KEGG   PATHWAY: stru04146
Entry
stru04146                   Pathway                                
Name
Peroxisome - Salmo trutta (river trout)
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
stru04146  Peroxisome
stru04146

Other DBs
GO: 0005777
Organism
Salmo trutta (river trout) [GN:stru]
Gene
115166770  peroxisomal membrane protein PEX16-like [KO:K13335]
115203628  peroxisomal membrane protein PEX16-like [KO:K13335]
115174784  pex3; peroxisomal biogenesis factor 3 [KO:K13336]
115169510  peroxisomal biogenesis factor 19-like [KO:K13337]
115157288  peroxisomal biogenesis factor 19-like [KO:K13337]
115153101  ATP-binding cassette sub-family D member 3-like [KO:K05677] [EC:7.6.2.4]
115169885  ATP-binding cassette sub-family D member 3-like [KO:K05677] [EC:7.6.2.4]
115156814  ATP-binding cassette sub-family D member 3-like isoform X1 [KO:K05677] [EC:7.6.2.4]
115195350  ATP-binding cassette sub-family D member 3 isoform X1 [KO:K05677] [EC:7.6.2.4]
115175538  pex1; peroxisome biogenesis factor 1 [KO:K13338]
115178011  pex6; LOW QUALITY PROTEIN: peroxisome biogenesis factor 6 [KO:K13339]
115208502  peroxisome assembly factor 2-like [KO:K13339]
115199020  peroxisome assembly protein 26-like [KO:K13340]
115193633  pex7; peroxisomal biogenesis factor 7 [KO:K13341]
115176496  peroxisomal targeting signal 1 receptor-like isoform X1 [KO:K13342]
115158938  PEX5-related protein-like [KO:K13342]
115177276  peroxisomal targeting signal 1 receptor-like isoform X1 [KO:K13342]
115156563  PEX5-related protein-like isoform X1 [KO:K13342]
115151522  PEX5-related protein-like isoform X1 [KO:K13342]
115165923  pex14; peroxisomal membrane protein PEX14 [KO:K13343]
115193495  peroxisomal membrane protein PEX13-like [KO:K13344]
115152765  peroxisomal membrane protein PEX13-like [KO:K13344]
115154254  pex12; peroxisome assembly protein 12 [KO:K13345]
115165369  peroxisome biogenesis factor 10-like [KO:K13346]
115152242  pex2; peroxisome biogenesis factor 2 [KO:K06664]
115200223  pxmp2; peroxisomal membrane protein 2 [KO:K13347]
115192333  mpv17; protein Mpv17 [KO:K13348]
115174759  protein Mpv17-like [KO:K13348]
115156745  mpv17-like protein 2 [KO:K13348]
115151672  mpv17-like protein 2 [KO:K13348]
115173486  mpv17-like protein [KO:K13349]
115189255  mpv17-like protein [KO:K13349]
115174138  mpv17-like protein [KO:K13349]
115178055  mpv17-like protein [KO:K13349]
115147287  mpv17-like protein isoform X1 [KO:K13349]
115150109  pxmp4; peroxisomal membrane protein 4 [KO:K13350]
115152025  pex11a; peroxisomal membrane protein 11A [KO:K13351]
115173634  peroxisomal membrane protein 11B-like [KO:K13352]
115175834  peroxisomal membrane protein 11B-like [KO:K13352]
115151692  pex11g; peroxisomal membrane protein 11C [KO:K13353]
115171651  peroxisomal membrane protein PMP34-like [KO:K13354]
115196170  peroxisomal membrane protein PMP34-like [KO:K13354]
115205252  peroxisomal membrane protein PMP34-like [KO:K13354]
115187725  2-hydroxyacyl-CoA lyase 1-like isoform X1 [KO:K12261] [EC:4.1.2.63]
115187759  2-hydroxyacyl-CoA lyase 1-like isoform X1 [KO:K12261] [EC:4.1.2.63]
115159327  amacr; alpha-methylacyl-CoA racemase [KO:K01796] [EC:5.1.99.4]
115180488  phyh; phytanoyl-CoA dioxygenase, peroxisomal [KO:K00477] [EC:1.14.11.18]
115198831  phytanoyl-CoA dioxygenase, peroxisomal-like isoform X1 [KO:K00477] [EC:1.14.11.18]
115178807  peroxisomal acyl-coenzyme A oxidase 1-like isoform X1 [KO:K00232] [EC:1.3.3.6]
115208632  peroxisomal acyl-coenzyme A oxidase 1-like isoform X1 [KO:K00232] [EC:1.3.3.6]
115198552  acox3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
115164957  hsd17b4; peroxisomal multifunctional enzyme type 2 [KO:K12405] [EC:1.1.1.- 4.2.1.107 4.2.1.119]
115157509  scp2; non-specific lipid-transfer protein [KO:K08764] [EC:2.3.1.176]
115208005  acyl-coenzyme A thioesterase 1-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
