KEGG   PATHWAY: pcad03013
Entry
pcad03013                   Pathway                                
Name
Nucleocytoplasmic transport - Physeter catodon (sperm whale)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
pcad03013  Nucleocytoplasmic transport
pcad03013

Other DBs
GO: 0050658
Organism
Physeter catodon (sperm whale) [GN:pcad]
Gene
102985226  AAAS; aladin isoform X1 [KO:K14320]
102981326  NUP42; nucleoporin NUP42 [KO:K14321]
102980615  GLE1; mRNA export factor GLE1 isoform X3 [KO:K18723]
102988391  ATP-dependent RNA helicase DDX19B isoform X1 [KO:K18655] [EC:5.6.2.7]
102989045  ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
102991445  mRNA export factor RAE1 [KO:K14298]
102992241  nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
114485016  nuclear pore complex protein Nup98-Nup96 [KO:K14297]
102989932  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
102991448  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
102994007  E3 SUMO-protein ligase RanBP2 isoform X3 [KO:K12172] [EC:2.3.2.-]
102982461  RANGAP1; ran GTPase-activating protein 1 isoform X1 [KO:K14319]
102973769  SUMO-conjugating enzyme UBC9-B [KO:K10577]
102996261  LOW QUALITY PROTEIN: SUMO-conjugating enzyme UBC9-like [KO:K10577]
112064068  LOW QUALITY PROTEIN: small ubiquitin-related modifier 2-like [KO:K12160]
102974991  small ubiquitin-related modifier 1 isoform X1 [KO:K12160]
102980006  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
112067620  small ubiquitin-related modifier 1-like [KO:K12160]
102983211  SUMO3; small ubiquitin-related modifier 3 isoform X4 [KO:K12160]
102983021  small ubiquitin-related modifier 2-like [KO:K12160]
102988673  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
102994668  small ubiquitin-related modifier 1-like [KO:K12160]
102979930  small ubiquitin-related modifier 2-like [KO:K12160]
102993873  small ubiquitin-related modifier 2-like [KO:K12160]
102986472  LOW QUALITY PROTEIN: small ubiquitin-related modifier 1-like [KO:K12160]
102993581  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
102981684  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
102979658  SEC13; protein SEC13 homolog [KO:K14004]
102979553  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
102974517  NUP133; nuclear pore complex protein Nup133 isoform X1 [KO:K14300]
102986519  SEH1L; nucleoporin SEH1 [KO:K14299]
102983531  NUP43; nucleoporin Nup43 [KO:K14305]
102991131  NUP37; nucleoporin Nup37 [KO:K14302]
102979828  AHCTF1; protein ELYS isoform X1 [KO:K25129]
102992215  NUP62CL; nucleoporin-62 C-terminal-like protein isoform X1 [KO:K14306]
102991208  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
102994461  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
102980541  NUP54; nucleoporin p54 isoform X2 [KO:K14308]
102987338  NUP205; nuclear pore complex protein Nup205 isoform X1 [KO:K14310]
102995511  NUP188; nucleoporin NUP188 isoform X2 [KO:K14311]
102981421  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
102973645  NUP93; nuclear pore complex protein Nup93 isoform X2 [KO:K14309]
102991218  NUP35; nucleoporin NUP35 isoform X1 [KO:K14313]
102990727  NDC1; nucleoporin NDC1 isoform X1 [KO:K14315]
102975841  nuclear pore membrane glycoprotein 210 isoform X1 [KO:K14314]
102996098  NUP210L; nuclear pore membrane glycoprotein 210-like [KO:K14314]
114484188  NUP210; nuclear pore membrane glycoprotein 210 [KO:K14314]
102984355  nuclear envelope pore membrane protein POM 121C isoform X1 [KO:K14316]
102981452  LOW QUALITY PROTEIN: POM121-like protein 2 [KO:K14316]
102993849  TMEM33; transmembrane protein 33 isoform X1 [KO:K20724]
102993712  TPR; nucleoprotein TPR isoform X2 [KO:K09291]
102983250  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
112064336  LOW QUALITY PROTEIN: nuclear pore complex protein Nup153-like [KO:K14296]
102996747  NUP153; nuclear pore complex protein Nup153 [KO:K14296]
102981595  LOW QUALITY PROTEIN: sentrin-specific protease 2-like [KO:K03345] [EC:3.4.22.68]
102992884  SENP2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
102991965  KPNA1; importin subunit alpha-5 [KO:K23940]
102976045  KPNA7; importin subunit alpha-8 isoform X4 [KO:K15043]
102983234  KPNA2; importin subunit alpha-1 [KO:K15043]
112062043  LOW QUALITY PROTEIN: importin subunit alpha-8-like [KO:K15043]
102978516  LOW QUALITY PROTEIN: importin subunit alpha-1-like [KO:K15043]
102979876  LOW QUALITY PROTEIN: importin subunit alpha-1-like [KO:K15043]
102983770  LOW QUALITY PROTEIN: importin subunit alpha-1-like [KO:K15043]
102983729  KPNA4; importin subunit alpha-3 [KO:K23583]
102979853  KPNA3; importin subunit alpha-4 [KO:K23583]
102975984  KPNA5; importin subunit alpha-6 [KO:K15042]
