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ENTRY	nt06266
Name	Non-small cell lung cancer
Category	Disease view; Cancer
Pathway	hsa05223 Non-small cell lung cancer
Disease	H00014 Non-small cell lung cancer
Display	drug-target relation   disease type

N00001    EGF → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1 N10005        (Gefitinib,Erlotinib,Afatinib,Dacomitinib) ⊥ N10006        Osimertinib ⊥ N00014        EGFR* → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1 N00041        EGFR* → GRB2 → SOS → RAS → RAF → MEK → ERK N10009        (Trastuzumab,Trastuzumab_emtansine,Pertuzumab,Lapatinib,Neratinib,Tucatinib,Margetuximab) ⊥ N00022    EGF → (ERBB2*+EGFR) → GRB2 → SOS → RAS → RAF → MEK → ERK N10025                Selpercatinib,Pralsetinib ⊥ N00008                RET* → RAS → RAF → MEK → ERK N10003                Crizotinib ⊥ N10004                (Alectinib,Ceritinib,Brigatinib,Lorlatinib) ⊥ N00007                EML4-ALK → RAS → RAF → MEK → ERK → CCND1 N10027                    Sotorasib ⊥ N00012                    (KRAS*,NRAS*) → RAF → MEK → ERK → CCND1 N00216    HGF → MET → GRB2 → SOS → RAS → RAF → MEK → ERK N10024        (Capmatinib,Tepotinib) ⊥ N01062        MET* → GRB2 → SOS → RAS → RAF → MEK → ERK   N00023    EGF → EGFR → PLCG → IP3 → (Ca2+,DAG) → PKC → RAF → MEK → ERK → CCND1 N10005        (Gefitinib,Erlotinib,Afatinib,Dacomitinib) ⊥ N10006        Osimertinib ⊥ N00024        EGFR* → PLCG → IP3 → (Ca2+,DAG) → PKC → RAF → MEK → ERK → CCND1 N10003        Crizotinib ⊥ N10004        (Alectinib,Ceritinib,Brigatinib,Lorlatinib) ⊥ N00025        EML4-ALK → PLCG → IP3 → (Ca2+,DAG) → PKC → RAF → MEK → ERK → CCND1   N00033    EGF → EGFR → PI3K → PIP3 → AKT ⊣ BAD N10005        (Gefitinib,Erlotinib,Afatinib,Dacomitinib) ⊥ N10006        Osimertinib ⊥ N00036        EGFR* → PI3K → PIP3 → AKT ⊣ BAD N10003        Crizotinib ⊥ N10004        (Alectinib,Ceritinib,Brigatinib,Lorlatinib) ⊥ N00047        EML4-ALK → PI3K → PIP3 → AKT ⊣ BAD N10027        Sotorasib ⊥ N00032        (KRAS*,NRAS*) → PI3K → PIP3 → AKT ⊣ BAD N00043    HGF → MET → GAB1 → PI3K → PIP3 → AKT ⊣ BAD N10024        (Capmatinib,Tepotinib) ⊥ N01063        MET* → GAB1 → PI3K → PIP3 → AKT → MTOR   N00096    EGF → EGFR → GRB2 → SOS → RAS → (RASSF1+RASSF5) → STK4 N00097                    RAS ⌿ (RASSF1*+RASSF5) ⌿ STK4   N00053    Cytokine → Receptor → JAK → STAT ⇒ PIM1 N10003        Crizotinib ⊥ N10004        (Alectinib,Ceritinib,Brigatinib,Lorlatinib) ⊥ N00105        EML4-ALK → JAK3 → STAT3,STAT5   N00066    CDKN2A ⊣ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00070                CDKN2A* ⌿ (CCND+CDK4/6) → RB1 ⌿ E2F   N00115    TP53* ⌿ (CDKN1A,GADD45,BAX..