common subunit beta-like [KO:K04738]
104016942  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
104009839  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
104009847  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
104012887  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
104012893  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
104009742  growth hormone receptor [KO:K05080]
104020641  GHR; growth hormone receptor [KO:K05080]
104014001  PRLR; prolactin receptor isoform X1 [KO:K05081]
104015561  MPL; LOW QUALITY PROTEIN: thrombopoietin receptor [KO:K05082]
104017904  granulocyte colony-stimulating factor receptor-like [KO:K05061]
104009244  LEPR; leptin receptor [KO:K05062]
104014605  interleukin-6 receptor subunit beta-like [KO:K05060]
104013731  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
104017598  IL11RA; interleukin-11 receptor subunit alpha [KO:K05056]
104018782  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
104009324  LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-2-like [KO:K05064]
104013733  IL31RA; LOW QUALITY PROTEIN: interleukin-31 receptor subunit alpha [KO:K22630]
104017599  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
104009179  leukemia inhibitory factor receptor-like [KO:K05058]
104022972  oncostatin-M-specific receptor subunit beta-like [KO:K05057]
104019035  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
104020119  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
104008815  IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]
104023436  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
104017856  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
104017737  IFNLR1; interferon lambda receptor 1 [KO:K05140]
104020173  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
104020172  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
104008886  IFNGR1; interferon gamma receptor 1 [KO:K05132]
104020120  IFNGR2; interferon gamma receptor 2 [KO:K05133]
104019340  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
104015670  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
104019397  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
104019341  interleukin-1 receptor type 1-like [KO:K05172]
104019344  IL18R1; interleukin-18 receptor 1 [KO:K05173]
104019398  IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]
104019342  IL1RL1; interleukin-1 receptor-like 1 isoform X1 [KO:K05171]
104020208  IL17RA; interleukin-17 receptor A [KO:K05164]
104010829  IL17RB; LOW QUALITY PROTEIN: interleukin-17 receptor B [KO:K05165]
104016976  IL17RE; interleukin-17 receptor E [KO:K05168]
104022494  T-cell surface glycoprotein CD4-like [KO:K06454]
104014195  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
104008622  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
104009084  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
104020059  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
104013978  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
104019542  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B [KO:K04722]
104014737  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
104019359  EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162]
104012916  EDA2R; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 27 [KO:K05163]
104012242  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
104018001  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
104021923  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
104009007  TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145]
104018331  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
104008967  TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
104009060  TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
104015019  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
104015113  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
104021708  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
104023032  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
104022767  RELT; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 19L [KO:K05156]
104016576  RELL2; RELT-like protein 2 [KO:K26541]
104009815  RELL1; RELT-like protein 1 [KO:K26541]
104021869  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
104020241  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
104013882  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
104011976  ACVRL1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
104009770  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
104010202  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
104014900  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
104011977  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
104012352  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
104012353  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
104013448  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
104021195  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   
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