KEGG ORTHOLOGY: K09446

ORTHOLOGY: K09446

Entry

K09446                      KO

Symbol

IRF5

Name

interferon regulatory factor 5

Pathway

map04620

Toll-like receptor signaling pathway

Disease

H00080

Systemic lupus erythematosus

H00630

Rheumatoid arthritis

H01227

Inflammatory bowel disease (IBD)

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K09446  IRF5; interferon regulatory factor 5
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09446  IRF5; interferon regulatory factor 5
Transcription factors [BR:ko03000]
Eukaryotic type
  Helix-turn-helix
   Tryptophan clusters interferon-regulating factors
    K09446  IRF5; interferon regulatory factor 5

Genes

HSA:	3663(IRF5)

PTR:	472512(IRF5)

PPS:	100990704(IRF5)

GGO:	101145333(IRF5)

PON:	100448322(IRF5)

PPYG:

129041715(IRF5)

NLE:	100596283(IRF5)

HMH:	116814338(IRF5)

SSYN:

129484984(IRF5)

MCC:	700725(IRF5)

MCF:	102117457(IRF5)

MTHB:

126949759

MNI:

105476633

CSAB:

103226874(IRF5)

CATY:

105598557(IRF5)

PANU:

101025947(IRF5)

TGE:	112620125(IRF5)

MLEU:

105550836(IRF5)

RRO:	104674441(IRF5)

RBB:	108544866(IRF5)

TFN:	117073259(IRF5)

PTEH:

111550223(IRF5)

CANG:

105510009(IRF5)

CJC:	100396202(IRF5)

SBQ:	101044656(IRF5)

CIMI:

108318476(IRF5)

ANAN:

105732060(IRF5)

CSYR:

103265949(IRF5)

MMUR:

105884852(IRF5)

LCAT:

123647000(IRF5)

PCOQ:

105826763(IRF5)

OGA:	100956488(IRF5)

MMU:	27056(Irf5)

MCAL:

110295576(Irf5)

MPAH:

110317040(Irf5)

RNO:	296953(Irf5)

MCOC:

116098667(Irf5)

ANU:	117720399(Irf5)

MUN:	110550974(Irf5)

CGE:	100753482(Irf5)

MAUA:

101826027(Irf5)

PROB:

127215391(Irf5)

PLEU:

114691081(Irf5)

MORG:

121463302(Irf5)

MFOT:

126501057

AAMP:

119806350(Irf5)

NGI:	103744552(Irf5)

HGL:	101713015(Irf5)

CPOC:

100731125(Irf5)

CCAN:

109684116(Irf5)

DORD:

105988384(Irf5)

DSP:	122121889(Irf5)

PLOP:

125347117(Irf5)

NCAR:

124990365

MMMA:

107149065(Irf5)

OCU:

100350244

OPI:	101530471(IRF5)

TUP:	102481617(IRF5)

GVR:

103605362

CFA:	482264(IRF5)

CLUD:

112675069(IRF5)

VVP:	112928914(IRF5)

VLG:	121474694(IRF5)

NPO:	129498172(IRF5)

AML:	100482224(IRF5)

UMR:	103676645(IRF5)

UAH:	113263966(IRF5)

UAR:	123788973(IRF5)

ELK:

111152072

LLV:

125080590

MPUF:

101689259(IRF5)

MNP:	132015721(IRF5)

MLK:	131829743(IRF5)

NVS:	122905055(IRF5)

ORO:	101363526 101369106(IRF5)

EJU:	114210686(IRF5)

ZCA:	113911273(IRF5) 113931155

MLX:	118021067(IRF5)

NSU:	110588916(IRF5)

LWW:	102737824(IRF5)

FCA:	101082480(IRF5)

PYU:	121028359(IRF5)

PCOO:

112866545(IRF5)

PBG:	122488248(IRF5)

PVIV:

125155424(IRF5)

LRUF:

124525096

PTG:	102959755(IRF5)

PPAD:

109268969(IRF5)

PUC:

125930136

AJU:

106973897

HHV:	120238853(IRF5)

BTA:	615340(IRF5)

BOM:	102265267(IRF5)

BIU:	109557613(IRF5)

BBUB:

102396744(IRF5)

BBIS:

104982338(IRF5)

CHX:	102177495(IRF5)

OAS:	101105408(IRF5)

BTAX:

128046582(IRF5)

ODA:	120877335(IRF5)

CCAD:

122438623(IRF5)

MBEZ:

129552632(IRF5)

SSC:	100515633(IRF5)

CFR:	102521248(IRF5)

CBAI:

105063094(IRF5)

CDK:	105085373(IRF5)

VPC:	102540618(IRF5)

BACU:

102999899(IRF5)

BMUS:

118901091(IRF5)

