KEGG   PATHWAY: rno00590
Entry
rno00590                    Pathway                                
Name
Arachidonic acid metabolism - Rattus norvegicus (rat)
Class
Metabolism; Lipid metabolism
Pathway map
rno00590  Arachidonic acid metabolism
rno00590

Other DBs
GO: 0019369
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100360601  Cbr1l3; carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
100361492  Cyp2c55; cytochrome P450 2C55 precursor [KO:K07413] [EC:1.14.14.1]
100361547  Cyp2c7l1; cytochrome P450 2C7-like [KO:K07413] [EC:1.14.14.1]
100911718  [KO:K07413] [EC:1.14.14.1]
100912265  Cyp2c66; cytochrome P450 2C42-like isoform X1 [KO:K07413] [EC:1.14.14.1]
100912642  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
102556347  Cbr1l2; carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
103691072  Cyp2b14; cytochrome P450 2B15 [KO:K07412] [EC:1.14.14.1]
103691092  [KO:K07412] [EC:1.14.14.1]
114097  Ltc4s; leukotriene C4 synthase [KO:K00807] [EC:4.4.1.20]
116568  Ggt1; glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
120093077  [KO:K07413] [EC:1.14.14.1]
120093083  Cbr1l1; carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
120098584  [KO:K07413] [EC:1.14.14.1]
120102953  Cyp4a2l1; cytochrome P450, family 4, subfamily a, polypeptide 2 like 1 [KO:K07425] [EC:1.14.14.80]
134483996  [KO:K07413] [EC:1.14.14.1]
134485234  [KO:K07413] [EC:1.14.14.1]
171518  Cyp2c22; cytochrome P450 2C70 precursor [KO:K07413] [EC:1.14.14.1]
171521  Cyp2c13; cytochrome P450 2C13, male-specific [KO:K07413] [EC:1.14.14.1]
192227  Ptgr1; prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
192259  Plb1; phospholipase B1, membrane-associated precursor [KO:K14621] [EC:3.1.1.4 3.1.1.5]
24300  Cyp2b1; cytochrome P450 2B1 precursor [KO:K07412] [EC:1.14.14.1]
24306  Cyp4a2; cytochrome P450 4A2 [KO:K07425] [EC:1.14.14.80]
24653  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
24693  Ptgs1; prostaglandin G/H synthase 1 precursor [KO:K00509] [EC:1.14.99.1]
24886  Tbxas1; thromboxane-A synthase [KO:K01832] [EC:5.3.99.5]
24913  Plaat3; phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
25011  Cyp2c12; cytochrome P450 2C12, female-specific precursor [KO:K07413] [EC:1.14.14.1]
25086  Cyp2e1; cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
25290  Alox5; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
25526  Ptgds; prostaglandin-H2 D-isomerase precursor [KO:K01830] [EC:5.3.99.2]
25527  Ptgis; prostacyclin synthase [KO:K01831] [EC:5.3.99.4]
266604  Alox15b; polyunsaturated fatty acid lipoxygenase ALOX15B [KO:K08022] [EC:1.13.11.33 1.13.11.-]
266674  Cyp4a8; cytochrome P450 4A12 [KO:K07425] [EC:1.14.14.80]
286953  Cyp2b3; cytochrome P450 2B3 precursor [KO:K07412] [EC:1.14.14.1]
287424  Aloxe3; hydroperoxide isomerase ALOXE3 [KO:K18684] [EC:4.2.1.152 5.4.4.7]
287425  Alox12b; arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]
287454  Alox12; polyunsaturated fatty acid lipoxygenase ALOX12 [KO:K00458] [EC:1.13.11.31]
289733  Pla2g3; group 3 secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
291403  Ptgr3; prostaglandin reductase 3 [KO:K07119] [EC:1.3.1.48]
29224  Cbr1; carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
292728  Cyp2b21; cytochrome P450, family 2, subfamily b, polypeptide 21 precursor [KO:K07412] [EC:1.14.14.1]
29277  Cyp2c11; cytochrome P450 2C11 [KO:K07413] [EC:1.14.14.1]
29295  Cyp2b12; cytochrome P450 2B12 precursor [KO:K07412] [EC:1.14.14.1]
29298  Cyp2c7; cytochrome P450 2C7 precursor [KO:K07413] [EC:1.14.14.1]
29328  Gpx4; phospholipid hydroperoxide glutathione peroxidase isoform A precursor [KO:K05361] [EC:1.11.1.12]
29354  Pla2g5; phospholipase A2 group V precursor [KO:K01047] [EC:3.1.1.4]
