KEGG    Network variation - Complement cascade
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ENTRYnt06513
NameComplement cascade
CategoryPathway view; Innate immunity
Pathwayhsa04610
DiseaseH00102 Classic complement pathway component defects
H00105 Mannose-binding lectin pathway component defects
H00104 Alternative complement pathway component defects
H00103 Late complement pathway defects
H00106 Complement regulatory protein defects
Display drug-target relation   disease type
N01487   
    C4a deficiency
    C4b deficiency
    C2 deficiency/ARMD14
    C1qa deficiency
    C1qb deficiency
    C1qc deficiency
    C1r deficiency/EDSPD1
    C1s deficiency/EDSPD2
N01314    SARS-CoV-2
N00213    KSHV
 
N01491   
    LCAPD1
    LCAPD2
    LCAPD3
    3MC1
    3MC2
    3MC3
N01312    SARS-CoV-2
 
N01489   
    C3 deficiency/ARMD9/AHUS5
N00589    HSV
 
N01493   
    CFB deficiency/ARMD14/AHUS4
   
N01494   
    CFP deficiency
 
N01490   
    C5D
    C6D
    C7D
    C8D1
    C8D2
    C9D/ARMD15
N01505   
    CD59 deficiency
 
N01495   
N01527    KSHV
N01496   
    CFH deficiency/C3G1/BLD/ARMD4/AHUS1
    CD55 deficiency
    CFI deficiency/C3G2/ARMD13/AHUS3
    AHUS2
N01528    KSHV
N01504   
    ARMD1/AHUS1
    ARMD1/AHUS1
    C3G3
 
N01520   
    C1NH deficiency

C4a deficiencyH00102Classic complement pathway component defects
C4b deficiencyH00102Classic complement pathway component defects
C2 deficiencyH00102Classic complement pathway component defects
ARMD14H00821Age-related macular degeneration
C1qa deficiencyH00102Classic complement pathway component defects
C1qb deficiencyH00102Classic complement pathway component defects
C1qc deficiencyH00102Classic complement pathway component defects
C1r deficiencyH00102Classic complement pathway component defects
EDSPD1H02240Ehlers-Danlos syndrome periodontal type
C1s deficiencyH00102Classic complement pathway component defects
EDSPD2H02240Ehlers-Danlos syndrome periodontal type
SARS-CoV-2H02398COVID-19
KSHVH00041Kaposi sarcoma
LCAPD1H00105Mannose-binding lectin pathway component defects
LCAPD2H00105Mannose-binding lectin pathway component defects
LCAPD3H00105Mannose-binding lectin pathway component defects
3MC1H018873MC syndrome
3MC2H018873MC syndrome
3MC3H018873MC syndrome
C3 deficiencyH00102Classic complement pathway component defects
ARMD9H00821Age-related macular degeneration
AHUS5H01434Atypical hemolytic uremic syndrome
HSVH00365Herpes simplex virus infection
CFB deficiencyH00104Alternative complement pathway component defects
AHUS4H01434Atypical hemolytic uremic syndrome
CFP deficiencyH00104Alternative complement pathway component defects
C5DH00103Late complement pathway defects
C6DH00103Late complement pathway defects
C7DH00103Late complement pathway defects
C8D1H00103Late complement pathway defects
C8D2H00103Late complement pathway defects
C9DH00103Late complement pathway defects
ARMD15H00821Age-related macular degeneration
CD59 deficiencyH00106Complement regulatory protein defects
CFH deficiencyH00104Alternative complement pathway component defects
C3G1H02579C3 glomerulopathy
BLDH02108Basal laminar drusen
ARMD4H00821Age-related macular degeneration
AHUS1H01434Atypical hemolytic uremic syndrome
CD55 deficiencyH00106Complement regulatory protein defects
CFI deficiencyH00106Complement regulatory protein defects
C3G2H02579C3 glomerulopathy
ARMD13H00821Age-related macular degeneration
AHUS3H01434Atypical hemolytic uremic syndrome
AHUS2H01434Atypical hemolytic uremic syndrome
ARMD1H00821Age-related macular degeneration
C3G3H02579C3 glomerulopathy
C1NH deficiencyH00106Complement regulatory protein defects