KEGG   PATHWAY: stru04012
Entry
stru04012                   Pathway                                
Name
ErbB signaling pathway - Salmo trutta (river trout)
Description
The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including proliferation, differentiation, cell motility, and survival. Ligand binding to the four closely related members of this RTK family -epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4)-induces the formation of receptor homo- and heterodimers and the activation of the intrinsic kinase domain, resulting in phosphorylation on specific tyrosine residues (pY) within the cytoplasmic tail. Signaling effectors containing binding pockets for pY-containing peptides are recruited to activated receptors and induce the various signaling pathways. The Shc- and/or Grb2-activated mitogen-activated protein kinase (MAPK) pathway is a common target downstream of all ErbB receptors. Similarly, the phosphatidylinositol-3-kinase (PI-3K) pathway is directly or indirectly activated by most ErbBs. Several cytoplasmic docking proteins appear to be recruited by specific ErbB receptors and less exploited by others. These include the adaptors Crk, Nck, the phospholipase C gamma (PLCgamma), the intracellular tyrosine kinase Src, or the Cbl E3 ubiquitin protein ligase.
Class
Environmental Information Processing; Signal transduction
Pathway map
stru04012  ErbB signaling pathway
stru04012

Organism
Salmo trutta (river trout) [GN:stru]
Gene
115205115  egf; pro-epidermal growth factor [KO:K04357]
115150355  protransforming growth factor alpha-like [KO:K08774]
115208075  protransforming growth factor alpha-like [KO:K08774]
115169555  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
115157224  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
115150387  melanoma receptor tyrosine-protein kinase-like isoform X1 [KO:K04361] [EC:2.7.10.1]
115195550  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
115162108  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
115168907  plcg1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
115158661  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like [KO:K01116] [EC:3.1.4.11]
115151896  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
115194123  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
115189418  calcium/calmodulin-dependent protein kinase type II delta chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115180818  calcium/calmodulin-dependent protein kinase type II delta 2 chain-like [KO:K04515] [EC:2.7.11.17]
115193805  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
115153189  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115154883  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
115159892  calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
115164110  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
115156739  calcium/calmodulin-dependent protein kinase type II delta 1 chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115200524  calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
115201212  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115203793  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115198135  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
115204505  calcium/calmodulin-dependent protein kinase type II subunit alpha-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115171658  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
115177626  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
115208609  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
115205322  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
115181935  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
115182231  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
115154245  E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
115162940  cbl; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
115148783  E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
115205894  E3 ubiquitin-protein ligase CBL-like isoform X1 [KO:K04707] [EC:2.3.2.27]
115155003  cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
115171115  signal transducer and activator of transcription 5B-like [KO:K11224]
115161213  signal transducer and activator of transcription 5B-like isoform X1 [KO:K11224]
115198021  signal transducer and activator of transcription 5B-like isoform X1 [KO:K11224]
115167934  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
115165589  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
115150079  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
115208382  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
115185451  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
115174064  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
115175580  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
115176657  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
115154108  adapter molecule crk-like [KO:K04438]
115159631  crk-like protein [KO:K04438]
115163100  adapter molecule crk-like [KO:K04438]
115148620  adapter molecule crk-like [KO:K04438]
115204025  crk-like protein [KO:K04438]
115206046  adapter molecule crk-like [KO:K04438]
115159563  tyrosine-protein kinase ABL1-like isoform X1 [KO:K06619] [EC:2.7.10.2]
115204069  tyrosine-protein kinase ABL1-like isoform X1 [KO:K06619] [EC:2.7.10.2]
115192490  tyrosine-protein kinase ABL2-like isoform X1 [KO:K08887] [EC:2.7.10.2]
115158396  tyrosine-protein kinase ABL2-like isoform X1 [KO:K08887] [EC:2.7.10.2]
115148925  cytoplasmic protein NCK1-like isoform X1 [KO:K07365]
115195312  cytoplasmic protein NCK1-like isoform X1 [KO:K07365]
115155881  cytoplasmic protein NCK2-like [KO:K19862]
115179149  cytoplasmic protein NCK2-like [KO:K19862]
