Entry Name Endometrial cancer - Pan troglodytes (chimpanzee)
Description Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification.
Class Human Diseases; Cancer: specific typesBRITE hierarchy
Pathway map Ortholog table Organism Pan troglodytes (chimpanzee) [GN:
ptr ]
Gene 461435 EGF; pro-epidermal growth factor isoform X3 [KO:K04357 ]
460858 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
457922 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
471079 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
456565 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649 ]
461836 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
455855 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
737245 GRB2; growth factor receptor-bound protein 2 [KO:K04364 ]
459171 SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099 ]
452897 SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099 ]
460182 RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366 ] [EC:2.7.11.1 ]
456390 MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369 ] [EC:2.7.12.2 ]
473591 ELK1; ETS domain-containing protein Elk-1 [KO:K04375 ]
747104 MLH1; DNA mismatch repair protein Mlh1 isoform X1 [KO:K08734 ]
461999 APC; adenomatous polyposis coli protein isoform X10 [KO:K02085 ]
455551 APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085 ]
745839 TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620 ]
744526 TCF7L1; transcription factor 7-like 1 isoform X2 [KO:K04490 ]
450743 TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491 ]
461425 LEF1; lymphoid enhancer-binding factor 1 isoform X5 [KO:K04492 ]
455214 TP53; cellular tumor antigen p53 isoform X2 [KO:K04451 ]
104001067 CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625 ]
464585 GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
744311 GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
456929 GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X2 [KO:K04402 ]
451165 DDB2; DNA damage-binding protein 2 isoform X2 [KO:K10140 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Ryan AJ, Susil B, Jobling TW, Oehler MK.
Title Endometrial cancer.
Journal Reference Authors Lax SF.
Title Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
Journal Reference Authors Shiozawa T, Konishi I.
Title Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
Journal Reference Authors Hecht JL, Mutter GL.
Title Molecular and pathologic aspects of endometrial carcinogenesis.
Journal Reference Authors Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
Title Molecular pathology of endometrial hyperplasia and carcinoma.
Journal Reference Authors Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
Title Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
Journal Reference Authors Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
Title Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
Journal Cancer Res 55:5693-8 (1995)
Reference Authors Kim D, Chung J.
Title Akt: versatile mediator of cell survival and beyond.
Journal Related ptr04060 Cytokine-cytokine receptor interaction
KO pathway LinkDB All DBs
