KEGG   PATHWAY: npo04020
Entry
npo04020                    Pathway                                
Name
Calcium signaling pathway - Nyctereutes procyonoides (raccoon dog)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
npo04020  Calcium signaling pathway
npo04020

Other DBs
GO: 0019722
Organism
Nyctereutes procyonoides (raccoon dog) [GN:npo]
Gene
129493567  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
129493604  HTR2B; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2B [KO:K04157]
129493759  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
129493821  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
129493891  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
129494044  P2RX3; P2X purinoceptor 3 [KO:K05217]
129494118  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
129494407  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
129494612  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
129494895  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
129495048  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
129495049  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
129495115  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
129495214  TNNC2; troponin C, skeletal muscle [KO:K12042]
129495445  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
129495495  [KO:K04189]
129495833  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
129495972  CALM1; calmodulin-1 [KO:K02183]
129496180  BDKRB2; B2 bradykinin receptor [KO:K03916]
129496181  BDKRB1; B1 bradykinin receptor [KO:K03915]
129496250  NTSR1; neurotensin receptor type 1 [KO:K04211]
129496345  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
129496894  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
129496986  ADORA2B; adenosine receptor A2b [KO:K04267]
129497471  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
129497477  SLN; sarcolipin [KO:K22642]
129497646  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
129497741  CALML6; calmodulin-like protein 6 [KO:K02183]
129497753  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
129497792  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
129497848  [KO:K04632]
129497947  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
129498939  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
129498957  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
129499133  FGF4; LOW QUALITY PROTEIN: fibroblast growth factor 4 [KO:K04358]
129499171  MRLN; myoregulin [KO:K22643]
129499185  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
129499244  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
129499256  RYR2; ryanodine receptor 2 [KO:K04962]
129499511  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
129499558  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
129499796  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
129499873  FGF21; fibroblast growth factor 21 [KO:K22429]
129499901  HRC; LOW QUALITY PROTEIN: sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
129499919  RYR1; ryanodine receptor 1 [KO:K04961]
129500162  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
129500218  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
129500272  TRDN; triadin isoform X1 [KO:K23449]
129500281  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
129500302  GNA14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
129500385  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
129500488  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
129500550  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
129500583  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
129500594  TPCN2; two pore channel protein 2 isoform X1 [KO:K14077]
129500619  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
129500644  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
129500678  PLN; cardiac phospholamban [KO:K05852]
129500769  CALM3; calmodulin-3 [KO:K02183]
129501189  CASQ2; calsequestrin-2 [KO:K23445]
129501409  TACR1; substance-P receptor [KO:K04222]
129501424  NGF; beta-nerve growth factor [KO:K02582]
129501850  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
129502651  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
129502672  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
129502777  MET; LOW QUALITY PROTEIN: hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
129502839  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
129503172  FGF3; fibroblast growth factor 3 [KO:K04358]
129503174  FGF19; fibroblast growth factor 19 [KO:K22603]
129503274  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
129503368  FGF23; fibroblast growth factor 23 [KO:K22428]
129503382  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
129503472  FGF6; fibroblast growth factor 6 isoform X1 [KO:K04358]
129503580  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
129503986  [KO:K04161]
129504033  MYLK; LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
129504075  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
129504130  RYR3; ryanodine receptor 3 [KO:K04963]
129504266  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
129504276  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
129504328  FGF2; fibroblast growth factor 2 [KO:K18497]
129504390  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
129504554  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
129504579  FGF9; fibroblast growth factor 9 [KO:K04358]
129504994  SMIM6; small integral membrane protein 6 [KO:K26468]
129505084  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
129505123  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
129505383  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
129505465  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
129505606  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
129505656  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
129505762  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
129505927  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
129505976  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
129505985  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
129506303  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
129506414  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
129506662  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
129506710  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
129506787  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
129506931  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
129507359  AGTR1; type-1 angiotensin II receptor [KO:K04166]
129507501  P2RX4; P2X purinoceptor 4 [KO:K05218]
129507502  P2RX7; P2X purinoceptor 7 [KO:K05220]
129507521  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
129507735  TPCN1; two pore channel protein 1 isoform X1 [KO:K16896]
129507958  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
129508024  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
129508049  ADORA2A; adenosine receptor A2a [KO:K04266]
129508071  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
129508073  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
129508386  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
129508633  GNAL; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
129508761  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
129509029  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
129509323  ADRB2; beta-2 adrenergic receptor [KO:K04142]
129509339  FGF10; fibroblast growth factor 10 [KO:K04358]
129509353  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
129509379  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
129509395  P2RX1; P2X purinoceptor 1 [KO:K05215]
129509461  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
129509471  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
129509507  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
129509516  VDAC2; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2 [KO:K15040]
129509546  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
129509550  TACR2; substance-K receptor [KO:K04223]
129509565  FGF18; fibroblast growth factor 18 [KO:K04358]
129509604  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129509757  DRD1; D(1A) dopamine receptor [KO:K04144]
