KEGG   PATHWAY: plai04115
Entry
plai04115                   Pathway                                
Name
p53 signaling pathway - Poecilia latipinna (sailfin molly)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
plai04115  p53 signaling pathway
plai04115

Organism
Poecilia latipinna (sailfin molly) [GN:plai]
Gene
106934467  [KO:K04570]
106934607  [KO:K02187] [EC:3.4.22.56]
106935036  ccne1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
106935459  tp73; tumor protein p73 isoform X1 [KO:K10148]
106935516  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
106935580  [KO:K06509]
106935709  [KO:K08738]
106935887  aifm2; apoptosis-inducing factor 2 [KO:K22745]
106936137  [KO:K04722]
106936141  [KO:K10138]
106936725  [KO:K10151]
106937458  [KO:K06625]
106937569  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
106939193  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
106939438  tsc2; tuberin isoform X1 [KO:K07207]
106939452  cd82; CD82 antigen [KO:K06509]
106939814  [KO:K04402]
106939815  [KO:K04402]
106940749  chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
106940896  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
106941141  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
106941275  [KO:K06625]
106941969  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
106942003  pidd1; p53-induced death domain-containing protein 1 [KO:K10130]
106945347  [KO:K08738]
106945376  [KO:K08738]
106945561  [KO:K21770]
106945775  tp53; cellular tumor antigen p53 [KO:K04451]
106946034  zmat3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
106946279  siah1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
106946496  steap3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
106946700  sesn1; sestrin-1 isoform X1 [KO:K10141]
106947072  [KO:K10135]
106947673  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106947675  [KO:K04390]
106947759  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
106947780  [KO:K04402]
106948623  [KO:K10138]
106949058  [KO:K10147] [EC:3.1.3.16]
106949142  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
106949318  [KO:K06509]
106949561  [KO:K05459]
106949811  [KO:K10141]
106950076  mdm4; protein Mdm4 isoform X1 [KO:K10127]
106950753  [KO:K10128]
106950806  [KO:K26543]
106951580  ei24; etoposide-induced protein 2.4 homolog [KO:K10134]
106952815  rprm; protein reprimo [KO:K10128]
106952847  gorab; RAB6-interacting golgin [KO:K19748]
106953050  [KO:K10146]
106953103  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
106953297  [KO:K02091] [EC:2.7.11.22]
106953382  [KO:K10151]
106953491  gtse1; G2 and S phase-expressed protein 1 isoform X1 [KO:K10129]
106953639  siva1; apoptosis regulatory protein Siva [KO:K22744]
106953868  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
106953891  [KO:K02159]
106954415  [KO:K08738]
106954434  [KO:K26543]
106954702  [KO:K02206] [EC:2.7.11.22]
106954847  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
106954850  [KO:K06625]
106955107  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
106955393  ccng1; cyclin-G1 [KO:K10145]
106955817  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
106956049  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
106956156  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
106956175  [KO:K10151]
106956493  [KO:K10808] [EC:1.17.4.1]
106957006  ppm1d; protein phosphatase 1D isoform X1 [KO:K10147] [EC:3.1.3.16]
106957381  perp; p53 apoptosis effector related to PMP-22 [KO:K10136]
106957659  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
106958301  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
106958472  rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
106958504  [KO:K04398] [EC:3.4.22.61]
106960034  [KO:K16857]
106960487  [KO:K02159]
106960769  igf1; insulin-like growth factor I [KO:K05459]
106960788  thbs1; thrombospondin-1 [KO:K16857]
106960824  [KO:K20394]
106961113  [KO:K02089] [EC:2.7.11.22]
106961129  adgrb1; brain-specific angiogenesis inhibitor 1 isoform X1 [KO:K04596]
106961421  [KO:K08738]
106961428  [KO:K04398] [EC:3.4.22.61]
106961846  apaf1; apoptotic protease-activating factor 1 [KO:K02084]
106962110  rfwd2; E3 ubiquitin-protein ligase RFWD2 [KO:K10143] [EC:2.3.2.27]
106962281  [KO:K04402]
106962490  [KO:K02159]
106963026  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
106963167  ppp1r13l; relA-associated inhibitor isoform X1 [KO:K27356]
106963609  [KO:K10146]
106963907  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106964002  [KO:K04722]
106964569  casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
106964584  [KO:K21770]
106964932  bcl2l1; bcl-2-like protein 1 [KO:K04570]
106965031  tp53i3; quinone oxidoreductase PIG3 isoform X1 [KO:K10133] [EC:1.-.-.-]
106965248  [KO:K10151]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
plai04110  Cell cycle
plai04210  Apoptosis
plai04218  Cellular senescence
KO pathway
ko04115   

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