KEGG   PATHWAY: srx04141
Entry
srx04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Sinocyclocheilus rhinocerous
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
srx04141  Protein processing in endoplasmic reticulum
srx04141

Other DBs
GO: 0030433 0034976
Organism
Sinocyclocheilus rhinocerous [GN:srx]
Gene
107750248  protein transport protein Sec61 subunit alpha-like 2 [KO:K10956]
107713494  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
107748391  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
107711044  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
107723518  protein transport protein Sec61 subunit beta-like [KO:K09481]
107706198  protein transport protein Sec61 subunit beta-like [KO:K09481]
107758289  protein transport protein Sec61 subunit gamma [KO:K07342]
107727235  protein transport protein Sec61 subunit gamma [KO:K07342]
107738178  translocation protein SEC62-like [KO:K12275]
107706392  translocation protein SEC62-like [KO:K12275]
107726458  translocation protein SEC63 homolog [KO:K09540]
107726621  translocation protein SEC63 homolog isoform X1 [KO:K09540]
107744844  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1-like [KO:K12666]
107714495  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1-like [KO:K12666]
107742905  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like [KO:K12667]
107745341  rpn2; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
107713681  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad1-like [KO:K12668]
107729986  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad1 [KO:K12668]
107726313  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1-like [KO:K12668]
107716121  ddost; LOW QUALITY PROTEIN: dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
107737669  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670]
107705745  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
107730945  stt3a; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
107713794  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B-like [KO:K07151] [EC:2.4.99.18]
107758586  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A-like [KO:K07151] [EC:2.4.99.18]
107751681  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B-like isoform X1 [KO:K07151] [EC:2.4.99.18]
107733409  magnesium transporter protein 1 [KO:K19478]
107747398  tumor suppressor candidate 3-like [KO:K19478]
107731701  tumor suppressor candidate 3 [KO:K19478]
107717863  oligosaccharyltransferase complex subunit ostc [KO:K26501]
107717864  oligosaccharyltransferase complex subunit ostc [KO:K26501]
107732277  transmembrane protein 258-like [KO:K26502]
107734672  transmembrane protein 258 [KO:K26502]
107719770  mannosyl-oligosaccharide glucosidase-like isoform X1 [KO:K01228] [EC:3.2.1.106]
107711520  mannosyl-oligosaccharide glucosidase-like [KO:K01228] [EC:3.2.1.106]
107725794  myosin-10-like isoform X1 [KO:K13999]
107715739  ribosome-binding protein 1-like isoform X1 [KO:K14000]
107705351  ribosome-binding protein 1-like [KO:K14000]
107724390  rrbp1; ribosome-binding protein 1 isoform X1 [KO:K14000]
107741526  ribosome-binding protein 1-like isoform X1 [KO:K14000]
107742487  nucleotide exchange factor SIL1-like [KO:K14001]
107740135  nucleotide exchange factor SIL1-like isoform X1 [KO:K14001]
107747001  hypoxia up-regulated protein 1-like [KO:K09486]
107744629  hyou1; hypoxia up-regulated protein 1 [KO:K09486]
107743071  78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
107734414  78 kDa glucose-regulated protein-like [KO:K09490] [EC:3.6.4.10]
107734415  78 kDa glucose-regulated protein-like [KO:K09490] [EC:3.6.4.10]
107734417  78 kDa glucose-regulated protein-like [KO:K09490] [EC:3.6.4.10]
107731764  dnaJ homolog subfamily B member 11 [KO:K09517]
107719809  dnaJ homolog subfamily B member 11 [KO:K09517]
107718098  dnaJ homolog subfamily C member 1-like [KO:K09521]
107722591  dnaJ homolog subfamily C member 1-like [KO:K09521]
107707053  dnaJ homolog subfamily C member 3-like isoform X1 [KO:K09523]
107706087  dnajc3; dnaJ homolog subfamily C member 3 [KO:K09523]
107738010  dnaJ homolog subfamily C member 3-like [KO:K09523]
107755373  dnaJ homolog subfamily C member 10-like [KO:K09530] [EC:1.8.4.-]
107739439  dnaJ homolog subfamily C member 10-like [KO:K09530] [EC:1.8.4.-]
107743417  endoplasmin-like [KO:K09487]
107726017  endoplasmin [KO:K09487]
