KEGG   PATHWAY: npo04723
Entry
npo04723                    Pathway                                
Name
Retrograde endocannabinoid signaling - Nyctereutes procyonoides (raccoon dog)
Description
Endogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic acid; the two best characterized are arachydonoyl ethanolamide (anandamide, AEA) and 2-arachydonoil glycerol (2AG). They are released from postsynaptic neurons upon postsynaptic depolarization and/or receptor activation. The released endocannabinoids then activate the CB1 receptors (CB1R) at presynaptic terminals and suppress the release of inhibitory transmitter GABA (depolarization-induced suppression of inhibition, DSI) or excitatory transmitter glutamate (depolarization-induced suppression of excitation, DSE) by inhibiting Ca2+ channels. Besides the well-known expression of the CB1R in the plasma membrane, this receptor is also present in mitochondrial membranes, where it reduces the mitochondrial respiration and contributes to DSI. Whereas DSI and DSE result in short-term synaptic plasticity, endocannabinoids also mediate long-term synaptic changes (eCB-LTD). Persistent activation of CB1 receptors over a period of minutes triggers eCB-LTD by a RIM1alpha-dependent mechanism.
Class
Organismal Systems; Nervous system
Pathway map
npo04723  Retrograde endocannabinoid signaling
npo04723

Other DBs
GO: 0071926
Organism
Nyctereutes procyonoides (raccoon dog) [GN:npo]
Gene
129505037  SLC17A6; vesicular glutamate transporter 2 [KO:K12302]
129499656  SLC17A7; vesicular glutamate transporter 1 [KO:K12302]
129516867  SLC17A8; vesicular glutamate transporter 3 [KO:K12302]
129509702  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
129516741  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
129518361  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
129497696  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
129503382  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
129521343  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
129517804  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
129505985  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
129500488  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
129506787  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
129500644  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
129496894  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
129504276  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
129497646  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
129500550  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
129521608  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
129505465  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
129512495  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
129494215  NAPEPLD; N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D [KO:K13985] [EC:3.1.4.54]
129494612  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
129519978  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
129500385  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
129501883  DAGLA; diacylglycerol lipase-alpha isoform X1 [KO:K13806] [EC:3.1.1.116]
129519957  DAGLB; diacylglycerol lipase-beta isoform X1 [KO:K13806] [EC:3.1.1.116]
129505764  PTGS2; prostaglandin G/H synthase 2 isoform X1 [KO:K11987] [EC:1.14.99.1]
129521831  ABHD6; monoacylglycerol lipase ABHD6 [KO:K13700] [EC:3.1.1.23]
129520627  fatty-acid amide hydrolase 1 [KO:K15528] [EC:3.5.1.99]
129520659  fatty-acid amide hydrolase 1-like isoform X1 [KO:K15528] [EC:3.5.1.99]
129513163  CNR1; cannabinoid receptor 1 [KO:K04277]
129494269  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
129519569  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
129522106  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
129513852  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
129497735  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
129520313  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
129503454  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
129498348  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
129506463  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
129496421  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
129501173  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
129499161  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1 [KO:K04541]
129520219  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
129520847  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
129522362  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
129499702  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
129494664  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
129498223  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
129519244  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
129521436  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
129519415  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
129498294  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
129512848  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
129498792  KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
129501980  KCNJ6; G protein-activated inward rectifier potassium channel 2 isoform X1 [KO:K05000]
129515270  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
129497495  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
129522364  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
129515558  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
129502349  mitogen-activated protein kinase 3-like [KO:K04371] [EC:2.7.11.24]
129507918  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129519082  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129494670  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129501796  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
129522825  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129511619  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
129511620  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
129512956  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
129512957  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
129515724  LOW QUALITY PROTEIN: adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
129516202  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
129498939  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
129510932  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
129499511  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
129503910  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
129517234  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
129513386  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
129502672  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
129519450  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
129519960  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
129521768  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
129522532  MGLL; monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
8690253  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
8690241  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
8690247  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
8690249  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
8690248  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
8690250  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
8690251  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
129503083  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
129508699  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