LVE:	103087058(IRF5)

OOR:	101276514(IRF5)

DLE:	111178628(IRF5)

PCAD:

102995023(IRF5)

PSIU:

116759101(IRF5)

NASI:

112411486(IRF5)

ECB:	100071786(IRF5)

EPZ:	103545019(IRF5)

EAI:	106839537(IRF5)

MYB:	102247368(IRF5)

MYD:	102755684(IRF5)

MMYO:

118666426(IRF5)

MLF:	102425960(IRF5)

MDT:	132242741(IRF5)

PKL:	118712574(IRF5)

EFUS:

103297336(IRF5)

MNA:	107537322(IRF5)

DRO:	112299882(IRF5)

SHON:

118989165(IRF5)

AJM:	119065652(IRF5)

PDIC:

114507644(IRF5)

PHAS:

123829796(IRF5)

MMF:	118620151(IRF5)

PPAM:

129062793(IRF5)

HAI:	109384583(IRF5)

RFQ:	117018334(IRF5)

PALE:

102893406(IRF5)

PGIG:

120601202(IRF5)

PVP:	105290190(IRF5)

RAY:	107512801(IRF5)

MJV:	108403349 118966857

TOD:	119246610(IRF5)

SARA:

101536846(IRF5)

SETR:

126011090(IRF5)

LAV:	100667576(IRF5)

TMU:

101346244

ETF:	101664252(IRF5)

DNM:	101430961(IRF5)

MDO:	100019623(IRF5)

GAS:	123249939(IRF5)

SHR:	100934633(IRF5)

AFZ:

127539025

PCW:	110219197(IRF5)

TVP:	118849648(IRF5)

OAA:	100078605(IRF5)

GGA:	430409(IRF5)

PCOC:

116236439(IRF5)

MGP:	100539274(IRF5)

CJO:	107309479(IRF5)

TPAI:

128079663(IRF5)

LMUT:

125686786(IRF5)

NMEL:

110392185(IRF5)

ACYG:

106048923(IRF5)

CATA:

118260787(IRF5)

AFUL:

116497862(IRF5)

TGU:	100231310(IRF5)

LSR:	110479578(IRF5)

SCAN:

103822497(IRF5)

PMOA:

120500105(IRF5)

OTC:	121337176(IRF5)

PRUF:

121355077(IRF5)

GFR:	102039737(IRF5)

FAB:	101807998(IRF5)

OMA:	130248371(IRF5)

PHI:	102110301(IRF5)

PMAJ:

107198772(IRF5)

CCW:	120411902(IRF5)

CBRC:

103619219(IRF5)

ZLE:	135442868(IRF5)

SVG:	106861999(IRF5)

HRT:	120751485(IRF5)

SATI:

136361199(IRF5)

FPG:	101924441(IRF5)

FCH:	102049457(IRF5)

SHAB:

115604755(IRF5)

ACHC:

115341524(IRF5)

HLE:	104832552(IRF5)

AGEN:

126044312

GCL:

127019363

DPUB:

104300047(IRF5)

NNI:	104010502(IRF5)

CUCA:

104061381(IRF5)

ACAR:

104524162

RTD:	128904389(IRF5)

AROW:

112978046(IRF5)

DNE:

112994183

ASN:	102380712(IRF5)

AMJ:	102561832(IRF5)

CPOO:

109315872(IRF5)

GGN:	109292288(IRF5)

CMY:	102942921(IRF5)

CCAY:

125630619(IRF5)

DCC:	119849847(IRF5)

CPIC:

101948988(IRF5)

TST:	117873852(IRF5)

CABI:

116827321(IRF5)

MRV:	120395530(IRF5)

ASAO:

132775629(IRF5)

PVT:	110089403(IRF5)

SUND:

121932322(IRF5)

PBI:	103048444(IRF5)

PMUR:

107296491(IRF5)

CTIG:

120308971(IRF5)

TSR:

106543909

PGUT:

117658990(IRF5)

APRI:

131201849(IRF5)

PTEX:

113451326(IRF5)

NSS:

113431709

VKO:	123023031(IRF5)

PMUA:

114605519(IRF5)

PRAF:

128421665(IRF5)

ZVI:	118091540(IRF5)

HCG:	128326785(IRF5)

GJA:	107123977(IRF5)

STOW:

125434721(IRF5)

EMC:	129336291(IRF5)

XLA:	108713026(irf5.S) 494760(irf5.L)

XTR:	734065(irf5)

NPR:	108787502(IRF5)

RTEM:

120931612(IRF5)

BBUF:

120985316(IRF5)

BGAR:

122924623(IRF5)

MUO:	115478961(IRF5)

GSH:	117367273(IRF5)

DRE:	405811(irf5)

SRX:	107725599 107757280

SANH:

