KEGG   PATHWAY: xtr04814
Entry
xtr04814                    Pathway                                
Name
Motor proteins - Xenopus tropicalis (tropical clawed frog)
Class
Cellular Processes; Cell motility
Pathway map
xtr04814  Motor proteins
xtr04814

Organism
Xenopus tropicalis (tropical clawed frog) [GN:xtr]
Gene
100380107  dync2h1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
407935  dync1i2; cytoplasmic dynein 1 intermediate chain 2 [KO:K10415]
100127187  dync1i1; cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
779754  dync1li1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
100498465  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
101734949  dync2li1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
448652  dynll1; dynein light chain 1, cytoplasmic [KO:K10418]
100038056  dynll2; dynein light chain 2, cytoplasmic [KO:K10418]
549149  dynlrb2; dynein light chain roadblock-type 2 [KO:K10419]
100101695  dynlrb1; dynein light chain roadblock-type 1 [KO:K10419]
496911  dynlt1; dynein light chain Tctex-type 1 [KO:K10420]
101732306  dynlt3; dynein light chain Tctex-type 3 [KO:K10420]
101732884  tctex1d4; tctex1 domain-containing protein 4 [KO:K25420]
493200  tctex1d1; tctex1 domain-containing protein 1 [KO:K25421]
100036734  dnah1; dynein heavy chain 1, axonemal isoform X1 [KO:K10408]
100490919  dnah3; dynein heavy chain 3, axonemal [KO:K10408]
100490346  dynein heavy chain 3, axonemal [KO:K10408]
100170584  dnah2; dynein heavy chain 2, axonemal isoform X1 [KO:K10408]
100495128  dnah7; dynein heavy chain 7, axonemal isoform X2 [KO:K10408]
100492041  dnah5; dynein heavy chain 5, axonemal isoform X3 [KO:K10408]
100487613  dnah6; dynein heavy chain 6, axonemal isoform X1 [KO:K10408]
100494609  dnah9; dynein heavy chain 9, axonemal [KO:K10408]
100494270  dnah11; dynein heavy chain 11, axonemal [KO:K10408]
100216154  dnah12; dynein heavy chain 12, axonemal [KO:K10408]
100497531  dynein heavy chain 11, axonemal [KO:K10408]
100492440  dnah10; dynein heavy chain 10, axonemal [KO:K10408]
100036695  dnah14; dynein heavy chain 14, axonemal [KO:K10408]
100488102  dynein heavy chain 5, axonemal isoform X1 [KO:K10408]
100144946  dnai1; uncharacterized protein LOC100144946 [KO:K10409]
100495747  dnai2; dynein intermediate chain 2, axonemal isoform X2 [KO:K11143]
100145513  wdr63; WD repeat domain 63 [KO:K24722]
100127694  wdr78; WD repeat-containing protein 78 [KO:K24723]
549441  dnali1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
549066  dnal1; dynein light chain 1, axonemal [KO:K10411]
448476  dnal4; dynein light chain 4, axonemal [KO:K10412]
447948  dctn1; dynactin subunit 1 isoform X8 [KO:K04648]
548423  dctn2; dynactin subunit 2 [KO:K10424]
100125086  dctn3; uncharacterized protein LOC100125086 [KO:K10425]
595065  dctn4; dynactin subunit 4 [KO:K10426]
496622  dctn5; dynactin subunit 5 [KO:K10427]
733845  dctn6; dynactin subunit 6 [KO:K10428]
100101796  actr1a; alpha-centractin [KO:K16575]
496410  actr10; actin-related protein 10 [KO:K16576]
550008  capza2; F-actin-capping protein subunit alpha-2 [KO:K10364]
550078  capza1; F-actin-capping protein subunit alpha-1 [KO:K10364]
100494073  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
779781  bicdl1; BICD family-like cargo adapter 1 [KO:K16756]
448330  bicdl2; BICD family-like cargo adapter 2 [KO:K16756]
100145808  hook3; protein Hook homolog 3 isoform X4 [KO:K16536]
394675  tuba1c; tubulin alpha 1c [KO:K07374]
394734  tuba1cl.3; tubulin alpha chain 1c like [KO:K07374]
407878  tubal3.1; tubulin alpha chain like 3 [KO:K07374]
548558  tubal3.2; tubulin alpha chain like 3 [KO:K07374]
548688  tuba3c; tubulin, alpha 3c [KO:K07374]
549448  tuba4b; tubulin alpha chain [KO:K07374]
100038108  tuba1b; 1 [KO:K07374]
100038123  tuba1a; tubulin alpha-1A chain [KO:K07374]
100497157  tubulin alpha-1A chain [KO:K07374]
100037894  tuba8; tubulin alpha-8 chain [KO:K07374]
100144986  tuba1l; LOW QUALITY PROTEIN: tubulin alpha-8 chain [KO:K07374]
100486465  tuba1al; LOW QUALITY PROTEIN: tubulin alpha-8 chain [KO:K07374]