129502163  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
129496000  LOW QUALITY PROTEIN: uncharacterized protein LOC129496000 [KO:K03944]
129509004  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
129518265  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
129510084  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
129514260  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
129500932  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
129516053  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
129521197  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
129494510  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
129494624  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
129503020  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
129506342  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
129511392  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
129511553  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
129513361  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
129521225  LOW QUALITY PROTEIN: cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
129508091  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
129498109  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
129499056  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
129509859  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
129513410  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
129511720  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
129522012  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
129516722  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
129503435  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1 [KO:K03953]
129521758  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial-like [KO:K03953]
129493906  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
129519296  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
129504115  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
129521377  NDUFA11; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
129516999  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
129521333  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
129516190  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
129518682  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial-like [KO:K03958]
129522803  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
129503594  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
129498921  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
129494756  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
129522449  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
129493660  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
129502473  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
129507967  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10-like [KO:K03966]
129519719  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
129517809  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
129522770  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
129515347  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
129502501  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
129509375  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
129519941  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial-like [KO:K03937]
129520872  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
129498876  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
129521661  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
129501962  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
129503595  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
129504424  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
129506735  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
129497302  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
129512916  RIMS1; regulating synaptic membrane exocytosis protein 1 isoform X1 [KO:K15291]
129509634  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
129509772  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
129510385  GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
129518493  GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 isoform X1 [KO:K05175]
129518942  GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 isoform X1 [KO:K05175]
129519943  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175]
129509631  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 [KO:K05181]
129510508  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
129520639  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 isoform X1 [KO:K05181]
129509332  GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
129510567  GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186]
129519006  GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
129497728  GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184]
129518490  GABRE; gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
129518135  GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192]
129509744  GABRP; gamma-aminobutyric acid receptor subunit pi isoform X1 [KO:K05189]
129503736  GABRR3; LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
129512346  GABRR1; gamma-aminobutyric acid receptor subunit rho-1 [KO:K05190]
129512927  GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00116  Glycerol
C00157  Phosphatidylcholine
C00165  Diacylglycerol
C00189  Ethanolamine
C00219  Arachidonate
C00238  Potassium cation
C00334  4-Aminobutanoate
C00350  Phosphatidylethanolamine
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00689  alpha,alpha'-Trehalose 6-phosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C11695  Anandamide
C13856  2-Arachidonoylglycerol
C19912  N-Arachidonoyl-phosphatidylethanolamine
C19913  Phospho-anandamide
Reference
PMID:17419048
  Authors
Hashimotodani Y, Ohno-Shosaku T, Kano M
  Title
Ca(2+)-assisted receptor-driven endocannabinoid release: mechanisms that associate presynaptic and postsynaptic activities.
  Journal
Curr Opin Neurobiol 17:360-5 (2007)
DOI:10.1016/j.conb.2007.03.012
Reference
PMID:21531987
  Authors
Ohno-Shosaku T, Tanimura A, Hashimotodani Y, Kano M
  Title
Endocannabinoids and retrograde modulation of synaptic transmission.
  Journal
Neuroscientist 18:119-32 (2012)
DOI:10.1177/1073858410397377
Reference
PMID:18084639
  Authors
Basavarajappa BS
  Title
Neuropharmacology of the endocannabinoid signaling system-molecular mechanisms, biological actions and synaptic plasticity.
  Journal
Curr Neuropharmacol 5:81-97 (2007)
DOI:10.2174/157015907780866910
Reference
PMID:16968947
  Authors
Pacher P, Batkai S, Kunos G
  Title
The endocannabinoid system as an emerging target of pharmacotherapy.
  Journal
Pharmacol Rev 58:389-462 (2006)
DOI:10.1124/pr.58.3.2
Reference
PMID:15340387
  Authors
Di Marzo V, Bifulco M, De Petrocellis L
  Title
The endocannabinoid system and its therapeutic exploitation.
  Journal
Nat Rev Drug Discov 3:771-84 (2004)
DOI:10.1038/nrd1495
Reference
PMID:17404373
  Authors
Hashimotodani Y, Ohno-Shosaku T, Kano M
  Title
Endocannabinoids and synaptic function in the CNS.
  Journal
Neuroscientist 13:127-37 (2007)
DOI:10.1177/1073858406296716
Reference
PMID:19126760
  Authors
Kano M, Ohno-Shosaku T, Hashimotodani Y, Uchigashima M, Watanabe M
  Title
Endocannabinoid-mediated control of synaptic transmission.
  Journal
Physiol Rev 89:309-80 (2009)
DOI:10.1152/physrev.00019.2008
Reference
PMID:19640475
  Authors
Regehr WG, Carey MR, Best AR
  Title
Activity-dependent regulation of synapses by retrograde messengers.
