KEGG   PATHWAY: rphi00310
Entry
rphi00310                   Pathway                                
Name
Lysine degradation - Ruditapes philippinarum (Manila clam)
Class
Metabolism; Amino acid metabolism
Pathway map
rphi00310  Lysine degradation
rphi00310

Module
rphi_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:rphi00310]
Other DBs
GO: 0006554
Organism
Ruditapes philippinarum (Manila clam) [GN:rphi]
Gene
132736418  alpha-aminoadipic semialdehyde synthase, mitochondrial-like [KO:K14157] [EC:1.5.1.8 1.5.1.9]
132730326  alpha-aminoadipic semialdehyde synthase, mitochondrial-like [KO:K14157] [EC:1.5.1.8 1.5.1.9]
132737852  LOW QUALITY PROTEIN: alpha-aminoadipic semialdehyde dehydrogenase-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
132733425  kynurenine/alpha-aminoadipate aminotransferase, mitochondrial-like [KO:K00825] [EC:2.6.1.7 2.6.1.39]
132735946  kynurenine/alpha-aminoadipate aminotransferase, mitochondrial-like [KO:K00825] [EC:2.6.1.7 2.6.1.39]
132725162  kynurenine/alpha-aminoadipate aminotransferase, mitochondrial-like [KO:K00825] [EC:2.6.1.7 2.6.1.39]
132729562  2-oxoadipate dehydrogenase complex component E1-like [KO:K15791] [EC:1.2.4.-]
132716158  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial-like [KO:K00658] [EC:2.3.1.61]
132745245  dihydrolipoyl dehydrogenase, mitochondrial-like isoform X1 [KO:K00382] [EC:1.8.1.4]
132729945  glutaryl-CoA dehydrogenase, mitochondrial-like [KO:K00252] [EC:1.3.8.6]
132717855  trifunctional enzyme subunit alpha, mitochondrial-like [KO:K07515] [EC:4.2.1.17 1.1.1.211]
132751977  peroxisomal bifunctional enzyme-like [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
132719617  enoyl-CoA hydratase, mitochondrial-like [KO:K07511] [EC:4.2.1.17]
132747108  hydroxyacyl-coenzyme A dehydrogenase, mitochondrial-like [KO:K00022] [EC:1.1.1.35]
132756593  acetyl-CoA acetyltransferase, mitochondrial-like [KO:K00626] [EC:2.3.1.9]
132719071  acetyl-CoA acetyltransferase, cytosolic-like [KO:K00626] [EC:2.3.1.9]
132724011  hydroxylysine kinase-like [KO:K18201] [EC:2.7.1.81]
132725724  hydroxylysine kinase-like [KO:K18201] [EC:2.7.1.81]
132713290  hydroxylysine kinase-like [KO:K18201] [EC:2.7.1.81]
132718161  hydroxylysine kinase-like [KO:K18201] [EC:2.7.1.81]
132718162  hydroxylysine kinase-like isoform X1 [KO:K18201] [EC:2.7.1.81]
132751580  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
132751587  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
132759708  calmodulin-lysine N-methyltransferase-like [KO:K18826] [EC:2.1.1.60]
132721309  histone-lysine N-methyltransferase SETD1A-like [KO:K11422] [EC:2.1.1.354]
132727273  zinc finger protein ZFP2-like [KO:K20796] [EC:2.1.1.354]
132741575  zinc finger protein 737-like [KO:K20796] [EC:2.1.1.354]
132718351  zinc finger protein 737-like [KO:K20796] [EC:2.1.1.354]
132716373  histone-lysine N-methyltransferase SMYD3-like [KO:K11426] [EC:2.1.1.354 2.1.1.357]
132750786  histone-lysine N-methyltransferase SUV39H2-like [KO:K11419] [EC:2.1.1.355]
132729110  histone-lysine N-methyltransferase SUV39H2-like [KO:K11419] [EC:2.1.1.355]
132749876  uncharacterized protein LOC132749876 [KO:K11420] [EC:2.1.1.355]
132725447  LOW QUALITY PROTEIN: histone-lysine N-methyltransferase EHMT1-like [KO:K11420] [EC:2.1.1.355]
132726729  histone-lysine N-methyltransferase SETDB1-like isoform X1 [KO:K11421] [EC:2.1.1.366]
132732154  histone-lysine N-methyltransferase EZH2-like [KO:K11430] [EC:2.1.1.356]
132732499  LOW QUALITY PROTEIN: histone-lysine N-methyltransferase EZH2-like [KO:K11430] [EC:2.1.1.356]
132749212  histone-lysine N-methyltransferase SETMAR-like [KO:K11433] [EC:2.1.1.357]
132725569  histone-lysine N-methyltransferase SETMAR-like [KO:K11433] [EC:2.1.1.357]
132738971  histone-lysine N-methyltransferase SETMAR-like [KO:K11433] [EC:2.1.1.357]
132740493  histone-lysine N-methyltransferase SETMAR-like [KO:K11433] [EC:2.1.1.357]
132741673  histone-lysine N-methyltransferase SETMAR-like [KO:K11433] [EC:2.1.1.357]
132755551  histone-lysine N-methyltransferase SETMAR-like [KO:K11433] [EC:2.1.1.357]
132756739  histone-lysine N-methyltransferase SETMAR-like [KO:K11433] [EC:2.1.1.357]
132716513  probable histone-lysine N-methyltransferase set-23 [KO:K11433] [EC:2.1.1.357]
132718124  histone-lysine N-methyltransferase SETMAR-like [KO:K11433] [EC:2.1.1.357]
132719006  histone-lysine N-methyltransferase SETMAR-like [KO:K11433] [EC:2.1.1.357]
132741445  histone-lysine N-methyltransferase NSD2-like isoform X1 [KO:K11424] [EC:2.1.1.357]
132754519  LOW QUALITY PROTEIN: N-lysine methyltransferase KMT5A-like [KO:K11428] [EC:2.1.1.361]
132731694  histone-lysine N-methyltransferase KMT5B-B-like [KO:K11429] [EC:2.1.1.362]
132750575  histone-lysine N-methyltransferase PRDM16-like isoform X1 [KO:K04462] [EC:2.1.1.367]
132721204  LOW QUALITY PROTEIN: aldehyde dehydrogenase family 16 member A1-like [KO:K00128] [EC:1.2.1.3]
132737429  aldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
132730707  aldehyde dehydrogenase family 16 member A1-like [KO:K00128] [EC:1.2.1.3]
132744781  aldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
132752550  4-trimethylaminobutyraldehyde dehydrogenase A-like [KO:K00149] [EC:1.2.1.47 1.2.1.3]
132720434  LOW QUALITY PROTEIN: procollagen-lysine,2-oxoglutarate 5-dioxygenase 2-like [KO:K13645] [EC:1.14.11.4]
132724076  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2-like [KO:K13646] [EC:1.14.11.4 2.4.1.50 2.4.1.66]
132737997  LOW QUALITY PROTEIN: procollagen-lysine,2-oxoglutarate 5-dioxygenase 2-like [KO:K13646] [EC:1.14.11.4 2.4.1.50 2.4.1.66]
132738885  procollagen-lysine,2-oxoglutarate 5-dioxygenase 1-like [KO:K13646] [EC:1.14.11.4 2.4.1.50 2.4.1.66]
132755660  procollagen galactosyltransferase 1-like isoform X1 [KO:K11703] [EC:2.4.1.50]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
rphi00020  Citrate cycle (TCA cycle)
rphi00300  Lysine biosynthesis
rphi00780  Biotin metabolism
KO pathway
ko00310   
LinkDB

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