115161267  cytoplasmic protein NCK2-like [KO:K19862]
115195131  cytoplasmic protein NCK2-like [KO:K19862]
115163308  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
115206247  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
115192529  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
115158347  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
115196222  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
115154727  serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
115202625  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
115163187  serine/threonine-protein kinase PAK 4-like [KO:K05734] [EC:2.7.11.1]
115206131  serine/threonine-protein kinase PAK 4-like [KO:K05734] [EC:2.7.11.1]
115174486  pak5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
115198731  serine/threonine-protein kinase PAK 5-like [KO:K05736] [EC:2.7.11.1]
115175082  serine/threonine-protein kinase PAK 6-like [KO:K05735] [EC:2.7.11.1]
115162395  serine/threonine-protein kinase PAK 6-like isoform X1 [KO:K05735] [EC:2.7.11.1]
115172677  serine/threonine-protein kinase PAK 6-like [KO:K05735] [EC:2.7.11.1]
115171440  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
115156176  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
115201273  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
115202704  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
115178289  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
115208730  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
115194041  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115157756  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
115174527  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115152965  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115159070  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115149487  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
115201108  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115204538  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
115192441  transcription factor AP-1-like [KO:K04448]
115169534  transcription factor AP-1-like [KO:K04448]
115158459  transcription factor AP-1-like [KO:K04448]
115157247  transcription factor AP-1-like [KO:K04448]
115149542  transcription factor AP-1-like [KO:K04448]
115160168  transcription factor AP-1-like [KO:K04448]
115168566  ETS domain-containing protein Elk-1-like isoform X1 [KO:K04375]
115159328  probetacellulin-like [KO:K09783]
115149253  probetacellulin-like [KO:K09783]
115168302  proheparin-binding EGF-like growth factor [KO:K08523]
115153925  proheparin-binding EGF-like growth factor [KO:K08523]
115205616  proheparin-binding EGF-like growth factor [KO:K08523]
115165036  ereg; proepiregulin isoform X1 [KO:K09784]
115167852  receptor tyrosine-protein kinase erbB-3-like isoform X1 [KO:K05084] [EC:2.7.10.1]
115165511  receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
115150566  erbb3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
115207844  receptor tyrosine-protein kinase erbB-3-like isoform X1 [KO:K05084] [EC:2.7.10.1]
115160077  nrg1; pro-neuregulin-1, membrane-bound isoform isoform X1 [KO:K05455]
115203779  pro-neuregulin-1, membrane-bound isoform-like isoform X1 [KO:K05455]
115154825  pro-neuregulin-2, membrane-bound isoform-like isoform X1 [KO:K05456]
115164112  pro-neuregulin-2, membrane-bound isoform-like [KO:K05456]
115204439  pro-neuregulin-2, membrane-bound isoform-like [KO:K05456]
115205565  pro-neuregulin-2, membrane-bound isoform-like isoform X1 [KO:K05456]
115155636  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
115179194  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
115160978  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
115196466  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
115186485  SHC-transforming protein 1-like isoform X1 [KO:K06279]
115176818  SHC-transforming protein 1-like isoform X1 [KO:K06279]
115192606  SHC-transforming protein 2-like isoform X1 [KO:K17447]
115158273  SHC-transforming protein 2-like [KO:K17447]
115149458  shc3; SHC-transforming protein 3 [KO:K17448]
115171377  growth factor receptor-bound protein 2 [KO:K04364]
115177728  growth factor receptor-bound protein 2-like [KO:K04364]
115147195  growth factor receptor-bound protein 2-like isoform X1 [KO:K04364]
115201822  growth factor receptor-bound protein 2 [KO:K04364]
115161897  son of sevenless homolog 2-like [KO:K03099]
115178772  son of sevenless homolog 1-like isoform X1 [KO:K03099]
115172982  sos2; son of sevenless homolog 2 [KO:K03099]
115208487  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
115152114  GTPase HRas-like [KO:K02833]
115197299  GTPase HRas isoform X1 [KO:K02833]
115152163  GTPase KRas isoform X1 [KO:K07827]
115171866  GTPase HRas-like [KO:K07827]
115207704  GTPase HRas-like [KO:K07827]
115197360  GTPase KRas isoform X1 [KO:K07827]
115164256  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
115200393  serine/threonine-protein kinase A-Raf-like isoform X1 [KO:K08845] [EC:2.7.11.1]
115183182  serine/threonine-protein kinase B-raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
115183708  serine/threonine-protein kinase B-raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
115168396  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
115166136  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
115149903  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
115192967  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
115192626  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
115169411  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
115158253  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
