KEGG   PATHWAY: stru04150
Entry
stru04150                   Pathway                                
Name
mTOR signaling pathway - Salmo trutta (river trout)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
stru04150  mTOR signaling pathway
stru04150

Organism
Salmo trutta (river trout) [GN:stru]
Gene
115147195  [KO:K04364]
115147613  tsc2; tuberin isoform X1 [KO:K07207]
115148215  [KO:K04526]
115148245  [KO:K01384]
115148553  [KO:K20400]
115148602  [KO:K23081]
115148709  [KO:K02842]
115148872  [KO:K04688] [EC:2.7.11.1]
115148895  [KO:K01384]
115148954  [KO:K16172]
115149054  [KO:K16185]
115149229  [KO:K08267]
115149232  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
115149295  [KO:K10421]
115149903  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
115149919  [KO:K00572]
115150031  sec13; protein SEC13 homolog [KO:K14004]
115150164  [KO:K03258]
115150176  [KO:K15728] [EC:3.1.3.4]
115150254  [KO:K04513]
115150267  [KO:K07208]
115150574  [KO:K07208]
115150658  [KO:K00408]
115150837  [KO:K20402]
115150940  [KO:K20405]
115150990  [KO:K00182]
115150994  [KO:K04513]
115151433  [KO:K02145] [EC:7.1.2.2]
115151679  [KO:K02649]
115151715  [KO:K04373] [EC:2.7.11.1]
115151815  [KO:K07298] [EC:2.7.11.1]
115151831  [KO:K03068]
115151845  [KO:K13780]
115151978  [KO:K05087] [EC:2.7.10.1]
115152099  [KO:K20411]
115152114  [KO:K02833]
115152163  [KO:K07827]
115152320  [KO:K00182]
115152742  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
115153160  [KO:K02147]
115153219  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
115153350  [KO:K00714]
115153375  [KO:K03259]
115153452  [KO:K04373] [EC:2.7.11.1]
115153600  [KO:K02375]
115153684  [KO:K04526]
115154054  [KO:K15705] [EC:2.3.2.27]
115154077  [KO:K23081]
115154203  [KO:K02842]
115154330  [KO:K04688] [EC:2.7.11.1]
115154354  [KO:K01384]
115154413  [KO:K16172]
115154548  [KO:K01384]
115154573  [KO:K15728] [EC:3.1.3.4]
115154659  [KO:K06519]
115154782  [KO:K04373] [EC:2.7.11.1]
115154796  [KO:K02145] [EC:7.1.2.2]
115154910  [KO:K04456] [EC:2.7.11.1]
115155022  [KO:K02353]
115155072  [KO:K20400]
115155413  [KO:K02432]
115155564  [KO:K02375]
115155817  [KO:K03083] [EC:2.7.11.26]
115156103  [KO:K01357]
115156104  [KO:K00445]
115156658  [KO:K00922] [EC:2.7.1.153]
115156743  [KO:K02649]
115156765  [KO:K02353]
115156871  [KO:K02375]
115157034  [KO:K15705] [EC:2.3.2.27]
115157104  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
115157195  [KO:K00312]
115157197  [KO:K01064]
115157257  [KO:K02649]
115157409  [KO:K04369] [EC:2.7.12.2]
115157419  [KO:K07298] [EC:2.7.11.1]
115157526  [KO:K04527] [EC:2.7.10.1]
115157597  [KO:K07208]
115157691  [KO:K02144]
115158103  [KO:K02649]
115158222  [KO:K07298] [EC:2.7.11.1]
115158253  [KO:K04369] [EC:2.7.12.2]
115158422  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
115158435  [KO:K00312]
115158481  [KO:K07198] [EC:2.7.11.31]
115158753  [KO:K02649]