107730665  neutral alpha-glucosidase AB-like isoform X1 [KO:K05546] [EC:3.2.1.207]
107756491  neutral alpha-glucosidase AB-like [KO:K05546] [EC:3.2.1.207]
107740022  neutral alpha-glucosidase AB-like [KO:K05546] [EC:3.2.1.207]
107722752  neutral alpha-glucosidase AB-like [KO:K05546] [EC:3.2.1.207]
107725022  glucosidase 2 subunit beta-like [KO:K08288]
107754018  glucosidase 2 subunit beta-like [KO:K08288]
107746060  calnexin-like isoform X1 [KO:K08054]
107733432  LOW QUALITY PROTEIN: calnexin-like [KO:K08054]
107746155  calnexin-like [KO:K08054]
107716732  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
107732473  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
107741739  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
107754819  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
107711304  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
107753598  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
107717161  calreticulin-like [KO:K08057]
107752434  calreticulin-like [KO:K08057]
107742789  calreticulin-like [KO:K08057]
107750920  calreticulin-like [KO:K08057]
107743868  calreticulin-like [KO:K08057]
107723933  calreticulin-like [KO:K08057]
107729795  mannosyl-oligosaccharide 1,2-alpha-mannosidase IC-like [KO:K01230] [EC:3.2.1.113]
107724469  mannosyl-oligosaccharide 1,2-alpha-mannosidase IB-like isoform X1 [KO:K01230] [EC:3.2.1.113]
107712247  mannosyl-oligosaccharide 1,2-alpha-mannosidase IB-like [KO:K01230] [EC:3.2.1.113]
107713850  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
107743323  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
107727625  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like isoform X1 [KO:K01230] [EC:3.2.1.113]
107736907  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
107739703  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
107757969  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
107709694  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
107717402  vesicular integral-membrane protein VIP36-like [KO:K10082]
107741050  vesicular integral-membrane protein VIP36-like isoform X1 [KO:K10082]
107719069  protein ERGIC-53-like isoform X1 [KO:K10080]
107739740  protein ERGIC-53-like [KO:K10080]
107725280  prolactin regulatory element-binding protein-like [KO:K14003]
107737028  prolactin regulatory element-binding protein-like [KO:K14003]
107708324  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
107713617  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
107732763  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
107757866  GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
107720356  protein SEC13 homolog [KO:K14004]
107719942  protein SEC13 homolog [KO:K14004]
107715884  protein transport protein Sec31A-like isoform X1 [KO:K14005]
107720384  protein transport protein Sec31A-like [KO:K14005]
107732750  protein transport protein Sec31A-like [KO:K14005]
107715455  protein transport protein Sec31A-like [KO:K14005]
107729285  protein transport protein Sec23A [KO:K14006]
107734238  protein transport protein Sec23A-like [KO:K14006]
107753900  protein transport protein Sec23A-like [KO:K14006]
107752097  protein transport protein Sec23A [KO:K14006]
107755462  protein transport protein Sec24C-like isoform X1 [KO:K14007]
107713614  protein transport protein Sec24A-like [KO:K14007]
107740605  LOW QUALITY PROTEIN: protein transport protein Sec24D-like [KO:K14007]
107743336  protein transport protein Sec24C-like isoform X1 [KO:K14007]
107731363  protein transport protein Sec24B-like isoform X1 [KO:K14007]
107729318  protein transport protein Sec24B-like [KO:K14007]
107749843  protein transport protein Sec24C-like isoform X1 [KO:K14007]
107757847  protein transport protein Sec24A-like [KO:K14007]
107732696  protein transport protein Sec24D-like isoform X1 [KO:K14007]
107720140  UDP-glucose:glycoprotein glucosyltransferase 2-like [KO:K11718] [EC:2.4.1.-]
107727334  UDP-glucose:glycoprotein glucosyltransferase 1-like isoform X1 [KO:K11718] [EC:2.4.1.-]
107706079  UDP-glucose:glycoprotein glucosyltransferase 1-like [KO:K11718] [EC:2.4.1.-]
107733619  UDP-glucose:glycoprotein glucosyltransferase 2-like [KO:K11718] [EC:2.4.1.-]
107748935  UDP-glucose:glycoprotein glucosyltransferase 1-like [KO:K11718] [EC:2.4.1.-]
107750244  ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
