KEGG   PATHWAY: pcoq04145
Entry
pcoq04145                   Pathway                                
Name
Phagosome - Propithecus coquereli (Coquerel's sifaka)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
pcoq04145  Phagosome
pcoq04145

Other DBs
GO: 0045335
Organism
Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]
Gene
105805061  C1R; complement C1r subcomponent isoform X1 [KO:K01330] [EC:3.4.21.41]
105805075  M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
105805171  NCF4; neutrophil cytosol factor 4 [KO:K08012]
105805404  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
105805953  ACTB; actin, cytoplasmic 1 [KO:K05692]
105805988  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105806269  [KO:K08057]
105806406  [KO:K06463]
105806465  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b [KO:K12560]
105806468  FCGR2A; low affinity immunoglobulin gamma Fc region receptor II-a isoform X1 [KO:K06472]
105806792  NCF2; neutrophil cytosol factor 2 [KO:K08010]
105807046  NCF1; neutrophil cytosol factor 1 [KO:K08011]
105807516  MSR1; macrophage scavenger receptor types I and II [KO:K06558]
105807737  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
105807760  [KO:K06563]
105807808  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
105807890  CALR; calreticulin [KO:K08057]
105808035  ITGB5; integrin beta-5 [KO:K06588]
105808432  [KO:K21421] [EC:1.-.-.-]
105808525  ITGB1; integrin beta-1 [KO:K05719]
105808789  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
105809009  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform 4 [KO:K02154]
105809630  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
105809748  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
105809778  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
105810148  [KO:K06752]
105810492  TLR6; toll-like receptor 6 [KO:K10169]
105810624  MARCO; macrophage receptor MARCO [KO:K13884]
105811134  TLR2; toll-like receptor 2 [KO:K10159]
105811707  STX12; syntaxin-12 [KO:K13813]
105811847  C3; LOW QUALITY PROTEIN: complement C3 [KO:K03990]
105811880  TUBB4A; tubulin beta-4A chain isoform X1 [KO:K07375]
105812065  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
105812425  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
105812600  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
105812855  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
105813115  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
105813680  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
105813958  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
105814028  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
105814097  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
105814426  THBS1; thrombospondin-1 [KO:K16857]
105814658  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
105815203  CD36; platelet glycoprotein 4 isoform X1 [KO:K06259]
105815320  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
105815384  TUBA1A; tubulin alpha-1A chain isoform X1 [KO:K07374]
105815399  [KO:K07374]
105815409  [KO:K07374]
105815498  [KO:K07374]
105815573  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
105815801  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
105815811  TUBA8; tubulin alpha-8 chain [KO:K07374]
105815885  [KO:K07374]
105816062  [KO:K07375]
105816430  CTSV; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
105816621  COLEC12; collectin-12 [KO:K10062]
105816666  OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
105816757  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
105816954  ITGA5; integrin alpha-5 [KO:K06484]
105817083  ITGB2; LOW QUALITY PROTEIN: integrin beta-2 [KO:K06464]
105817268  [KO:K06751]
105817283  TUBB; tubulin beta chain [KO:K07375]
105817288  [KO:K06751]
105817290  [KO:K06751]
105817294  [KO:K06751]
105817358  RILP; rab-interacting lysosomal protein isoform X1 [KO:K13883]
105817835  [KO:K06752]
105817842  RAB5B; ras-related protein Rab-5B [KO:K07888]
105817846  [KO:K06751]
105817908  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
105817910  [KO:K06751]
105817913  [KO:K06752]
105817973  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
105818166  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
105818686  TUBB4B; tubulin beta-4B chain [KO:K07375]
105819095  ITGA2; integrin alpha-2 [KO:K06481]
105819538  PLA2R1; secretory phospholipase A2 receptor [KO:K06560]
105819624  [KO:K07374]
105819700  RAB7A; ras-related protein Rab-7a [KO:K07897]
105819857  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
105819999  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105820038  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
105820072  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
105820210  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform 1 [KO:K02154]
105820246  RAB5C; ras-related protein Rab-5C [KO:K07889]
105820466  COLEC11; collectin-11 isoform X1 [KO:K10066]
105820645  [KO:K07375]
105821044  [KO:K08009]
105821193  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
105821782  [KO:K06498]
105821963  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
105821989  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
105822039  SEC61A1; protein transport protein Sec61 subunit alpha isoform 1 isoform X1 [KO:K10956]
105822040  [KO:K10956]
105822162  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
105822404  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
105822637  MBL2; mannose-binding protein C [KO:K03991]
105822640  [KO:K06493]
105822769  [KO:K06856]
105823085  [KO:K06461]
105823153  CORO1A; coronin-1A [KO:K13882]
105823264  CANX; calnexin [KO:K08054]
105823367  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
105823368  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
105823649  MRC1; macrophage mannose receptor 1 [KO:K06560]
105823681  SEC61A2; protein transport protein Sec61 subunit alpha isoform 2 isoform X1 [KO:K10956]
105823861  [KO:K02152]
105823912  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
105824036  CD14; monocyte differentiation antigen CD14 [KO:K04391]
105824057  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
105824372  [KO:K06752]
105824378  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
105824379  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
105824381  [KO:K06752]
105824383  [KO:K06752]
105824384  [KO:K06752]
105824385  [KO:K06752]
105824386  [KO:K06752]
105824388  [KO:K06752]
105824389  [KO:K06752]
105824521  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
105824615  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
105824951  VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
105825142  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
105825159  STX18; syntaxin-18 [KO:K08492]
105825164  MRC2; C-type mannose receptor 2 [KO:K06560]
105825169  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
105825189  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
105825211  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
105825459  SFTPD; pulmonary surfactant-associated protein D [KO:K10068]
105825461  [KO:K10067]
105825519  [KO:K03991]
105825562  SCARB1; scavenger receptor class B member 1 [KO:K13885]
105825687  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform 2 [KO:K02154]
105825770  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
105825941  [KO:K06856]
105826084  EEA1; early endosome antigen 1 [KO:K12478]
105826386  RAB5A; ras-related protein Rab-5A [KO:K07887]
105826455  TLR4; toll-like receptor 4 [KO:K10160]
105826536  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
105826755  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
105826784  THBS2; thrombospondin-2 [KO:K04659]
105826892  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
105827070  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
105827151  STX7; syntaxin-7 [KO:K08488]
105827242  [KO:K07375]
105827412  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform 3 isoform X1 [KO:K02154]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
pcoq04142  Lysosome
pcoq04144  Endocytosis
pcoq04610  Complement and coagulation cascades
pcoq04612  Antigen processing and presentation
pcoq04620  Toll-like receptor signaling pathway
pcoq04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   

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