115155396  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
115183174  acaa1; 3-ketoacyl-CoA thiolase, peroxisomal [KO:K07513] [EC:2.3.1.16]
115159799  decr2; peroxisomal 2,4-dienoyl-CoA reductase isoform X1 [KO:K13237] [EC:1.3.1.124]
115163171  ech1; delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial [KO:K12663] [EC:5.3.3.21]
115165266  ATP-binding cassette sub-family D member 1-like [KO:K05675] [EC:7.6.2.4]
115180031  ATP-binding cassette sub-family D member 2-like [KO:K05676] [EC:7.6.2.4]
115198656  ATP-binding cassette sub-family D member 2-like [KO:K05676] [EC:7.6.2.4]
115152611  abcd4; ATP-binding cassette sub-family D member 4 isoform X1 [KO:K05678] [EC:7.6.2.8]
115182355  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
115182366  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
115192876  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
115166758  very long-chain acyl-CoA synthetase-like isoform X1 [KO:K08746] [EC:6.2.1.- 6.2.1.3]
115166760  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
115161673  acsl5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
115168052  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
115192069  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
115169833  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
115154012  long-chain-fatty-acid--CoA ligase 6-like isoform X1 [KO:K01897] [EC:6.2.1.3]
115154458  long-chain-fatty-acid--CoA ligase 4-like isoform X1 [KO:K01897] [EC:6.2.1.3]
115163632  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
115156865  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
115164541  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
115148550  long-chain-fatty-acid--CoA ligase 6-like isoform X1 [KO:K01897] [EC:6.2.1.3]
115149000  long-chain-fatty-acid--CoA ligase 4-like isoform X1 [KO:K01897] [EC:6.2.1.3]
115206524  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
115202052  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
115205514  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
115200105  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
115157681  pecr; peroxisomal trans-2-enoyl-CoA reductase [KO:K07753] [EC:1.3.1.38]
115154068  eci2; enoyl-CoA delta isomerase 2, mitochondrial isoform X1 [KO:K13239] [EC:5.3.3.8]
115195859  enoyl-CoA delta isomerase 2, mitochondrial-like [KO:K13239] [EC:5.3.3.8]
115197275  nudt7; peroxisomal coenzyme A diphosphatase NUDT7 [KO:K17879] [EC:3.6.1.77]
115167646  nudt12; peroxisomal NADH pyrophosphatase NUDT12 [KO:K03426] [EC:3.6.1.22]
115157480  nudt13; nucleoside diphosphate-linked moiety X motif 13 isoform X1 [KO:K03426] [EC:3.6.1.22]
115202720  nucleoside diphosphate-linked moiety X motif 19-like [KO:K13355] [EC:3.6.1.77]
115203672  nucleoside diphosphate-linked moiety X motif 19-like [KO:K13355] [EC:3.6.1.77]
115203673  nucleoside diphosphate-linked moiety X motif 19-like [KO:K13355] [EC:3.6.1.77]
115207230  acot8; acyl-coenzyme A thioesterase 8 [KO:K11992] [EC:3.1.2.27]
115176029  carnitine O-acetyltransferase-like [KO:K00624] [EC:2.3.1.7]
115160021  carnitine O-acetyltransferase-like [KO:K00624] [EC:2.3.1.7]
115164595  carnitine O-acetyltransferase-like [KO:K00624] [EC:2.3.1.7]
115200049  carnitine O-acetyltransferase-like isoform X1 [KO:K00624] [EC:2.3.1.7]
115187336  peroxisomal carnitine O-octanoyltransferase-like [KO:K05940] [EC:2.3.1.137]
115187353  peroxisomal carnitine O-octanoyltransferase-like isoform X1 [KO:K05940] [EC:2.3.1.137]
115177235  peroxisomal carnitine O-octanoyltransferase-like isoform X1 [KO:K05940] [EC:2.3.1.137]
115151917  malonyl-CoA decarboxylase, mitochondrial-like [KO:K01578] [EC:4.1.1.9]
115196852  malonyl-CoA decarboxylase, mitochondrial-like [KO:K01578] [EC:4.1.1.9]
115174808  gnpat; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
115208265  dihydroxyacetone phosphate acyltransferase-like isoform X1 [KO:K00649] [EC:2.3.1.42]
