KEGG   PATHWAY: otw00280
Entry
otw00280                    Pathway                                
Name
Valine, leucine and isoleucine degradation - Oncorhynchus tshawytscha (Chinook salmon)
Class
Metabolism; Amino acid metabolism
Pathway map
otw00280  Valine, leucine and isoleucine degradation
otw00280

Module
otw_M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:otw00280]
otw_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:otw00280]
Other DBs
GO: 0006550 0006552 0006574
Organism
Oncorhynchus tshawytscha (Chinook salmon) [GN:otw]
Gene
112237346  bcat2; branched-chain-amino-acid aminotransferase, cytosolic isoform X1 [KO:K00826] [EC:2.6.1.42]
112215031  branched-chain-amino-acid aminotransferase, cytosolic-like [KO:K00826] [EC:2.6.1.42]
112234087  branched-chain-amino-acid aminotransferase, cytosolic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
112217172  branched-chain-amino-acid aminotransferase, cytosolic-like [KO:K00826] [EC:2.6.1.42]
112266925  L-amino-acid oxidase isoform X1 [KO:K03334] [EC:1.4.3.2]
112265402  L-amino-acid oxidase [KO:K03334] [EC:1.4.3.2]
112238969  bckdha; 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial [KO:K00166] [EC:1.2.4.4]
112232547  2-oxoisovalerate dehydrogenase subunit beta, mitochondrial [KO:K00167] [EC:1.2.4.4]
112223149  2-oxoisovalerate dehydrogenase subunit beta, mitochondrial [KO:K00167] [EC:1.2.4.4]
112250705  dbt; lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial [KO:K09699] [EC:2.3.1.168]
112252089  lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial-like [KO:K09699] [EC:2.3.1.168]
112221332  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
112218211  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
112220230  short-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00248] [EC:1.3.8.1]
112230855  short-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K00248] [EC:1.3.8.1]
112247894  acadm; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
112262118  ivd; isovaleryl-CoA dehydrogenase, mitochondrial [KO:K00253] [EC:1.3.8.4]
112236388  acadsb; short/branched chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K09478] [EC:1.3.8.5]
112265552  acad8; isobutyryl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K11538] [EC:1.3.99.-]
112261537  hadhab; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b [KO:K07515] [EC:4.2.1.17 1.1.1.211]
112256902  trifunctional enzyme subunit alpha, mitochondrial [KO:K07515] [EC:4.2.1.17 1.1.1.211]
112218409  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
112252753  echs1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
112239253  hadh; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
112221480  hsd17b10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
112235894  acaa1; 3-ketoacyl-CoA thiolase, peroxisomal [KO:K07513] [EC:2.3.1.16]
112248600  3-ketoacyl-CoA thiolase, mitochondrial [KO:K07508] [EC:2.3.1.16]
112262751  acaa2; 3-ketoacyl-CoA thiolase, mitochondrial [KO:K07508] [EC:2.3.1.16]
112238055  hadhb; trifunctional enzyme subunit beta, mitochondrial [KO:K07509] [EC:2.3.1.16]
112267650  pcca; propionyl-CoA carboxylase alpha chain, mitochondrial [KO:K01965] [EC:6.4.1.3]
112240046  propionyl-CoA carboxylase beta chain, mitochondrial [KO:K01966] [EC:6.4.1.3 2.1.3.15]
112242452  propionyl-CoA carboxylase beta chain, mitochondrial [KO:K01966] [EC:6.4.1.3 2.1.3.15]
112249131  mcee; methylmalonyl-CoA epimerase, mitochondrial isoform X2 [KO:K05606] [EC:5.1.99.1]
112235776  methylmalonyl-CoA epimerase, mitochondrial-like [KO:K05606] [EC:5.1.99.1]
112232961  methylmalonyl-CoA mutase, mitochondrial-like isoform X1 [KO:K01847] [EC:5.4.99.2]
112235297  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial [KO:K05605] [EC:3.1.2.4]
112238245  hibadhb; 3-hydroxyisobutyrate dehydrogenase b [KO:K00020] [EC:1.1.1.31]
112234305  3-hydroxyisobutyrate dehydrogenase, mitochondrial isoform X2 [KO:K00020] [EC:1.1.1.31]
112217831  methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial [KO:K00140] [EC:1.2.1.18 1.2.1.27]
112250560  methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial [KO:K00140] [EC:1.2.1.18 1.2.1.27]
112261765  methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial isoform X1 [KO:K00140] [EC:1.2.1.18 1.2.1.27]
112227395  aldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
112216717  aldh3a2b; aldehyde dehydrogenase family 3 member A2b [KO:K00128] [EC:1.2.1.3]
112245903  aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
