KEGG ORTHOLOGY: K13646

ORTHOLOGY: K13646

Entry

K13646                      KO

Symbol

PLOD3

Name

lysyl hydroxylase/galactosyltransferase/glucosyltransferase [EC:1.14.11.4 2.4.1.50 2.4.1.66]

Pathway

map00310

Lysine degradation

map00514

Other types of O-glycan biosynthesis

map01100

Metabolic pathways

Reaction

R03376

[procollagen]-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)

R03380

UDP-alpha-D-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase

R04491

UDPglucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase

Disease

H01192

Lysyl hydroxylase 3 deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K13646  PLOD3; lysyl hydroxylase/galactosyltransferase/glucosyltransferase
  09107 Glycan biosynthesis and metabolism
   00514 Other types of O-glycan biosynthesis
    K13646  PLOD3; lysyl hydroxylase/galactosyltransferase/glucosyltransferase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K13646  PLOD3; lysyl hydroxylase/galactosyltransferase/glucosyltransferase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.4  procollagen-lysine 5-dioxygenase
     K13646  PLOD3; lysyl hydroxylase/galactosyltransferase/glucosyltransferase
2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.50  procollagen galactosyltransferase
     K13646  PLOD3; lysyl hydroxylase/galactosyltransferase/glucosyltransferase
    2.4.1.66  procollagen glucosyltransferase
     K13646  PLOD3; lysyl hydroxylase/galactosyltransferase/glucosyltransferase
Glycosyltransferases [BR:ko01003]
O-Glycan biosynthesis
  O-linked Gal type
   K13646  PLOD3; lysyl hydroxylase/galactosyltransferase/glucosyltransferase
Glycosyltransferase reactions [br08203.html]
Galactosyltransferase reactions
  K13646

Other DBs

GO:	0008475 0050211 0033823

Genes

HSA:	8985(PLOD3)

PTR:	463618(PLOD3)

PPS:	100968399(PLOD3)

GGO:	101151570(PLOD3)

PON:	100189797(PLOD3)

PPYG:

129041134(PLOD3)

NLE:	100597272(PLOD3)

HMH:	116810964(PLOD3)

SSYN:

129489687(PLOD3)

MCC:	714283(PLOD3)

MCF:	101867014(PLOD3)

MTHB:

126950346

MNI:	105492738(PLOD3)

CSAB:

103246688(PLOD3)

CATY:

105593407(PLOD3)

PANU:

101020298(PLOD3)

TGE:	112620036(PLOD3)

MLEU:

105543347(PLOD3)

RRO:	104681188(PLOD3)

RBB:	108518931(PLOD3)

TFN:	117072346(PLOD3)

PTEH:

111527915(PLOD3)

CANG:

105524674(PLOD3)

CJC:	100390092(PLOD3)

SBQ:	101043341(PLOD3)

CIMI:

108307954(PLOD3)

ANAN:

105714990(PLOD3)

MMUR:

105868206 105874704

LCAT:

123632023(PLOD3)

ERUF:

138394113(PLOD3)

PCOQ:

105826035(PLOD3)

OGA:	100962184(PLOD3)

MMU:	26433(Plod3)

MCAL:

110294972(Plod3)

MPAH:

110339077(Plod3)

RNO:	288583(Plod3)

MCOC:

116068572(Plod3)

ANU:	117697873(Plod3)

ASYL:

127672543(Plod3)

MUN:	110566258(Plod3)

MAUA:

106021964(Plod3)

PROB:

127236975(Plod3)

PLEU:

114710313(Plod3)

PMAV:

102907476(Plod3)

MORG:

121446082(Plod3)

MFOT:

126491910

AAMP:

119824992(Plod3)

CNL:	130871140(Plod3)

NGI:	103733492(Plod3)

HGL:	101701075(Plod3)

CPOC:

100733225(Plod3)

CCAN:

109692822(Plod3)

DORD:

105997327(Plod3)

DSP:	122113534(Plod3)

DMER:

138804792(Plod3)

PLOP:

125367859(Plod3)

NCAR:

124970077

MMMA:

107146598(Plod3)

ITI:	101959530(Plod3)

OCU:

103345704

OPI:	101533570(PLOD3)

OCZ:	121151464(PLOD3)

TUP:	102476916(PLOD3)

