KEGG   PATHWAY: panu00830
Entry
panu00830                   Pathway                                
Name
Retinol metabolism - Papio anubis (olive baboon)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
panu00830  Retinol metabolism
panu00830

Other DBs
GO: 0006776
Organism
Papio anubis (olive baboon) [GN:panu]
Gene
101002112  BCO1; beta,beta-carotene 15,15'-dioxygenase [KO:K00515] [EC:1.13.11.63]
101017481  all-trans-retinol dehydrogenase [NAD(+)] ADH1B [KO:K13951] [EC:1.1.1.1]
101017122  alcohol dehydrogenase 1C isoform X1 [KO:K13951] [EC:1.1.1.1]
101018063  ADH7; all-trans-retinol dehydrogenase [NAD(+)] ADH7 isoform X1 [KO:K13951] [EC:1.1.1.1]
110743301  alcohol dehydrogenase 1A [KO:K13951] [EC:1.1.1.1]
101014044  ADH4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
101012957  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
101014386  ADH6; alcohol dehydrogenase 6 [KO:K13952] [EC:1.1.1.1]
101025196  DHRS3; short-chain dehydrogenase/reductase 3 isoform X1 [KO:K11146] [EC:1.1.1.300]
101009538  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
101012719  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
101009008  DHRS9; dehydrogenase/reductase SDR family member 9 isoform X1 [KO:K11149] [EC:1.1.-.-]
101015346  RDH8; retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
101021993  RDH10; retinol dehydrogenase 10 [KO:K11151] [EC:1.1.1.-]
103875541  RDH11; retinol dehydrogenase 11 isoform X1 [KO:K11152] [EC:1.1.1.300]
101000507  RDH12; retinol dehydrogenase 12 isoform X1 [KO:K11153] [EC:1.1.1.300]
101011773  RDH13; retinol dehydrogenase 13 [KO:K11161] [EC:1.1.1.300]
101005769  RDH16; LOW QUALITY PROTEIN: retinol dehydrogenase 16 [KO:K11154] [EC:1.1.1.-]
100998417  SDR16C5; epidermal retinol dehydrogenase 2 isoform X1 [KO:K15734] [EC:1.1.1.105]
101020435  LRAT; lecithin retinol acyltransferase [KO:K00678] [EC:2.3.1.135]
101020467  DGAT1; diacylglycerol O-acyltransferase 1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
116271873  AWAT2; acyl-CoA wax alcohol acyltransferase 2 [KO:K11156] [EC:2.3.1.75 2.3.1.76]
100998508  acyl-CoA wax alcohol acyltransferase 2 [KO:K11156] [EC:2.3.1.75 2.3.1.76]
101008623  patatin-like phospholipase domain-containing protein 4 isoform X1 [KO:K11157] [EC:3.1.1.-]
101017887  RPE65; retinoid isomerohydrolase [KO:K11158] [EC:3.1.1.64 5.3.3.22]
101020375  RDH5; retinol dehydrogenase 5 [KO:K00061] [EC:1.1.1.315]
101001006  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
101002286  AOX4; aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
101002632  AOX2; aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
101010190  ALDH1A1; retinal dehydrogenase 1 isoform X2 [KO:K07249] [EC:1.2.1.36]
101022100  retinal dehydrogenase 2 [KO:K07249] [EC:1.2.1.36]
116273020  retinal dehydrogenase 2 [KO:K07249] [EC:1.2.1.36]
101011792  ALDH1A3; aldehyde dehydrogenase family 1 member A3 [KO:K07249] [EC:1.2.1.36]
116275817  retinal dehydrogenase 2 [KO:K07249] [EC:1.2.1.36]
101013243  cytochrome P450 26A1 isoform X1 [KO:K07437] [EC:1.14.14.-]
101001697  cytochrome P450 26B1 isoform X1 [KO:K12664] [EC:1.14.14.-]
110744052  LOW QUALITY PROTEIN: cytochrome P450 26C1 [KO:K12665] [EC:1.14.14.-]
101001307  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
101002117  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
101001292  cytochrome P450 2B6 [KO:K17709] [EC:1.14.14.-]
101023648  cytochrome P450 2C20-like [KO:K17718] [EC:1.14.14.1]
101022842  CYP2C8; cytochrome P450 2C20 [KO:K17718] [EC:1.14.14.1]
100997824  cytochrome P450 2C9 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
101012978  cytochrome P450 2C9-like isoform X1 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
101021773  cytochrome P450 2C18 [KO:K17720] [EC:1.14.14.1]
101026117  LOW QUALITY PROTEIN: cytochrome P450 2C31-like [KO:K07413] [EC:1.14.14.1]
101012275  cytochrome P450 2C3-like [KO:K07413] [EC:1.14.14.1]
101003616  cytochrome P450 2S1 [KO:K07420] [EC:1.14.14.1]
101026757  cytochrome P450 3A8 isoform X1 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
100997418  cytochrome P450 3A5 [KO:K17690] [EC:1.14.14.1]
100997059  cytochrome P450 3A7 isoform X1 [KO:K17691] [EC:1.14.14.1]
101001033  cytochrome P450 2W1 [KO:K07423] [EC:1.14.14.-]
101017012  UDP-glucuronosyltransferase 2A2 isoform X2 [KO:K00699] [EC:2.4.1.17]
101020325  UGT2A3; UDP-glucuronosyltransferase 2A3 [KO:K00699] [EC:2.4.1.17]
101010645  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1-3 [KO:K00699] [EC:2.4.1.17]
101019271  UDP-glucuronosyltransferase 2B30 isoform X1 [KO:K00699] [EC:2.4.1.17]
100126698  UGT1A4; UDP-glucuronosyltransferase 1-4 precursor [KO:K00699] [EC:2.4.1.17]
100126700  UGT1A5A; UDP glycosyl transferase 1A5A precursor [KO:K00699] [EC:2.4.1.17]
100126701  UGT1A1; UDP-glucuronosyltransferase 1-1 precursor [KO:K00699] [EC:2.4.1.17]
100126702  UGT1A6; UDP-glucuronosyltransferase 1-6 [KO:K00699] [EC:2.4.1.17]
100126703  UGT1A9; UDP-glucuronosyltransferase 1-9 precursor [KO:K00699] [EC:2.4.1.17]
100126705  UGT1A7; UDP-glucuronosyltransferase 1-7 precursor [KO:K00699] [EC:2.4.1.17]
100126761  UGT1A5B; UDP glycosyl transferase 1A5B precursor [KO:K00699] [EC:2.4.1.17]
100126762  UGT1A10B; UDP glycosyl transferase 1A10B precursor [KO:K00699] [EC:2.4.1.17]
100337517  UGT2B39; UDP-glucuronosyltransferase 2B39 precursor [KO:K00699] [EC:2.4.1.17]
100337521  UGT2B42; UDP-glucuronosyltransferase 2B42 precursor [KO:K00699] [EC:2.4.1.17]
100337522  UGT2B15; UDP-glucuronosyltransferase 2B15 precursor [KO:K00699] [EC:2.4.1.17]
100337523  UGT2B44; UDP-glucuronosyltransferase 2B44 precursor [KO:K00699] [EC:2.4.1.17]
100337524  UGT2B45; UDP-glucuronosyltransferase 2B45 precursor [KO:K00699] [EC:2.4.1.17]
101018628  RETSAT; all-trans-retinol 13,14-reductase [KO:K09516] [EC:1.3.99.23]
101003912  cytochrome P450 27C1 [KO:K17951] [EC:1.14.19.53]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   
LinkDB

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