112260528  aldehyde dehydrogenase family 16 member A1-like [KO:K00128] [EC:1.2.1.3]
112256007  aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00128] [EC:1.2.1.3]
112247463  aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
112239159  aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
112237680  aldehyde dehydrogenase family 16 member A1-like [KO:K00128] [EC:1.2.1.3]
112240293  aldehyde dehydrogenase, dimeric NADP-preferring isoform X1 [KO:K00128] [EC:1.2.1.3]
112220006  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
112260713  aldh9a1b; 4-trimethylaminobutyraldehyde dehydrogenase B isoform X1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
112251350  aldh9a1a.1; 4-trimethylaminobutyraldehyde dehydrogenase A [KO:K00149] [EC:1.2.1.47 1.2.1.3]
112266560  aox5; aldehyde oxidase 5 [KO:K00157] [EC:1.2.3.1]
112253972  aox6; aldehyde oxidase 1 isoform X1 [KO:K00157] [EC:1.2.3.1]
112249120  LOW QUALITY PROTEIN: malonate--CoA ligase ACSF3, mitochondrial-like [KO:K18660] [EC:6.2.1.76 6.2.1.-]
112263579  acsf3; malonate--CoA ligase ACSF3, mitochondrial [KO:K18660] [EC:6.2.1.76 6.2.1.-]
112238371  4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
121844302  4-aminobutyrate aminotransferase, mitochondrial-like [KO:K13524] [EC:2.6.1.19 2.6.1.22]
121844402  LOW QUALITY PROTEIN: 4-aminobutyrate aminotransferase, mitochondrial-like [KO:K13524] [EC:2.6.1.19 2.6.1.22]
112257351  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
112248469  methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial isoform X1 [KO:K01968] [EC:6.4.1.4]
112251045  methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial isoform X1 [KO:K01968] [EC:6.4.1.4]
112250988  si:ch211-198n5.11; methylcrotonoyl-coenzyme A carboxylase 2 isoform X1 [KO:K01969] [EC:6.4.1.4]
112238607  mccc2; methylcrotonoyl-CoA carboxylase beta chain, mitochondrial [KO:K01969] [EC:6.4.1.4]
112219980  auh; methylglutaconyl-CoA hydratase, mitochondrial [KO:K05607] [EC:4.2.1.18]
112256594  hydroxymethylglutaryl-CoA lyase, mitochondrial [KO:K01640] [EC:4.1.3.4]
112261937  hydroxymethylglutaryl-CoA lyase, mitochondrial [KO:K01640] [EC:4.1.3.4]
112256863  3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic [KO:K01640] [EC:4.1.3.4]
112224629  3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic-like isoform X1 [KO:K01640] [EC:4.1.3.4]
112230953  succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial [KO:K01027] [EC:2.8.3.5]
112248824  oxct1a; 3-oxoacid CoA transferase 1a isoform X1 [KO:K01027] [EC:2.8.3.5]
112262590  succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial [KO:K01027] [EC:2.8.3.5]
112246718  aacs; acetoacetyl-CoA synthetase [KO:K01907] [EC:6.2.1.16]
112217796  acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
112228596  acat1; acetyl-CoA acetyltransferase, mitochondrial [KO:K00626] [EC:2.3.1.9]
112219999  hmgcs1; hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1 [KO:K01641] [EC:2.3.3.10]
Compound
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00164  Acetoacetate
C00183  L-Valine
C00233  4-Methyl-2-oxopentanoate
C00332  Acetoacetyl-CoA
C00349  2-Methyl-3-oxopropanoate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00407  L-Isoleucine
C00630  2-Methylpropanoyl-CoA
C00671  (S)-3-Methyl-2-oxopentanoic acid
C00683  (S)-Methylmalonyl-CoA
C01205  (R)-3-Amino-2-methylpropanoate
C01213  (R)-Methylmalonyl-CoA
C02170  Methylmalonate
C02939  3-Methylbutanoyl-CoA
C03069  3-Methylcrotonyl-CoA
C03231  3-Methylglutaconyl-CoA
C03284  L-3-Aminoisobutanoate
C03344  2-Methylacetoacetyl-CoA
C03345  2-Methylbut-2-enoyl-CoA
C03460  2-Methylprop-2-enoyl-CoA
C04405  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
C05996  Branched chain fatty acid
C05998  3-Hydroxyisovaleryl-CoA
C06000  (S)-3-Hydroxyisobutyryl-CoA
C06001  (S)-3-Hydroxyisobutyrate
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C15974  3-Methyl-1-hydroxybutyl-ThPP
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  2-Methyl-1-hydroxypropyl-ThPP
C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  2-Methyl-1-hydroxybutyl-ThPP
C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  (S)-2-Methylbutanoyl-CoA
C20827  3-Hydroxyisovalerate
Related
pathway
otw00020  Citrate cycle (TCA cycle)
otw00240  Pyrimidine metabolism
otw00290  Valine, leucine and isoleucine biosynthesis
otw00640  Propanoate metabolism
otw00900  Terpenoid backbone biosynthesis
KO pathway
ko00280   
LinkDB

DBGET integrated database retrieval system