KEGG   PATHWAY: snh00600
Entry
snh00600                    Pathway                                
Name
Sphingolipid metabolism - Salvelinus namaycush (lake trout)
Class
Metabolism; Lipid metabolism
Pathway map
snh00600  Sphingolipid metabolism
snh00600

Module
snh_M00066  Lactosylceramide biosynthesis [PATH:snh00600]
snh_M00094  Ceramide biosynthesis [PATH:snh00600]
snh_M00099  Sphingosine biosynthesis [PATH:snh00600]
snh_M00100  Sphingosine degradation [PATH:snh00600]
Other DBs
GO: 0006665
Organism
Salvelinus namaycush (lake trout) [GN:snh]
Gene
120019173  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
120024283  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
120025987  sptlc1; serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
120045310  serine palmitoyltransferase 3-like [KO:K00654] [EC:2.3.1.50]
120060527  sptlc2a; serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
120019972  3-ketodihydrosphingosine reductase-like isoform X1 [KO:K04708] [EC:1.1.1.102]
120055941  3-ketodihydrosphingosine reductase-like [KO:K04708] [EC:1.1.1.102]
120054066  ceramide synthase 1-like [KO:K04710] [EC:2.3.1.299]
120054711  ceramide synthase 1-like isoform X1 [KO:K04710] [EC:2.3.1.299]
120039499  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
120041139  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
120027398  cers2a; ceramide synthase 2a [KO:K24621] [EC:2.3.1.297]
120056277  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
120055180  cers4a; ceramide synthase 4a [KO:K24621] [EC:2.3.1.297]
120057070  cers3a; ceramide synthase 2 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
120057836  ceramide synthase 5-like isoform X1 [KO:K23727] [EC:2.3.1.291]
120058239  ceramide synthase 6-like isoform X1 [KO:K23727] [EC:2.3.1.291]
120064402  cers6; ceramide synthase 6 isoform X1 [KO:K23727] [EC:2.3.1.291]
120065488  ceramide synthase 5-like [KO:K23727] [EC:2.3.1.291]
120061373  ceramide synthase 5-like [KO:K23727] [EC:2.3.1.291]
120035101  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
120052865  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
120029582  asah2; neutral ceramidase [KO:K12349] [EC:3.5.1.23]
120049652  alkaline ceramidase 2-like [KO:K01441] [EC:3.5.1.23]
120052755  alkaline ceramidase 2-like [KO:K01441] [EC:3.5.1.23]
120054480  acer1; alkaline ceramidase 1 [KO:K01441] [EC:3.5.1.23]
120045171  alkaline ceramidase 3-like [KO:K04711] [EC:3.5.1.-]
120057093  acer3; alkaline ceramidase 3 isoform X1 [KO:K04711] [EC:3.5.1.-]
120017624  sphingolipid delta(4)-desaturase DES1-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
120046548  sphingolipid delta(4)-desaturase DES1-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
120056467  sphingolipid delta(4)-desaturase/C4-monooxygenase DES2-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
120059789  degs2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
120017652  phosphatidylcholine:ceramide cholinephosphotransferase 1-like [KO:K04714] [EC:2.7.8.27 3.1.4.62]
120030069  sgms1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
120040811  phosphatidylcholine:ceramide cholinephosphotransferase 2-like isoform X1 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
120034663  phosphatidylcholine:ceramide cholinephosphotransferase 2-like [KO:K04714] [EC:2.7.8.27 3.1.4.62]
120034670  phosphatidylcholine:ceramide cholinephosphotransferase 2-like [KO:K04714] [EC:2.7.8.27 3.1.4.62]
120046136  phosphatidylcholine:ceramide cholinephosphotransferase 1-like [KO:K04714] [EC:2.7.8.27 3.1.4.62]
120021651  smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
120065020  smpd2b; sphingomyelin phosphodiesterase 2 isoform X1 [KO:K12351] [EC:3.1.4.12]
120031300  smpd5; sphingomyelin phosphodiesterase 5 [KO:K12352] [EC:3.1.4.12]
120053197  sphingomyelin phosphodiesterase 3-like [KO:K12352] [EC:3.1.4.12]
120065824  sphingomyelin phosphodiesterase 3-like [KO:K12352] [EC:3.1.4.12]
120021685  sphingomyelin phosphodiesterase 4-like isoform X1 [KO:K12353] [EC:3.1.4.12]
120025938  sphingomyelin phosphodiesterase 4-like isoform X1 [KO:K12353] [EC:3.1.4.12]
120034352  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
120045976  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
120035931  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
120036162  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
120032228  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
120052373  ceramide kinase-like isoform X1 [KO:K04715] [EC:2.7.1.138]
120059591  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
120066130  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