100490289  tuba1cl.1; tubulin alpha-1A chain [KO:K07374]
100497528  tuba1cl.2; tubulin alpha-1A chain [KO:K07374]
779904  tubb4b; tubulin beta 4B class IVb [KO:K07375]
448742  tubb; tubulin beta chain [KO:K07375]
493418  tubb6; tubulin beta-6 chain [KO:K07375]
394889  tubb2b; tubulin beta 2B class IIb [KO:K07375]
395045  tubb3; tubulin beta-3 chain [KO:K07375]
394927  tubb4a; tubulin beta-4A chain [KO:K07375]
101730558  tubb1; tubulin beta-1 chain isoform X1 [KO:K07375]
779964  tubg1; tubulin gamma 1 [KO:K10389]
108648950  uncharacterized protein LOC108648950 [KO:K10389]
448419  tubd1; tubulin delta chain [KO:K10390]
100488997  tube1; tubulin epsilon chain [KO:K10391]
100124766  kif5a; kinesin heavy chain [KO:K10396]
100038146  kif5b; kinesin-1 heavy chain [KO:K10396]
100493873  kif5c; kinesin heavy chain [KO:K10396]
550001  klc1; kinesin light chain 1 [KO:K10407]
100216226  uncharacterized protein LOC100216226 [KO:K10407]
100145686  kif3a; kinesin-like protein KIF3A isoform X2 [KO:K10394]
100494561  kif3b; kinesin-like protein KIF3B [KO:K20196]
100038301  kifap3; kinesin-associated protein 3 [KO:K25388]
100491018  kif3c; kinesin-like protein KIF3C isoform X1 [KO:K20197]
100036648  kif17; uncharacterized protein LOC100036648 [KO:K20198]
100127546  kif1a; kinesin-like protein KIF1A isoform X11 [KO:K10392]
100379810  kif1b; kinesin-like protein KIF1B isoform X10 [KO:K10392]
779557  kif1c; kinesin-like protein KIF1C [KO:K10392]
100490129  kif13a; kinesin-like protein KIF13A isoform X1 [KO:K17914]
100490836  kinesin-like protein KIF13B [KO:K17914]
100492799  kif13b; kinesin-like protein KIF13B isoform X1 [KO:K17914]
108648793  kinesin-like protein Klp98A [KO:K17914]
116407776  kinesin-like protein KIF13B [KO:K17914]
108648901  uncharacterized protein LOC108648901 [KO:K17914]
100497128  uncharacterized protein LOC100497128 [KO:K17914]
100145032  kif14l; kinesin-like protein KIF14 isoform X1 [KO:K17915]
100493263  kif14; kinesin-like protein KIF14 [KO:K17915]
100489716  kif16b; kinesin-like protein KIF16B isoform X2 [KO:K17916]
100489699  stard9; stAR-related lipid transfer protein 9 isoform X1 [KO:K16491]
448410  kif4a; chromosome-associated kinesin KIF4A [KO:K10395]
100124946  kif7; kinesin-like protein KIF7 isoform X1 [KO:K18806]
100485713  kif21a; kinesin-like protein KIF21A [KO:K24185]
779607  kif21b; kinesin-like protein KIF21B isoform X1 [KO:K24185]
100497455  kif27; kinesin-like protein KIF27 [KO:K24186]
548870  kif11; kinesin-like protein KIF11 [KO:K10398]
496538  kif20a; kinesin-like protein KIF20A isoform X1 [KO:K10402]
100489788  kinesin-like protein KIF20A [KO:K10402]
100145121  kif20b; kinesin-like protein KIF20B isoform X2 [KO:K10402]
496517  kif23; kinesin-like protein KIF23 [KO:K17387]
100126678  cenpe; centromere-associated protein E [KO:K11498]
548999  kif18a; kinesin-like protein KIF18A [KO:K10401]
100490953  kif18b; kinesin-like protein KIF18B [KO:K26156]
100145702  kif19; kinesin-like protein KIF19 [KO:K26157]
100494536  kinesin-like protein KIF19 [KO:K26157]
100127668  kif6; kinesin-like protein KIF6 [KO:K10397]
100492300  kif9; kinesin-like protein KIF9 isoform X1 [KO:K10397]
394855  kif22; kinesin-like protein KIF22 [KO:K10403]
100127581  kif26b; kinesin-like protein KIF26B [KO:K10404]
100491850  kif26a; kinesin-like protein KIF26A isoform X3 [KO:K10404]
100487512  kif15; kinesin-like protein KIF15 [KO:K10400]
448620  kif2c; kinesin-like protein KIF2C [KO:K10393]
100379688  kif2a; kinesin-like protein KIF2A isoform X1 [KO:K10393]
101731767  kif24; kinesin-like protein KIF24 isoform X1 [KO:K10393]
100038104  kifc1; kinesin-like protein KIFC1 isoform X2 [KO:K10405]
548839  kifc3; kinesin-like protein KIFC3 [KO:K10406]
100485082  kifc2; kinesin-like protein KIFC3 [KO:K10406]
496494  myo1e.2; myosin IE, gene 2 [KO:K10356]
493425  myo1a; unconventional myosin-Ia [KO:K10356]
100380193  myo1c; unconventional myosin-Ic isoform X1 [KO:K10356]
100492763  myo1h; unconventional myosin-Ih [KO:K10356]
