KEGG   PATHWAY: pvp04010
Entry
pvp04010                    Pathway                                
Name
MAPK signaling pathway - Pteropus vampyrus (large flying fox)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pvp04010  MAPK signaling pathway
pvp04010

Other DBs
GO: 0000165
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105307194  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
105298593  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
105297298  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
105304363  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
105292879  CACNA1E; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
105309056  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105295395  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X7 [KO:K04854]
105303376  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
105298101  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
105296936  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
105295536  voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
105295184  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
105304362  voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
105297299  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
105308383  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
105294917  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
105297519  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
105292163  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
105297754  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
105311392  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
105308817  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
105297753  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
105297752  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
105309464  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
105309463  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
105309480  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
105289063  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105308501  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
105297702  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105308818  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105309462  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105294560  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
105307158  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
105295886  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
105288852  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105296533  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105293031  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105296266  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105295781  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
105301643  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
105303773  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
105288616  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
105297993  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
105300076  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
105300188  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
105294479  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X2 [KO:K08018]
105291944  NF1; neurofibromin isoform X1 [KO:K08052]
105304708  RASA1; ras GTPase-activating protein 1 [KO:K04352]
105290358  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
105296884  RAP1A; ras-related protein Rap-1A [KO:K04353]
105302160  RAP1B; ras-related protein Rap-1b [KO:K07836]
105293045  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
105295757  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
105292346  EREG; proepiregulin [KO:K09784]
105292347  AREG; amphiregulin [KO:K09782]
105297044  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105288737  FGF7; fibroblast growth factor 7 [KO:K04358]
105296547  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105304647  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105292122  FGF9; fibroblast growth factor 9 [KO:K04358]
105292386  FGF5; fibroblast growth factor 5 [KO:K04358]
105299317  FGF18; fibroblast growth factor 18 [KO:K04358]
105293259  FGF6; fibroblast growth factor 6 [KO:K04358]
105301286  FGF10; fibroblast growth factor 10 [KO:K04358]
105308889  FGF16; fibroblast growth factor 16 [KO:K04358]
105309888  fibroblast growth factor 4-like [KO:K04358]
105311363  FGF4; fibroblast growth factor 4 [KO:K04358]
105295548  FGF20; fibroblast growth factor 20 [KO:K04358]
105302250  FGF22; fibroblast growth factor 22 [KO:K04358]
105307123  fibroblast growth factor 19-like [KO:K22603]
105307127  fibroblast growth factor 19-like [KO:K22603]
105301799  FGF21; fibroblast growth factor 21 [KO:K22429]
105293279  FGF23; fibroblast growth factor 23 [KO:K22428]
105296475  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
105293721  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
105295984  NTF3; neurotrophin-3 [KO:K04356]
105301755  neurotrophin-4 [KO:K12457]
105301756  NTF4; neurotrophin-4 [KO:K12457]
105310714  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
105299512  IGF2; insulin-like growth factor II [KO:K13769]
105294593  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
105298078  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
105297442  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105292199  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105297143  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
105293228  KITLG; kit ligand isoform X1 [KO:K05461]
105301742  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
105310803  fms-related tyrosine kinase 3 ligand-like isoform X1 [KO:K05454]
105288488  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105297988  VEGFB; vascular endothelial growth factor B [KO:K16858]
105299223  PGF; placenta growth factor isoform X1 [KO:K16859]
105299636  VEGFC; vascular endothelial growth factor C [KO:K05449]
105293998  VEGFD; vascular endothelial growth factor D [KO:K05449]
105295521  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105298291  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
105305272  ANGPT2; angiopoietin-2 [KO:K05466]
105305482  ANGPT4; angiopoietin-4 [KO:K05467]
105296373  EFNA1; ephrin-A1 [KO:K05462]
105296374  EFNA4; ephrin-A4 [KO:K05462]
105296443  EFNA3; ephrin-A3 [KO:K05462]
105302235  EFNA2; ephrin-A2 [KO:K05462]
105295466  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
105299104  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
105311595  LOW QUALITY PROTEIN: neurturin [KO:K25414]
105301078  PSPN; persephin [KO:K25416]
105306141  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
105307498  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105302594  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
105291094  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
105300315  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105291441  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105301871  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
105293516  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
105295432  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
105296416  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
105300054  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
105307438  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
105290270  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105293808  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105299436  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105299435  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105293773  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105292132  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
105292131  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105307777  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
105300011  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
105293771  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105300269  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105308731  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
105294337  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
105309193  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X4 [KO:K05126] [EC:2.7.10.1]
105293353  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
105292949  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105309535  SOS2; son of sevenless homolog 2 [KO:K03099]
105305933  HRAS; GTPase HRas isoform X1 [KO:K02833]
105294059  KRAS; GTPase KRas isoform X2 [KO:K07827]
105296550  NRAS; GTPase NRas isoform X1 [KO:K07828]
105301735  RRAS; ras-related protein R-Ras [KO:K07829]
105301479  RRAS2; ras-related protein R-Ras2 [KO:K07830]
105308953  ras-related protein M-Ras isoform X1 [KO:K07831]
105305459  ARAF; serine/threonine-protein kinase A-Raf isoform X8 [KO:K08845] [EC:2.7.11.1]
105291659  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105299021  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105309827  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
105306744  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105293038  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
105289326  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
105304566  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105297153  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
105300455  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
105307369  ribosomal protein S6 kinase alpha-2-like [KO:K04373] [EC:2.7.11.1]