GVR:	103604904(PLOD3)

CFA:	479730(PLOD3)

CLUD:

112646206(PLOD3)

VVP:	112935697(PLOD3)

VLG:	121487921(PLOD3)

NPO:	129520270(PLOD3)

AML:	100484476(PLOD3)

UMR:	103670197(PLOD3)

UAH:	113267834(PLOD3)

UAR:	123777278(PLOD3)

ELK:

111146121

LLV:

125090429

MPUF:

101679995(PLOD3)

MNP:	132026581(PLOD3)

MLK:	131819146(PLOD3)

NVS:	122895290(PLOD3)

ORO:	101383290(PLOD3)

EJU:	114214465(PLOD3)

ZCA:	113933351(PLOD3)

MLX:	117999442(PLOD3)

NSU:	110589725(PLOD3)

LWW:	102736053(PLOD3)

FCA:	101089668(PLOD3)

PYU:	121017669(PLOD3)

PBG:	122471319(PLOD3)

PVIV:

125154551(PLOD3)

LRUF:

124519191

LGF:	123589392(PLOD3)

AJU:

106988106

PTG:	102950927(PLOD3)

PPAD:

109250535(PLOD3)

PUC:

125928208

PLEZ:

122209753(PLOD3)

HHV:	120239329(PLOD3)

BTA:	514996(PLOD3)

BOM:	102276636(PLOD3)

BIU:	109578633(PLOD3)

BBUB:

102415837(PLOD3)

BKE:	129637409(PLOD3)

BBIS:

104998970(PLOD3)

CHX:	100861039(PLOD3)

OAS:	101121738(PLOD3)

BTAX:

128062470(PLOD3)

CSUM:

138075312(PLOD3)

ODA:	120878960(PLOD3)

CCAD:

122433016(PLOD3)

MREE:

136160791(PLOD3)

OVR:	110126444(PLOD3)

MBEZ:

129545655(PLOD3)

SSC:	100624420(PLOD3)

CFR:	102505707(PLOD3)

CBAI:

105067244(PLOD3)

CDK:	105092397(PLOD3)

VPC:	102527284(PLOD3)

BACU:

103018042(PLOD3)

BMUS:

118881352(PLOD3)

LVE:	103090807(PLOD3)

OOR:	101272678(PLOD3)

LALB:

132504658(PLOD3)

GMF:	115861352(PLOD3)

DDP:	132438269(PLOD3)

DLE:	111181992(PLOD3)

PCAD:

102994038(PLOD3)

PSIU:

116739866(PLOD3)

PPHC:

136135695(PLOD3)

NASI:

112399927(PLOD3)

ECB:	100059479(PLOD3)

EPZ:	103566973(PLOD3)

EAI:	106839342(PLOD3)

MYB:	102249872(PLOD3)

MYD:	102755224(PLOD3)

MMYO:

118656360(PLOD3)

MLF:	102417167(PLOD3)

MDT:	132233236(PLOD3)

MYUM:

139008928(PLOD3)

PKL:	118703384(PLOD3)

EFUS:

103286244(PLOD3)

MNA:	107526507(PLOD3)

DRO:	112314858(PLOD3)

SHON:

118992841(PLOD3)

AJM:	119044717(PLOD3)

PDIC:

114500553(PLOD3)

PHAS:

123806488(PLOD3)

MMF:	118641652(PLOD3)

PPAM:

129083802(PLOD3)

HAI:	109385048(PLOD3)

RFQ:	117024816(PLOD3)

PALE:

102879015(PLOD3)

PGIG:

120591731(PLOD3)

PVP:	105299719(PLOD3)

RAY:	107511774(PLOD3)

MJV:	108395755(PLOD3)

TOD:	119241561(PLOD3)

SARA:

101558289(PLOD3)

SFUM:

130017498(PLOD3)

SETR:

126029561(PLOD3)

LAV:	100675876(PLOD3)

TMU:

101349481

ETF:	101640056(PLOD3)

DNM:	101416474(PLOD3)

MDO:	100017782(PLOD3)

GAS:	123244749(PLOD3)

SHR:	100921874(PLOD3)

AFZ:

127560952

PCW:	110194378(PLOD3)

TVP:	118855912(PLOD3)

PBRV:

138142209(PLOD3)

MLAO:

141514499(PLOD3)