  Journal
Neuron 63:154-70 (2009)
DOI:10.1016/j.neuron.2009.06.021
Reference
PMID:17636069
  Authors
Benarroch E
  Title
Endocannabinoids in basal ganglia circuits: implications for Parkinson disease.
  Journal
Neurology 69:306-9 (2007)
DOI:10.1212/01.wnl.0000267407.79757.75
Reference
PMID:16085309
  Authors
Ohno-Shosaku T, Hashimotodani Y, Maejima T, Kano M
  Title
Calcium signaling and synaptic modulation: regulation of endocannabinoid-mediated synaptic modulation by calcium.
  Journal
Cell Calcium 38:369-74 (2005)
DOI:10.1016/j.ceca.2005.06.014
Reference
PMID:18801434
  Authors
Harkany T, Mackie K, Doherty P
  Title
Wiring and firing neuronal networks: endocannabinoids take center stage.
  Journal
Curr Opin Neurobiol 18:338-45 (2008)
DOI:10.1016/j.conb.2008.08.007
Reference
PMID:18515270
  Authors
Hosking RD, Zajicek JP
  Title
Therapeutic potential of cannabis in pain medicine.
  Journal
Br J Anaesth 101:59-68 (2008)
DOI:10.1093/bja/aen119
Reference
PMID:21187849
  Authors
Di Marzo V
  Title
Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight.
  Journal
Nat Neurosci 14:9-15 (2011)
DOI:10.1038/nn.2720
Reference
PMID:18948642
  Authors
McPartland JM
  Title
The endocannabinoid system: an osteopathic perspective.
  Journal
J Am Osteopath Assoc 108:586-600 (2008)
DOI:10.7556/jaoa.2008.108.10.586
Reference
PMID:17553427
  Authors
Chevaleyre V, Heifets BD, Kaeser PS, Sudhof TC, Castillo PE
  Title
Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha.
  Journal
Neuron 54:801-12 (2007)
DOI:10.1016/j.neuron.2007.05.020
Reference
PMID:19553483
  Authors
Lafourcade CA
  Title
Presynaptic mechanisms of endocannabinoid-mediated long-term depression in the hippocampus.
  Journal
J Neurophysiol 102:2009-12 (2009)
DOI:10.1152/jn.00441.2009
Reference
PMID:21328621
  Authors
Ueda N, Tsuboi K, Uyama T, Ohnishi T
  Title
Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol.
  Journal
Biofactors 37:1-7 (2011)
DOI:10.1002/biof.131
Reference
PMID:14978245
  Authors
Guo J, Ikeda SR
  Title
Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons.
  Journal
Mol Pharmacol 65:665-74 (2004)
DOI:10.1124/mol.65.3.665
Reference
PMID:22388959
  Authors
Benard G, Massa F, Puente N, Lourenco J, Bellocchio L, Soria-Gomez E, Matias I, Delamarre A, Metna-Laurent M, Cannich A, Hebert-Chatelain E, Mulle C, Ortega-Gutierrez S, Martin-Fontecha M, Klugmann M, Guggenhuber S, Lutz B, Gertsch J, Chaouloff F, Lopez-Rodriguez ML, Grandes P, Rossignol R, Marsicano G
  Title
Mitochondrial CB(1) receptors regulate neuronal energy metabolism.
  Journal
Nat Neurosci 15:558-64 (2012)
DOI:10.1038/nn.3053
Reference
PMID:26260530
  Authors
Busquets-Garcia A, Desprez T, Metna-Laurent M, Bellocchio L, Marsicano G, Soria-Gomez E
  Title
Dissecting the cannabinergic control of behavior: The where matters.
  Journal
Bioessays 37:1215-25 (2015)
DOI:10.1002/bies.201500046
Reference
PMID:28076767
  Authors
Harkany T, Horvath TL
  Title
(S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity.
  Journal
Cell Metab 25:8-10 (2017)
DOI:10.1016/j.cmet.2016.12.020
Reference
PMID:22449955
  Authors
Alger BE, Tang AH
  Title
Do cannabinoids reduce brain power?
  Journal
Nat Neurosci 15:499-501 (2012)
DOI:10.1038/nn.3072
Related
pathway
npo00190  Oxidative phosphorylation
npo04020  Calcium signaling pathway
npo04721  Synaptic vesicle cycle
npo04724  Glutamatergic synapse
npo04727  GABAergic synapse
KO pathway
ko04723   
LinkDB

DBGET integrated database retrieval system