KEGG   PATHWAY: psex04540
Entry
psex04540                   Pathway                                
Name
Gap junction - Polypterus senegalus (gray bichir)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
psex04540  Gap junction
psex04540

Other DBs
GO: 0005921
Organism
Polypterus senegalus (gray bichir) [GN:psex]
Gene
120525404  gap junction alpha-1 protein [KO:K07372]
120518954  gjd2b; gap junction protein delta 2b [KO:K07373]
120541383  gjd6; gap junction protein delta 6 [KO:K07373]
120533698  gap junction delta-2 protein-like [KO:K07373]
120527424  lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
120540294  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
120525896  gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
120533926  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
120542103  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
120523158  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
120527165  pdgfc; platelet-derived growth factor C [KO:K05450]
120533101  egf; pro-epidermal growth factor [KO:K04357]
120527608  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
120542138  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
120529821  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
120517145  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
120516982  son of sevenless homolog 1-like isoform X1 [KO:K03099]
120518289  sos2; son of sevenless homolog 2 [KO:K03099]
120523258  GTPase HRas [KO:K02833]
120534191  GTPase KRas isoform X1 [KO:K07827]
120542190  GTPase HRas-like [KO:K07827]
120526283  nras; GTPase NRas [KO:K07828]
120540276  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
120541670  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
120537759  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
120540631  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
120536571  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
120514252  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
120531266  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
120541660  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
120519620  mapk7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
120537565  tubulin alpha-8 chain-like [KO:K07374]
120537566  tubulin alpha-8 chain-like [KO:K07374]
120537949  tubulin alpha-8 chain-like [KO:K07374]
120531271  tubulin alpha-1A chain-like [KO:K07374]
120531272  tubulin alpha chain [KO:K07374]
120531273  tubulin alpha-1D chain-like [KO:K07374]
120531274  tubulin alpha chain [KO:K07374]
120532507  tubulin alpha-8 chain-like [KO:K07374]
120532509  tubulin alpha-8 chain-like [KO:K07374]
120525205  tubulin alpha-1B chain-like [KO:K07374]
120525208  tubulin alpha-1A chain [KO:K07374]
120525209  tubulin alpha-1B chain [KO:K07374]
120525211  tubulin alpha-1C chain [KO:K07374]
120525489  tubulin alpha-1B chain-like [KO:K07374]
120526300  tubulin alpha-1 chain-like [KO:K07374]
120534363  tubulin alpha-8 chain-like [KO:K07374]
120534465  tubulin alpha chain, testis-specific-like isoform X1 [KO:K07374]
120534482  tubulin alpha-2/alpha-4 chain-like [KO:K07374]
120530389  tubb6; tubulin beta-5 chain [KO:K07375]
120539667  tubulin beta chain [KO:K07375]
120514390  tubb1; tubulin beta-1 chain [KO:K07375]
120541106  tubulin beta-4B chain-like [KO:K07375]
120542025  tubulin beta-4B chain-like [KO:K07375]
120542069  tubulin beta-4B chain isoform X1 [KO:K07375]
120542070  tubulin beta-4B chain-like [KO:K07375]
120535509  tubulin beta-3 chain [KO:K07375]
120529550  tubulin beta chain-like isoform X1 [KO:K07375]
120529553  tubulin beta chain-like [KO:K07375]
120529554  tubulin beta-2B chain [KO:K07375]
120517703  casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
120540527  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
120543090  adrb1; beta-1 adrenergic receptor [KO:K04141]
120543021  D(1) dopamine receptor-like [KO:K04144]
120514201  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
120540112  D(2) dopamine receptor-like [KO:K04145]
120535873  D(2) dopamine receptor B-like [KO:K04145]
120529518  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
120515751  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
120526110  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
120524043  adenylate cyclase type 2-like [KO:K08044] [EC:4.6.1.1]
120530718  adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
120524822  adcy6a; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
120535204  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
120529809  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
120543008  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
120514851  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
120541109  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
120537502  htr2cl1; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 [KO:K04157]
120523692  5-hydroxytryptamine receptor 2A-like [KO:K04157]
120537461  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
120525332  grm1b; metabotropic glutamate receptor 1b isoform X1 [KO:K04603]
120523150  grm5b; metabotropic glutamate receptor 5b isoform X1 [KO:K04604]
120537716  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
120527303  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
120518946  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
120539203  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
120516316  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
120516513  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
120540181  inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
120534185  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
120526198  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
120517149  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
120542651  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
120518916  protein kinase C alpha type-like isoform X1 [KO:K19663] [EC:2.7.11.13]
120523165  gucy1a2; guanylate cyclase soluble subunit alpha-2 isoform X1 [KO:K12318] [EC:4.6.1.2]
120527161  gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
120524430  gucy1b2; guanylate cyclase soluble subunit beta-2 [KO:K12319] [EC:4.6.1.2]
120527162  gucy1b1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
120527311  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
120538748  cGMP-dependent protein kinase 1-like [KO:K07376] [EC:2.7.11.12]
120532132  prkg2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
120525826  prkg3; cGMP-dependent protein kinase 1 [KO:K19477] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
psex04010  MAPK signaling pathway
psex04020  Calcium signaling pathway
psex04060  Cytokine-cytokine receptor interaction
psex04070  Phosphatidylinositol signaling system
psex04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
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