KEGG   PATHWAY: oas04510
Entry
oas04510                    Pathway                                
Name
Focal adhesion - Ovis aries (sheep)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
oas04510  Focal adhesion
oas04510

Other DBs
GO: 0005925
Organism
Ovis aries (sheep) [GN:oas]
Gene
100101233  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100126571  CAV2; caveolin-2 [KO:K12958]
100127211  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100144763  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100147798  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
100147799  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100169938  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
100196904  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100196905  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
100216328  LAMC2; laminin subunit gamma-2 precursor [KO:K06246]
100216462  FN1; fibronectin isoform X4 [KO:K05717]
100270714  MRCL3; myosin regulatory light chain MRCL3 [KO:K12757]
100270715  MYL11; myosin regulatory light chain 11 [KO:K12758]
100294600  CTNNB1; catenin beta-1 [KO:K02105]
100294652  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100302078  RHOA; transforming protein RhoA [KO:K04513]
100423047  ITGB3; integrin beta-3 isoform X2 [KO:K06493]
100820740  TNXB; tenascin-X isoform X2 [KO:K06252]
100913157  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
101102442  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
101102692  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
101102732  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101102790  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
101102792  CDC42; cell division control protein 42 homolog [KO:K04393]
101102873  VEGFD; vascular endothelial growth factor D [KO:K05449]
101102992  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
101103084  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101103190  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
101103800  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
101104357  HRAS; GTPase HRas isoform X1 [KO:K02833]
101105123  [KO:K12757]
101105162  ITGA11; integrin alpha-11 [KO:K06587]
101105176  LAMB3; laminin subunit beta-3 [KO:K06244]
101105588  LAMC1; laminin subunit gamma-1 [KO:K05635]
101105629  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
101105743  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
101106012  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101106246  [KO:K04513]
101106284  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101106317  RAP1B; ras-related protein Rap-1b [KO:K07836]
101106433  THBS1; thrombospondin-1 isoform X6 [KO:K16857]
101106490  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
101106520  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
101106682  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
101106719  [KO:K06243]
101107228  CAV3; caveolin-3 [KO:K12959]
101107354  VAV1; proto-oncogene vav [KO:K05730]
101107438  BRAF; serine/threonine-protein kinase B-raf isoform X3 [KO:K04365] [EC:2.7.11.1]
101107517  ITGB8; integrin beta-8 isoform X2 [KO:K06591]
101107592  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
101107656  EMP2; epithelial membrane protein 2 [KO:K26256]
101107667  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X2 [KO:K00889] [EC:2.7.1.68]
101107864  COMP; cartilage oligomeric matrix protein [KO:K04659]
101107882  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
101107936  SHC3; SHC-transforming protein 3 [KO:K17448]
101107969  LAMA4; laminin subunit alpha-4 isoform X2 [KO:K06241]
101109363  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
101109432  EMP1; epithelial membrane protein 1 [KO:K26255]
101109759  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101109832  ITGA9; integrin alpha-9 isoform X2 [KO:K06585]
101109893  GRB2; growth factor receptor-bound protein 2 isoform X5 [KO:K04364]
101109956  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
101110015  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101110074  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101110137  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
101110241  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
101110391  PAK3; serine/threonine-protein kinase PAK 3 isoform X2 [KO:K05733] [EC:2.7.11.1]
101110931  VWF; von Willebrand factor [KO:K03900]
101111424  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
101111491  PXN; paxillin isoform X4 [KO:K05760]
101111546  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
101111737  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
101111756  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101111897  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101111927  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
101112406  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X2 [KO:K07861]
101112573  PAK6; serine/threonine-protein kinase PAK 6 isoform X2 [KO:K05735] [EC:2.7.11.1]
101112600  PDGFC; platelet-derived growth factor C isoform X4 [KO:K05450]
101112706  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
101112735  TLN2; talin-2 isoform X1 [KO:K06271]
101113014  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
101113128  COL4A6; collagen alpha-6(IV) chain isoform X2 [KO:K06237]
101113548  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
101113616  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
101113656  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
101113784  MYLK3; myosin light chain kinase 3 isoform X2 [KO:K00907] [EC:2.7.11.18]
101113847  SHC2; SHC-transforming protein 2 [KO:K17447]
101113988  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101114069  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X7 [KO:K00889] [EC:2.7.1.68]
101114307  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
101114596  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X4 [KO:K12329]
101114674  TLN1; talin-1 isoform X2 [KO:K06271]
101115080  RAP1A; ras-related protein Rap-1A [KO:K04353]
101115152  PAK4; serine/threonine-protein kinase PAK 4 isoform X2 [KO:K05734] [EC:2.7.11.1]
101115211  THBS4; thrombospondin-4 [KO:K04659]
101115380  CRK; adapter molecule crk isoform X1 [KO:K04438]
101115445  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
101115485  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
101115537  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X7 [KO:K00889] [EC:2.7.1.68]
101115552  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
101115719  ITGA2B; integrin alpha-IIb isoform X2 [KO:K06476]
101115805  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