107713500  ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
107723131  edem2; LOW QUALITY PROTEIN: ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
107705666  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
107717559  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
107750782  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
107739696  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
107736877  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
107710277  p4hb; protein disulfide-isomerase isoform X1 [KO:K09580] [EC:5.3.4.1]
107710009  protein disulfide-isomerase-like [KO:K09580] [EC:5.3.4.1]
107741760  protein disulfide-isomerase A4-like [KO:K09582] [EC:5.3.4.1]
107727231  protein disulfide-isomerase A4-like [KO:K09582] [EC:5.3.4.1]
107726466  protein disulfide-isomerase A6-like [KO:K09584] [EC:5.3.4.1]
107732640  protein disulfide-isomerase A6-like [KO:K09584] [EC:5.3.4.1]
107730007  thioredoxin domain-containing protein 5-like [KO:K13984] [EC:5.3.4.1]
107742257  txndc5; thioredoxin domain-containing protein 5 [KO:K13984] [EC:5.3.4.1]
107723685  ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
107751763  ero1a; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
107706893  ero1b; ERO1-like protein beta isoform X1 [KO:K10976] [EC:1.8.4.-]
107711069  protein OS-9-like isoform X1 [KO:K10088]
107733587  protein OS-9-like isoform X1 [KO:K10088]
107739892  endoplasmic reticulum lectin 1-like [KO:K14008]
107736811  endoplasmic reticulum lectin 1-like [KO:K14008]
107705415  erlec1; endoplasmic reticulum lectin 1 isoform X1 [KO:K14008]
107729946  ssr1; translocon-associated protein subunit alpha isoform X1 [KO:K13249]
107756852  translocon-associated protein subunit alpha-like [KO:K13249]
107748705  translocon-associated protein subunit beta-like [KO:K13250]
107739538  translocon-associated protein subunit beta [KO:K13250]
107711770  translocon-associated protein subunit gamma-like [KO:K13251]
107745421  translocon-associated protein subunit gamma [KO:K13251]
107741342  translocon-associated protein subunit delta-like [KO:K04571]
107737640  translocon-associated protein subunit delta-like [KO:K04571]
107743126  B-cell receptor-associated protein 31-like [KO:K14009]
107734501  B-cell receptor-associated protein 31-like [KO:K14009]
107736961  translocating chain-associated membrane protein 1-like [KO:K14010]
107758802  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
107724418  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
107714267  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
107714924  derlin-1-like [KO:K11519]
107736822  derlin-1 [KO:K11519]
107711881  derl3; derlin-3 [KO:K13989]
107724876  derlin-2-like [KO:K13989]
107709760  derl2; derlin-2 isoform X1 [KO:K13989]
107744323  derlin-2-like [KO:K13989]
107740723  UBX domain-containing protein 4-like [KO:K24348]
107730668  UBX domain-containing protein 1-like [KO:K24348]
107742702  UBX domain-containing protein 2A-like isoform X1 [KO:K24349]
107750080  UBX domain-containing protein 2A-like isoform X1 [KO:K24349]
107719551  UBX domain-containing protein 6-like isoform X1 [KO:K14011]
107717977  UBX domain-containing protein 6-like [KO:K14011]
107715867  UBX domain-containing protein 8-like [KO:K24351]
107741325  NSFL1 cofactor p47-like [KO:K14012]
107737635  NSFL1 cofactor p47-like [KO:K14012]
107752470  svip; small VCP/p97-interacting protein isoform X1 [KO:K14014]
107708640  transitional endoplasmic reticulum ATPase [KO:K13525]
107714114  transitional endoplasmic reticulum ATPase-like [KO:K13525]
107746855  LOW QUALITY PROTEIN: transitional endoplasmic reticulum ATPase-like [KO:K13525]
107755457  nuclear protein localization protein 4 homolog [KO:K14015]
107753241  nploc4; nuclear protein localization protein 4 homolog [KO:K14015]
107714583  ubiquitin fusion degradation protein 1 homolog isoform X1 [KO:K14016]
107713022  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
107713435  heat shock cognate 71 kDa protein-like [KO:K03283]
107745199  heat shock cognate 71 kDa protein-like [KO:K03283]
107739404  LOW QUALITY PROTEIN: heat shock 70 kDa protein-like [KO:K03283]
107747002  heat shock cognate 71 kDa protein [KO:K03283]
107751398  heat shock cognate 71 kDa protein-like [KO:K03283]
107748584  heat shock cognate 71 kDa protein-like [KO:K03283]
107720316  dnaJ homolog subfamily A member 1-like [KO:K09502]