OAA:	100086224(PLOD3)

TACU:

119947299(PLOD3)

OMA:

130263335

CCIC:

134055728

AGEN:

126034626

BBUT:

142037778(PLOD3)

CBOY:

140645283(PLOD3)

ASN:

102379166

AMJ:	102561107(PLOD3)

PSS:	102444474(PLOD3)

CIZ:	142005943(PLOD3)

CCAY:

125628614(PLOD3)

DCC:	119849255(PLOD3)

CPIC:

101943910(PLOD3)

MRV:	120381391(PLOD3)

ACS:	100558042(plod3)

ASAO:

132777682(PLOD3)

PVT:	110087641(PLOD3)

SUND:

121933382(PLOD3)

PBI:	103051832(PLOD3)

PMUR:

107291310(PLOD3)

CTIG:

120301057(PLOD3)

PGUT:

117679687(PLOD3)

PCAE:

139324977(PLOD3)

APRI:

131197737(PLOD3)

PTEX:

113449472(PLOD3)

NSS:	113422790(PLOD3)

VKO:	123018930(PLOD3)

PMUA:

114581701(PLOD3)

PRAF:

128399618(PLOD3)

ZVI:	118094932(PLOD3)

HCG:	128331910(PLOD3)

GJA:	107118151(PLOD3)

STOW:

125444847(PLOD3)

EMC:	129339034(PLOD3)

XLA:	380138(plod3.L) 495489

XTR:	734090(plod3)

NPR:	108800474(PLOD3)

RTEM:

120933651(PLOD3)

ACAT:

141133587

PADS:

140322134

BBUF:

120990542

DTC:	141050278(PLOD3)

PWL:	138268742(PLOD3)

MUO:	115456999(PLOD3)

GSH:	117350186(PLOD3)

DRE:	556077(plod3)

SRX:	107709211 107737962

SANH:

107673154 107676175

SGH:	107567109 107575731

CCAR:

109048207 109069691

CAUA:

113041328(plod3)

CGIB:

128011419

PTET:

122334528(plod3) 122334587

LROH:

127154944(plod3)

GRF:	141290723 141290762

OMC:	131531651(plod3)

PPRM:

120463468(plod3)

RKG:	130069421(plod3)

MAMB:

125260123(plod3)

CIDE:

127505558

CERY:

137009233(plod3)

MASI:

127419328 127419824

TROS:

130544911(plod3)

TDW:	130409310(plod3)

MANU:

129430632(plod3)

PDAB:

135764966(plod3)

IPU:

108275691

IFU:	128619223(plod3)

PHYP:

113525458

SMEO:

124398795(plod3)

TFD:	113646092(plod3)

TVC:	132862771(plod3)

CGAR:

128510665(plod3)

NGRA:

132896806(plod3)

TRN:	134333085(plod3)

AMEX:

103037645(plod3)

CMAO:

118799343(plod3)

EEE:

113568782

CHAR:

105891472(plod3)

SPIL:

134060153(plod3)

ASAD:

121689556(plod3)

TRU:	100101242(plod3)

TFS:	130523051(plod3)

TNG:	GSTEN00003803G001

TBEN:

117480844(plod3)

EMAC:

134875696(plod3)

ELY:	117245834(plod3)

EFO:	125883736(plod3)

PLEP:

121965451(plod3)

SLUC:

116065859(plod3)

PFLV:

114574041(plod3)

GAT:	120822297(plod3)

PPUG:

119221736(plod3)

AFB:	129093099(plod3)

CLUM:

117748197(plod3)

PSWI:

130212044(plod3)

CANA:

137792404(plod3)

CVE:	137874394(plod3)

MSAM:

119912035 119912612(plod3)

SCHU:

122870115(plod3)

EARM:

139305553(plod3)

CUD:	121504490(plod3)

SPUL:

138600676(plod3)

LMIX:

132958102(plod3)

HTC:	141811100(plod3)

ALAT:

119026698(plod3)

ASTR:

137590682(plod3)

PKLU:

139223296(plod3)

MZE:

101473400

ONL:

100697420

OAU:	116334646(plod3)

OLA:	101154842(plod3)

OML:	112141494(plod3)

CSAI:

133420117(plod3)

XMA:

102223949

XHE:	116732017(plod3)

PFOR:

103129610

PLAI:

