Entry Name Bacterial invasion of epithelial cells - Ovis aries (sheep)
Description Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signalling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton.
Class Human Diseases; Infectious disease: bacterialBRITE hierarchy
Pathway map oas05100 Bacterial invasion of epithelial cells
Ortholog table Organism Ovis aries (sheep) [GN:
oas ]
Gene 101107633 ARHGAP10; rho GTPase-activating protein 10 isoform X3 [KO:K13736 ]
101123247 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
101111546 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649 ]
101121455 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649 ]
101109759 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
101110015 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
101117348 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922 ] [EC:2.7.1.153 ]
101106932 WASL; actin nucleation-promoting factor WASL isoform X1 [KO:K23612 ]
101120599 LOW QUALITY PROTEIN: actin-binding protein WASF2-like [KO:K05748 ]
101113558 ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X2 [KO:K05757 ]
101105166 LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 1A-like [KO:K05757 ]
101105028 ARPC3; actin-related protein 2/3 complex subunit 3 isoform X2 [KO:K05756 ]
105601868 ARPC4; actin-related protein 2/3 complex subunit 4 isoform X2 [KO:K05755 ]
100037671 ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
101117693 BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726 ]
101112078 MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728 ]
101113898 ARHGEF26; rho guanine nucleotide exchange factor 26 isoform X1 [KO:K13744 ]
101114771 ELMO1; engulfment and cell motility protein 1 isoform X2 [KO:K12366 ]
101114633 ELMO2; engulfment and cell motility protein 2 isoform X1 [KO:K18985 ]
101107217 ELMO3; engulfment and cell motility protein 3 isoform X1 [KO:K19241 ]
Reference Authors Mostowy S, Cossart P
Title Cytoskeleton rearrangements during Listeria infection: clathrin and septins as new players in the game.
Journal Reference Authors Hauck CR, Ohlsen K
Title Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus.
Journal Reference Authors Wang B, Li S, Dedhar S, Cleary PP
Title Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion.
Journal Reference Authors Matsumoto H, Young GM
Title Translocated effectors of Yersinia.
Journal Reference Authors McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title Salmonella takes control: effector-driven manipulation of the host.
Journal Reference Authors Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson PK, Kotani S, Sasakawa C
Title A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling.
Journal Related oas04810 Regulation of actin cytoskeleton
KO pathway LinkDB All DBs