107655585 107694268

SGH:	107577905 107587141

CCAR:

109051373 109067118

CAUA:

113047997 113048008 113060421 113071158

CGIB:

127956141 127975816

PTET:

122342544(irf5)

LROH:

127163902(irf5)

OMC:	131538879(irf5)

PPRM:

120476891(irf5)

RKG:	130078790(irf5)

MAMB:

125244783(irf5)

CERY:

137024383(irf5)

MASI:

127434971 127436400

TROS:

130547817(irf5)

TDW:	130420332(irf5)

MANU:

129432276(irf5)

IPU:

108279540

IFU:	128623614(irf5)

PHYP:

113544569(irf5)

SMEO:

124401019(irf5)

TFD:	113645427(irf5)

TVC:	132858869(irf5)

TRN:	134313025(irf5)

AMEX:

103026301(irf5)

CMAO:

118812089(irf5)

EEE:	113579994(irf5)

CHAR:

105904102(irf5)

TRU:	101069931(irf5)

TFS:	130519233(irf5)

TNG:	GSTEN00005042G001

LCO:	104938442(irf5)

NCC:

104962668

TBEN:

117469156(irf5)

CGOB:

115004774(irf5)

GACU:

117535252(irf5)

EMAC:

134878956(irf5)

ELY:	117249602(irf5)

EFO:	125882779(irf5)

PLEP:

121961362 121961700

SLUC:

116065897(irf5)

ECRA:

117939024

ESP:

116679300

PFLV:

114550224(irf5)

GAT:	120817159(irf5)

PPUG:

119211595(irf5)

AFB:	129112860(irf5)

CLUM:

117726284(irf5)

PSWI:

130200505(irf5)

MSAM:

119884218 119895517

SCHU:

122870965(irf5)

CUD:	121505731(irf5)

ALAT:

119032679(irf5)

MZE:	101473648(irf5)

ONL:	100705073(irf5)

OAU:	116313766(irf5)

OLA:	101173363(irf5)

OML:	112155073(irf5)

CSAI:

133423808(irf5)

XMA:	102228154(irf5)

XCO:	114161220(irf5)

XHE:	116736568(irf5)

PRET:

103459824(irf5)

PFOR:

103129968(irf5)

PLAI:

106935067(irf5)

PMEI:

106931755(irf5)

GAF:	122826477(irf5)

PPRL:

129351945(irf5)

CVG:	107092964(irf5)

CTUL:

119778955(irf5)

GMU:	124883361(irf5)

NFU:	107395293(irf5)

KMR:	108250552(irf5)

ALIM:

106535219

NWH:

119428361

AOCE:

111567780(irf5)

CSEM:

103382593(irf5)

POV:

109641645

SSEN:

122766419(irf5)

HHIP:

117757300(irf5)

HSP:	118101511(irf5)

PPLT:

128428712(irf5)

SMAU:

118282778 124850820

LCF:

108892410

SDU:	111238871(irf5)

SLAL:

111670438(irf5)

XGL:	120787040(irf5)

HCQ:	109532666(irf5)

SSCV:

125992458

SBIA:

133493228(irf5)

PEE:	133397338(irf5)

PTAO:

133472190(irf5)

BPEC:

110161549(irf5)

MALB:

109967725(irf5)

BSPL:

114862379(irf5)

SJO:	128385141(irf5)

SASA:

100194823(irf5) 106609132

STRU:

115180513 115198674

OTW:	112214399 112216804(irf5)

OMY:	110490197 110500261

OGO:	123994702 124013705

ONE:	115106895 115133223

OKI:	109864361 109896803

OKE:	118366165 118392283

SALP:

111950925 111951284

SNH:	120032130 120049858

CCLU:

121543721 121546289

ELS:	105020171(irf5)

SFM:	108918775 108936304

PKI:	111833265(irf5)

AANG:

118232460(irf5)

LOC:	102682374(irf5)

PSPA:

121318179 121319896

ARUT:

117415964 117420155 117967638

PSEX:

120534124(irf5)

LCM:	102347224(IRF5)

RTP:

CPLA:

HOC:

LERI:

PMRN:

BFO:

CIN:	100169882(ci-irf-like-2) 100177097

SCLV:

120333105 120339349

PCAN:

112576908

BGT:

106057524

GAE:	121388450 121389486

HRF:

PMAX:

LJP:

LAK:

LLON:

AQU:	100631948 105316800

» show all

Reference

PMID:15695821

Authors

Schoenemeyer A, Barnes BJ, Mancl ME, Latz E, Goutagny N, Pitha PM, Fitzgerald KA, Golenbock DT

Title

The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.

Journal

J Biol Chem 280:17005-12 (2005)
DOI:10.1074/jbc.M412584200

Sequence

[hsa:3663]

LinkDB

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