115158830  [KO:K04527] [EC:2.7.10.1]
115158948  [KO:K04467] [EC:2.7.11.10]
115159090  [KO:K02149]
115159257  [KO:K10421]
115159348  [KO:K08267]
115159466  depdc5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
115159506  [KO:K07206]
115159572  [KO:K06276] [EC:2.7.11.1]
115159639  [KO:K21357] [EC:2.7.11.1]
115159675  [KO:K20408]
115159695  [KO:K02649]
115159717  [KO:K02152]
115159798  [KO:K07198] [EC:2.7.11.31]
115160083  slc38a9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
115160134  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
115160598  [KO:K08272]
115160681  [KO:K00445]
115160682  [KO:K01357]
115160889  [KO:K02375]
115161154  [KO:K03083] [EC:2.7.11.26]
115161897  [KO:K03099]
115162180  [KO:K04370]
115162196  [KO:K03259]
115162386  [KO:K04456] [EC:2.7.11.1]
115162503  [KO:K02329]
115162510  [KO:K15728] [EC:3.1.3.4]
115162588  [KO:K04373] [EC:2.7.11.1]
115162780  [KO:K04467] [EC:2.7.11.10]
115162875  [KO:K02353]
115162986  [KO:K06519]
115163206  [KO:K02842]
115163489  [KO:K04688] [EC:2.7.11.1]
115163563  [KO:K08269] [EC:2.7.11.1]
115163651  [KO:K00922] [EC:2.7.1.153]
115163653  [KO:K08272]
115163684  [KO:K04456] [EC:2.7.11.1]
115163703  fzd4; frizzled-4 [KO:K02354]
115163713  [KO:K20397]
115164069  [KO:K00714]
115164135  [KO:K23080]
115164228  [KO:K08267]
115164452  [KO:K07205]
115164471  [KO:K10421]
115164603  [KO:K02842]
115164692  [KO:K00714]
115165075  [KO:K04371] [EC:2.7.11.24]
115165260  [KO:K04513]
115165346  [KO:K16344]
115165415  [KO:K03258]
115165508  [KO:K03209]
115165509  [KO:K01357]
115165905  [KO:K04513]
115165908  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
115166038  [KO:K13780]
115166084  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
115166122  [KO:K04373] [EC:2.7.11.1]
115166130  [KO:K00572]
115166136  [KO:K04366] [EC:2.7.11.1]
115166252  [KO:K04513]
115166716  [KO:K13780]
115167114  [KO:K02329]
115167650  [KO:K02649]
115167676  tsc1; hamartin isoform X1 [KO:K07206]
115167848  [KO:K03209]
115167850  [KO:K01357]
115168153  tti1; TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
115168240  [KO:K04513]
115168296  [KO:K04513]
115168396  [KO:K04366] [EC:2.7.11.1]
115168407  [KO:K00572]
115168542  wnt5a; protein Wnt-5a [KO:K00444]
115168670  [KO:K16344]
115168869  [KO:K02353]
115168924  [KO:K13780]
115169000  [KO:K03258]
115169288  [KO:K04527] [EC:2.7.10.1]
115169353  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
115169402  [KO:K07298] [EC:2.7.11.1]
115169411  [KO:K04369] [EC:2.7.12.2]
115169527  [KO:K02649]
115169581  [KO:K01064]
115169582  [KO:K00312]
115169742  [KO:K15705] [EC:2.3.2.27]
115169824  [KO:K02375]
115169930  [KO:K02353]
115169950  [KO:K02649]
115170061  [KO:K00922] [EC:2.7.1.153]
115170258  [KO:K02144]
115170800  [KO:K04371] [EC:2.7.11.24]
115170879  [KO:K03259]
115171126  [KO:K02235]
115171144  [KO:K01064]
115171189  [KO:K06276] [EC:2.7.11.1]