106958328(plod3)

PMEI:

106904637(plod3)

GAF:	122820891(plod3)

PPRL:

129376666

CVG:	107102307(plod3)

CTUL:

119774676(plod3)

GMU:	124880767(plod3)

KMR:	108229421(plod3)

ALIM:

106511660

NWH:	119410195(plod3)

AOCE:

111567088(plod3)

EJA:	138215210(plod3)

BFRE:

138636712(plod3)

MCEP:

125008878(plod3)

CSEM:

103389255

POV:	109643399(plod3)

SSEN:

122767094(plod3)

SSOE:

131456324(plod3)

HHIP:

117751848(plod3)

HSP:	118102891(plod3)

PPLT:

128429938(plod3)

SMAU:

118319902(plod3)

LCF:	108892696 108892807

SDU:

111239991

SLAL:

111647817

XGL:	120797240(plod3)

HCQ:	109518414(plod3)

SSCV:

125992156(plod3)

SBIA:

133494654(plod3)

PEE:	133398097(plod3)

PTAO:

133472377(plod3)

BPEC:

110174873

ENY:	140371425(plod3)

MALB:

109952454(plod3)

BSPL:

114851242(plod3)

SJO:	128384062(plod3)

SSCO:

134006098(plod3)

TTY:	137174882(plod3)

GMH:

115529392

SASA:

100196315(plod3)

STRU:

115183238(plod3)

OTW:	112235044 121847355

OMY:	110532881(plod3)

OGO:

124008310

OKI:

109886259

OKE:	118381469(plod3)

OMM:	135510165(plod3)

OCLA:

139415746

SFON:

129842572(plod3)

CCLU:

121557767(plod3)

ELS:

105008588

OEP:	134009873(plod3)

SFM:	108920367 108923182

PKI:	111835052 111860867

AANG:

118223708(plod3)

AROT:

135251491(plod3)

CCOG:

133123774(plod3)

LOC:

102685790

PSPA:

121305608 121306609

ARUT:

117404435 117967929

PSEX:

120525067(plod3)

LCM:	102347396(PLOD3)

RTP:

109923769

CPLA:

122544351

CPUN:

140492538

HOC:	132835223(plod3)

HAKA:

PMRN:

LRJ:

BBEL:

CIN:

SCLV:

CLEP:

LPIC:

LVG:

AJJ:

ARUN:

AAMU:

AFIL:

FEX:

TPRE:

LHT:

LBD:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:	124216834(Plod)

NFB:

NVG:

AROA:

AGB:

LDC:

APLN:

OTU:

DCI:

HVI:

MQU:	128991601 128992403

FOC:

TPAL:

SGRE:

IEL:

DPZ:

PJA:	122246560 122260753 122262496

PCHN:

125036057 125041711 125042482

PMOO:

119581816 119594377

HAME:

121857217 121863340 121868820

PCLA:

123759111 123759160 123760181(Plod) 123768393

CQD:	128684105 128689496

PTRU:

ESN:

HAZT:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

DFR:

UDV:

SDM:	118192558 118196474

LPOL:

106474399

PMEO:

129586199

TSP:

Tsp_03029

HRO:	HELRODRAFT_185714

PVUL:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HCRA:

CRG:

CANU:

CVN:

OED:

PMAX:

MCAF:

MMER:

RPHI:

132724076 132737997 132738885

DPOL:

OBI:

OSN:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HSY:	130656162 130656165

RES:

135688088

SRE:	PTSG_00122

» show all

Reference

PMID:9582318

Authors

Valtavaara M, Szpirer C, Szpirer J, Myllyla R

Title

Primary structure, tissue distribution, and chromosomal localization of a novel isoform of lysyl hydroxylase (lysyl hydroxylase 3)

Journal

J Biol Chem 273:12881-6 (1998)
DOI:10.1074/jbc.273.21.12881

Sequence

[hsa:8985]

Reference

PMID:16467571

Authors

Ruotsalainen H, Sipila L, Vapola M, Sormunen R, Salo AM, Uitto L, Mercer DK, Robins SP, Risteli M, Aszodi A, Fassler R, Myllyla R

Title

Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes.

Journal

J Cell Sci 119:625-35 (2006)
DOI:10.1242/jcs.02780

LinkDB

DBGET integrated database retrieval system