Entry Name Wnt signaling pathway - Pan troglodytes (chimpanzee)
Description Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Pan troglodytes (chimpanzee) [GN:
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Gene 450685 BTRC; F-box/WD repeat-containing protein 1A isoform X11 [KO:K03362 ]
450743 TCF7L2; transcription factor 7-like 2 isoform X2 [KO:K04491 ]
450898 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348 ] [EC:3.1.3.16 ]
451088 LGR4; leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1 [KO:K04309 ]
451290 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
451380 LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068 ]
451838 PRICKLE1; prickle-like protein 1 isoform X1 [KO:K04511 ]
452821 NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X6 [KO:K17334 ]
453330 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
454184 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X6 [KO:K17333 ]
455214 TP53; cellular tumor antigen p53 isoform X2 [KO:K04451 ]
455236 DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353 ]
455485 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X6 [KO:K04446 ]
455551 APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085 ]
456380 TLE6; transducin-like enhancer protein 6 isoform X1 [KO:K04497 ]
456381 TLE2; transducin-like enhancer protein 2 isoform X4 [KO:K04497 ]
456910 ROR1; inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1 [KO:K05122 ] [EC:2.7.10.1 ]
457191 DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353 ]
457537 CACYBP; calcyclin-binding protein isoform X1 [KO:K04507 ]
457627 LGR6; leucine-rich repeat-containing G-protein coupled receptor 6 isoform X2 [KO:K08399 ]
458093 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5 [KO:K05858 ] [EC:3.1.4.11 ]
460882 DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353 ]
461014 RHOA; transforming protein RhoA isoform X1 [KO:K04513 ]
461425 LEF1; lymphoid enhancer-binding factor 1 isoform X15 [KO:K04492 ]
461445 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3 [KO:K04515 ] [EC:2.7.11.17 ]
461999 APC; adenomatous polyposis coli protein isoform X5 [KO:K02085 ]
462002 MCC; colorectal mutant cancer protein isoform X1 [KO:K26734 ]
462063 SKP1; S-phase kinase-associated protein 1 [KO:K03094 ]
462189 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
462263 FBXW11; F-box/WD repeat-containing protein 11 isoform X9 [KO:K03362 ]
462670 DAAM2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512 ]
462689 CCND3; G1/S-specific cyclin-D3 isoform X2 [KO:K10152 ]
463188 PPARD; peroxisome proliferator-activated receptor delta isoform X2 [KO:K04504 ]
463356 SFRP4; secreted frizzled-related protein 4 [KO:K02185 ]
464047 CCAR2; cell cycle and apoptosis regulator protein 2 isoform X4 [KO:K25816 ]
464544 TLE4; transducin-like enhancer protein 4 isoform X9 [KO:K04497 ]
464546 TLE1; transducin-like enhancer protein 1 isoform X3 [KO:K04497 ]
464589 ROR2; tyrosine-protein kinase transmembrane receptor ROR2 isoform X1 [KO:K05123 ] [EC:2.7.10.1 ]
465217 PRICKLE2; prickle-like protein 2 isoform X3 [KO:K04511 ]
465295 LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068 ]
465981 TBL1Y; LOW QUALITY PROTEIN: F-box-like/WD repeat-containing protein TBL1Y [KO:K04508 ]
466173 SFRP5; secreted frizzled-related protein 5 [KO:K02222 ]
466256 LZTS2; leucine zipper putative tumor suppressor 2 isoform X1 [KO:K26471 ]
467472 DAAM1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512 ]
467717 TLE3; transducin-like enhancer protein 3 isoform X7 [KO:K04497 ]
468137 SERPINF1; pigment epithelium-derived factor isoform X1 [KO:K19614 ]
468537 SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501 ]
469367 PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X6 [KO:K04345 ] [EC:2.7.11.11 ]
469875 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858 ] [EC:3.1.4.11 ]
469972 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X3 [KO:K17332 ]
471003 TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1 isoform X2 [KO:K04508 ]
473872 PRICKLE3; prickle planar cell polarity protein 3 isoform X3 [KO:K04511 ]
736186 SFRP1; secreted frizzled-related protein 1 [KO:K02166 ]
738167 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
738330 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X4 [KO:K04515 ] [EC:2.7.11.17 ]
739740 PSEN1; presenilin-1 isoform X1 [KO:K04505 ] [EC:3.4.23.-]
739837 CHD8; chromodomain-helicase-DNA-binding protein 8 isoform X2 [KO:K04494 ] [EC:5.6.2.-]
741354 TBL1X; F-box-like/WD repeat-containing protein TBL1X isoform X1 [KO:K04508 ]
741907 RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
742398 SFRP2; secreted frizzled-related protein 2 precursor [KO:K02176 ]
742406 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348 ] [EC:3.1.3.16 ]
742552 FRZB; secreted frizzled-related protein 3 [KO:K25481 ]
742575 RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860 ]
743138 LGR5; leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1 [KO:K04308 ]
744526 TCF7L1; transcription factor 7-like 1 isoform X2 [KO:K04490 ]
744778 CSNK2B; casein kinase II subunit beta isoform X2 [KO:K03115 ]
745034 BAMBI; BMP and activin membrane-bound inhibitor homolog isoform X3 [KO:K10162 ]
747131 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
748161 SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605 ]
749394 CTNNBIP1; beta-catenin-interacting protein 1 [KO:K04493 ]
Compound Reference Authors Hatsell S, Rowlands T, Hiremath M, Cowin P.
Title Beta-catenin and Tcfs in mammary development and cancer.
Journal Reference Authors Yang Y.
Title Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
Journal Reference Authors Kalderon D.
Title Similarities between the Hedgehog and Wnt signaling pathways.
Journal Reference Authors Nusse R.
Title Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Journal Reference Authors Jope RS, Johnson GV.
Title The glamour and gloom of glycogen synthase kinase-3.
Journal Reference Authors Veeman MT, Axelrod JD, Moon RT.
Title A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
Journal Reference Authors Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
Title PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Journal Reference Authors Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
Title The way Wnt works: Components and mechanism.
Journal Reference Authors Carethers JM
Title Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
Journal Reference Authors Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
Title The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
Journal Reference Authors Niehrs C
Title The complex world of WNT receptor signalling.
Journal Reference Authors Abou Ziki MD, Mani A
Title Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
Journal Reference Authors He Y, Ki H, Kim H, Kim K
Title delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
Journal Reference Authors Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
Title The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Journal Reference Authors Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
Title A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
Journal Related KO pathway