115171211  [KO:K20406]
115171377  [KO:K04364]
115171487  [KO:K16184]
115171527  [KO:K08271]
115171658  [KO:K02677] [EC:2.7.11.13]
115171866  [KO:K07827]
115172306  [KO:K16186]
115172467  [KO:K04370]
115172478  [KO:K03259]
115172667  [KO:K04456] [EC:2.7.11.1]
115172796  [KO:K02329]
115172803  [KO:K15728] [EC:3.1.3.4]
115172888  [KO:K04373] [EC:2.7.11.1]
115172982  sos2; son of sevenless homolog 2 [KO:K03099]
115173834  [KO:K20064]
115174101  [KO:K13302] [EC:2.7.11.1]
115174125  [KO:K03156]
115174538  [KO:K02329]
115174611  [KO:K02149]
115174699  [KO:K04456] [EC:2.7.11.1]
115175311  [KO:K03156]
115175599  [KO:K16186]
115175621  [KO:K13302] [EC:2.7.11.1]
115175628  [KO:K20064]
115175800  [KO:K02432]
115176264  seh1l; nucleoporin SEH1 [KO:K14299]
115176348  [KO:K02376]
115176393  [KO:K20064]
115176472  [KO:K02432]
115176536  [KO:K02148]
115176742  [KO:K03158]
115176831  [KO:K20398]
115176944  [KO:K16186]
115176971  [KO:K20407]
115177135  [KO:K16186]
115177195  [KO:K00408]
115177316  [KO:K09594]
115177626  [KO:K02677] [EC:2.7.11.13]
115177728  [KO:K04364]
115177992  [KO:K20407]
115178632  [KO:K20398]
115178760  [KO:K04456] [EC:2.7.11.1]
115178772  [KO:K03099]
115179315  [KO:K02432]
115179743  [KO:K02375]
115179761  [KO:K08272]
115179842  [KO:K03083] [EC:2.7.11.26]
115180012  [KO:K02150]
115180444  [KO:K01558]
115180496  wnt7b; protein Wnt-7b [KO:K00572]
115180501  [KO:K05459]
115180502  [KO:K20064]
115180643  [KO:K20399]
115180644  [KO:K02151]
115181208  [KO:K02148]
115181837  [KO:K02432]
115181935  [KO:K19662] [EC:2.7.11.13]
115182107  [KO:K17532]
115182202  [KO:K02376]
115182231  [KO:K19662] [EC:2.7.11.13]
115182470  [KO:K20402]
115182685  [KO:K05087] [EC:2.7.10.1]
115183182  [KO:K04365] [EC:2.7.11.1]
115183708  [KO:K04365] [EC:2.7.11.1]
115184904  [KO:K07208]
115185210  [KO:K00408]
115187313  [KO:K13302] [EC:2.7.11.1]
115187990  [KO:K03158]
115188006  [KO:K00408]
115188256  [KO:K00444]
115188450  [KO:K20411]
115188810  [KO:K09594]
115188988  [KO:K14299]
115188993  [KO:K14299]
115189372  [KO:K20394]
115189771  [KO:K17532]
115189962  [KO:K00444]
115190165  [KO:K04526]
115190905  [KO:K20402]
115191758  [KO:K04456] [EC:2.7.11.1]
115191963  [KO:K04688] [EC:2.7.11.1]
115192082  [KO:K02991]
115192138  [KO:K04371] [EC:2.7.11.24]
115192162  [KO:K04527] [EC:2.7.10.1]
115192204  [KO:K02649]
115192283  [KO:K20396]
115192416  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
115192626  [KO:K04369] [EC:2.7.12.2]
115192675  [KO:K00572]
115192967  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
115193565  [KO:K03259]
115193596  [KO:K00714]
115193598  [KO:K08270]
115193756  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
115193839  [KO:K02147]
115194272  [KO:K16172]
115194276  [KO:K02353]
115194718  [KO:K06519]
115195476  [KO:K02145] [EC:7.1.2.2]
115195564  [KO:K07208]
115195788  [KO:K15728] [EC:3.1.3.4]
115195862  [KO:K15705] [EC:2.3.2.27]