115155483  alkyldihydroxyacetonephosphate synthase, peroxisomal-like isoform X1 [KO:K00803] [EC:2.5.1.26]
115160788  alkyldihydroxyacetonephosphate synthase, peroxisomal-like [KO:K00803] [EC:2.5.1.26]
115152262  fatty acyl-CoA reductase 1-like isoform X1 [KO:K13356] [EC:1.2.1.84]
115180093  fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
115197475  fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
115199001  fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
115164855  mevalonate kinase-like isoform X1 [KO:K00869] [EC:2.7.1.36]
115199805  mvk; mevalonate kinase [KO:K00869] [EC:2.7.1.36]
115176604  pmvk; phosphomevalonate kinase [KO:K13273] [EC:2.7.4.2]
115179734  phosphomevalonate kinase-like isoform X1 [KO:K13273] [EC:2.7.4.2]
115156690  serine--pyruvate aminotransferase-like isoform X1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
115151468  serine--pyruvate aminotransferase, mitochondrial-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
115200217  dao; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
115161995  ddo; D-aspartate oxidase [KO:K00272] [EC:1.4.3.1]
115184000  isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
115155568  isocitrate dehydrogenase [NADP] cytoplasmic-like isoform X1 [KO:K00031] [EC:1.1.1.42]
115160892  isocitrate dehydrogenase [NADP] cytoplasmic-like [KO:K00031] [EC:1.1.1.42]
115152014  isocitrate dehydrogenase [NADP], mitochondrial [KO:K00031] [EC:1.1.1.42]
115194051  paox; peroxisomal N(1)-acetyl-spermine/spermidine oxidase [KO:K00308] [EC:1.5.3.13]
115206471  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
115153431  3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic-like isoform X1 [KO:K01640] [EC:4.1.3.4]
115162442  hydroxymethylglutaryl-CoA lyase, mitochondrial-like [KO:K01640] [EC:4.1.3.4]
115172729  hydroxymethylglutaryl-CoA lyase, mitochondrial-like [KO:K01640] [EC:4.1.3.4]
115201598  3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic-like isoform X1 [KO:K01640] [EC:4.1.3.4]
115162207  hao1; hydroxyacid oxidase 1 isoform X1 [KO:K11517] [EC:1.1.3.15]
115155767  hydroxyacid oxidase 2-like isoform X1 [KO:K11517] [EC:1.1.3.15]
115161100  hydroxyacid oxidase 2-like isoform X1 [KO:K11517] [EC:1.1.3.15]
115178817  catalase-like [KO:K03781] [EC:1.11.1.6]
115208531  catalase-like [KO:K03781] [EC:1.11.1.6]
115197208  catalase isoform X1 [KO:K03781] [EC:1.11.1.6]
115154678  peroxiredoxin-5, mitochondrial-like [KO:K11187] [EC:1.11.1.24]
115204276  peroxiredoxin-5, mitochondrial-like [KO:K11187] [EC:1.11.1.24]
115153809  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
115204664  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
115174463  sod2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
115206488  nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
115169524  peroxiredoxin-1-like [KO:K13279] [EC:1.11.1.24]
115178400  peroxiredoxin-1-like [KO:K13279] [EC:1.11.1.24]
115157276  peroxiredoxin [KO:K13279] [EC:1.11.1.24]
115147330  peroxiredoxin-1-like [KO:K13279] [EC:1.11.1.24]
115201535  peroxiredoxin-like [KO:K13279] [EC:1.11.1.24]
115161918  bifunctional epoxide hydrolase 2-like [KO:K08726] [EC:3.3.2.10 3.1.3.76]
115172954  bifunctional epoxide hydrolase 2-like [KO:K08726] [EC:3.3.2.10 3.1.3.76]
115172967  xdh; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
115194402  dehydrogenase/reductase SDR family member 4-like isoform X1 [KO:K11147] [EC:1.1.-.-]
115198403  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
stru00071  Fatty acid degradation
stru00120  Primary bile acid biosynthesis
stru00230  Purine metabolism
stru00564  Glycerophospholipid metabolism
stru00565  Ether lipid metabolism
stru00830  Retinol metabolism
stru00900  Terpenoid backbone biosynthesis
stru03320  PPAR signaling pathway
KO pathway
ko04146   
LinkDB

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