KEGG   PATHWAY: pvp04510
Entry
pvp04510                    Pathway                                
Name
Focal adhesion - Pteropus vampyrus (large flying fox)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pvp04510  Focal adhesion
pvp04510

Other DBs
GO: 0005925
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105294361  COL1A2; collagen alpha-2(I) chain [KO:K06236]
105295430  COL1A1; collagen alpha-1(I) chain [KO:K06236]
105297573  COL2A1; collagen alpha-1(II) chain [KO:K19719]
105294766  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
105296151  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
105301331  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
105294764  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
105301330  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
105296119  collagen alpha-5(IV) chain isoform X1 [KO:K06237]
105288504  collagen alpha-6(VI) chain [KO:K06238]
105288515  collagen alpha-4(VI) chain-like [KO:K06238]
105305972  collagen alpha-1(VI) chain-like [KO:K06238]
105308836  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
105308677  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
105304051  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
105292803  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
105301451  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
105291179  LAMA2; laminin subunit alpha-2 [KO:K05637]
105296207  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
105292271  LAMA3; laminin subunit alpha-3 isoform X2 [KO:K06240]
105301444  LAMA5; laminin subunit alpha-5 [KO:K06240]
105295219  LAMA4; laminin subunit alpha-4 [KO:K06241]
105300344  LAMB1; laminin subunit beta-1 [KO:K05636]
105302419  LAMB2; laminin subunit beta-2 [KO:K06243]
105302420  LOW QUALITY PROTEIN: laminin subunit beta-2-like [KO:K06243]
105300311  laminin subunit beta-3 [KO:K06244]
105300342  LAMB4; laminin subunit beta-4 [KO:K06245]
105292827  LAMC1; laminin subunit gamma-1 isoform X1 [KO:K05635]
105292869  LAMC2; laminin subunit gamma-2 [KO:K06246]
105298668  LAMC3; laminin subunit gamma-3 [KO:K06247]
105295400  CHAD; chondroadherin [KO:K06248]
105295497  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
105288620  THBS1; thrombospondin-1 [KO:K16857]
105296367  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
105296582  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
105303667  THBS4; thrombospondin-4 [KO:K04659]
105303727  THBS2; thrombospondin-2 [KO:K04659]
105291123  FN1; fibronectin [KO:K05717]
105289571  SPP1; osteopontin [KO:K06250]
105292010  VTN; vitronectin [KO:K06251]
105305336  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
105292688  TNC; tenascin [KO:K06252]
105292895  TNN; tenascin-N [KO:K06252]
105292894  TNR; tenascin-R [KO:K06252]
105296024  VWF; von Willebrand factor [KO:K03900]
105289573  IBSP; bone sialoprotein 2 [KO:K06253]
105307929  ITGA1; integrin alpha-1 [KO:K06480]
105307927  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
105303529  ITGA2B; integrin alpha-IIb [KO:K06476]
105295411  ITGA3; integrin alpha-3 isoform X2 [KO:K06482]
105291916  ITGA4; integrin alpha-4 [KO:K06483]
105302702  ITGA5; integrin alpha-5 [KO:K06484]
105290414  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
105302613  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
105305015  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
105288745  ITGA9; integrin alpha-9 [KO:K06585]
105297781  ITGA10; integrin alpha-10 [KO:K06586]
105310261  ITGA11; integrin alpha-11 [KO:K06587]
105289673  ITGAV; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
105303008  ITGB1; integrin beta-1 [KO:K05719]
105303446  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105293425  ITGB4; integrin beta-4 [KO:K06525]
105297528  ITGB5; integrin beta-5 [KO:K06588]
105291118  ITGB6; integrin beta-6 isoform X4 [KO:K06589]
105302663  ITGB7; integrin beta-7 [KO:K06590]
105293829  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
105294593  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
105298078  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
105297442  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105292199  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105293045  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
105310714  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
105288488  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105297988  VEGFB; vascular endothelial growth factor B [KO:K16858]
105299223  PGF; placenta growth factor isoform X1 [KO:K16859]
105299636  VEGFC; vascular endothelial growth factor C [KO:K05449]
105293998  VEGFD; vascular endothelial growth factor D [KO:K05449]
105295521  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105293808  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105299436  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105290270  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105293771  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105306141  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
105292131  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105307777  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
105300011  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
105300269  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105307498  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105302784  EMP1; epithelial membrane protein 1 [KO:K26255]
105296513  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105297317  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
105303054  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
105302383  RHOA; transforming protein RhoA [KO:K04513]
105297028  DIAPH1; protein diaphanous homolog 1 isoform X2 [KO:K05740]
105292284  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
105295461  ROCK2; LOW QUALITY PROTEIN: rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
105289221  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
105309865  MYL5; myosin light chain 5 isoform X2 [KO:K12753]
105308760  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
105296470  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
105299781  MYL10; LOW QUALITY PROTEIN: myosin regulatory light chain 10 [KO:K12756]
105305242  myosin regulatory light chain 12B [KO:K12757]
105305243  myosin regulatory light polypeptide 9 [KO:K12757]
