KEGG   PATHWAY: tmu04728
Entry
tmu04728                    Pathway                                
Name
Dopaminergic synapse - Trichechus manatus latirostris (Florida manatee)
Description
Dopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning and memory, and endocrine regulation. Once released from presynaptic axonal terminals, DA interacts with at least five receptor subtypes in the central nervous system (CNS), which have been divided into two groups: the D1-like receptors (D1Rs), comprising D1 and D5 receptors, both positively coupled to adenylyl cyclase and cAMP production, and the D2-like receptors (D2Rs), comprising D2, D3, and D4 receptors, whose activation results in inhibition of adenylyl cyclase and suppression of cAMP production. In addition, D1Rs and D2Rs modulate intracellular Ca2+ levels and a number of Ca2+ -dependent intracellular signaling processes. Through diverse cAMP- and Ca2+-dependent and - independent mechanisms, DA influences neuronal activity, synaptic plasticity, and behavior. Presynaptically localized D2Rs regulate synthesis and release of DA as the main autoreceptor of the dopaminergic system.
Class
Organismal Systems; Nervous system
Pathway map
tmu04728  Dopaminergic synapse
tmu04728

Other DBs
GO: 0001963
Organism
Trichechus manatus latirostris (Florida manatee) [GN:tmu]
Gene
101347132  tyrosine 3-monooxygenase isoform X1 [KO:K00501] [EC:1.14.16.2]
101348227  aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
101351670  synaptic vesicular amine transporter isoform X1 [KO:K08155]
101346156  LOW QUALITY PROTEIN: chromaffin granule amine transporter [KO:K08155]
101349260  D(1A) dopamine receptor [KO:K04144]
101357326  D(1B) dopamine receptor [KO:K05840]
101361599  neuron-specific vesicular protein calcyon [KO:K15493]
101347192  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
101352296  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101349967  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101344242  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
101361375  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
101346534  inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
101356404  inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101354392  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101347126  calmodulin-2 isoform X2 [KO:K02183]
101361121  LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
101358846  LOW QUALITY PROTEIN: calmodulin-like protein 3 [KO:K02183]
101346240  calmodulin-3 [KO:K02183]
101358487  calmodulin [KO:K02183]
101346473  calmodulin-like protein 4 [KO:K02183]
101359111  calmodulin-like [KO:K02183]
101359224  calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
101353435  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
101353082  calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
101361961  calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
101353424  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
101357894  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101347440  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
101348250  protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
101356454  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101351254  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101357016  proto-oncogene c-Fos [KO:K04379]
101361837  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632]
101348142  neuroendocrine secretory protein 55 [KO:K04632]
101346169  guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
101346041  adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101342638  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101348995  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101356881  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101359884  cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
101345357  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101355964  cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
101349137  cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
101344337  cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
101344076  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101352607  cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101345798  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
101359783  cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
101352466  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101347350  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101361614  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101361872  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101351734  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101351967  mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
101343546  mitogen-activated protein kinase 8 isoform X4 [KO:K04440] [EC:2.7.11.24]
101353914  protein phosphatase 1 regulatory subunit 1B [KO:K15494]
101346316  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101344889  serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101345455  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101344289  sodium channel protein type 1 subunit alpha [KO:K04833]
101360945  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101357085  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101341628  voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
101351661  voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101354503  G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
101359245  G protein-activated inward rectifier potassium channel 2 [KO:K05000]
101356093  G protein-activated inward rectifier potassium channel 3 [KO:K05002]
101341082  G protein-activated inward rectifier potassium channel 4 [KO:K04999]
101353801  D(3) dopamine receptor isoform X1 [KO:K04146]
101352591  D(4) dopamine receptor [KO:K04147]
101341952  guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
101346092  guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
101343271  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101357613  guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
101350742  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101345319  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101355136  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101348280  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101341327  guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
101352593  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
101342107  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101357541  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101345326  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
101347845  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X2 [KO:K04543]
111821467  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
111819711  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
101341777  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101351188  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111819060  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101351136  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101342034  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101360148  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101349901  D(2) dopamine receptor isoform X1 [KO:K04145]
101354945  beta-arrestin-1 [KO:K04439]
101341907  beta-arrestin-2 isoform X2 [KO:K04439]
101358337  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101350333  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
101344236  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3 [KO:K03456]
101347357  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101347198  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
101343363  protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
101352293  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
101358479  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
101356463  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
101353925  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
101360090  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
101349860  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
101345308  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
101353776  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
101350461  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4 [KO:K11584]
101355704  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
101360493  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101356099  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101350197  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101361052  glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
101349186  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101353799  glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
101340402  glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101351830  glutamate receptor 1 isoform X1 [KO:K05197]
101358855  glutamate receptor 2 isoform X1 [KO:K05198]
101345464  glutamate receptor 3 isoform X1 [KO:K05199]
101354195  glutamate receptor 4 [KO:K05200]
101348254  kinesin heavy chain isoform X1 [KO:K10396]
101359636  kinesin heavy chain isoform X1 [KO:K10396]
101345488  kinesin-1 heavy chain isoform X1 [KO:K10396]
101347694  circadian locomoter output cycles protein kaput [KO:K02223] [EC:2.3.1.48]
101353204  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X4 [KO:K02296]
101341243  sodium-dependent dopamine transporter [KO:K05036]
101360324  amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
101351235  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
101346549  catechol O-methyltransferase isoform X2 [KO:K00545] [EC:2.1.1.6]
105756588  transmembrane O-methyltransferase homolog [KO:K00545] [EC:2.1.1.6]
Compound
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00238  Potassium cation
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C01161  3,4-Dihydroxyphenylacetate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C03758  Dopamine
C05582  Homovanillate
C05587  3-Methoxytyramine
Reference
PMID:21303898
  Authors
Beaulieu JM, Gainetdinov RR
  Title
The physiology, signaling, and pharmacology of dopamine receptors.
