KEGG   PATHWAY: pcao00230
Entry
pcao00230                   Pathway                                
Name
Purine metabolism - Phalacrocorax carbo (great cormorant)
Class
Metabolism; Nucleotide metabolism
Pathway map
pcao00230  Purine metabolism
pcao00230

Module
pcao_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:pcao00230]
pcao_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:pcao00230]
pcao_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:pcao00230]
pcao_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:pcao00230]
pcao_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:pcao00230]
pcao_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:pcao00230]
Other DBs
GO: 0006163 0042278
Organism
Phalacrocorax carbo (great cormorant) [GN:pcao]
Gene
104048820  NUDT9; ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
104050308  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
104050688  LOW QUALITY PROTEIN: phosphoglucomutase-1-like [KO:K01835] [EC:5.4.2.2]
104041152  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
104049883  LOW QUALITY PROTEIN: ribose-phosphate pyrophosphokinase 1-like [KO:K00948] [EC:2.7.6.1]
104051290  ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
104045264  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
104042539  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
104042541  trifunctional purine biosynthetic protein adenosine-3-like [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
104050423  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
104051816  uncharacterized protein LOC104051816 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
104039666  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
104042263  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
104046448  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
104042317  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
104039576  5'(3')-deoxyribonucleotidase, mitochondrial-like [KO:K01081] [EC:3.1.3.5]
104043116  NT5C2; cytosolic purine 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
104049227  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
104050344  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
104052453  5'(3')-deoxyribonucleotidase, cytosolic type-like [KO:K01081] [EC:3.1.3.5]
104042351  NT5E; LOW QUALITY PROTEIN: 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
104044898  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
104047674  LACC1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
104040799  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
104040611  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
104047706  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
104043698  NME2; nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
104049386  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
104045771  NME7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
104039592  nucleoside diphosphate kinase A isoform X1 [KO:K00940] [EC:2.7.4.6]
104047358  LOW QUALITY PROTEIN: nucleoside diphosphate kinase 3-like [KO:K00940] [EC:2.7.4.6]
104044552  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
104044507  LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
104050493  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
104051740  LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
104051749  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
104041576  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
104049618  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
104045178  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
104039872  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
104045666  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
104046320  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
104044735  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
104046049  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
104046042  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
104047560  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
104044764  GUK1; guanylate kinase [KO:K00942] [EC:2.7.4.8]
104041608  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
104053148  RRM2; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
104045352  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
104049781  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
104044371  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
104050706  deoxycytidine kinase-like [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
104052958  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
104050888  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
104042414  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
104052519  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
104040226  GUCY1A3; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
104044251  GUCY1B3; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
104041311  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
104052962  GUCY2C; LOW QUALITY PROTEIN: heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
104041478  atrial natriuretic peptide receptor 1-like [KO:K12324] [EC:4.6.1.2]
104041570  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like [KO:K13755] [EC:3.1.4.17]
104051676  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
104049772  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
104047424  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
104051496  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
104046127  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
104044242  retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma-like [KO:K13759]
104051797  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
104049018  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
104052500  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
104052374  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
104051891  ADSSL1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
104041581  ADSS; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
104042505  AMPD3; AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
104051962  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
104041164  ADK; adenosine kinase [KO:K00856] [EC:2.7.1.20]
104049194  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
104051564  CECR1; adenosine deaminase CECR1 [KO:K19572] [EC:3.5.4.4]
104046617  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
104051874  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
104041379  AK2; adenylate kinase 2, mitochondrial [KO:K00939] [EC:2.7.4.3]
104046750  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
104047406  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
104039627  AK6; adenylate kinase isoenzyme 6 {ECO:0000255 [KO:K18532] [EC:2.7.4.3]
104040327  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
104052530  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
104048248  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
104049983  ectonucleotide pyrophosphatase/phosphodiesterase family member 3-like [KO:K01513] [EC:3.1.4.1 3.6.1.9]
104052641  ENPP1; LOW QUALITY PROTEIN: ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
104042500  cAMP-specific 3',5'-cyclic phosphodiesterase 4D [KO:K13293] [EC:3.1.4.53]
104039875  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
104044715  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
104044739  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A [KO:K18436] [EC:3.1.4.53]
104042503  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
104043232  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
104049421  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
104048986  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1-like [KO:K13811] [EC:2.7.7.4 2.7.1.25]
104044701  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
104049055  uricase-like [KO:K00365] [EC:1.7.3.3]
104045270  uricase-like [KO:K00365] [EC:1.7.3.3]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
pcao00030  Pentose phosphate pathway
pcao00220  Arginine biosynthesis
pcao00250  Alanine, aspartate and glutamate metabolism
pcao00260  Glycine, serine and threonine metabolism
pcao00340  Histidine metabolism
pcao00630  Glyoxylate and dicarboxylate metabolism
pcao00730  Thiamine metabolism
pcao00740  Riboflavin metabolism
pcao00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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