KEGG   PATHWAY: stow04512
Entry
stow04512                   Pathway                                
Name
ECM-receptor interaction - Sphaerodactylus townsendi (Townsend's least gecko)
Description
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
stow04512  ECM-receptor interaction
stow04512

Other DBs
GO: 0005201
Organism
Sphaerodactylus townsendi (Townsend's least gecko) [GN:stow]
Gene
125440960  COL1A2; collagen alpha-2(I) chain [KO:K06236]
125444006  COL1A1; collagen alpha-1(I) chain [KO:K06236]
125428289  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
125435038  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
125435045  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
125442929  COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
125438334  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
125438371  collagen alpha-3(IV) chain-like [KO:K06237]
125434906  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
125434912  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
125440610  collagen alpha-6(VI) chain-like [KO:K06238]
125440828  collagen alpha-6(VI) chain-like [KO:K06238]
125435412  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
125432595  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
125433412  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
125429621  LAMA2; laminin subunit alpha-2 [KO:K05637]
125439359  LAMA1; laminin subunit alpha-1 [KO:K05637]
125433409  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
125439433  LAMA3; laminin subunit alpha-3 [KO:K06240]
125430550  LAMA4; laminin subunit alpha-4 [KO:K06241]
125434542  LAMB1; laminin subunit beta-1 [KO:K05636]
125429270  laminin subunit beta-1-like isoform X1 [KO:K06243]
125427756  LAMB2; laminin subunit beta-2 [KO:K06243]
125433092  LAMB3; laminin subunit beta-3 [KO:K06244]
125435712  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
125425025  LAMC1; laminin subunit gamma-1 [KO:K05635]
125425026  LAMC2; laminin subunit gamma-2 [KO:K06246]
125441580  LAMC3; laminin subunit gamma-3 [KO:K06247]
125429320  CHAD; chondroadherin [KO:K06248]
125434479  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
125426101  THBS1; thrombospondin-1 [KO:K16857]
125436612  THBS4; thrombospondin-4 [KO:K04659]
125425364  THBS3; LOW QUALITY PROTEIN: thrombospondin-3 [KO:K04659]
125432826  cartilage oligomeric matrix protein [KO:K04659]
125427520  THBS2; thrombospondin-2 [KO:K04659]
125425836  FN1; fibronectin [KO:K05717]
125440303  SPP1; osteopontin [KO:K06250]
125445444  VTN; vitronectin [KO:K06251]
125428522  TNXB; tenascin-X [KO:K06252]
125441717  TNC; tenascin isoform X1 [KO:K06252]
125433321  TNN; tenascin-N [KO:K06252]
125433465  TNR; tenascin-R isoform X1 [KO:K06252]
125440296  NPNT; nephronectin isoform X1 [KO:K06824]
125440119  FRAS1; extracellular matrix organizing protein FRAS1 [KO:K23379]
125436702  FREM1; FRAS1-related extracellular matrix protein 1 isoform X1 [KO:K23380]
125432449  FRAS1-related extracellular matrix protein 1-like isoform X1 [KO:K23380]
125443325  VWF; von Willebrand factor [KO:K03900]
125440419  bone sialoprotein 2 [KO:K06253]
125440125  MEPE; matrix extracellular phosphoglycoprotein [KO:K26442]
125445483  AGRN; LOW QUALITY PROTEIN: agrin [KO:K06254]
125445556  HSPG2; LOW QUALITY PROTEIN: basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
125436559  ITGA1; integrin alpha-1 [KO:K06480]
125436042  ITGA2; integrin alpha-2 [KO:K06481]
125443986  ITGA2B; integrin alpha-IIb [KO:K06476]
125444920  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
125426006  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
125425972  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
125428032  ITGA7; integrin alpha-7 [KO:K06583]
125441062  ITGA8; integrin alpha-8 [KO:K06584]
125441198  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
125424422  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
125424675  ITGA11; integrin alpha-11 [KO:K06587]