105290495  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
105292768  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
105294032  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
105298070  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105305461  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
105300663  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
105292561  MYC; myc proto-oncogene protein [KO:K04377]
105288466  SRF; serum response factor isoform X1 [KO:K04378]
105299213  FOS; proto-oncogene c-Fos [KO:K04379]
105303449  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
105290479  STMN1; stathmin [KO:K04381]
105288668  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
105288669  PLA2G4F; cytosolic phospholipase A2 zeta isoform X2 [KO:K16342] [EC:3.1.1.4]
105288785  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
105288787  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
105295052  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
105305325  TNF; tumor necrosis factor [KO:K03156]
105303981  IL1A; interleukin-1 alpha [KO:K04383]
105303982  IL1B; interleukin-1 beta [KO:K04519]
105307945  TGFB1; transforming growth factor beta-1 [KO:K13375]
105296163  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
105299206  TGFB3; transforming growth factor beta-3 [KO:K13377]
105295979  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105298727  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
105306481  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
105296245  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
105292451  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
105299797  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105293104  FAS; tumor necrosis factor receptor superfamily member 6 isoform X5 [KO:K04390]
105306974  CD14; monocyte differentiation antigen CD14 [KO:K04391]
105294623  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105311532  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
105301137  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
105290433  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105305700  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105294710  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105298613  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
105300991  DAXX; death domain-associated protein 6 [KO:K02308]
105295639  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
105310642  interleukin-1 receptor-associated kinase 1-like [KO:K04730] [EC:2.7.11.1]
105302526  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
105297485  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
105290063  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
105300252  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
105300424  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
105295887  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
105298074  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
105289440  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
105305632  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
105292946  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
105298724  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X2 [KO:K04407] [EC:2.7.11.1]
105300187  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X3 [KO:K04408] [EC:2.7.11.1]
105297614  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
105310172  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
105298222  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
105300612  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
105297860  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
105298317  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
105299360  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
105297902  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
105294444  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
105297731  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X3 [KO:K04421] [EC:2.7.11.25]
105308820  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
105300213  MAP3K10; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
105302651  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
105307825  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
105290343  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
105290511  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
105289473  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
105297002  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
105305679  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
105289256  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
105304558  TAOK2; serine/threonine-protein kinase TAO2 isoform X2 [KO:K04429] [EC:2.7.11.1]
105291895  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
105291271  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X4 [KO:K04430] [EC:2.7.12.2]
105307700  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
105304165  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
105298936  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
105290007  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
105308290  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
105303314  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X10 [KO:K04436]
105302494  FLNA; filamin-A isoform X1 [KO:K04437]
105289311  CRKL; crk-like protein [KO:K04438]
105291866  CRK; adapter molecule crk isoform X1 [KO:K04438]
105297636  ARRB1; beta-arrestin-1 isoform X2 [KO:K04439]
105291748  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
105288933  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105289628  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
105299978  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105308283  mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
105301035  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105301036  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105289230  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X2 [KO:K04442] [EC:2.7.11.1]
105308925  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
105295137  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
105300805  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
105297857  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
105298511  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
105303020  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
105305747  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
105303436  JUN; transcription factor AP-1 [KO:K04448]
105290195  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
105291226  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
105307377  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
105308374  MAX; protein max isoform X1 [KO:K04453]
105303959  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
105299697  HSPB1; heat shock protein beta-1 [KO:K04455]
105303899  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105300159  RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
105298702  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105308782  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
105301546  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
105303912  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
105296910  PTPN7; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
105299303  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
105308545  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105306817  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105294546  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105299853  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105295122  DUSP7; LOW QUALITY PROTEIN: dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105302795  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105293229  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
105302522  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
105301688  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
105303507  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
105297326  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
105292928  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
105305304  heat shock 70 kDa protein 1-like [KO:K03283]
105307477  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
105305980  MECOM; MDS1 and EVI1 complex locus protein EVI1 [KO:K04462] [EC:2.1.1.367]
105309698  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
105291313  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
105307011  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
105303461  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
105304619  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105301022  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105302532  IKBKG; NF-kappa-B essential modulator [KO:K07210]
105291932  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
105293029  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105309663  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
105297999  RELA; transcription factor p65 [KO:K04735]
105297418  RELB; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Trends Immunol 34:307-16 (2013)
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Related
pathway
pvp04070  Phosphatidylinositol signaling system
pvp04110  Cell cycle
pvp04115  p53 signaling pathway
pvp04210  Apoptosis
pvp04310  Wnt signaling pathway
pvp04668  TNF signaling pathway
KO pathway
ko04010   
LinkDB

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