KEGG   PATHWAY: pcad04640
Entry
pcad04640                   Pathway                                
Name
Hematopoietic cell lineage - Physeter catodon (sperm whale)
Description
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
Class
Organismal Systems; Immune system
Pathway map
pcad04640  Hematopoietic cell lineage
pcad04640

Organism
Physeter catodon (sperm whale) [GN:pcad]
Gene
102973751  KITLG; kit ligand isoform X1 [KO:K05461]
102976783  IL7; interleukin-7 [KO:K05431]
102983897  IL4; interleukin-4 [KO:K05430]
102973226  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
102983555  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X3 [KO:K05454]
102983351  IL5; interleukin-5 [KO:K05428]
102988264  CSF3; granulocyte colony-stimulating factor [KO:K05423]
102973496  interleukin-3 [KO:K04736]
102980126  IL6; interleukin-6 [KO:K05405]
102982190  IL11; interleukin-11 [KO:K05417]
102993910  IL1A; interleukin-1 alpha [KO:K04383]
102994188  IL1B; interleukin-1 beta [KO:K04519]
102983069  TNF; tumor necrosis factor [KO:K03156]
102974293  CSF1; macrophage colony-stimulating factor 1 isoform X5 [KO:K05453]
102981762  EPO; erythropoietin [KO:K05437]
102978432  THPO; thrombopoietin isoform X2 [KO:K06854]
102984320  CD34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
102989448  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
102994470  DNTT; DNA nucleotidylexotransferase [KO:K00977] [EC:2.7.7.31]
102994322  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
102973944  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
102976012  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X2 [KO:K06752]
102973764  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752]
102976287  HLA class II histocompatibility antigen, DQ alpha 2 chain isoform X2 [KO:K06752]
102992942  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
102974479  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
102994605  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
102978546  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
102978862  CD44; CD44 antigen isoform X1 [KO:K06256]
102985479  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
102974550  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
102992873  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
102985437  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
102981972  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
102975926  CD7; T-cell antigen CD7 [KO:K06457]
102973763  CD2; T-cell surface antigen CD2 [KO:K06449]
102979497  CD5; T-cell surface glycoprotein CD5 [KO:K06455]
102989428  T-cell surface glycoprotein CD1b-2-like [KO:K06448]
102990233  CD1D; antigen-presenting glycoprotein CD1d isoform X2 [KO:K06448]
102977953  CD8A; T-cell surface glycoprotein CD8 alpha chain isoform X2 [KO:K06458]
102977193  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
102979567  T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
102979279  T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
102980039  T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
102991612  MME; neprilysin isoform X1 [KO:K01389] [EC:3.4.24.11]
102991812  CD9; CD9 antigen [KO:K06460]
102980055  CD19; B-lymphocyte antigen CD19 [KO:K06465]
102991918  CD22; B-cell receptor CD22 isoform X1 [KO:K06467]
114486503  LOW QUALITY PROTEIN: signal transducer CD24-like [KO:K06469]
112062100  CD24; signal transducer CD24 [KO:K06469]
102984445  B-lymphocyte antigen CD20-like [KO:K06466]
102977150  CR2; complement receptor type 2 [KO:K04012]
102979790  CD37; leukocyte antigen CD37 isoform X2 [KO:K06475]
102987016  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
102987302  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
102979109  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
102994451  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
