KEGG    Network variation - JAK-STAT signaling
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ENTRYnt06518
NameJAK-STAT signaling
CategoryPathway view; Signal transduction
Pathwayhsa04630 JAK-STAT signaling pathway
Display drug-target relation   disease type
N01554    (IL2,IL4,IL7,IL9,I..((IL2RG+IL2RB+(IL2..(JAK1+JAK3)(STAT1,STAT3,STAT5..
    IMD63   IL2RB*
    SCID/IMD6   IL2RG*
    SCID   IL7R*
    SCID     JAK3*
N00491    HTLV-1 P12IL2RB/GJAK1/3STAT5IL2
N00486    EBV   LMP1JAK3(STAT3+STAT1)
 
N01804    (IL3/5,CSF2)(IL3RA,IL5RA,CSF2R..JAK2STAT5
    SMDP4   CSF2RA*
    SMDP5   CSF2RB*
 
N01556    (IL6,IL11,IL13,IL2..((IL6ST+(IL6R,IL11..(JAK1+JAK2+TYK2)(STAT1,STAT3,STAT6..
    CISS2 CLCF1*
    HIES4/STWS2   IL6ST*
    HIES5   IL6R*
    PLCA1   OSMR*
    PLCA2   IL31RA*
    STWS1   LIFR*
    AIIDE     JAK1*
    HIES1       STAT3*
    ADMIO1       STAT3*
    HIES6       STAT6*
N00181    KSHV vIL6IL6STJAK2STAT3
N00548    HBV     XSTAT3
 
N00415    (IL10,IL19,IL20,IL..((IL10RB+(IL10RA,I..(JAK1+TYK2)STAT3
    IBD28   IL10RA*
    IBD25   IL10RB*
N00416    HCMV vIL10IL10RJAK1STAT3
 
N01557    (IL12,IL23A)((IL12RB1+IL12RB2)..(JAK2+TYK2)(STAT3,STAT4)
    IMD29 IL12B*
    IMD30   IL12RB1*
    IBD17   IL23R*
 
   D1
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N01555    (EPO,GH,PRL,THPO,C..(EPOR,GHR,PRLR,MPL..JAK2(STAT5A,STAT5B,STA..
    THCYT1 THPO*
    ECYT5 EPO*
    IGHD1 GH*
    LEPD LEP*
    THCYT2/MF   MPL*
    ECYT1   EPOR*
    Laron syndrome   GHR*
    SCN7   CSF3R*
    LEPRD   LEPR*
    HPRL   PRLR*
    THCYT3/ECYT1/MF     JAK2*
    GHISID       STAT5B*
 
N01558    (IFNA,IFNB1,IFNW1,..(IFNAR1+IFNAR2)(JAK1+TYK2)(STAT1+STAT2)=IRF9
    IMD45   IFNAR2*
    IMD44       STAT2*
    PTORCH3       STAT2*
    IMD65         IRF9*
N01560    USP18(IFNAR2,STAT2)
    PTORCH2 USP18*
 
N01559    IFNG(IFNGR1,IFNGR2)(JAK1+JAK2)(STAT1,STAT3)(IL27,IFNA,IFNG)
    IMD27   IFNGR1*
    IMD28   IFNGR2*
    IMD31/CANDF7       STAT1*

Disease nameDisease category
IMD63H02525Disorders of innate immunityImmune system disease
SCID/IMD6H00091T-B+Severe combined immunodeficiencyPrimary immunodeficiency
H00093Combined immunodeficiencyPrimary immunodeficiency
SCIDH00091T-B+Severe combined immunodeficiencyPrimary immunodeficiency
HTLV-1H00009Adult T-cell leukemiaCancer
EBVH00008Burkitt lymphomaCancer
H00007Hodgkin lymphomaCancer
H00054Nasopharyngeal cancerCancer
SMDP4H01122Congenital pulmonary alveolar proteinosisRespiratory system disease
SMDP5H01122Congenital pulmonary alveolar proteinosisRespiratory system disease
CISS2H00935Cold-induced sweating syndromeCongenital malformation
HIES4/STWS2H01968Hyper-IgE syndromeImmune system disease
H00462Stuve-Wiedemann syndromeCongenital malformation
HIES5H01968Hyper-IgE syndromeImmune system disease
PLCA1H01217Primary localized cutaneous amyloidosisSkin disease
PLCA2H01217Primary localized cutaneous amyloidosisSkin disease
STWS1H00462Stuve-Wiedemann syndromeCongenital malformation
AIIDEH02537Autoinflammation, immune dysregulation, and eosinophiliaImmune system disease
HIES1H01968Hyper-IgE syndromeImmune system disease
ADMIO1H02540Infantile-onset multisystem autoimmune diseaseImmune system disease
HIES6H01968Hyper-IgE syndromeImmune system disease
KSHVH00041Kaposi sarcomaCancer
HBVH00048Hepatocellular carcinomaCancer
IBD28H01227Inflammatory bowel disease (IBD)Immune system disease
IBD25H01227Inflammatory bowel disease (IBD)Immune system disease
HCMVH00368Cytomegalovirus infectionViral infectious disease
IMD29H00089IFN-gamma/IL-12 axisPrimary immunodeficiency
IMD30H00089IFN-gamma/IL-12 axisPrimary immunodeficiency
IBD17H01227Inflammatory bowel disease (IBD)Immune system disease
THCYT1H01612Essential thrombocythemiaHematologic disease
ECYT5 H00236Congenital polycythemiaHematologic disease
IGHD1H02035Isolated growth hormone deficiencyEndocrine and metabolic disease
LEPDH02059Leptin deficiencyEndocrine and metabolic disease
THCYT2/MFH01612Essential thrombocythemiaHematologic disease
H01605MyelofibrosisCancer
ECYT1H00236Congenital polycythemiaHematologic disease
Laron syndromeH02037Laron syndromeEndocrine and metabolic disease
SCN7H00100Neutropenic disordersPrimary immunodeficiency
LEPRDH02060Leptin receptor deficiencyEndocrine and metabolic disease
HPRLH01388HyperprolactinemiaEndocrine and metabolic disease
THCYT3/ECYT1/MFH01612Essential thrombocythemiaHematologic disease
H00236Congenital polycythemiaHematologic disease
H01605MyelofibrosisCancer
GHISIDH00931Growth hormone insensitivity with immunodeficiencyEndocrine and metabolic disease
IMD45H02525Disorders of innate immunityImmune system disease
IMD44H02525Disorders of innate immunityImmune system disease
PTORCH3H00840Pseudo-TORCH syndromeCongenital malformation
IMD65H02525Disorders of innate immunityImmune system disease
PTORCH2H00840Pseudo-TORCH syndromeCongenital malformation
IMD27H00089IFN-gamma/IL-12 axisPrimary immunodeficiency
IMD28H00089IFN-gamma/IL-12 axisPrimary immunodeficiency
IMD31/CANDF7H00089IFN-gamma/IL-12 axisPrimary immunodeficiency
H01109Chronic mucocutaneous candidiasisImmune system disease


Drug name
D1D03297Mecasermin (USAN/INN)