KEGG   PATHWAY: plop04727
Entry
plop04727                   Pathway                                
Name
GABAergic synapse - Perognathus longimembris pacificus (Pacific pocket mouse)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
plop04727  GABAergic synapse
plop04727

Other DBs
GO: 0051932
Organism
Perognathus longimembris pacificus (Pacific pocket mouse) [GN:plop]
Gene
125341457  sodium-coupled neutral amino acid transporter 1-like [KO:K14990]
125365645  Slc38a1; sodium-coupled neutral amino acid transporter 1 [KO:K14990]
125365630  Slc38a2; sodium-coupled neutral amino acid transporter 2 isoform X1 [KO:K14207]
125362698  Gls2; glutaminase liver isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
125350459  Gls; glutaminase kidney isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
125366848  Gad2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
125349983  Gad1; glutamate decarboxylase 1 isoform X1 [KO:K01580] [EC:4.1.1.15]
125352370  Slc32a1; vesicular inhibitory amino acid transporter [KO:K15015]
125340340  Abat; 4-aminobutyrate aminotransferase, mitochondrial isoform X1 [KO:K13524] [EC:2.6.1.19 2.6.1.22]
125368217  Gabra5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
125341910  Gabra6; gamma-aminobutyric acid receptor subunit alpha-6 isoform X1 [KO:K05175]
125342115  Gabra1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
125343515  Gabra3; gamma-aminobutyric acid receptor subunit alpha-3 [KO:K05175]
125364802  Gabra4; gamma-aminobutyric acid receptor subunit alpha-4 isoform X1 [KO:K05175]
125364831  Gabra2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175]
125368372  Gabrb3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
125341862  Gabrb2; gamma-aminobutyric acid receptor subunit beta-2 [KO:K05181]
125364759  Gabrb1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
125368301  Gabrg3; gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186]
125341850  Gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
125364574  Gabrg1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
125354208  Gabrd; LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit delta [KO:K05184]
125343882  Gabre; gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
125343663  Gabrq; gamma-aminobutyric acid receptor subunit theta isoform X1 [KO:K05192]
125341914  gamma-aminobutyric acid receptor subunit pi [KO:K05189]
125348811  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
125355340  Prkacb; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
125353459  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
125366443  Prkca; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
125340531  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
125338673  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
125366107  Hap1; huntingtin-associated protein 1 isoform X1 [KO:K04647]
125342882  LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
125358174  Gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
125365250  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
125352295  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
125366516  Nsf; vesicle-fusing ATPase [KO:K06027] [EC:3.6.4.6]
125350397  Trak2; trafficking kinesin-binding protein 2 isoform X1 [KO:K15374]
125350429  Plcl1; inactive phospholipase C-like protein 1 [KO:K15375]
125362911  Gphn; gephyrin isoform X1 [KO:K15376] [EC:2.10.1.1 2.7.7.75]
125353850  Slc12a5; solute carrier family 12 member 5 isoform X1 [KO:K23967]
125357137  Gabrr2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
125357660  Gabrr1; gamma-aminobutyric acid receptor subunit rho-1 isoform X1 [KO:K05190]
125351251  Gabrr3; gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
125348843  Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
125352032  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
125342716  Cacna1c; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
125358578  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
125343296  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
125360227  Cacna1s; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
125345678  Gabbr2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
125352841  Gabbr1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
125346949  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
125342659  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
125363844  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
125358438  Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
125354342  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like [KO:K04536]
125354476  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
125367713  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
125351951  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
125340508  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
125362976  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
125362753  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
125367180  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
125355344  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
125348661  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
125338821  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
125346482  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
125366881  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
125347860  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
125364853  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
125365699  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
125347011  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
125355284  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
125340963  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
125345835  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
125365469  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
125345732  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
125367715  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
125356676  Adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
125363469  Adcy4; LOW QUALITY PROTEIN: adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
125345042  LOW QUALITY PROTEIN: adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
125351778  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
125365347  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
125358478  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
125360503  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
125340976  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
125351176  Kcnj6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
125358136  Slc6a1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
125342890  Slc6a13; LOW QUALITY PROTEIN: sodium- and chloride-dependent GABA transporter 2 [KO:K05046]
125358135  Slc6a11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
125359085  Glul; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
125342660  Slc38a3; sodium-coupled neutral amino acid transporter 3 [KO:K13576]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
plop00020  Citrate cycle (TCA cycle)
plop00250  Alanine, aspartate and glutamate metabolism
plop04144  Endocytosis
plop04721  Synaptic vesicle cycle
KO pathway
ko04727   
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