29359  Pla2g10; group 10 secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
29387  Pla2g2c; group IIC secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
293989  Cyp2c6v1; cytochrome P450 2C6 precursor [KO:K07413] [EC:1.14.14.1]
29526  Pla2g1b; phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
29527  Ptgs2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
29566  Ggt5; glutathione hydrolase 5 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
296091  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
29692  Pla2g2a; phospholipase A2, membrane associated precursor [KO:K01047] [EC:3.1.1.4]
298423  Cyp4a3; cytochrome P450 4A14 [KO:K07425] [EC:1.14.14.80]
298579  Pla2g2d; group IID secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
298581  Pla2g2e; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
299194  Ptgr2; prostaglandin reductase 2 isoform 2 [KO:K13949] [EC:1.3.1.48]
299732  Lta4h; leukotriene A-4 hydrolase [KO:K01254] [EC:3.3.2.6]
303252  Alox12e; polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type [KO:K00458] [EC:1.13.11.31]
304078  Cbr3; carbonyl reductase [NADPH] 3 [KO:K00084] [EC:1.1.1.184]
310848  Cyp2u1; cytochrome P450 2U1 [KO:K07422] [EC:1.14.14.80]
311341  Pla2g4b; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
311865  Ptges2; prostaglandin E synthase 2 [KO:K05309] [EC:5.3.99.3]
313373  Cyp2j10; cytochrome P450, family 2, subfamily j, polypeptide 10 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
313375  Cyp2j3; cytochrome P450 2J3 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
360426  Pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform 1 [KO:K16343] [EC:3.1.1.4]
361267  Akr1c15; aldo-keto reductase family 1 member C15 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
361523  Cyp2b2; cytochrome P450 2B2 precursor [KO:K07412] [EC:1.14.14.1]
362039  Pla2g12a; group XIIA secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
362676  Prxl2b; prostamide/prostaglandin F synthase [KO:K15717] [EC:1.11.1.20]
362809  Ptges3; prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
367415  Pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X2 [KO:K01047] [EC:3.1.1.4]
367808  Ptges3l1; prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
499353  Cyp2c24; cytochrome P450, family 2, subfamily c, polypeptide 24 precursor [KO:K07413] [EC:1.14.14.1]
502969  Cyp2j16; cytochrome P450 2J4-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
50549  Cyp4a1; cytochrome P450 4A10 [KO:K07425] [EC:1.14.14.80]
58962  Hpgds; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
59103  Ptges; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]
65030  Ephx2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
65210  Cyp2j4; cytochrome P450 2J4 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
685222  Cyp2b15; cytochrome P450 2B15 precursor [KO:K07412] [EC:1.14.14.1]
688320  Cbr2; carbonyl reductase [NADPH] 2 [KO:K00081] [EC:1.1.1.184]
688321  Cbr2l1; carbonyl reductase [NADPH] 2-like isoform X1 [KO:K00081] [EC:1.1.1.184]
690388  Pla2g2f; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
691810  Pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
691905  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
691907  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
79242  Hpgd; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
81639  Alox15; polyunsaturated fatty acid lipoxygenase ALOX15 [KO:K00460] [EC:1.13.11.33]
83790  Cyp2c23; cytochrome P450 2C23 [KO:K07413] [EC:1.14.14.1]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
rno00591  Linoleic acid metabolism
KO pathway
ko00590   

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