107746728  dnaJ homolog subfamily A member 1-like [KO:K09502]
107723138  dnaJ homolog subfamily A member 2-like [KO:K09503]
107705812  dnaJ homolog subfamily A member 2-like [KO:K09503]
107757777  dnaJ homolog subfamily A member 2 [KO:K09503]
107735561  dnaJ homolog subfamily A member 2-like [KO:K09503]
107711204  dnaJ homolog subfamily B member 1-like [KO:K09507]
107747146  dnaJ homolog subfamily B member 1-like [KO:K09507]
107736624  dnaJ homolog subfamily B member 1-like [KO:K09507]
107728686  dnaJ homolog subfamily B member 1-like [KO:K09507]
107716785  dnaJ homolog subfamily B member 2-like isoform X1 [KO:K09508]
107721618  dnaJ homolog subfamily B member 2-like isoform X1 [KO:K09508]
107716349  dnaJ homolog subfamily B member 12-like [KO:K09518]
107732760  dnaJ homolog subfamily B member 12-like isoform X1 [KO:K09518]
107715202  dnajb12; dnaJ homolog subfamily B member 12 [KO:K09518]
107707369  dnaJ homolog subfamily B member 12-like isoform X1 [KO:K09518]
107716684  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
107710433  dnaJ homolog subfamily C member 5-like [KO:K09525]
107731253  dnaJ homolog subfamily C member 5-like [KO:K09525]
107745759  dnaJ homolog subfamily C member 5-like [KO:K09525]
107747984  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
107719908  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
107721861  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
107727634  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
107733578  dnaJ homolog subfamily C member 5-like [KO:K09525]
107705201  dnaJ homolog subfamily C member 5-like [KO:K09525]
107730601  heat shock protein HSP 90-alpha 1 [KO:K04079]
107730604  heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
107732486  heat shock protein HSP 90-beta [KO:K04079]
107726698  heat shock protein HSP 90-beta-like [KO:K04079]
107728111  heat shock protein HSP 90-alpha 1-like [KO:K04079]
107718856  heat shock 70 kDa protein 4L-like isoform X1 [KO:K09485]
107732597  heat shock 70 kDa protein 4-like [KO:K09485]
107746903  BAG family molecular chaperone regulator 1-like [KO:K09555]
107732557  BAG family molecular chaperone regulator 1-like [KO:K09555]
107751465  bag2; BAG family molecular chaperone regulator 2 [KO:K09556]
107731474  hspbp1; hsp70-binding protein 1 [KO:K09562]
107718622  hsp70-binding protein 1-like [KO:K09562]
107712549  alpha-crystallin A chain [KO:K09541]
107742640  alpha-crystallin A chain-like [KO:K09541]
107747664  alpha-crystallin A chain-like [KO:K09542]
107713461  alpha-crystallin B chain-like [KO:K09542]
107721632  alpha-crystallin B chain-like [KO:K09542]
107745202  alpha-crystallin B chain-like [KO:K09542]
107743805  cryab; alpha-crystallin B chain [KO:K09542]
107743281  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
107751243  ubiquitin thioesterase OTU1-like [KO:K13719] [EC:3.1.2.-]
107757893  phospholipase A-2-activating protein-like [KO:K14018]
107711093  phospholipase A-2-activating protein-like [KO:K14018]
107717165  UV excision repair protein RAD23 homolog B-like [KO:K10839]
107717761  UV excision repair protein RAD23 homolog B-like [KO:K10839]
107724711  UV excision repair protein RAD23 homolog B-like [KO:K10839]
107742788  UV excision repair protein RAD23 homolog B-like [KO:K10839]
107757047  UV excision repair protein RAD23 homolog A-like [KO:K10839]
107747426  UV excision repair protein RAD23 homolog A-like [KO:K10839]
107726678  ubiquilin-4-like [KO:K04523]
107756885  ubiquilin-4-like [KO:K04523]
107748685  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase-like [KO:K01456] [EC:3.5.1.52]
107739561  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
107749541  atxn3; ataxin-3 [KO:K11863] [EC:3.4.22.-]
107718816  ubiquitin conjugation factor E4 B-like [KO:K10597] [EC:2.3.2.27]
107708838  ube4b; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
107733739  eukaryotic translation initiation factor 2-alpha kinase 3-like [KO:K08860] [EC:2.7.11.1]
107747580  eukaryotic translation initiation factor 2-alpha kinase 3-like [KO:K08860] [EC:2.7.11.1]
107732494  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
107726707  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
107707695  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
107752763  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
107716922  nuclear factor erythroid 2-related factor 2-like [KO:K05638]