102994970  KPNA6; importin subunit alpha-7 isoform X2 [KO:K15042]
102992859  KPNB1; importin subunit beta-1 [KO:K14293]
102978963  TNPO1; transportin-1 isoform X1 [KO:K18752]
102985503  LOW QUALITY PROTEIN: transportin-1-like [KO:K18752]
102991351  TNPO2; transportin-2 isoform X1 [KO:K18727]
102995309  TNPO3; transportin-3 isoform X1 [KO:K15436]
102992204  IPO4; importin-4 [KO:K20221]
102986500  IPO5; importin-5 [KO:K20222]
102981328  IPO7; importin-7 [KO:K20223]
112064548  LOW QUALITY PROTEIN: importin-7-like [KO:K20223]
102987608  IPO8; importin-8 isoform X2 [KO:K18755]
102988791  IPO9; importin-9 [KO:K20224]
102976820  IPO11; importin-11 [KO:K25201]
102990289  IPO13; importin-13 isoform X1 [KO:K25202]
102979714  SNUPN; snurportin-1 [KO:K13151]
102982682  XPO1; exportin-1 [KO:K14290]
102977288  CSE1L; exportin-2 [KO:K18423]
102993373  XPOT; exportin-T isoform X2 [KO:K14288]
102987320  XPO4; exportin-4 [KO:K25203]
102978353  XPO5; exportin-5 [KO:K14289]
102977614  XPO6; exportin-6 isoform X1 [KO:K25204]
102982032  LOW QUALITY PROTEIN: exportin-6-like [KO:K25204]
102991834  XPO7; exportin-7 isoform X1 [KO:K18460]
102991942  RANBP17; ran-binding protein 17 isoform X2 [KO:K24115]
102985469  RAN; GTP-binding nuclear protein Ran isoform X2 [KO:K07936]
102976572  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
102986013  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
102990102  LOW QUALITY PROTEIN: elongation factor 1-alpha 1 [KO:K03231]
102986325  LOW QUALITY PROTEIN: elongation factor 1-alpha 1-like [KO:K03231]
102984890  elongation factor 1-alpha 1-like [KO:K03231]
102993431  LOW QUALITY PROTEIN: elongation factor 1-alpha 1-like [KO:K03231]
114484313  LOW QUALITY PROTEIN: elongation factor 1-alpha 1-like [KO:K03231]
102990568  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
102993683  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
102985544  NCBP2; nuclear cap-binding protein subunit 2 isoform X2 [KO:K12883]
112066142  NCBP2L; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2-like [KO:K12883]
102980813  nuclear cap-binding protein subunit 2-like [KO:K12883]
102984696  NMD3; 60S ribosomal export protein NMD3 isoform X2 [KO:K07562]
102994170  60S ribosomal export protein NMD3-like [KO:K07562]
102981663  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
102983009  RNA-binding protein 8A-like [KO:K12876]
114483854  MAGOHB; protein mago nashi homolog 2 isoform X2 [KO:K12877]
102990179  MAGOH; protein mago nashi homolog [KO:K12877]
102986085  CASC3; protein CASC3 isoform X1 [KO:K14323]
102979387  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
102980214  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
102988173  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
102981144  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
102978259  LOW QUALITY PROTEIN: RNA-binding protein with serine-rich domain 1-like [KO:K14325]
102990934  PNN; pinin [KO:K13114]
102993393  ALYREF; THO complex subunit 4 [KO:K12881]
102975873  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
102984577  UPF2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
102976918  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
102985235  UPF3A; LOW QUALITY PROTEIN: regulator of nonsense transcripts 3A [KO:K14328]
102977911  NXF1; nuclear RNA export factor 1 [KO:K14284]
102977204  nuclear RNA export factor 2 [KO:K14284]
114484661  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
102973772  LOW QUALITY PROTEIN: nuclear RNA export factor 3-like [KO:K14284]
102986802  nuclear RNA export factor 3-like [KO:K14284]
102994592  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
112066110  NTF2-related export protein 2-like [KO:K14285]
102976925  NTF2-related export protein 2-like [KO:K14285]
102996136  NXT1; NTF2-related export protein 1 [KO:K14285]
102978168  NTF2-related export protein 2 [KO:K14285]
102984110  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
102980515  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
102994724  PYM1; partner of Y14 and mago [KO:K14294]
102988826  THOC1; THO complex subunit 1 [KO:K12878]
102973141  THOC2; THO complex subunit 2 isoform X5 [KO:K12879]
102980422  THOC5; THO complex subunit 5 homolog [KO:K13174]
102996131  THOC6; THO complex subunit 6 homolog isoform X1 [KO:K13175]
102982230  THO complex subunit 7 homolog [KO:K13176]
102980973  THOC7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
102973399  THO complex subunit 7 homolog [KO:K13176]
102985405  THOC3; THO complex subunit 3 isoform X1 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
pcad03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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