KEGG   PATHWAY: tsr04540
Entry
tsr04540                    Pathway                                
Name
Gap junction - Thamnophis sirtalis (common garter snake)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
tsr04540  Gap junction
tsr04540

Other DBs
GO: 0005921
Organism
Thamnophis sirtalis (common garter snake) [GN:tsr]
Gene
106543595  GJA1; gap junction alpha-1 protein [KO:K07372]
106555093  GJD2; gap junction delta-2 protein [KO:K07373]
106544059  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
106555676  lysophosphatidic acid receptor 1-B-like [KO:K04289]
106556950  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
106543690  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
106539143  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
106544589  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
106541330  platelet-derived growth factor C [KO:K05450]
106551812  PDGFD; platelet-derived growth factor D [KO:K05450]
106554022  pro-epidermal growth factor-like [KO:K04357]
106555130  pro-epidermal growth factor-like [KO:K04357]
106547766  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
106539158  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
106553913  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
106545945  SOS2; son of sevenless homolog 2 [KO:K03099]
106544570  HRAS; GTPase HRas [KO:K02833]
106556456  GTPase KRas [KO:K07827]
106538715  GTPase KRas-like isoform X1 [KO:K07827]
106556469  GTPase NRas [KO:K07828]
106542299  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
106541257  RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
106549118  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
106555305  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106554657  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106539801  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
106551377  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
106548568  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
106538564  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
106557409  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
106545766  tubulin alpha-1A chain [KO:K07374]
106556095  tubulin alpha-3 chain [KO:K07374]
106545017  tubulin alpha-8 chain-like [KO:K07374]
106540316  tubulin alpha-4A chain [KO:K07374]
106543324  tubulin alpha-8 chain [KO:K07374]
106546597  tubulin alpha-1B chain-like [KO:K07374]
106546598  tubulin alpha chain-like [KO:K07374]
106546601  tubulin alpha-1C chain [KO:K07374]
106550675  tubulin alpha-3 chain [KO:K07374]
106553405  tubulin beta-4B chain-like [KO:K07375]
106541969  TUBB4B; tubulin beta-4B chain [KO:K07375]
106553108  tubulin beta-7 chain [KO:K07375]
106557274  TUBB6; tubulin beta-6 chain [KO:K07375]
106546655  tubulin beta-6 chain [KO:K07375]
106537622  TUBB3; tubulin beta-3 chain [KO:K07375]
106546741  CSNK1D; casein kinase I isoform delta isoform X1 [KO:K08959] [EC:2.7.11.1]
106549230  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
106549310  TJP1; tight junction protein ZO-1 [KO:K05701]
106545862  ADRB1; beta-1 adrenergic receptor [KO:K04141]
106539019  D(1A) dopamine receptor-like [KO:K04144]
106539023  D(1A) dopamine receptor-like [KO:K04144]
106537887  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
106543976  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
106545186  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
106555200  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
106549385  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
106553086  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
106539925  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
106554339  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
106542281  adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
106551564  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
106555867  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
106544707  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
106553044  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
106547938  5-hydroxytryptamine receptor 2C-like [KO:K04157]
106543701  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
106543622  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
106554628  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
106556348  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
106555020  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
106544747  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
106543825  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
106550123  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like [KO:K05858] [EC:3.1.4.11]
106542534  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
106553941  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858] [EC:3.1.4.11]
106541049  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
106541215  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
106538799  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
106544999  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
106538053  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
106555835  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
106553741  GUCY1A3; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
106549047  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
106556501  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
106539796  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
106539263  GUCY1B3; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
106547680  PRKG2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
106545902  cGMP-dependent protein kinase 2-like [KO:K19477] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
tsr04010  MAPK signaling pathway
tsr04020  Calcium signaling pathway
tsr04060  Cytokine-cytokine receptor interaction
tsr04070  Phosphatidylinositol signaling system
tsr04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
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