115157409  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
115165075  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
115192138  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115170800  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115200671  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115154720  transcriptional regulator Myc-like [KO:K04377]
115156503  myc; myc proto-oncogene protein [KO:K04377]
115195764  transcriptional regulator Myc [KO:K04377]
115208402  transcriptional regulator Myc-2-like [KO:K04377]
115151122  transcriptional regulator Myc-2-like [KO:K04377]
115191781  GRB2-associated-binding protein 1-like isoform X1 [KO:K09593]
115202248  GRB2-associated-binding protein 1-like isoform X1 [KO:K09593]
115193657  pro-neuregulin-3, membrane-bound isoform-like isoform X1 [KO:K05457]
115153298  pro-neuregulin-3, membrane-bound isoform-like isoform X1 [KO:K05457]
115162600  pro-neuregulin-3, membrane-bound isoform-like [KO:K05457]
115200999  pro-neuregulin-3, membrane-bound isoform-like [KO:K05457]
115151311  nrg4; pro-neuregulin-4, membrane-bound isoform [KO:K05458]
115196755  pro-neuregulin-4, membrane-bound isoform-like [KO:K05458]
115170061  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
115158422  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
115165908  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
115163651  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
115156658  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
115206538  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
115192204  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
115169527  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
115158103  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
115169950  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115158753  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115159695  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
115156743  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115167650  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
115157257  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
115151679  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
115203963  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
115191758  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115174699  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115162386  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
115154910  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115163684  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115178760  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115172667  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115206563  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115201509  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115208587  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115204542  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
115166084  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
115191963  ribosomal protein S6 kinase beta-2-like isoform X1 [KO:K04688] [EC:2.7.11.1]
115154330  ribosomal protein S6 kinase beta-1-like isoform X1 [KO:K04688] [EC:2.7.11.1]
115163489  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
115148872  ribosomal protein S6 kinase beta-1-like isoform X1 [KO:K04688] [EC:2.7.11.1]
115206403  ribosomal protein S6 kinase beta-1-like isoform X1 [KO:K04688] [EC:2.7.11.1]
115202102  ribosomal protein S6 kinase beta-2-like isoform X1 [KO:K04688] [EC:2.7.11.1]
115164452  eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
115200186  eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
115184996  bcl2-associated agonist of cell death-like [KO:K02158]
115154667  uncharacterized protein LOC115154667 isoform X1 [KO:K02158]
115204267  bcl2-associated agonist of cell death-like [KO:K02158]
115155817  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
115161154  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
115179842  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
115195960  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
115180610  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
115192669  cyclin-dependent kinase inhibitor 1B-like isoform X1 [KO:K06624]
115196967  cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
115198635  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
115180438  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
115150615  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
115207794  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
115198721  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14967450
  Authors
Marmor MD, Skaria KB, Yarden Y.
  Title
Signal transduction and oncogenesis by ErbB/HER receptors.
  Journal
Int J Radiat Oncol Biol Phys 58:903-13 (2004)
DOI:10.1016/j.ijrobp.2003.06.002
Reference
PMID:11252954
  Authors
Yarden Y, Sliwkowski MX.
  Title
Untangling the ErbB signalling network.
  Journal
Nat Rev Mol Cell Biol 2:127-37 (2001)
DOI:10.1038/35052073
Reference
PMID:16829981
  Authors
Citri A, Yarden Y.
  Title
EGF-ERBB signalling: towards the systems level.
  Journal
Nat Rev Mol Cell Biol 7:505-16 (2006)
DOI:10.1038/nrm1962
Reference
PMID:17000658
  Authors
Scaltriti M, Baselga J.
  Title
The epidermal growth factor receptor pathway: a model for targeted therapy.
  Journal
Clin Cancer Res 12:5268-72 (2006)
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Related
pathway
stru04010  MAPK signaling pathway
stru04020  Calcium signaling pathway
stru04110  Cell cycle
stru04150  mTOR signaling pathway
KO pathway
ko04012   
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