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ENTRY	nt06160
Name
Display	drug-target relation   disease type

N00390    EGF → EGFR → PI3K → PIP3 → AKT → IKK → NFKBIA → NFKB N00501        TAX → PI3K N00220            PTEN ⊣ PIP3 → AKT N00502    TAX ⊣ DLG1 → PTEN N00063    TGFB → (TGFBR2+TGFBR1) → (SMAD2,SMAD3) = SMAD4 N00507        TAX ⊣ (SMAD2,SMAD3) N00053    Cytokine → Receptor → JAK → STAT ⇒ PIM1 N00491    P12 → IL2RB/G → JAK1/3 → STAT5 ⇒ IL2 N00487    IGH → (LYN,SYK) → (BTK,BLNK) → PLCG2 → IP3 → Ca2+ → CALM = CN → NFAT N00490                P12 = (CALR,CANX) → Ca2+ N00446    TNF → TNFRSF1A → (RIPK1+TRADD+TRAF2.. → (TAK1+TAB1/2) → MKK4/7 → JNK → AP1 N00503                    TAX → (MAPK8,MAPK9,MAPK1.. → JUN ⇒ MMP7 N00151    TNF → TNFRSF1A → (RIPK1+TRADD+TRAF2.. → (TAB1/2/3+TAK1) → IKK → NFKBIA → NFKB N00504            TAX → IKK → NFKBIA → NFKB N00505    CD40LG → CD40 → (TRAF2+TRAF3) → NIK → IKKA → (NFKB2+RELB) N00506            TAX = IKBKG → IKKA → (NFKB2+RELB) N00363    TAP1/2 = TAPBP = (PDIA3+CALR) → (MHCI+B2M) N00492            P12 ⊣ (MHCI+B2M) N00069                CDKN2A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00494            TAX ⊣ CDKN2A N00090        (MYC+MAX) ⊣ ZBTB17 ⇒ CDKN2B ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00495            TAX ⊣ CDKN2B N00499    (ATM,ATR) → CHEK1 → TP53 ⇒ CDKN1A ⊣ (CDK1+CCNB) N00500    TAX ⊣ CHEK1 N00493        MAD1L1 → (MAD2L1/2+BUB1B+BU.. ⊣ (ANAPC+CDC20) ⊣ PTTG ⊣ ESPL1 N00222    TAX ⊣ MAD1L1 N00221            TAX → (ANAPC+CDC20) ⊣ PTTG ⊣ ESPL1 N00489    P30II → (MYC+TRRAP+KAT5) ⇒ CCND2 N00497        TAX ⊣ TP53 ⇒ CDKN1A ⊣ (CDK2+CCNE) → RB1 ⌿ E2F N00498            TAX ⊣ CDKN1A ⊣ (CDK2+CCNE) → RB1 ⌿ E2F N00508    TAX → NFYB ⇒ MHCII N00509    TAX → SRF ⇒ (FOS,FOSL1,EGR1,EG.. N00510    TAX → CREB3 ⇒ CCND1 N00511    TAX ⊣ E47 ⇒ (POLB,LCK,BAX,CDKN.. N00512    TAX ⊣ MYC ⇒ TERT