129509841  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
129509949  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
129509961  MCU; LOW QUALITY PROTEIN: calcium uniporter protein, mitochondrial [KO:K20858]
129509978  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
129510115  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
129510132  DRD5; D(1B) dopamine receptor [KO:K05840]
129510148  CCKAR; cholecystokinin receptor type A [KO:K04194]
129510326  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
129510377  [KO:K04809]
129510440  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
129510495  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
129510932  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
129510994  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
129511259  AVPR1A; vasopressin V1a receptor [KO:K04226]
129511332  ERBB3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
129511343  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
129511439  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
129511504  TGFA; protransforming growth factor alpha [KO:K08774]
129511712  CALM2; calmodulin-2 isoform X1 [KO:K02183]
129511777  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
129511858  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
129512083  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
129512183  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
129512495  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
129512682  TFEB; transcription factor EB [KO:K15590]
129512833  [KO:K04632]
129512852  VEGFA; vascular endothelial growth factor A [KO:K05448]
129513052  [KO:K04189]
129513386  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
129513401  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
129513676  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
129513685  [KO:K02183]
129513755  PTAFR; platelet-activating factor receptor [KO:K04279]
129513765  CALML5; calmodulin-like protein 5 [KO:K02183]
129513818  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
129513950  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
129514194  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
129514485  [KO:K04446]
129514745  [KO:K04189]
129514783  [KO:K05126] [EC:2.7.10.1]
129514833  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
129514977  [KO:K10784]
129515030  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
129515076  VEGFC; LOW QUALITY PROTEIN: vascular endothelial growth factor C [KO:K05449]
129515091  AVPR1B; vasopressin V1b receptor [KO:K04227]
129515097  CASQ1; calsequestrin-1 [KO:K23468]
129515367  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
129515548  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
129515558  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
129515649  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
129515655  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
129515724  [KO:K08041] [EC:4.6.1.1]
129515852  KDR; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
129515870  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
129515953  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
129515997  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
129516073  ADRB3; beta-3 adrenergic receptor [KO:K04143]
129516165  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
129516170  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
129516186  FGF20; fibroblast growth factor 20 [KO:K04358]
129516202  [KO:K08041] [EC:4.6.1.1]
129516513  EDNRB; endothelin receptor type B [KO:K04198]
129516551  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
129516662  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
129516825  EDNRA; endothelin-1 receptor [KO:K04197]
129516845  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
129516878  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
129517144  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
129517403  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
129517447  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
129517475  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
129517677  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
129517708  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
129517742  [KO:K05126] [EC:2.7.10.1]
129517804  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
129518285  GRPR; gastrin-releasing peptide receptor [KO:K04169]
129518363  FGF16; fibroblast growth factor 16 [KO:K04358]
129518504  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
129518520  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
129518657  VEGFD; vascular endothelial growth factor D [KO:K05449]
129518875  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
129519140  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
129519281  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
129519347  ORAI2; protein orai-2 [KO:K16057]
129519450  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
129519538  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
129519557  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
129519644  ORAI3; protein orai-3 [KO:K16058]
129519824  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
129519901  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
129519919  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
129519960  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
129519978  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
129520006  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
129520020  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
129520194  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
129520268  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
129520884  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
129521053  F2R; proteinase-activated receptor 1 [KO:K03914]
129521159  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
129521162  CUNH4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
129521210  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
129521218  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
129521230  TACR3; neuromedin-K receptor [KO:K04224]
129521323  TBXA2R; thromboxane A2 receptor isoform X1 [KO:K04264]
129521343  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
129521440  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
129521550  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
129521560  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
129521608  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
129521768  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
129521809  HRH1; histamine H1 receptor [KO:K04149]
129521848  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
129521858  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
129521887  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
129521996  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
129522045  OXTR; oxytocin receptor [KO:K04229]
129522061  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
129522101  [KO:K04282]
129522103  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
129522251  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
129522311  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
129522345  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
129522364  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
129522380  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
129522820  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
129522975  [KO:K05126] [EC:2.7.10.1]
129523016  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
129523256  ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141]
129523273  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
129523284  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
129523357  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
129523448  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
npo04010  MAPK signaling pathway
npo04070  Phosphatidylinositol signaling system
npo04210  Apoptosis
npo04720  Long-term potentiation
npo04730  Long-term depression
KO pathway
ko04020   

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