KEGG   PATHWAY: pleu04914
Entry
pleu04914                   Pathway                                
Name
Progesterone-mediated oocyte maturation - Peromyscus leucopus (white-footed mouse)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
pleu04914  Progesterone-mediated oocyte maturation
pleu04914

Other DBs
GO: 0001556
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680630  Anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
114680782  Pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
114681520  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
114681524  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114681779  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
114682732  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114683470  Stk10; serine/threonine-protein kinase 10 [KO:K08837] [EC:2.7.11.1]
114683729  Cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
114684032  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
114684152  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
114685117  Mad1l1; LOW QUALITY PROTEIN: mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
114686218  [KO:K04079]
114688374  Fzr1; fizzy-related protein homolog [KO:K03364]
114688632  [KO:K06631] [EC:2.7.11.21]
114688873  [KO:K06631] [EC:2.7.11.21]
114688966  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
114689636  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114690660  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114690838  Ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
114690903  Anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
114691347  Rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
114691497  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
114691694  [KO:K04079]
114691777  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114692205  Plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
114692776  Anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
114693019  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
114693020  Mapk11; mitogen-activated protein kinase 11 isoform X5 [KO:K04441] [EC:2.7.11.24]
114693536  Anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
114693559  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114693962  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
114695174  Ins; insulin [KO:K04526]
114695335  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114695462  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
114695676  Pgr; progesterone receptor [KO:K08556]
114695787  Rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
114695883  Ccna1; cyclin-A1 [KO:K06627]
114696121  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
114696205  Cpeb1; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602]
114696283  Spdya; speedy protein A [KO:K08694]
114697107  Adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
114697604  Pde3b; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
114697724  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
114698264  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
114698532  Cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
114699348  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114699513  Cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
114699988  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
114700602  [KO:K06631] [EC:2.7.11.21]
114700619  Igf1; insulin-like growth factor I isoform X2 [KO:K05459]
114700919  Mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
114701233  Cdc16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
114701641  Anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
114702279  Cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
114702440  Cpeb3; cytoplasmic polyadenylation element-binding protein 3 isoform X1 [KO:K02602]
114703046  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114703084  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
114703714  Rps6ka6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
114703850  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114703855  Ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
114703900  Araf; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
114704332  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114704358  Kif22; kinesin-like protein KIF22 [KO:K10403]
114704554  Anapc5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
114704561  Anapc7; anaphase-promoting complex subunit 7 isoform X3 [KO:K03354]
114704732  Anapc16; anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
114704841  Adcy5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
114705113  Cdc25c; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
114705117  Cdc23; cell division cycle protein 23 homolog [KO:K03355]
114705236  Cdc25a; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
114705974  Rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
114706162  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
114706165  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
114706596  Anapc15; anaphase-promoting complex subunit 15 isoform X2 [KO:K25228]
114706830  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
114706924  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114707180  Ccna2; cyclin-A2 [KO:K06627]
114707572  [KO:K08694]
114707573  [KO:K08694]
114707842  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
114708228  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
114708477  Kras; GTPase KRas isoform X2 [KO:K07827]
114708501  Adcy7; LOW QUALITY PROTEIN: adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
114708522  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
114708701  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
114709230  Cpeb2; LOW QUALITY PROTEIN: cytoplasmic polyadenylation element-binding protein 2 [KO:K02602]
114709478  Cpeb4; cytoplasmic polyadenylation element-binding protein 4 isoform X3 [KO:K02602]
114709511  [KO:K08694]
114709522  Anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
114709524  Bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X2 [KO:K02178] [EC:2.7.11.1]
114709647  Mad2l2; mitotic spindle assembly checkpoint protein MAD2B isoform X3 [KO:K13728]
114709997  Ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
114710220  Mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
114710523  [KO:K04371] [EC:2.7.11.24]
114710615  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
114710969  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
pleu04010  MAPK signaling pathway
pleu04110  Cell cycle
KO pathway
ko04914   

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