120060961  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
120020040  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
120039926  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
120040861  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
120025489  phospholipid phosphatase 1-like isoform X1 [KO:K01080] [EC:3.1.3.4]
120044516  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
120033554  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
120044928  phospholipid phosphatase 1-like isoform X1 [KO:K01080] [EC:3.1.3.4]
120038717  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
120055999  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
120063388  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
120051357  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
120051805  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
120052563  plpp3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
120054790  phospholipid phosphatase 2-like isoform X1 [KO:K01080] [EC:3.1.3.4]
120054902  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
120024085  si:ch211-212g7.6; sphingosine-1-phosphate phosphatase 1 isoform X1 [KO:K04716] [EC:3.1.3.-]
120060345  sgpp1; sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
120028482  sgpp2; sphingosine-1-phosphate phosphatase 2 [KO:K04717] [EC:3.1.3.-]
120030942  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
120032730  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
120044616  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
120034002  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
120047263  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
120065968  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
120017520  sgpl1; sphingosine-1-phosphate lyase 1 isoform X1 [KO:K01634] [EC:4.1.2.27]
120046462  sphingosine-1-phosphate lyase 1-like isoform X1 [KO:K01634] [EC:4.1.2.27]
120042623  ugcg; ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
120026327  ceramide glucosyltransferase-like [KO:K00720] [EC:2.4.1.80]
120048680  gba; lysosomal acid glucosylceramidase isoform X1 [KO:K01201] [EC:3.2.1.45]
120048861  lysosomal acid glucosylceramidase-like isoform X1 [KO:K01201] [EC:3.2.1.45]
120030367  gba2; non-lysosomal glucosylceramidase isoform X1 [KO:K17108] [EC:3.2.1.45]
120052627  beta-1,4-galactosyltransferase 6-like [KO:K07553] [EC:2.4.1.274]
120055009  beta-1,4-galactosyltransferase 6-like isoform X1 [KO:K07553] [EC:2.4.1.274]
120041225  b4galt5; beta-1,4-galactosyltransferase 5 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
120052855  glb1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
120060472  galcb; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
120042998  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
120046352  galactose-3-O-sulfotransferase 3 [KO:K01019] [EC:2.8.2.11]
120063069  gal3st1a; galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
120053998  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
120060619  arsa; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
120022463  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
120018926  neu4; sialidase-4 [KO:K12357] [EC:3.2.1.18]
120021762  sialidase-3-like [KO:K12357] [EC:3.2.1.18]
120057270  sialidase-3-like isoform X1 [KO:K12357] [EC:3.2.1.18]
120047992  gla; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
120058804  beta-1,4 N-acetylgalactosaminyltransferase 1-like [KO:K00725] [EC:2.4.1.92]
120065186  beta-1,4 N-acetylgalactosaminyltransferase 1-like isoform X1 [KO:K00725] [EC:2.4.1.92]
120061253  beta-1,4 N-acetylgalactosaminyltransferase 1-like [KO:K00725] [EC:2.4.1.92]
120020927  beta-hexosaminidase subunit beta-like isoform X1 [KO:K12373] [EC:3.2.1.52]
120039940  beta-hexosaminidase subunit alpha-like isoform X1 [KO:K12373] [EC:3.2.1.52]
120026090  beta-hexosaminidase subunit beta-like isoform X1 [KO:K12373] [EC:3.2.1.52]
120047864  ganglioside GM2 activator-like [KO:K12383]
120062520  gm2a; ganglioside GM2 activator [KO:K12383]
120021313  sftpba; prosaposin isoform X1 [KO:K12382]
120024444  prosaposin-like [KO:K12382]
120046070  prosaposin-like [KO:K12382]
120029707  prosaposin-like isoform X1 [KO:K12382]
120063498  prosaposin-like [KO:K12382]
120025593  prosaposin-like [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
snh00260  Glycine, serine and threonine metabolism
snh00601  Glycosphingolipid biosynthesis - lacto and neolacto series
snh00603  Glycosphingolipid biosynthesis - globo and isoglobo series
snh00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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