115195960  [KO:K03083] [EC:2.7.11.26]
115196030  [KO:K02432]
115196262  [KO:K08272]
115196473  [KO:K02375]
115196490  [KO:K17532]
115196778  [KO:K05087] [EC:2.7.10.1]
115196921  [KO:K13780]
115196935  [KO:K03068]
115196973  [KO:K00572]
115197201  prr5l; proline-rich protein 5-like [KO:K20411]
115197299  [KO:K02833]
115197360  [KO:K07827]
115197429  [KO:K02150]
115197546  [KO:K00182]
115197999  [KO:K03259]
115198123  [KO:K02235]
115198259  [KO:K01064]
115198274  [KO:K16172]
115198278  [KO:K02353]
115198639  [KO:K00572]
115198682  [KO:K02151]
115198683  [KO:K20399]
115198728  [KO:K06276] [EC:2.7.11.1]
115198810  [KO:K01558]
115198922  [KO:K20406]
115198928  [KO:K02150]
115198940  [KO:K05459]
115200038  [KO:K21357] [EC:2.7.11.1]
115200042  [KO:K02842]
115200158  clip1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
115200186  [KO:K07205]
115200286  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
115200500  [KO:K23080]
115200671  [KO:K04371] [EC:2.7.11.24]
115200773  [KO:K11137]
115200920  [KO:K20408]
115200924  [KO:K06276] [EC:2.7.11.1]
115201018  [KO:K04467] [EC:2.7.11.10]
115201053  [KO:K00312]
115201167  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
115201358  [KO:K08266]
115201509  [KO:K04456] [EC:2.7.11.1]
115201621  [KO:K04373] [EC:2.7.11.1]
115201822  [KO:K04364]
115202045  [KO:K02991]
115202102  [KO:K04688] [EC:2.7.11.1]
115202775  [KO:K03259]
115203079  [KO:K16184]
115203598  [KO:K13780]
115203659  [KO:K05087] [EC:2.7.10.1]
115203661  wdr59; GATOR complex protein WDR59 [KO:K20409]
115203857  [KO:K07198] [EC:2.7.11.31]
115203868  [KO:K08271]
115203920  [KO:K02147]
115203955  [KO:K02152]
115203963  [KO:K02649]
115204015  [KO:K21357] [EC:2.7.11.1]
115204136  [KO:K07206]
115204257  [KO:K06519]
115204387  [KO:K04373] [EC:2.7.11.1]
115204399  [KO:K02145] [EC:7.1.2.2]
115204542  [KO:K04456] [EC:2.7.11.1]
115205322  [KO:K02677] [EC:2.7.11.13]
115205550  [KO:K08272]
115205827  irs1; insulin receptor substrate 1 isoform X1 [KO:K16172]
115205843  [KO:K02353]
115206151  [KO:K02842]
115206403  [KO:K04688] [EC:2.7.11.1]
115206463  [KO:K08269] [EC:2.7.11.1]
115206538  [KO:K00922] [EC:2.7.1.153]
115206541  [KO:K08272]
115206563  [KO:K04456] [EC:2.7.11.1]
115206582  [KO:K02354]
115206591  [KO:K20397]
115207437  [KO:K00182]
115207491  [KO:K20405]
115207704  [KO:K07827]
115207837  [KO:K07208]
115208179  [KO:K04513]
115208294  [KO:K15728] [EC:3.1.3.4]
115208311  [KO:K03258]
115208487  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
115208587  [KO:K04456] [EC:2.7.11.1]
115208609  [KO:K02677] [EC:2.7.11.13]
115208651  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
stru00561  Glycerolipid metabolism
stru04010  MAPK signaling pathway
stru04140  Autophagy - animal
stru04810  Regulation of actin cytoskeleton
stru04910  Insulin signaling pathway
KO pathway
ko04150   

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