Entry Name VEGF signaling pathway - Pteropus vampyrus (large flying fox)
Description There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic angiogenesis. The binding of VEGF to VEGFR-2 leads to a cascade of different signaling pathways, resulting in the up-regulation of genes involved in mediating the proliferation and migration of endothelial cells and promoting their survival and vascular permeability. For example, the binding of VEGF to VEGFR-2 leads to dimerization of the receptor, followed by intracellular activation of the PLCgamma;PKC-Raf kinase-MEK-mitogen-activated protein kinase (MAPK) pathway and subsequent initiation of DNA synthesis and cell growth, whereas activation of the phosphatidylinositol 3' -kinase (PI3K)-Akt pathway leads to increased endothelial-cell survival. Activation of PI3K, FAK, and p38 MAPK is implicated in cell migration signaling.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Pteropus vampyrus (large flying fox) [GN:
pvp ]
Gene 105288488 VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448 ]
105288852 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105296533 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105293031 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105296040 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
105290433 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
105307215 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
105307575 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
105308956 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922 ] [EC:2.7.1.153 ]
105296605 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
105297140 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
105299371 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649 ]
105294623 RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
105311532 RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Cross MJ, Dixelius J, Matsumoto T, Claesson-Welsh L.
Title VEGF-receptor signal transduction.
Journal Reference Authors Matsumoto T, Claesson-Welsh L.
Title VEGF receptor signal transduction.
Journal Reference Authors Hoeben A, Landuyt B, Highley MS, Wildiers H, Van Oosterom AT, De Bruijn EA.
Title Vascular endothelial growth factor and angiogenesis.
Journal Reference Authors Takahashi H, Shibuya M.
Title The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions.
Journal Reference Authors Zachary I.
Title VEGF signalling: integration and multi-tasking in endothelial cell biology.
Journal Reference Authors Munoz-Chapuli R, Quesada AR, Angel Medina M.
Title Angiogenesis and signal transduction in endothelial cells.
Journal Reference Authors Lamalice L, Houle F, Jourdan G, Huot J.
Title Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38.
Journal Reference Authors Shu X, Wu W, Mosteller RD, Broek D.
Title Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases.
Journal Related KO pathway LinkDB All DBs