125426725  ITGAV; integrin alpha-V [KO:K06487]
125440489  ITGB1; integrin beta-1 [KO:K05719]
125445133  ITGB3; LOW QUALITY PROTEIN: integrin beta-3 [KO:K06493]
125429564  ITGB4; integrin beta-4 [KO:K06525]
125425945  ITGB5; integrin beta-5 [KO:K06588]
125427213  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
125429605  ITGB7; integrin beta-7 [KO:K06590]
125440812  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
125425763  CD44; CD44 antigen isoform X1 [KO:K06256]
125434032  SDC1; syndecan-1 [KO:K06257]
125432632  SDC4; syndecan-4 isoform X1 [KO:K16338]
125440311  synaptic vesicle glycoprotein 2A-like [KO:K06258]
125424609  SV2B; synaptic vesicle glycoprotein 2B [KO:K06258]
125436742  SV2C; synaptic vesicle glycoprotein 2C isoform X1 [KO:K06258]
125435890  CD36; platelet glycoprotein 4 isoform X1 [KO:K06259]
125444453  platelet glycoprotein Ib alpha chain-like [KO:K06261]
125442910  GP1BB; platelet glycoprotein Ib beta chain isoform X1 [KO:K06262]
125430073  platelet glycoprotein IX-like [KO:K06263]
125430074  platelet glycoprotein IX-like [KO:K06263]
125428489  DAG1; dystroglycan 1 [KO:K06265]
125430527  CD47; leukocyte surface antigen CD47 isoform X1 [KO:K06266]
125429396  HMMR; hyaluronan mediated motility receptor isoform X1 [KO:K06267]
Compound
G10505  Hyaluronic acid
Reference
PMID:11572082
  Authors
van der Flier A, Sonnenberg A.
  Title
Function and interactions of integrins.
  Journal
Cell Tissue Res 305:285-98 (2001)
DOI:10.1007/s004410100417
Reference
PMID:12921709
  Authors
Reddy KV, Mangale SS.
  Title
Integrin receptors: the dynamic modulators of endometrial function.
  Journal
Tissue Cell 35:260-73 (2003)
DOI:10.1016/S0040-8166(03)00039-9
Reference
PMID:12125070
  Authors
Milner R, Campbell IL.
  Title
The integrin family of cell adhesion molecules has multiple functions within the CNS.
  Journal
J Neurosci Res 69:286-91 (2002)
DOI:10.1002/jnr.10321
Reference
PMID:12796473
  Authors
Cichy J, Pure E.
  Title
The liberation of CD44.
  Journal
J Cell Biol 161:839-43 (2003)
DOI:10.1083/jcb.200302098
Reference
PMID:7698997
  Authors
Elenius K, Jalkanen M.
  Title
Function of the syndecans--a family of cell surface proteoglycans.
  Journal
J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference
PMID:10617638
  Authors
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
  Title
The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
  Journal
J Biol Chem 275:451-60 (2000)
DOI:10.1074/jbc.275.1.451
Reference
PMID:15036264
  Authors
Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
  Title
Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
  Journal
Crit Rev Oncol Hematol 49:245-58 (2004)
DOI:10.1016/j.critrevonc.2003.09.009
Reference
PMID:15381249
  Authors
Canobbio I, Balduini C, Torti M.
  Title
Signalling through the platelet glycoprotein Ib-V-IX complex.
  Journal
Cell Signal 16:1329-44 (2004)
DOI:10.1016/j.cellsig.2004.05.008
Reference
PMID:11331578
  Authors
Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
  Title
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
  Journal
EMBO J 20:2120-30 (2001)
DOI:10.1093/emboj/20.9.2120
Reference
PMID:12736199
  Authors
Martin PT.
  Title
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
  Journal
Glycobiology 13:55R-66R (2003)
DOI:10.1093/glycob/cwg076
Reference
PMID:15229478
  Authors
Toole BP.
  Title
Hyaluronan: from extracellular glue to pericellular cue.
  Journal
Nat Rev Cancer 4:528-39 (2004)
DOI:10.1038/nrc1391
Reference
PMID:12845610
  Authors
Bosman FT, Stamenkovic I.
  Title
Functional structure and composition of the extracellular matrix.
  Journal
J Pathol 200:423-8 (2003)
DOI:10.1002/path.1437
Reference
PMID:29079659
  Authors
van der Ven AT, Vivante A, Hildebrandt F
  Title
Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
  Journal
J Am Soc Nephrol 29:36-50 (2018)
DOI:10.1681/ASN.2017050561
Related
pathway
stow04510  Focal adhesion
KO pathway
ko04512   
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