105304537  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
105289220  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
105299132  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
105309924  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
105301889  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X3 [KO:K06270]
105296949  protein phosphatase 1 regulatory subunit 12B-like [KO:K12329]
105304953  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
105305528  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
105288842  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
105307680  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
105301197  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
105307133  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
105300480  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
105303834  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
105301152  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105294565  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
105301643  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
105292618  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
105300184  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
105308049  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
105306467  TLN1; talin-1 [KO:K06271]
105294314  TLN2; talin-2 [KO:K06271]
105302494  FLNA; filamin-A isoform X1 [KO:K04437]
105299870  FLNB; filamin-B [KO:K27392]
105289271  paxillin isoform X3 [KO:K05760]
105309085  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
105304133  ZYX; zyxin [KO:K06273]
105297337  VASP; vasodilator-stimulated phosphoprotein isoform X6 [KO:K06274]
105288870  VCL; vinculin isoform X1 [KO:K05700]
105307463  uncharacterized protein LOC105307463 [KO:K06275]
105307458  PARVG; gamma-parvin [KO:K06275]
105301472  PARVA; alpha-parvin [KO:K06275]
105303144  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
105303899  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105300159  RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
105298702  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105301304  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105290328  CTNNB1; catenin beta-1 [KO:K02105]
105297702  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105308818  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105309462  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105307748  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105307215  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105307575  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105308956  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
105296605  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105297140  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105299371  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
105293112  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105308212  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
105298133  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
105301110  VAV1; proto-oncogene vav [KO:K05730]
105302942  rho guanine nucleotide exchange factor 25-like [KO:K05730]
105294623  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105311532  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
105301137  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
105297614  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
105310172  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
105301596  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
105300174  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
105299451  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
105288780  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
105290433  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105305354  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X4 [KO:K05726]
105289311  CRKL; crk-like protein [KO:K04438]
105291866  CRK; adapter molecule crk isoform X1 [KO:K04438]
105298681  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
105296884  RAP1A; ras-related protein Rap-1A [KO:K04353]
105302160  RAP1B; ras-related protein Rap-1b [KO:K07836]
105288933  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105289628  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
105299978  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105303436  JUN; transcription factor AP-1 [KO:K04448]
105291659  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105300272  CAV1; caveolin-1 isoform X1 [KO:K06278]
105300273  CAV2; caveolin-2 [KO:K12958]
105299067  CAV3; caveolin-3 [KO:K12959]
105295260  FYN; tyrosine-protein kinase Fyn [KO:K05703] [EC:2.7.10.2]
105296379  SHC1; SHC-transforming protein 1 isoform X3 [KO:K06279]
105302278  SHC2; SHC-transforming protein 2 [KO:K17447]
105300265  SHC3; SHC-transforming protein 3 [KO:K17448]
105288811  SHC4; SHC-transforming protein 4 [KO:K17449]
105293353  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
105292949  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105309535  SOS2; son of sevenless homolog 2 [KO:K03099]
105305933  HRAS; GTPase HRas isoform X1 [KO:K02833]
105299021  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105309827  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
105289326  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
105304566  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105305461  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
105307128  uncharacterized protein LOC105307128 [KO:K04503]
105293261  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105288434  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
105298277  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
105298278  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
105304241  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
105297848  BAD; bcl2-associated agonist of cell death [KO:K02158]
105292717  BCL2; apoptosis regulator Bcl-2 isoform X2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
pvp04010  MAPK signaling pathway
pvp04060  Cytokine-cytokine receptor interaction
pvp04070  Phosphatidylinositol signaling system
pvp04110  Cell cycle
pvp04151  PI3K-Akt signaling pathway
pvp04310  Wnt signaling pathway
pvp04512  ECM-receptor interaction
pvp04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

DBGET integrated database retrieval system