102996862  macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102974845  ANPEP; aminopeptidase N isoform X1 [KO:K11140] [EC:3.4.11.2]
102987095  integrin alpha-M [KO:K06461]
102990526  CD14; monocyte differentiation antigen CD14 [KO:K04391]
102995650  LOW QUALITY PROTEIN: interleukin-9 receptor [KO:K05073]
102973768  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
102973842  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
102980945  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
102990857  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
102980451  EPOR; erythropoietin receptor [KO:K05079]
102975405  LOW QUALITY PROTEIN: platelet glycoprotein 4-like [KO:K06259]
102973323  platelet glycoprotein 4 [KO:K06259]
102974359  platelet glycoprotein 4-like [KO:K06259]
102976693  CD55; complement decay-accelerating factor isoform X1 [KO:K04006]
102990204  CD59; CD59 glycoprotein [KO:K04008]
102983483  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
102988740  ITGB3; integrin beta-3 isoform X2 [KO:K06493]
102994051  ITGA2B; integrin alpha-IIb isoform X5 [KO:K06476]
112062559  GP9; platelet glycoprotein IX [KO:K06263]
102979776  GP1BA; platelet glycoprotein Ib alpha chain [KO:K06261]
102976747  GP1BB; platelet glycoprotein Ib beta chain [KO:K06262]
102976855  GP5; platelet glycoprotein V [KO:K06260]
102976588  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
102977795  ITGA2; integrin alpha-2 [KO:K06481]
102982420  ITGA3; integrin alpha-3 isoform X2 [KO:K06482]
102977938  ITGA4; integrin alpha-4 [KO:K06483]
102983046  ITGA5; integrin alpha-5 [KO:K06484]
102993444  ITGA6; integrin alpha-6 isoform X2 [KO:K06485]
Reference
  Authors
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ
  Title
Immunobiology - International editon: The immune system in health and disease
  Journal
Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001)
Reference
  Authors
Abe T
  Title
[Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (In Japanese)
  Journal
Nihonijishinhousya (2000)
Reference
PMID:15771582
  Authors
Rothenberg EV, Taghon T.
  Title
Molecular genetics of T cell development.
  Journal
Annu Rev Immunol 23:601-49 (2005)
DOI:10.1146/annurev.immunol.23.021704.115737
Reference
PMID:12415312
  Authors
Ceredig R, Rolink T.
  Title
A positive look at double-negative thymocytes.
  Journal
Nat Rev Immunol 2:888-97 (2002)
DOI:10.1038/nri937
Reference
PMID:15156179
  Authors
de Bruijn MF, Speck NA.
  Title
Core-binding factors in hematopoiesis and immune function.
  Journal
Oncogene 23:4238-48 (2004)
DOI:10.1038/sj.onc.1207763
Reference
PMID:14985712
  Authors
Radtke F, Wilson A, Mancini SJ, MacDonald HR.
  Title
Notch regulation of lymphocyte development and function.
  Journal
Nat Immunol 5:247-53 (2004)
DOI:10.1038/ni1045
Reference
PMID:12360214
  Authors
Spits H.
  Title
Development of alphabeta T cells in the human thymus.
  Journal
Nat Rev Immunol 2:760-72 (2002)
DOI:10.1038/nri913
Reference
PMID:9927518
  Authors
Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B.
  Title
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
  Journal
J Exp Med 189:563-74 (1999)
DOI:10.1084/jem.189.3.563
Reference
PMID:11905810
  Authors
Mak TW, Penninger JM, Ohashi PS.
  Title
Knockout mice: a paradigm shift in modern immunology.
  Journal
Nat Rev Immunol 1:11-9 (2001)
DOI:10.1038/35095551
Reference
PMID:15738953
  Authors
Shapiro-Shelef M, Calame K.
  Title
Regulation of plasma-cell development.
  Journal
Nat Rev Immunol 5:230-42 (2005)
DOI:10.1038/nri1572
Reference
PMID:14670296
  Authors
Maillard I, Adler SH, Pear WS.
  Title
Notch and the immune system.
  Journal
Immunity 19:781-91 (2003)
DOI:10.1016/S1074-7613(03)00325-X
Reference
PMID:15629410
  Authors
Alpdogan O, van den Brink MR.
  Title
IL-7 and IL-15: therapeutic cytokines for immunodeficiency.
  Journal
Trends Immunol 26:56-64 (2005)
DOI:10.1016/j.it.2004.11.002
KO pathway
ko04640   
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