107707001  nuclear factor erythroid 2-related factor 2-like [KO:K05638]
107740600  transcription factor NF-E2 45 kDa subunit-like isoform X1 [KO:K05638]
107725823  nuclear factor erythroid 2-related factor 2-like isoform X1 [KO:K05638]
107705915  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
107740611  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
107710053  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
107737987  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
107734605  ddit3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
107711715  apoptosis regulator Bcl-2-like [KO:K02161]
107757715  apoptosis regulator Bcl-2-like [KO:K02161]
107729657  apoptosis regulator Bcl-2-like [KO:K02161]
107727540  apoptosis regulator Bcl-2-like [KO:K02161]
107710557  cyclic AMP-dependent transcription factor ATF-6 alpha-like [KO:K09054]
107726471  cyclic AMP-dependent transcription factor ATF-6 alpha-like [KO:K09054]
107726167  cyclic AMP-dependent transcription factor ATF-6 beta-like isoform X1 [KO:K09049]
107724634  cyclic AMP-dependent transcription factor ATF-6 beta-like [KO:K09049]
107730573  wolframin-like isoform X1 [KO:K14020]
107749704  wolframin-like [KO:K14020]
107742510  wolframin-like [KO:K14020]
107726427  membrane-bound transcription factor site-1 protease-like [KO:K08653] [EC:3.4.21.112]
107733569  mbtps1; membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
107721932  membrane-bound transcription factor site-2 protease-like [KO:K07765] [EC:3.4.24.85]
107705275  membrane-bound transcription factor site-2 protease-like [KO:K07765] [EC:3.4.24.85]
107722925  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107725381  ern2; serine/threonine-protein kinase/endoribonuclease IRE2 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107718593  serine/threonine-protein kinase/endoribonuclease ire-1-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107729582  ern1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107757085  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107715757  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
107725098  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
107730336  traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
107715537  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
107746475  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
107709841  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
107705646  mitogen-activated protein kinase kinase kinase 5-like isoform X1 [KO:K04426] [EC:2.7.11.25]
107740525  map3k5; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
107755537  mitogen-activated protein kinase kinase kinase 5-like isoform X1 [KO:K04426] [EC:2.7.11.25]
107718577  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
107712243  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
107707207  mitogen-activated protein kinase 8B isoform X1 [KO:K04440] [EC:2.7.11.24]
107719076  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107720002  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107749917  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
107749009  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
107756804  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
107709004  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
107730726  apoptosis regulator BAX-like [KO:K02159]
107730775  apoptosis regulator BAX-like [KO:K02159]
107720019  apoptosis regulator BAX-like [KO:K02159]
107721480  apoptosis regulator BAX-like isoform X1 [KO:K02159]
107729426  apoptosis regulator R1-like [KO:K02159]
107729452  apoptosis regulator BAX-like [KO:K02159]
107729453  apoptosis regulator BAX-like [KO:K02159]
107730087  apoptosis regulator BAX-like isoform X1 [KO:K02159]
107727097  apoptosis regulator BAX-like isoform X1 [KO:K02159]
107755342  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
107732416  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107722661  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