  Journal
Pharmacol Rev 63:182-217 (2011)
DOI:10.1124/pr.110.002642
Reference
PMID:15521361
  Authors
Neve KA, Seamans JK, Trantham-Davidson H
  Title
Dopamine receptor signaling.
  Journal
J Recept Signal Transduct Res 24:165-205 (2004)
DOI:10.1081/RRS-200029981
Reference
PMID:17408758
  Authors
Surmeier DJ, Ding J, Day M, Wang Z, Shen W
  Title
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.
  Journal
Trends Neurosci 30:228-35 (2007)
DOI:10.1016/j.tins.2007.03.008
Reference
PMID:20224735
  Authors
Knab AM, Lightfoot JT
  Title
Does the difference between physically active and couch potato lie in the dopamine system?
  Journal
Int J Biol Sci 6:133-50 (2010)
DOI:10.7150/ijbs.6.133
Reference
PMID:10433257
  Authors
Greengard P, Allen PB, Nairn AC
  Title
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.
  Journal
Neuron 23:435-47 (1999)
DOI:10.1016/S0896-6273(00)80798-9
Reference
PMID:15590733
  Authors
Hu XT, Dong Y, Zhang XF, White FJ
  Title
Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons.
  Journal
J Neurophysiol 93:1406-17 (2005)
DOI:10.1152/jn.00771.2004
Reference
PMID:17349698
  Authors
Beaulieu JM, Gainetdinov RR, Caron MG
  Title
The Akt-GSK-3 signaling cascade in the actions of dopamine.
  Journal
Trends Pharmacol Sci 28:166-72 (2007)
DOI:10.1016/j.tips.2007.02.006
Reference
PMID:19138563
  Authors
De Mei C, Ramos M, Iitaka C, Borrelli E
  Title
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.
  Journal
Curr Opin Pharmacol 9:53-8 (2009)
DOI:10.1016/j.coph.2008.12.002
Reference
PMID:15381316
  Authors
Seamans JK, Yang CR
  Title
The principal features and mechanisms of dopamine modulation in the prefrontal cortex.
  Journal
Prog Neurobiol 74:1-58 (2004)
DOI:10.1016/j.pneurobio.2004.05.006
Reference
PMID:18353279
  Authors
Yao WD, Spealman RD, Zhang J
  Title
Dopaminergic signaling in dendritic spines.
  Journal
Biochem Pharmacol 75:2055-69 (2008)
DOI:10.1016/j.bcp.2008.01.018
Reference
PMID:20727368
  Authors
Li YC, Gao WJ
  Title
GSK-3beta activity and hyperdopamine-dependent behaviors.
  Journal
Neurosci Biobehav Rev 35:645-54 (2011)
DOI:10.1016/j.neubiorev.2010.08.001
Reference
PMID:15292232
  Authors
Tang TS, Bezprozvanny I
  Title
Dopamine receptor-mediated Ca(2+) signaling in striatal medium spiny neurons.
  Journal
J Biol Chem 279:42082-94 (2004)
DOI:10.1074/jbc.M407389200
Reference
PMID:12967774
  Authors
Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS
  Title
Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.
  Journal
Trends Pharmacol Sci 24:486-92 (2003)
DOI:10.1016/S0165-6147(03)00232-3
Reference
PMID:9457173
  Authors
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG
  Title
Dopamine receptors: from structure to function.
  Journal
Physiol Rev 78:189-225 (1998)
DOI:10.1152/physrev.1998.78.1.189
Reference
PMID:19251795
  Authors
Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ
  Title
Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?
  Journal
Eur Respir J 33:468-80 (2009)
DOI:10.1183/09031936.00056908
Related
pathway
tmu00350  Tyrosine metabolism
tmu04020  Calcium signaling pathway
tmu04721  Synaptic vesicle cycle
tmu04724  Glutamatergic synapse
tmu05012  Parkinson disease
KO pathway
ko04728   
LinkDB

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