100493342  myo1f; unconventional myosin-If [KO:K10356]
100497691  myo1d; unconventional myosin-Id isoform X1 [KO:K10356]
100158599  myo1e.1; unconventional myosin-Ie [KO:K10356]
101733172  unconventional myosin-Ig [KO:K10356]
100495574  myo3a; myosin-IIIa [KO:K08834] [EC:2.7.11.1]
100498312  myo3b; myosin-IIIb isoform X1 [KO:K08834] [EC:2.7.11.1]
100379760  myo5b; unconventional myosin-Vb isoform X1 [KO:K10357]
100495210  myo5c; unconventional myosin-Vc isoform X3 [KO:K10357]
100495365  myo5a; unconventional myosin-Va isoform X14 [KO:K10357]
493193  myo6; unconventional myosin-VI isoform X11 [KO:K10358]
100491335  myo7a; unconventional myosin-VIIa isoform X2 [KO:K10359]
100491953  myo7b; unconventional myosin-VIIb [KO:K21868]
100492218  myo9b; unconventional myosin-IXb isoform X1 [KO:K10360]
100216086  myo9a; unconventional myosin-IXa isoform X1 [KO:K10360]
100495096  myo10.2; unconventional myosin-X [KO:K12559]
548806  myo10; unconventional myosin-X [KO:K12559]
100488159  myo15a; unconventional myosin-XV [KO:K10361]
100485698  myo15b; myosin XVB [KO:K10361]
100486369  myo16; unconventional myosin-XVI [KO:K17481]
100496668  myo18b; unconventional myosin-XVIIIb isoform X1 [KO:K10362]
734140  myo19; unconventional myosin-XIX [KO:K25838]
100216111  myh7; myosin, heavy chain 7, cardiac muscle, beta [KO:K24220]
100379877  myh8; myosin-4 [KO:K24220]
100492956  myh13; myosin-4 [KO:K24220]
100493121  myosin-4 [KO:K24220]
100495212  myosin-4-like [KO:K24220]
100495638  myosin-4 [KO:K24220]
100495802  myosin-4-like [KO:K24220]
100495968  myosin-4 isoform X1 [KO:K24220]
101730386  myosin-4-like [KO:K24220]
407946  myh4; myosin, heavy chain 4, skeletal muscle [KO:K24220]
448514  myh2; myosin, heavy chain 2, skeletal muscle, adult [KO:K24220]
448762  myh3; myosin heavy chain IIa [KO:K24220]
100495065  myosin-3 [KO:K24220]
100486122  myh7b; myosin-7B [KO:K24220]
100487082  myh15; myosin-15 [KO:K24220]
100485637  myosin-7 [KO:K17751]
100216059  myh6; myosin-6 isoform X1 [KO:K17751]
100487997  myh9; myosin-9 isoform X1 [KO:K10352]
100490639  myh11; myosin-11 isoform X2 [KO:K10352]
100493774  myosin-10 isoform X1 [KO:K10352]
394551  myl1; myosin light chain 1/3, skeletal muscle isoform [KO:K05738]
394608  myl3; myosin light chain 3 [KO:K12749]
100124786  myl4; myosin light chain 4 [KO:K12750]
394742  myl6; myosin light polypeptide 6 [KO:K12751]
100135705  myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100135145  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
100124811  myl9; myosin regulatory light polypeptide 9 [KO:K12755]
100170437  myl10; myosin regulatory light chain 10 [KO:K12756]
448060  myl12b; myosin light chain 12B [KO:K12757]
394763  mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
496696  acta2; actin, aortic smooth muscle [KO:K12313]
394698  actc1; actin, alpha cardiac muscle 1 [KO:K12314]
394673  acta4; actin, striated muscle 3 [KO:K12314]
448346  acta1; actin, alpha skeletal muscle [KO:K12314]
394982  MGC75582; actin, alpha cardiac muscle 2 [KO:K12314]
394957  actg1; actin, cytoplasmic 2 [KO:K05692]
407952  actb; actin, cytoplasmic 1 [KO:K05692]
447990  tnnc1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
394556  tnni1.2; troponin I type 1 (skeletal, slow) [KO:K10371]
100125108  tnni1; troponin I, slow skeletal muscle [KO:K10371]
100493291  tnnt1; troponin T, slow skeletal muscle isoform X10 [KO:K10372]
394554  tnnc2; troponin C, skeletal muscle [KO:K12042]
496523  tnni2; troponin I, fast skeletal muscle [KO:K12043]
394748  tnnt3; troponin T, fast skeletal muscle [KO:K12046]
496889  tnni3; troponin I, cardiac muscle [KO:K12044]
100493699  tnnt2; troponin T, cardiac muscle isoform X2 [KO:K12045]
448541  tpm1; tropomyosin alpha-1 chain [KO:K10373]
594975  tpm2; tropomyosin 2 [KO:K10374]
394917  MGC76092; uncharacterized protein LOC394917 [KO:K09290]
116406865  tropomyosin alpha-3 chain-like [KO:K09290]
549841  tpm4; tropomyosin alpha-4 chain [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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