101115840  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
101116201  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101116381  XIAP; E3 ubiquitin-protein ligase XIAP isoform X2 [KO:K04725] [EC:2.3.2.27]
101116423  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101116748  TNN; tenascin-N [KO:K06252]
101116784  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
101116840  THBS2; thrombospondin-2 isoform X2 [KO:K04659]
101116866  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
101117156  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
101117205  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
101117211  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
101117247  FLT4; vascular endothelial growth factor receptor 3 isoform X2 [KO:K05097] [EC:2.7.10.1]
101117348  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
101117354  ARHGAP35; rho GTPase-activating protein 35 isoform X1 [KO:K05732]
101117377  ITGA10; integrin alpha-10 isoform X3 [KO:K06586]
101117424  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
101117435  TNR; tenascin-R isoform X1 [KO:K06252]
101117537  CRKL; crk-like protein [KO:K04438]
101117689  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
101117693  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
101117784  PDGFD; platelet-derived growth factor D isoform X3 [KO:K05450]
101118038  ITGA3; integrin alpha-3 isoform X2 [KO:K06482]
101118074  MYL10; myosin regulatory light chain 10 isoform X2 [KO:K12756]
101118172  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
101118176  PARVB; beta-parvin isoform X3 [KO:K06275]
101118337  TNC; tenascin isoform X1 [KO:K06252]
101118410  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101118462  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101118494  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
101118735  [KO:K12757]
101118865  SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099]
101119231  VTN; vitronectin [KO:K06251]
101119242  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101119264  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101119351  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101119602  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
101119848  ITGA2; integrin alpha-2 [KO:K06481]
101119919  ITGB4; integrin beta-4 isoform X3 [KO:K06525]
101119930  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
101120183  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
101120189  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
101120390  FLNA; filamin-A isoform X1 [KO:K04437]
101120460  LAMA3; laminin subunit alpha-3 isoform X6 [KO:K06240]
101120495  IBSP; bone sialoprotein 2 [KO:K06253]
101120658  RELN; reelin precursor [KO:K06249] [EC:3.4.21.-]
101120665  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
101120709  VAV3; guanine nucleotide exchange factor VAV3 isoform X5 [KO:K05730]
101120826  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101120842  PTK2; focal adhesion kinase 1 isoform X13 [KO:K05725] [EC:2.7.10.2]
101120887  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
101121164  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X3 [KO:K06277]
101121312  VCL; vinculin isoform X1 [KO:K05700]
101121444  LAMA5; laminin subunit alpha-5 [KO:K06240]
101121455  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
101121534  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
101121625  PARVA; alpha-parvin isoform X1 [KO:K06275]
101121906  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
101122194  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
101122429  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
101122546  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
101122783  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101123008  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101123197  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101123247  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101123330  FLNB; filamin-B isoform X6 [KO:K27392]
101123517  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101123626  ZYX; zyxin [KO:K06273]
101123635  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
105603910  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
105608408  CHAD; chondroadherin [KO:K06248]
105610645  PARVG; gamma-parvin isoform X2 [KO:K06275]
106991782  [KO:K06243]
114108599  [KO:K04393]
114110058  [KO:K04364]
114110564  PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
114113232  [KO:K07836]
114114919  [KO:K02833]
114116812  [KO:K04513]
443051  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
443052  ACTB; actin, cytoplasmic 1 [KO:K05692]
443058  SPP1; osteopontin precursor [KO:K06250]
443075  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
443076  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
443087  KDR; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
443088  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
443103  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
443140  ITGA5; integrin alpha-5 isoform X2 [KO:K06484]
443141  ITGB1; integrin beta-1 precursor [KO:K05719]
443143  ITGAV; integrin alpha-V precursor [KO:K06487]
443209  ITGB6; integrin beta-6 precursor [KO:K06589]
443219  JUN; transcription factor Jun [KO:K04448]
443245  PGF; placenta growth factor isoform X2 [KO:K16859]
443318  IGF1; insulin-like growth factor I precursor [KO:K05459]
443334  MYLK; myosin light chain kinase, smooth muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
443340  ACTG1; actin, cytoplasmic 2 [KO:K05692]
443483  COL1A1; collagen alpha-1(I) chain [KO:K06236]
443499  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
443512  COL1A2; collagen alpha-2(I) chain [KO:K06236]
443515  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
443545  PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386]
445468  CAV1; caveolin-1 [KO:K06278]
641303  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X5 [KO:K06270]
780444  BAD; bcl2-associated agonist of cell death [KO:K02158]
780479  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
780519  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X2 [KO:K05083] [EC:2.7.10.1]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
oas04010  MAPK signaling pathway
oas04060  Cytokine-cytokine receptor interaction
oas04070  Phosphatidylinositol signaling system
oas04110  Cell cycle
oas04151  PI3K-Akt signaling pathway
oas04310  Wnt signaling pathway
oas04512  ECM-receptor interaction
oas04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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