KEGG   PATHWAY: pvp04020
Entry
pvp04020                    Pathway                                
Name
Calcium signaling pathway - Pteropus vampyrus (large flying fox)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
pvp04020  Calcium signaling pathway
pvp04020

Other DBs
GO: 0019722
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105288337  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
105288426  TFEB; transcription factor EB [KO:K15590]
105288488  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105288600  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
105288660  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
105288737  FGF7; fibroblast growth factor 7 [KO:K04358]
105288773  RYR3; ryanodine receptor 3 [KO:K04963]
105288781  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105288836  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
105288842  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
105288852  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105288866  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2 [KO:K04515] [EC:2.7.11.17]
105288878  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
105288974  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
105288995  [KO:K04198]
105289056  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
105289063  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105289074  MCOLN2; mucolipin-2 [KO:K04993]
105289075  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
105289200  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
105289205  P2RX4; P2X purinoceptor 4 [KO:K05218]
105289207  P2RX7; P2X purinoceptor 7 [KO:K05220]
105289209  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
105289240  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
105289354  ADORA2A; adenosine receptor A2a isoform X1 [KO:K04266]
105289401  NOS1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
105289416  P2RX6; LOW QUALITY PROTEIN: P2X purinoceptor 6 [KO:K05221]
105289441  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
105289761  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
105289813  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
105289863  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
105290127  CALM1; calmodulin-1 [KO:K02183]
105290410  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
105290525  PTAFR; platelet-activating factor receptor isoform X3 [KO:K04279]
105290719  TACR1; substance-P receptor isoform X2 [KO:K04222]
105290959  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
105291058  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
105291094  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
105291157  TRDN; triadin isoform X1 [KO:K23449]
105291172  PLN; cardiac phospholamban [KO:K05852]
105291304  ADORA2B; adenosine receptor A2b [KO:K04267]
105291439  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
105291441  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105291472  ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141]
105291551  EDNRA; endothelin-1 receptor [KO:K04197]
105291625  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
105291722  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
105291808  P2RX1; P2X purinoceptor 1 [KO:K05215]
105291812  P2RX5; P2X purinoceptor 5 isoform X2 [KO:K05219]
105291934  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
105291989  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
105292087  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105292122  FGF9; fibroblast growth factor 9 [KO:K04358]
105292131  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105292181  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
105292199  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105292221  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
105292386  FGF5; fibroblast growth factor 5 [KO:K04358]
105292579  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
105292879  CACNA1E; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
105292901  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
105292913  CALM2; calmodulin-2 isoform X1 [KO:K02183]
105292942  SLC8A1; sodium/calcium exchanger 1 isoform X4 [KO:K05849]
105293021  TACR3; neuromedin-K receptor [KO:K04224]
105293031  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105293045  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
105293064  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
105293094  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
105293232  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
105293259  FGF6; fibroblast growth factor 6 [KO:K04358]
105293279  FGF23; fibroblast growth factor 23 [KO:K22428]
105293381  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
105293408  SMIM6; small integral membrane protein 6 [KO:K26468]
105293418  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
105293469  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
105293516  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
105293648  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
105293685  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
105293771  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105293808  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105293998  VEGFD; vascular endothelial growth factor D [KO:K05449]
105294006  GRPR; gastrin-releasing peptide receptor [KO:K04169]
105294024  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
105294112  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
105294211  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
105294593  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
105294703  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105294948  AGTR1; type-1 angiotensin II receptor [KO:K04166]
105295171  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
105295187  MST1R; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
105295334  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X3 [KO:K05857] [EC:3.1.4.11]
105295395  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X7 [KO:K04854]
105295473  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
105295516  [KO:K05863]
105295521  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105295548  FGF20; fibroblast growth factor 20 [KO:K04358]
105295698  CCKAR; cholecystokinin receptor type A [KO:K04194]
105295757  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
105295781  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
105295874  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
105295966  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
105296030  STIM2; stromal interaction molecule 2 [KO:K18196]
105296040  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
105296083  [KO:K04632]
105296125  [KO:K04161]
105296266  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105296292  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
105296416  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
105296475  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
105296521  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
105296533  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105296547  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105296734  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X2 [KO:K00871] [EC:2.7.11.19]
105296936  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
105297044  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105297298  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
105297322  CALM3; calmodulin-3 [KO:K02183]
105297442  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105297455  SLN; sarcolipin [KO:K22642]
105297702  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105297824  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105297846  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