107728026  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107723851  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107757007  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107758230  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107734280  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107755343  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107755344  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107755345  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107755925  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107724584  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107722658  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107722663  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107722669  calpain-2 catalytic subunit-like isoform X1 [KO:K03853] [EC:3.4.22.53]
107734257  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107746911  E3 ubiquitin-protein ligase MARCH6 [KO:K10661] [EC:2.3.2.27]
107732575  E3 ubiquitin-protein ligase MARCH6-like [KO:K10661] [EC:2.3.2.27]
107731500  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
107742990  ube2j1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
107706988  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
107714487  ubiquitin-conjugating enzyme E2 J2-like isoform X1 [KO:K04554] [EC:2.3.2.23]
107714985  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
107707137  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
107737856  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
107712369  ubiquitin-conjugating enzyme E2 G1-like isoform X1 [KO:K10575] [EC:2.3.2.23]
107722775  ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
107706614  ubiquitin-conjugating enzyme E2 G2-like [KO:K04555] [EC:2.3.2.23]
107713093  ube2g2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
107717405  syvn1; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
107741048  E3 ubiquitin-protein ligase synoviolin-like [KO:K10601] [EC:2.3.2.27]
107751700  E3 ubiquitin-protein ligase RNF5-like [KO:K10666] [EC:2.3.2.27]
107706573  E3 ubiquitin-protein ligase RNF5-like [KO:K10666] [EC:2.3.2.27]
107731307  E3 ubiquitin-protein ligase RNF185-like [KO:K10666] [EC:2.3.2.27]
107717344  rnf185; E3 ubiquitin-protein ligase RNF185 isoform X1 [KO:K10666] [EC:2.3.2.27]
107755643  selenoprotein S-like isoform X1 [KO:K14025]
107742306  selenoprotein S-like isoform X1 [KO:K14025]
107710235  protein sel-1 homolog 3-like isoform X1 [KO:K14026]
107721334  protein sel-1 homolog 1-like isoform X1 [KO:K14026]
107738749  herpud1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [KO:K14027]
107740310  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform X1 [KO:K14027]
107723982  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
107752457  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
107753027  STIP1 homology and U box-containing protein 1-like [KO:K09561] [EC:2.3.2.27]
107758797  STIP1 homology and U box-containing protein 1-like [KO:K09561] [EC:2.3.2.27]
107717106  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
107718494  ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
107721096  ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
107749768  ubiquitin-conjugating enzyme E2 D2-like isoform X1 [KO:K06689] [EC:2.3.2.23]
107750337  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
107708927  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
107746458  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
107747792  ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
107758532  ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
107733527  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
107733771  ubiquitin-conjugating enzyme E2 D2-like isoform X1 [KO:K06689] [EC:2.3.2.23]
107747547  ubiquitin-conjugating enzyme E2 D2-like isoform X1 [KO:K06689] [EC:2.3.2.23]
107739476  E3 ubiquitin-protein ligase parkin-like isoform X1 [KO:K04556] [EC:2.3.2.31]
107748812  E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
107723609  RING-box protein 1-like [KO:K03868] [EC:2.3.2.32]
107713664  cullin-1-like [KO:K03347]
107727219  cullin-1-like [KO:K03347]
107741709  cullin-1-like [KO:K03347]
107757822  cullin-1 [KO:K03347]
107742439  skp1; S-phase kinase-associated protein 1 [KO:K03094]
107728271  S-phase kinase-associated protein 1 [KO:K03094]
107751236  F-box only protein 2-like [KO:K10099]
107756640  F-box only protein 2-like [KO:K10099]
107707743  F-box only protein 6-like isoform X1 [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
srx00510  N-Glycan biosynthesis
srx03050  Proteasome
srx03060  Protein export
srx04210  Apoptosis
KO pathway
ko04141   
LinkDB

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