105297931  CASQ2; calsequestrin-2 [KO:K23445]
105297988  VEGFB; vascular endothelial growth factor B [KO:K16858]
105298078  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
105298101  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
105298203  TNNC2; troponin C, skeletal muscle [KO:K12042]
105298299  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
105298564  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
105298593  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
105298737  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105298795  BDKRB1; B1 bradykinin receptor [KO:K03915]
105298796  BDKRB2; B2 bradykinin receptor [KO:K03916]
105298918  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
105299028  HRH1; histamine H1 receptor [KO:K04149]
105299030  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
105299053  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
105299068  OXTR; oxytocin receptor [KO:K04229]
105299104  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
105299180  [KO:K02183]
105299317  FGF18; fibroblast growth factor 18 [KO:K04358]
105299375  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
105299420  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
105299422  ADRB2; beta-2 adrenergic receptor isoform X1 [KO:K04142]
105299436  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105299441  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
105299444  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105299556  P2RX2; P2X purinoceptor 2 [KO:K05216]
105299581  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105299636  VEGFC; vascular endothelial growth factor C [KO:K05449]
105299709  ORAI2; protein orai-2 [KO:K16057]
105300011  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
105300015  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
105300029  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
105300054  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
105300109  TACR2; substance-K receptor [KO:K04223]
105300150  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
105300178  ADRB3; beta-3 adrenergic receptor [KO:K04143]
105300232  RYR1; ryanodine receptor 1 [KO:K04961]
105300269  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105300298  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
105300315  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105300372  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
105300436  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
105300437  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
105300445  TBXA2R; thromboxane A2 receptor isoform X1 [KO:K04264]
105300538  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
105300627  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
105300650  [KO:K04227]
105300690  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
105300715  CASQ1; calsequestrin-1 [KO:K23468]
105300735  [KO:K04227]
105301042  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105301197  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
105301201  PHKB; phosphorylase b kinase regulatory subunit beta [KO:K07190]
105301250  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
105301286  FGF10; fibroblast growth factor 10 [KO:K04358]
105301449  NTSR1; neurotensin receptor type 1 [KO:K04211]
105301608  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
105301750  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
105301772  SPHK2; LOW QUALITY PROTEIN: sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
105301799  FGF21; fibroblast growth factor 21 [KO:K22429]
105301843  DRD5; D(1B) dopamine receptor [KO:K05840]
105301871  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
105302086  [KO:K04226]
105302096  [KO:K04226]
105302193  F2R; proteinase-activated receptor 1 [KO:K03914]
105302250  FGF22; fibroblast growth factor 22 [KO:K04358]
105302266  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
105302392  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
105302451  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
105302452  [KO:K04634]
105302474  ATP2B3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
105302594  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
105302622  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
105302767  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
105302783  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
105303020  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
105303095  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
105303376  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
105303526  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
105303606  CALML6; calmodulin-like protein 6 [KO:K02183]
105303674  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
105303769  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
105304199  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
105304212  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
105304363  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
105304450  [KO:K04961]
105304518  ORAI3; protein orai-3 [KO:K16058]
105304523  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
105304583  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
105304647  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105304783  P2RX3; P2X purinoceptor 3 [KO:K05217]
105305528  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
105305546  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
105305747  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
105306132  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
105306141  [KO:K04361] [EC:2.7.10.1]
105306348  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
105306725  [KO:K05101] [EC:2.7.10.1]
105307123  [KO:K22603]
105307127  [KO:K22603]
105307194  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
105307287  [KO:K04809]
105307429  [KO:K04992]
105307498  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105307680  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
105307759  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
105307777  [KO:K05096] [EC:2.7.10.1]
105307882  DRD1; D(1A) dopamine receptor [KO:K04144]
105307884  [KO:K04150]
105307885  [KO:K04150]
105307907  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
105308002  [KO:K05863]
105308299  [KO:K08041] [EC:4.6.1.1]
105308501  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
105308507  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
105308762  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
105308818  [KO:K19662] [EC:2.7.11.13]
105308879  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
105308889  FGF16; fibroblast growth factor 16 [KO:K04358]
105309056  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105309096  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
105309193  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X4 [KO:K05126] [EC:2.7.10.1]
105309399  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
105309400  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
105309403  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
105309462  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105309689  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
105309888  [KO:K04358]
105309972  [KO:K14077]
105311212  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
105311363  FGF4; fibroblast growth factor 4 [KO:K04358]
105311523  [KO:K05217]
111728760  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
111740186  MRLN; myoregulin [KO:K22643]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
pvp04010  MAPK signaling pathway
pvp04070  Phosphatidylinositol signaling system
pvp04210  Apoptosis
pvp04720  Long-term potentiation
pvp04730  Long-term depression
KO pathway
ko04020   

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